Search filters

List of works by Edith Sim

31P nuclear magnetic resonance studies of cell membranes labelled with phosphonium phosphatidylcholine

scientific article published on July 15, 1977

A fragment consisting of the first 204 amino-terminal amino acids of human arylamine N-acetyltransferase one (NAT1) and the first transacetylation step of catalysis

scientific article published on 01 January 1997

A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages

scientific journal article

A method for genotyping murine arylamine N-acetyltransferase type 2 (NAT2): a gene expressed in preimplantation embryonic stem cells encoding an enzyme acetylating the folate catabolite p-aminobenzoylglutamate

scientific article published on 01 September 1999

A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1

scientific article (publication date: 2013)

A novel mechanism for azoreduction

scientific article

A possible relationship between N-acetyl transferase and folate metabolism ⬇️

scientific article published on 01 August 1995

Acetohydroxamate, a urease inhibitor, inhibits the covalent binding reaction of complement proteins C3 and C4.

scientific article

Acetylation of arylamines by the placenta ⬇️

scientific article published on 01 October 1997

Acetylation status is associated with serological changes but not clinically significant disease in patients receiving procainamide

scientific article published on 01 August 1999

Activation of nitrofurazone by azoreductases: multiple activities in one enzyme

scientific article

An approach to identifying novel substrates of bacterial arylamine N-acetyltransferases

scientific article published in April 2003

An update on genetic, structural and functional studies of arylamine N-acetyltransferases in eucaryotes and procaryotes

scientific article

Analysis of C3-receptor activity on human B-lymphocytes and isolation of the complement receptor type 2 (CR2).

scientific article published on November 1984

Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase

scientific article published on 24 December 2010

Arylamine N-Acetyltransferases – from Drug Metabolism and Pharmacogenetics to Identification of Novel Targets for Pharmacological Intervention

scientific article published on January 1, 2012

Arylamine N-acetyl transferase in mice

scientific article published on May 1, 1992

Arylamine N-acetyltransferase

scientific article published on May 1, 1992

Arylamine N-acetyltransferase 1 expression in breast cancer cell lines: a potential marker in estrogen receptor-positive tumors

scientific article published on February 2008

Arylamine N-acetyltransferase 2 expression in the developing heart

scientific journal article

Arylamine N-acetyltransferase activity in human cultured cell lines

scientific article published on September 1993

Arylamine N-acetyltransferase from fast (C57BL6) and slow (A/J) N-acetylating strains of mice

scientific article published in February 1990

Arylamine N-acetyltransferase in Balb/c mice: identification of a novel mouse isoenzyme by cloning and expression in vitro

scientific journal article

Arylamine N-acetyltransferase in erythrocytes of cystic fibrosis patients

scientific article published on 01 April 1996

Arylamine N-acetyltransferase in human red blood cells

scientific article published on September 25, 1992

Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target

scientific article published on 26 April 2004

Arylamine N-acetyltransferase of Mycobacterium tuberculosis is a polymorphic enzyme and a site of isoniazid metabolism.

scientific article published in October 2001

Arylamine N-acetyltransferase type 2 (NAT2), chromosome 8 aneuploidy, and identification of a novel NAT1 cosmid clone: an investigation in bladder cancer by interphase FISH.

scientific article published in August 1999

Arylamine N-acetyltransferase-1 is highly expressed in breast cancers and conveys enhanced growth and resistance to etoposide in vitro.

scientific article published on September 2003

Arylamine N-acetyltransferases - of mice, men and microorganisms

scientific article

Arylamine N-acetyltransferases in mycobacteria

scientific article published on July 2008

Arylamine N-acetyltransferases.

scientific article published on April 2007

Arylamine N-acetyltransferases: a pharmacogenomic approach to drug metabolism and endogenous function

scientific article

Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery

scientific article

Arylamine N-acetyltransferases: from structure to function

scientific article published on 01 January 2008

Arylamine N-acetyltransferases: structural and functional implications of polymorphisms.

scientific article published on 12 September 2008

Arylarnine N-acetyltransferase as a potential biornarker in bladder cancer: fluorescent in situ hybridization and irnmunohistochernistry studies

scientific article published in January 1996

Association of metabolic gene polymorphisms with tobacco consumption in healthy controls

scientific article published in June 2004

Autolytic fragmentation of complement components C3 and C4 under denaturing conditions, a property shared with α 2-macroglobulin ⬇️

scientific article published on January 1, 1981

Binding of fluid-phase complement components C3 and C3b to human lymphocytes ⬇️

scientific article published on September 15, 1981

Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis.

scientific article published in March 2005

Changes in consensus arylamine N-acetyltransferase gene nomenclature

scientific article published on April 2008

Characterisation of CpG methylation in the upstream control region of mouse Nat2: evidence for a gene-environment interaction in a polymorphic gene implicated in folate metabolism

scientific article published on 21 December 2009

Characterisation of a putative AraC transcriptional regulator from Mycobacterium smegmatis

scientific article published on December 2014

Characterization of a Carbon-Carbon Hydrolase from Mycobacterium tuberculosis Involved in Cholesterol Metabolism

scientific article

Characterization of an oxidoreductase from the arylamine N-acetyltransferase operon in Mycobacterium smegmatis

scientific article

Characterization of the putative operon containing arylamine N-acetyltransferase (nat) in Mycobacterium bovis BCG.

scientific article published in January 2006

ChemInform Abstract: Synthesis of Arabino Glycosyl Triazoles as Potential Inhibitors of Mycobacterial Cell Wall Biosynthesis

scientific article published on 7 April 2009

Chromosomal localization of human genes for arylamine N-acetyltransferase

scientific article published on February 1994

Chromosome mapping of the genes for murine arylamine N-acetyltransferases (NATs), enzymes involved in the metabolism of carcinogens: identification of a novel upstream noncoding exon for murine Nat2.

scientific article

Cloning and characterization of arylamine N-acetyltransferase genes from Mycobacterium smegmatis and Mycobacterium tuberculosis: increased expression results in isoniazid resistance

scientific journal article

Cloning, functional expression and characterization of Mesorhizobium loti arylamine N-acetyltransferases: rhizobial symbiosis supplies leguminous plants with the xenobiotic N-acetylation pathway

article

Comparative analysis of xenobiotic metabolising N-acetyltransferases from ten non-human primates as in vitro models of human homologues.

scientific article

Comparison of the Arylamine N-acetyltransferase from Mycobacterium marinum and Mycobacterium tuberculosis.

scientific article published in August 2009

Comparison of the membrane-bound and detergent-solubilised hydrogenase from Paracoccus denitrificans. Isolation of the hydrogenase ⬇️

scientific article published on September 12, 1979

Complement activation and protein adsorption by carbon nanotubes

scientific article published on 16 March 2005

Complement receptors and related complement control proteins

scientific article

Confirmation of the role of N-acetyltransferase 2 in teratogen-induced cleft palate using transgenics and knockouts

scientific article published in June 2008

Current smoking, occupation, N-acetyltransferase-2 and bladder cancer: a pooled analysis of genotype-based studies ⬇️

scientific article published on 01 December 2001

Dapsone acetylation by human liver arylamine N-acetyltransferases and interaction with antiopportunistic infection drugs ⬇️

scientific article published on April 1, 1995

Deletion of a xenobiotic metabolizing gene in mice affects folate metabolism.

scientific article published on 15 October 2007

Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase

scientific article published on 22 February 2013

Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding.

scientific article

Divergence of cofactor recognition across evolution: coenzyme A binding in a prokaryotic arylamine N-acetyltransferase

scientific article

Downregulation of hepatic acetylation of drugs in chronic renal failure.

scientific article published on 16 April 2008

Drug metabolising N-acetyltransferase activity in human cell lines

scientific article published on April 1991

Drug metabolism and antibiotic resistance in micro-organisms

scientific article published on 30 April 2017

Drug-induced immune-complex disease

scientific article published on January 1989

Enzyme kinetic properties of human recombinant arylamine N-acetyltransferase 2 allotypic variants expressed in Escherichia coli

scientific article published on 01 August 1995

Enzymic assay of C3b receptor on intact cells and solubilized cells ⬇️

scientific article published on February 15, 1983

Erythrocyte complement receptor type 1 (CR1) expression and circulating immune complex (CIC) levels in hydralazine-induced SLE

scientific article published on 01 May 1987

Eubacterial arylamine N-acetyltransferases - identification and comparison of 18 members of the protein family with conserved active site cysteine, histidine and aspartate residues

scientific article

Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening

scientific article published on 24 November 2004

Evidence towards the role of arylamine N-acetyltransferase in Mycobacterium smegmatis and development of a specific antiserum against the homologous enzyme of Mycobacterium tuberculosis ⬇️

scientific article published on December 1, 2001

Exploration of Piperidinols as Potential Antitubercular Agents

Expression and purification of the rifamycin amide synthase, RifF, an enzyme homologous to the prokaryotic arylamine N-acetyltransferases

scientific article published in February 2002

Expression of arylamine N-acetyltransferase in human intestine ⬇️

scientific article published on March 1, 1998

Expression of arylamine N-acetyltransferases in pre-term placentas and in human pre-implantation embryos

scientific article

Expression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferase

scientific journal article

From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2

scientific article (publication date: 2014)

Gene expression profiling of primary male breast cancers reveals two unique subgroups and identifies N-acetyltransferase-1 (NAT1) as a novel prognostic biomarker

scientific article

Generation and analysis of mice with a targeted disruption of the arylamine N-acetyltransferase type 2 gene

scientific journal article

Genes for human arylamine N-acetyltransferases in relation to loss of the short arm of chromosome 8 in bladder cancer

article

Genetic aberrations of NAT2 and chromosome 8: their association with progression in transitional cell carcinoma of the urinary bladder

scientific article published on 01 January 2001

Genotyping human arylamine N-acetyltransferase type 1 (NAT1): the identification of two novel allelic variants

scientific article published on 01 February 1998

Genotyping human polymorphic arylamine N-acetyltransferase: identification of new slow allotypic variants.

scientific article

Homologues of xenobiotic metabolizing N-acetyltransferases in plant-associated fungi: Novel functions for an old enzyme family.

scientific article

Hydralazine binds covalently to complement component C4. Different reactivity of C4A and C4B gene products

scientific article published on 01 May 1985

Hydrogenase activity in Paracoccus denitrificans. Partial purification and interaction with the electron transport chain

scientific article published on January 1, 1978

Identification and functional characterization of novel polymorphisms associated with the genes for arylamine N-acetyltransferases in mice

scientific article published on July 2002

Identification of NAD(P)H Quinone Oxidoreductase Activity in Azoreductases from P. aeruginosa: Azoreductases and NAD(P)H Quinone Oxidoreductases Belong to the Same FMN-Dependent Superfamily of Enzymes

scientific article

Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars

scientific article (publication date: 2010)

Identification of novel members of the bacterial azoreductase family in Pseudomonas aeruginosa

scientific article

Immunochemical detection of arylamine N-acetyltransferase during mouse embryonic development and in adult mouse brain

scientific article published in November 1998

Immunochemical detection of arylamine N-acetyltransferase in normal and neoplastic bladder

scientific article published on September 1996

Immunogenetics and rheumatoid arthritis

scientific article published on 01 May 1988

Improvement of the expression and purification of Mycobacterium tuberculosis arylamine N-acetyltransferase (TBNAT) a potential target for novel anti-tubercular agents ⬇️

scientific article published on July 13, 2011

Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease

scientific article published in December 1995

Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris

scientific article published on 11 February 2007

Insight into the structure of Mesorhizobium loti arylamine N-acetyltransferase 2 (MLNAT2): a biochemical and computational study

scientific article published on 24 February 2006

Interaction of nucleophilic compounds with complement component C4.

scientific article published in January 1988

Investigation of the catalytic triad of arylamine N-acetyltransferases: essential residues required for acetyl transfer to arylamines

scientific article published on August 2005

Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach

scientific article

Kinetic characterisation of arylamine N-acetyltransferase from Pseudomonas aeruginosa

scientific article

Localization of polymorphic N-acetyltransferase (NAT2) in tissues of inbred mice

scientific article published in April 1997

Mapping AAC1 AAC2 and AACP, the genes for arylamine N-acetyltransferases, carcinogen metabolising enzymes on human chromosome 8p22, a region frequently deleted in tumours

article

Mechanism-based inhibition of HsaD: a C-C bond hydrolase essential for survival of Mycobacterium tuberculosis in macrophage.

scientific article published on 6 November 2013

Metabolic gene polymorphism frequencies in control populations

scientific article published in December 2001

Metabolic polymorphisms and cancer susceptibility.

scientific article published on January 1995

Molecular cloning, characterisation and ligand-bound structure of an azoreductase from Pseudomonas aeruginosa

scientific article

Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1.

scientific article published on 5 January 2008

Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system.

scientific article published on February 2008

Multiple routes of complement activation by Mycobacterium bovis BCG

scientific article published on 20 August 2009

Mutational and expression analysis of tbnat and its response to isoniazid

scientific article published in December 2005

N-Acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast.

scientific article published in July 2001

N-acetylation of the heterocyclic amine batracylin by human liver

scientific article published on 01 September 1999

N-acetyltransferase (Nat) 1 and 2 expression in Nat2 knockout mice

scientific article published on 20 July 2006

N-acetyltransferase in human urothelium and bladder cell lines

scientific article published on April 1991

N-acetyltransferase polymorphism. Comparison of phenotype and genotype in humans

scientific article published on 01 August 1991

NAT gene polymorphisms and susceptibility to Alzheimer's disease: identification of a novel NAT1 allelic variant

scientific article

NAT--from bugs to brains. An overview of the 2nd International Workshop on the arylamine N-acetyltransferases

scientific article published in January 2002

NMR investigation of the catalytic mechanism of arylamine N-acetyltransferase from Salmonella typhimurium

scientific article published in March 2003

Nomenclature for N-acetyltransferases

scientific article

Novel small-molecule inhibitors of arylamine N-acetyltransferases: drug discovery by high-throughput screening.

scientific article

Ocular defects associated with a null mutation in the mouse arylamine N-acetyltransferase 2 gene

scientific article published in April 2007

Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1.

scientific article published in February 2005

Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway

scientific article

Pattern of degradation of human complement fragment, C3b

scientific article published on 01 September 1981

Pharmacogenetics of the arylamine N-acetyltransferases.

scientific article

Pharmacogenomics of arylamine N-acetyltransferases--from drug metabolism to drug discovery

scientific article published on 01 November 2002

Phenotyping of human complement component C4, a class-III HLA antigen

scientific article published on November 1986

Physical studies on phosphonium phosphatidylcholine. A unique [31P]phosphorus nuclear-magnetic-resonance probe for model and biological membranes ⬇️

scientific article published on December 1, 1975

Piperidinols That Show Anti-Tubercular Activity as Inhibitors of Arylamine N-Acetyltransferase: An Essential Enzyme for Mycobacterial Survival Inside Macrophages

scientific article

Placental arylamine N-acetyltransferase type 1: potential contributory source of urinary folate catabolite p-acetamidobenzoylglutamate during pregnancy

scientific article published on 01 December 2000

Placental expression of arylamine N-acetyltransferases: evidence for linkage disequilibrium between NAT1*10 and NAT2*4 alleles of the two human arylamine N-acetyltransferase loci NAT1 and NAT2

scientific article published on 01 October 1998

Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site

scientific article

Prospective virtual screening with Ultrafast Shape Recognition: the identification of novel inhibitors of arylamine N-acetyltransferases

scientific article published on 6 February 2010

Purification of human C3b inactivator by monoclonal-antibody affinity chromatography

scientific article published on April 1982

Purification of recombinant human N-acetyltransferase type 1 (NAT1) expressed in E. coli and characterization of its potential role in folate metabolism

scientific article published on 01 June 1995

Purification, characterization, and crystallization of an N-hydroxyarylamine O-acetyltransferase from Salmonella typhimurium

scientific article published in April 1998

Reaction mechanism of azoreductases suggests convergent evolution with quinone oxidoreductases

scientific article published on 28 August 2010

Recent progress in N-acetyltransferase research: 7th international workshop on N-acetyltransferases (NAT): workshop report

scientific article published on 22 March 2017

Rifapentine and isoniazid in the continuation phase of a 6-month regimen. Interim report: no activity of isoniazid in the continuation phase

scientific article published on 01 March 2000

Role of tyrosine 131 in the active site of paAzoR1, an azoreductase with specificity for the inflammatory bowel disease prodrug balsalazide

scientific article

Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2.

scientific article

Skeletal Muscles Express the Xenobiotic-metabolizing Enzyme ArylamineN-acetyltransferase ⬇️

scientific article published on June 1, 2003

Slow N-acetylation genotype is a susceptibility factor in occupational and smoking related bladder cancer

scientific article published in February 1995

Small molecule colorimetric probes for specific detection of human arylamine N-acetyltransferase 1, a potential breast cancer biomarker

scientific article published in March 2010

Stereoselective synthesis of β-arabino glycosyl sulfones as potential inhibitors of mycobacterial cell wall biosynthesis

scientific article published in April 2009

Structural analysis of the genes for human arylamine N-acetyltransferases and characterisation of alternative transcripts

scientific article

Structural investigation of mutant Mycobacterium smegmatis arylamine N-acetyltransferase: a model for a naturally occurring functional polymorphism in Mycobacterium tuberculosis arylamine N-acetyltransferase.

scientific article

Structure and mechanism of arylamine N-acetyltransferases.

scientific article published on January 2006

Structure and transcriptional regulation of the Nat2 gene encoding for the drug-metabolizing enzyme arylamine N-acetyltransferase type 2 in mice.

scientific article published in November 2003

Structure of HsaD, a steroid-degrading hydrolase, from Mycobacterium tuberculosis

scientific article

Structure of Mesorhizobium loti arylamine N-acetyltransferase 1.

scientific article published on 24 December 2004

Structure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversity

scientific article

Structure of arylamine N-acetyltransferase reveals a catalytic triad

scientific article

Structure of arylamineN-acetyltransferase fromM. tuberculosis: triumph over adversity

scientific article published on 25 August 2013

Structure-activity relationships and colorimetric properties of specific probes for the putative cancer biomarker human arylamine N-acetyltransferase 1.

scientific article published on 28 March 2014

Synthesis and anticancer activities of 6-amino amonafide derivatives.

scientific article published on January 2008

Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs).

scientific article

Synthesis of Arabino glycosyl triazoles as potential inhibitors of mycobacterial cell wall biosynthesis

scientific article published on 26 September 2008

Synthesis of putative chain terminators of mycobacterial arabinan biosynthesis

scientific article published in 2007

Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis

scientific article published in March 2009

The COOH terminus of arylamine N-acetyltransferase from Salmonella typhimurium controls enzymic activity

scientific article published on 17 January 2002

The covalent-binding reaction of complement component C3 ⬇️

scientific article published on January 1, 1981

The generation of active fragments of complement receptor type 2 by trypsin digestion

scientific article published on 01 September 1985

The pharmacogenetics of NAT: structural aspects.

scientific article

The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis--an enzyme which inactivates the anti-tubercular drug, isoniazid

scientific article

The structure of mycobacterium marinum arylamine n-acetyltransferase

scientific article published on 2 October 2013

Update on consensus arylamine N-acetyltransferase gene nomenclature

scientific article published in June 2000

Update on the pharmacogenetics of NATs: structural considerations

scientific article

Xenogenetics in multifactorial disease susceptibility

scientific article published on December 1995

Paulina is supported by:

About Paulina

Help