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List of works by Chloe Orkin

'Just another vial…': a qualitative study to explore the acceptability and feasibility of routine blood-borne virus testing in an emergency department setting in the UK

1768. Efficacy and Safety of Switching From Boosted-Protease Inhibitors (bPI) Plus Emtricitabine/Tenofovir Disoproxil Fumarate (F/TDF) Regimens to the Once Daily (QD), Single-Tablet Regimen (STR) of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafen

1965. Safety and Efficacy of Glecaprevir/Pibrentasvir in Patients With Chronic Hepatitis C Virus Genotypes 1–6 and Human Immunodeficiency Virus-1 Co-Infection: An Integrated Analysis of Two Phase 3 Clinical Trials

543. An Integrated Safety Analysis Comparing Once-Daily Doravirine (DOR) to Darunavir+Ritonavir (DRV+r) and Efavirenz (EFV) in HIV-1-Infected, Antiretroviral Therapy (ART)-Naïve Adults

article

96-Week results of abacavir/lamivudine versus tenofovir/emtricitabine, plus efavirenz, in antiretroviral-naive, HIV-1-infected adults: ASSERT study

scientific article published on 31 July 2013

A double-blind, randomised, placebo-controlled parallel study to investigate the effect of sex and dietary nitrate on COVID-19 vaccine-induced vascular dysfunction in healthy men and women: protocol of the DiNOVasc-COVID-19 study

scientific article published on 16 September 2023

A qualitative study exploring the social and environmental context of recently acquired HIV infection among men who have sex with men in South-East England

scientific article

A randomized comparative trial of continued abacavir/lamivudine plus efavirenz or replacement with efavirenz/emtricitabine/tenofovir DF in hypercholesterolemic HIV-1 infected individuals

scientific article

A randomized comparative trial of continued zidovudine/lamivudine or replacement with tenofovir disoproxil fumarate/emtricitabine in efavirenz-treated HIV-1-infected individuals.

scientific article published in August 2009

A randomized study comparing a three- and four-drug HAART regimen in first-line therapy (QUAD study).

scientific article published on 17 December 2004

A randomized trial to investigate the recycling of stavudine and didanosine with and without hydroxyurea in salvage therapy (RESTART).

scientific article published on 4 February 2004

A week 48 randomized phase 3 trial of darunavir/cobicistat/emtricitabine/tenofovir alafenamide in treatment-naïve HIV-1 patients

scientific article published on 19 April 2018

An epidemiologic study to determine the prevalence of the HLA-B*5701 allele among HIV-positive patients in Europe

scientific article published in May 2010

An innovative joint approach to HIV and lymphoma care

scientific article published in December 2011

Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals

scientific article

Antiretrovirals, Fractures, and Osteonecrosis in a Large International HIV Cohort

scientific article

Are previous treatment interruptions associated with higher viral rebound rates in patients with viral suppression?

scientific article published in January 2008

Bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir, abacavir, and lamivudine for initial treatment of HIV-1 infection (GS-US-380-1489): a double-blind, multicentre, phase 3, randomised controlled non-inferiority trial

scientific article published on 31 August 2017

Brief Communication: Rituximab in HIV-Associated Multicentric Castleman Disease

article

Brief Report: Long-Term (96-Week) Efficacy and Safety After Switching From Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in HIV-Infected, Virologically Suppressed Adults

scientific article

British HIV Association guidelines for the management of hepatitis viruses in adults infected with HIV 2013.

scientific article published on November 2013

British HIV Association guidelines for the treatment of HIV-1-positive adults with antiretroviral therapy 2012 (Updated November 2013. All changed text is cast in yellow highlight.).

scientific article published on January 2014

British HIV Association guidelines for the treatment of HIV-1-positive adults with antiretroviral therapy 2012.

scientific article published in September 2012

British HIV Association guidelines for the treatment of HIV-1-positive adults with antiretroviral therapy 2015

article

CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK.

scientific article published on 31 March 2009

Change in vitamin D levels and risk of severe vitamin D deficiency over 48 weeks among HIV-1-infected, treatment-naive adults receiving rilpivirine or efavirenz in a Phase III trial (ECHO).

scientific article published on 16 January 2014

Changes in outcome of persons initiating highly active antiretroviral therapy at a CD4 count less than 50 Cells/mm3.

scientific article published on February 2008

Comparison of changes in bone density and turnover with abacavir-lamivudine versus tenofovir-emtricitabine in HIV-infected adults: 48-week results from the ASSERT study

scientific article published on October 2010

Data linkage reduces loss to follow-up in an observational HIV cohort study

scientific article

Disease Progression in HIV-1-Infected Viremic Controllers

scientific article published on December 2012

Does discordancy between the CD4 count and CD4 percentage in HIV-positive individuals influence outcomes on highly active antiretroviral therapy?

scientific article published in February 2012

Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate is Non-inferior to Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate in Treatment-naive Adults With Human Immunodeficiency Virus-1 Infection: Week 48 Results of the DRIVE-AHEAD Trial

scientific article published on 01 February 2019

Effects of age on antiretroviral plasma drug concentration in HIV-infected subjects undergoing routine therapeutic drug monitoring

scientific article published on 23 February 2013

Effects of hydroxychloroquine on immune activation and disease progression among HIV-infected patients not receiving antiretroviral therapy: a randomized controlled trial

scientific article published on July 2012

Efficacy and safety of grazoprevir (MK-5172) and elbasvir (MK-8742) in patients with hepatitis C virus and HIV co-infection (C-EDGE CO-INFECTION): a non-randomised, open-label trial.

scientific article

Efficacy and safety of switching from boosted protease inhibitors plus emtricitabine and tenofovir disoproxil fumarate regimens to single-tablet darunavir, cobicistat, emtricitabine, and tenofovir alafenamide at 48 weeks in adults with virologically

scientific article published on 5 October 2017

Excellent immunological recovery following CODOX-M/IVAC, an effective intensive chemotherapy for HIV-associated Burkitt's lymphoma

scientific article published in March 2010

Factors associated with virological rebound in HIV-infected patients receiving protease inhibitor monotherapy

scientific article

Factors influencing efavirenz and nevirapine plasma concentration: effect of ethnicity, weight and co-medication.

scientific article published in January 2008

Factors influencing lopinavir and atazanavir plasma concentration

scientific article published on January 2010

Failure to achieve a CD4+ cell count response on combination antiretroviral therapy despite consistent viral load suppression

scientific article published on March 2014

Few men who have sex with men (MSM) attending two inner-city clinics were tested for hepatitis C virus (HCV) despite high risk: a retrospective analysis of sexual health screening in East London

scientific article published on 20 July 2017

Final 192‐week efficacy and safety of once‐daily darunavir/ritonavir compared with lopinavir/ritonavir in HIV‐1‐infected treatment‐naïve patients in the ARTEMIS trial ⬇️

scientific article published on October 23, 2012

Fixed dose darunavir boosted with cobicistat combined with emtricitabine and tenofovir alafenamide fumarate

scientific article published on 9 March 2018

Gender disparities in international COVID-19 clinical trial leadership

preprint

HIV status does not impair the outcome of patients diagnosed with diffuse large B-cell lymphoma treated with R-CHOP in the cART era.

scientific article

HIV status does not influence outcome in patients with classical Hodgkin lymphoma treated with chemotherapy using doxorubicin, bleomycin, vinblastine, and dacarbazine in the highly active antiretroviral therapy era. ⬇️

scientific article published on 08 October 2012

HIV-associated central nervous system diseases in the recent combination antiretroviral therapy era.

scientific article published on 15 December 2010

Highlights from the 20th International Symposium on HIV and Emerging Infectious Diseases (ISHEID) 16-18 May 2018, Marseille, France: from HIV and comorbidities to global health

article

Impact of late diagnosis and treatment on life expectancy in people with HIV-1: UK Collaborative HIV Cohort (UK CHIC) Study

scientific article

Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy.

scientific article

Increased duration of viral suppression is associated with lower viral rebound rates in patients with previous treatment failures

article

Integrated Care Facilitation Model Reduces Use of Hospital Resources by Patients with Pediatric Asthma ⬇️

scientific article published on April 13, 2011

Is 1 alanine transaminase >200 IU enough to define an alanine transaminase flare in HIV-infected populations? A new definition derived from a large cohort study

scientific article

LB1. Doravirine/Lamivudine/Tenofovir DF Continues to Be NonInferior to Efavirenz/Emtricitabine/Tenofovir DF in Treatment-Naïve Adults With HIV-1 Infection: Week 96 Results of the DRIVE-AHEAD Trial

article

Late diagnosis in the HAART era: proposed common definitions and associations with mortality

scientific article published on 01 March 2010

Molecular Epidemiology of HIV-1 Subtype B Reveals Heterogeneous Transmission Risk: Implications for Intervention and Control

article

Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022

scientific article published on 21 July 2022

N-terminal-proB-type natriuretic peptide predicts cardiovascular disease events in HIV-infected patients

scientific article

NGX-4010, a capsaicin 8% patch, for the treatment of painful HIV-associated distal sensory polyneuropathy: integrated analysis of two phase III, randomized, controlled trials

scientific article published on 28 January 2013

Neurocognitive Function in HIV Infected Patients on Antiretroviral Therapy ⬇️

scientific article published on April 30, 2013

Neutralization activity in a geographically diverse East London cohort of human immunodeficiency virus type 1-infected patients: clade C infection results in a stronger and broader humoral immune response than clade B infection

scientific article

NtRTI sparing in patients at risk of bone disease

scientific article published on 30 September 2015

Once-daily dolutegravir versus raltegravir in antiretroviral-naive adults with HIV-1 infection: 48 week results from the randomised, double-blind, non-inferiority SPRING-2 study

scientific article

Outcomes in the First Year after Initiation of First-Line Haart among Heterosexual Men and Women in the Uk Chic Study ⬇️

scientific article published on January 1, 2011

Protease inhibitor monotherapy for long-term management of HIV infection: a randomised, controlled, open-label, non-inferiority trial

scientific article published on 14 September 2015

Rate of AIDS diseases or death in HIV-infected antiretroviral therapy-naive individuals with high CD4 cell count

article

Retrospective hepatitis C seroprevalence screening in the antenatal setting-should we be screening antenatal women?

scientific article

Risk factors and outcomes for the Q151M and T69 insertion HIV-1 resistance mutations in historic UK data

scientific article published on 16 April 2018

Risk of extensive virological failure to the three original antiretroviral drug classes over long-term follow-up from the start of therapy in patients with HIV infection: an observational cohort study

scientific article published in The Lancet

Rituximab as retreatment for rituximab pretreated HIV-associated multicentric Castleman disease

article

Safety and Efficacy of Ombitasvir, Paritaprevir With Ritonavir ± Dasabuvir With or Without Ribavirin in Patients With Human Immunodeficiency Virus-1 and Hepatitis C Virus Genotype 1 or Genotype 4 Coinfection: TURQUOISE-I Part 2.

scientific article published on 22 July 2017

Safety, immunogenicity and efficacy assessment of HIV immunotherapy in a multi-centre, double-blind, randomised, Placebo-controlled Phase Ib human trial

scientific article published on 08 October 2013

Second-line protease inhibitor-based antiretroviral therapy after non-nucleoside reverse transcriptase inhibitor failure: the effect of a nucleoside backbone

scientific article

Should HIV testing week be blood-borne-virus testing week?

scientific article

Simeprevir (TMC435) with pegylated interferon/ribavirin in patients coinfected with HCV genotype 1 and HIV-1: a phase 3 study

scientific article published on 5 September 2014

Simeprevir for the treatment of hepatitis C and HIV/hepatitis C co-infection

scientific article published on 11 September 2014

Sofosbuvir and Ribavirin for Treatment of Chronic Hepatitis C in Patients Coinfected With Hepatitis C Virus and HIV: The Impact on Patient-Reported Outcomes

scientific article published on 12 January 2015

Sofosbuvir plus ribavirin for treatment of hepatitis C virus in patients co-infected with HIV (PHOTON-2): a multicentre, open-label, non-randomised, phase 3 study

scientific article published on 4 February 2015

Successful treatment of acute hepatitis C virus in HIV positive patients using the European AIDS Treatment Network guidelines for treatment duration.

scientific article published on 15 September 2011

Switching from tenofovir disoproxil fumarate to tenofovir alafenamide coformulated with rilpivirine and emtricitabine in virally suppressed adults with HIV-1 infection: a randomised, double-blind, multicentre, phase 3b, non-inferiority study

scientific article published on March 2017

Switching from tenofovir disoproxil fumarate to tenofovir alafenamide in antiretroviral regimens for virologically suppressed adults with HIV-1 infection: a randomised, active-controlled, multicentre, open-label, phase 3, non-inferiority study

scientific article published on 30 October 2015

Tipranavir/T20-based salvage regimens highly effective and durable against HIV-1 with evidence for genotypic predictability of response in clinical practice

scientific article published on September 2007

Treatment switches after viral rebound in HIV-infected adults starting antiretroviral therapy: multicentre cohort study

article

Tuberculosis among people with HIV infection in the United Kingdom: opportunities for prevention?

scientific article

Uptake of tenofovir-based antiretroviral therapy among HIV-HBV-coinfected patients in the EuroSIDA study

scientific article

Virological response to initial antiretroviral regimens containing abacavir or tenofovir.

scientific article published in September 2009

Vitamin D deficiency in HIV: a shadow on long-term management?

scientific article published on April 2014

Week 48 Results of EMERALD: A Phase 3, Randomized, Non-inferiority Study Evaluating the Efficacy and Safety of Switching from Boosted-protease Inhibitors (bPI) Plus Emtricitabine (FTC)/Tenofovir Disoproxil Fumarate (TDF) Regimens to the Once Daily (

scientific article published on 4 October 2017

Week 96 efficacy and safety of rilpivirine in treatment-naive, HIV-1 patients in two Phase III randomized trials

article

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