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List of works by Chloe Orkin

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Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals

scientific article
Once-daily dolutegravir versus raltegravir in antiretroviral-naive adults with HIV-1 infection: 48 week results from the randomised, double-blind, non-inferiority SPRING-2 study

scientific article
Comparison of changes in bone density and turnover with abacavir-lamivudine versus tenofovir-emtricitabine in HIV-infected adults: 48-week results from the ASSERT study

scientific article published on October 2010
Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy.

scientific article
Impact of late diagnosis and treatment on life expectancy in people with HIV-1: UK Collaborative HIV Cohort (UK CHIC) Study

scientific article
Efficacy and safety of grazoprevir (MK-5172) and elbasvir (MK-8742) in patients with hepatitis C virus and HIV co-infection (C-EDGE CO-INFECTION): a non-randomised, open-label trial

scientific article
Switching from tenofovir disoproxil fumarate to tenofovir alafenamide in antiretroviral regimens for virologically suppressed adults with HIV-1 infection: a randomised, active-controlled, multicentre, open-label, phase 3, non-inferiority study

scientific article published on 30 October 2015
Sofosbuvir plus ribavirin for treatment of hepatitis C virus in patients co-infected with HIV (PHOTON-2): a multicentre, open-label, non-randomised, phase 3 study

scientific article published on February 4, 2015
British HIV Association guidelines for the treatment of HIV-1-positive adults with antiretroviral therapy 2012.

scientific article published in September 2012
Final 192‐week efficacy and safety of once‐daily darunavir/ritonavir compared with lopinavir/ritonavir in HIV‐1‐infected treatment‐naïve patients in the ARTEMIS trial

scientific article published on October 23, 2012
British HIV Association guidelines for the treatment of HIV-1-positive adults with antiretroviral therapy 2012 (Updated November 2013. All changed text is cast in yellow highlight.).

scientific article published on January 2014
Effects of hydroxychloroquine on immune activation and disease progression among HIV-infected patients not receiving antiretroviral therapy: a randomized controlled trial

scientific article published on July 2012
Brief Communication: Rituximab in HIV-Associated Multicentric Castleman Disease

article
Week 96 efficacy and safety of rilpivirine in treatment-naive, HIV-1 patients in two Phase III randomized trials

article
HIV status does not influence outcome in patients with classical Hodgkin lymphoma treated with chemotherapy using doxorubicin, bleomycin, vinblastine, and dacarbazine in the highly active antiretroviral therapy era.

scientific article published on 08 October 2012
Factors influencing efavirenz and nevirapine plasma concentration: effect of ethnicity, weight and co-medication.

scientific article published in January 2008
Rate of AIDS diseases or death in HIV-infected antiretroviral therapy-naive individuals with high CD4 cell count

article
Bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir, abacavir, and lamivudine for initial treatment of HIV-1 infection (GS-US-380-1489): a double-blind, multicentre, phase 3, randomised controlled non-inferiority trial

scientific article published on 31 August 2017
Protease inhibitor monotherapy for long-term management of HIV infection: a randomised, controlled, open-label, non-inferiority trial

scientific article published on September 14, 2015
A randomized comparative trial of continued zidovudine/lamivudine or replacement with tenofovir disoproxil fumarate/emtricitabine in efavirenz-treated HIV-1-infected individuals

scientific article published in August 2009
Simeprevir (TMC435) with pegylated interferon/ribavirin in patients coinfected with HCV genotype 1 and HIV-1: a phase 3 study

scientific article published on 5 September 2014
Risk of extensive virological failure to the three original antiretroviral drug classes over long-term follow-up from the start of therapy in patients with HIV infection: an observational cohort study

scientific article published in The Lancet
96-Week results of abacavir/lamivudine versus tenofovir/emtricitabine, plus efavirenz, in antiretroviral-naive, HIV-1-infected adults: ASSERT study

scientific article published on 31 July 2013
CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK.

scientific article published on 31 March 2009
Late diagnosis in the HAART era: proposed common definitions and associations with mortality

scientific article published on 01 March 2010
British HIV Association guidelines for the treatment of HIV-1-positive adults with antiretroviral therapy 2015

article
HIV-associated central nervous system diseases in the recent combination antiretroviral therapy era.

scientific article published on 15 December 2010
Neurocognitive Function in HIV Infected Patients on Antiretroviral Therapy

scientific article published on April 30, 2013
Tuberculosis among people with HIV infection in the United Kingdom: opportunities for prevention?

scientific article
Sofosbuvir and Ribavirin for Treatment of Chronic Hepatitis C in Patients Coinfected With Hepatitis C Virus and HIV: The Impact on Patient-Reported Outcomes

scientific article published on 12 January 2015
HIV status does not impair the outcome of patients diagnosed with diffuse large B-cell lymphoma treated with R-CHOP in the cART era.

scientific article
Switching from tenofovir disoproxil fumarate to tenofovir alafenamide coformulated with rilpivirine and emtricitabine in virally suppressed adults with HIV-1 infection: a randomised, double-blind, multicentre, phase 3b, non-inferiority study

scientific article published on March 2017
N-terminal-proB-type natriuretic peptide predicts cardiovascular disease events in HIV-infected patients

scientific article
Excellent immunological recovery following CODOX-M/IVAC, an effective intensive chemotherapy for HIV-associated Burkitt's lymphoma

scientific article published in March 2010
Change in vitamin D levels and risk of severe vitamin D deficiency over 48 weeks among HIV-1-infected, treatment-naive adults receiving rilpivirine or efavirenz in a Phase III trial (ECHO).

scientific article published on 16 January 2014
Efficacy and safety of switching from boosted protease inhibitors plus emtricitabine and tenofovir disoproxil fumarate regimens to single-tablet darunavir, cobicistat, emtricitabine, and tenofovir alafenamide at 48 weeks in adults with virologically

scientific article published on 5 October 2017
British HIV Association guidelines for the management of hepatitis viruses in adults infected with HIV 2013.

scientific article published on November 2013
Disease Progression in HIV-1-Infected Viremic Controllers

scientific article published on December 2012
Data linkage reduces loss to follow-up in an observational HIV cohort study

scientific article published on March 29, 2010
NGX-4010, a capsaicin 8% patch, for the treatment of painful HIV-associated distal sensory polyneuropathy: integrated analysis of two phase III, randomized, controlled trials

scientific article published on 28 January 2013
Brief Report: Long-Term (96-Week) Efficacy and Safety After Switching From Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in HIV-Infected, Virologically Suppressed Adults

scientific article
A week 48 randomized phase 3 trial of darunavir/cobicistat/emtricitabine/tenofovir alafenamide in treatment-naïve HIV-1 patients

scientific article published on 19 April 2018
Outcomes in the First Year after Initiation of First-Line Haart among Heterosexual Men and Women in the Uk Chic Study

scientific article published on January 1, 2011
Neutralization activity in a geographically diverse East London cohort of human immunodeficiency virus type 1-infected patients: clade C infection results in a stronger and broader humoral immune response than clade B infection

scientific article
Week 96 analysis of rilpivirine or efavirenz in HIV‐1‐infected patients with baseline viral load ≤ 100 000 copies/mL in the pooled ECHO and THRIVE phase 3, randomized, double‐blind trials

scientific article published on August 28, 2013
A Randomized Comparative Trial of Continued Abacavir/Lamivudine plus Efavirenz or Replacement with Efavirenz/Emtricitabine/Tenofovir DF in Hypercholesterolemic HIV-1 Infected Individuals

scientific article published on February 6, 2015
Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate is Non-inferior to Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate in Treatment-naive Adults With Human Immunodeficiency Virus-1 Infection: Week 48 Results of the DRIVE-AHEAD Trial

scientific article published on 01 February 2019
Treatment switches after viral rebound in HIV-infected adults starting antiretroviral therapy: multicentre cohort study

article
Are previous treatment interruptions associated with higher viral rebound rates in patients with viral suppression?

scientific article published in January 2008
An epidemiologic study to determine the prevalence of the HLA-B*5701 allele among HIV-positive patients in Europe

scientific article published in May 2010

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