List of works by Jan Wilschut

A Therapeutic Antibody against West Nile Virus Neutralizes Infection by Blocking Fusion within Endosomes

scientific article (publication date: May 2009)

A comparative study on the immunotherapeutic efficacy of recombinant Semliki Forest virus and adenovirus vector systems in a murine model for cervical cancer.

scientific article published on 11 October 2007

A fusion-loop antibody enhances the infectious properties of immature flavivirus particles

scientific article published on 31 August 2011

A single mutation in the E2 glycoprotein important for neurovirulence influences binding of sindbis virus to neuroblastoma cells

scientific article

A small molecule fusion inhibitor of dengue virus

scientific article

A synthetic peptide corresponding to the C-terminal 25 residues of phage MS2 coded lysis protein dissipates the protonmotive force in Escherichia coli membrane vesicles by generating hydrophilic pores

scientific article published on March 1988

A virosomal immunization strategy against cervical cancer and pre-malignant cervical disease.

scientific article published on January 2006

A virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A provides protection against viral challenge without priming for enhanced disease in cotton rats

scientific article

Activation of murine lymphocytes by lipopolysaccharide incorporated in fusogenic, reconstituted influenza virus envelopes (virosomes).

scientific article published in August 1996

Activation of peritoneal cells upon in vivo transfection with a recombinant alphavirus expressing GM-CSF.

scientific article published in February 2001

Adaptation of alphaviruses to heparan sulfate: interaction of Sindbis and Semliki forest viruses with liposomes containing lipid-conjugated heparin

scientific article

Alphavirus-based vaccines encoding nonstructural proteins of hepatitis C virus induce robust and protective T-cell responses

scientific article published on 27 December 2013

Alum boosts TH2-type antibody responses to whole-inactivated virus influenza vaccine in mice but does not confer superior protection.

scientific article

Antibodies against the envelope glycoprotein promote infectivity of immature dengue virus serotype 2

scientific article

Antiviral activity of human lactoferrin: inhibition of alphavirus interaction with heparan sulfate.

scientific article published on March 2005

Assembly and entry mechanisms of Semliki Forest virus.

scientific article published on January 1994

Augmentation of alphavirus vector-induced human papilloma virus-specific immune and anti-tumour responses by co-expression of interleukin-12.

scientific article published on 27 November 2008

Behavior of a photoactivatable analog of cholesterol, 6-photocholesterol, in model membranes

scientific article published in January 2002

Calcium/magnesium specificity in membrane fusion: kinetics of aggregation and fusion of phosphatidylserine vesicles and the role of bilayer curvature

scientific article

Cell-mediated immune responses to influenza vaccination in Wegener's granulomatosis

scientific article published on 12 July 2009

Cellular cytoplasmic delivery of a polypeptide toxin by reconstituted influenza virus envelopes (virosomes).

scientific article published on August 1994

Cellular delivery of siRNA mediated by fusion-active virosomes.

scientific article published on January 2007

Cellular gene transfer mediated by influenza virosomes with encapsulated plasmid DNA.

scientific article published on July 2007

Characterization of antigen-presenting properties of tumour cells using virus-specific cytotoxic T lymphocytes

scientific article published on April 2000

Characterization of the early events in dengue virus cell entry by biochemical assays and single-virus tracking

scientific article

Characterization of the functional requirements of West Nile virus membrane fusion

scientific article published on 14 October 2009

Characterization of the fusogenic properties of Sendai virus: kinetics of fusion with erythrocyte membranes

scientific article

Comparison of adjuvants for a spray freeze-dried whole inactivated virus influenza vaccine for pulmonary administration.

scientific article

Critical role of TLR7 signaling in the priming of cross-protective cytotoxic T lymphocyte responses by a whole inactivated influenza virus vaccine

scientific article

Deacylation of the transmembrane domains of Sindbis virus envelope glycoproteins E1 and E2 does not affect low-pH-induced viral membrane fusion activity

scientific article

Delivery of protein antigens to the immune system by fusion-active virosomes: a comparison with liposomes and ISCOMs

scientific article

Dengue virus life cycle: viral and host factors modulating infectivity

scientific article

Development of a dried influenza whole inactivated virus vaccine for pulmonary immunization.

scientific article published on 21 April 2011

Dissecting the cell entry pathway of dengue virus by single-particle tracking in living cells

scientific article (publication date: December 2008)

Effect of a second, booster, influenza vaccination on antibody responses in quiescent systemic lupus erythematosus: an open, prospective, controlled study

scientific article published on 19 August 2009

Effect of viral membrane fusion activity on antibody induction by influenza H5N1 whole inactivated virus vaccine

scientific article published on 27 July 2012

Effectiveness of A(H1N1)pdm09 influenza vaccine in adults recommended for annual influenza vaccination

scientific article

Effects of low pH on influenza virus. Activation and inactivation of the membrane fusion capacity of the hemagglutinin

scientific article published in December 1987

Efficacy and safety of an intranasal virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A in mice and cotton rats

scientific article

Enhancement of the immunogenicity and protective efficacy of a mucosal influenza subunit vaccine by the saponin adjuvant GPI-0100.

scientific article

Eradication of established HPV16-transformed tumours after immunisation with recombinant Semliki Forest virus expressing a fusion protein of E6 and E7.

scientific article published on March 2003

Evaluation of an intranasal virosomal vaccine against respiratory syncytial virus in mice: effect of TLR2 and NOD2 ligands on induction of systemic and mucosal immune responses

scientific article

Evaluation of monophosphoryl lipid A as adjuvant for pulmonary delivered influenza vaccine.

scientific article published on 21 November 2013

Evaluation of mucosal and systemic immune responses elicited by GPI-0100- adjuvanted influenza vaccine delivered by different immunization strategies

scientific article

Flavivirus cell entry and membrane fusion

scientific article

Functional importance of dengue virus maturation: infectious properties of immature virions

scientific article

Functional reconstitution of influenza virus envelopes

scientific article published on September 1987

Fusion activity of influenza virus. A comparison between biological and artificial target membrane vesicles

scientific article published in August 1986

Fusion of Semliki Forest virus with cholesterol-containing liposomes at low pH: a specific requirement for sphingolipids.

scientific article

Fusion of alphaviruses with liposomes is a non-leaky process

scientific article

Fusion of influenza virus with cardiolipin liposomes at low pH: mass action analysis of kinetics and extent

scientific article published in January 1986

Fusion of reconstituted influenza virus envelopes with liposomes mediated by streptavidin/biotin interactions

scientific article published in July 1996

Gene transfer mediated by fusion protein hemagglutinin reconstituted in cationic lipid vesicles

scientific article published in May 1999

Generation of heat shock protein-based vaccines by intracellular loading of gp96 with antigenic peptides

scientific article published on June 1, 1997

Genetic immunization against cervical carcinoma: induction of cytotoxic T lymphocyte activity with a recombinant alphavirus vector expressing human papillomavirus type 16 E6 and E7.

scientific article

Heterologous prime-boost immunizations with a virosomal and an alphavirus replicon vaccine

scientific article published on 23 September 2010

Heterosubtypic cross-protection induced by whole inactivated influenza virus vaccine in mice: influence of the route of vaccine administration

scientific article

Human Monoclonal Antibodies against West Nile Virus Induced by Natural Infection Neutralize at a Postattachment Step

scientific article (publication date: July 2009)

Human immunodeficiency virus (HIV) infection: psychiatric aspects

scientific article published on 01 November 1988

Immature Dengue Virus: A Veiled Pathogen?

scientific article (publication date: 2010)

Immature dengue virus is infectious in human immature dendritic cells via interaction with the receptor molecule DC-SIGN.

scientific article

Immunization strategy against cervical cancer involving an alphavirus vector expressing high levels of a stable fusion protein of human papillomavirus 16 E6 and E7.

scientific article published on January 2002

Immunogenicity and protective capacity of a virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A in mice

scientific article (publication date: 2012)

Induction of cytotoxic T lymphocyte activity by immunization with recombinant Semliki Forest virus: indications for cross-priming

scientific article published on March 2004

Induction of heterosubtypic cross-protection against influenza by a whole inactivated virus vaccine: the role of viral membrane fusion activity

scientific article

Induction of human papilloma virus E6/E7-specific cytotoxic T-lymphocyte activity in immune-tolerant, E6/E7-transgenic mice

scientific article

Induction of mucosal and systemic immunity against respiratory syncytial virus by inactivated virus supplemented with TLR9 and NOD2 ligands

scientific article

Influenza vaccines: the virosome concept

scientific article published on 25 December 2008

Influenza virosomes in vaccine development

scientific article published on 01 January 2003

Influenza virosomes supplemented with GPI-0100 adjuvant: a potent vaccine formulation for antigen dose sparing.

scientific article

Influenza virosomes: combining optimal presentation of hemagglutinin with immunopotentiating activity

scientific article

Inhibition of influenza virus fusion by polyanionic proteins

scientific article published in April 1997

Inhibition of various steps in the replication cycle of vesicular stomatitis virus contributes to its photoinactivation by AlPcS4 or Pc4 and red light

scientific article published on March 1999

Innate responses induced by whole inactivated virus or subunit influenza vaccines in cultured dendritic cells correlate with immune responses in vivo

scientific article published on May 2015

Intracellular membrane fusion

scientific article

Inulin sugar glasses preserve the structural integrity and biological activity of influenza virosomes during freeze-drying and storage.

scientific article

Involvement of morbilliviruses in the pathogenesis of demyelinating disease

scientific article published on July 2007

Kinetics of Ca2+-induced fusion of cardiolipin-phosphatidylcholine vesicles: correlation between vesicle aggregation, bilayer destabilization, and fusion.

scientific article published in August 1985

Kinetics of pH-dependent fusion between influenza virus and liposomes

scientific article published in June 1985

Lipopeptide-adjuvanted respiratory syncytial virus virosomes: A safe and immunogenic non-replicating vaccine formulation

scientific article published on 25 June 2010

Liposomes as Target Membranes in the Study of Virus Receptor Interaction and Membrane Fusion

scientific article published on January 1, 2003

Liposomes as an immunoadjuvant system for stimulation of mucosal and systemic antibody responses against inactivated measles virus administered intranasally to mice

scientific article published in October 1995

Low pH-induced fusion of liposomes with membrane vesicles derived from Bacillus subtilis

scientific article published on 01 September 1985

Membrane fusion activity of Semliki Forest virus in a liposomal model system: specific inhibition by Zn2+ ions

scientific article

Membrane fusion activity of influenza virus. Effects of gangliosides and negatively charged phospholipids in target liposomes

scientific article

Membrane fusion activity of the influenza virus hemagglutinin: interaction of HA2 N-terminal peptides with phospholipid vesicles

scientific article published in October 1991

Membrane fusion activity of tick-borne encephalitis virus and recombinant subviral particles in a liposomal model system

scientific article published in March 2000

Membrane fusion of Semliki Forest virus requires sphingolipids in the target membrane

scientific article

Modulation of membrane fusion by ionotropic and thermotropic phase transitions

scientific article published in July 1984

Modulation of membrane fusion by membrane fluidity: temperature dependence of divalent cation induced fusion of phosphatidylserine vesicles

scientific article published in January 1985

Molecular mechanisms involved in antibody-dependent enhancement of dengue virus infection in humans

scientific article published on 22 October 2012

Monitoring virus entry into living cells using DiD-labeled dengue virus particles

scientific article published on 10 August 2011

Mucosal immunoadjuvant activity of recombinant Escherichia coli heat-labile enterotoxin and its B subunit: induction of systemic IgG and secretory IgA responses in mice by intranasal immunization with influenza virus surface antigen

scientific article published in December 1998

Mutants of the Escherichia coli heat-labile enterotoxin with reduced ADP-ribosylation activity or no activity retain the immunogenic properties of the native holotoxin.

scientific article published on December 1996

Neuroinvasive flavivirus infections

scientific article

Parameters affecting fusion between Sendai virus and liposomes. Role of viral proteins, liposome composition, and pH.

scientific article published on December 1986

Partial maturation: an immune-evasion strategy of dengue virus?

scientific article published on 08 March 2011

Preclinical evaluation of the saponin derivative GPI-0100 as an immunostimulating and dose-sparing adjuvant for pandemic influenza vaccines

scientific article

Preparation, properties, and applications of reconstituted influenza virus envelopes (virosomes).

scientific article published in January 1993

Preservation of influenza virosome structure and function during freeze-drying and storage

scientific article published on January 2007

Preservation of the immunogenicity of dry-powder influenza H5N1 whole inactivated virus vaccine at elevated storage temperatures.

scientific article

Recombinant Semliki Forest virus as a vector system for fast and selective in vivo gene delivery into balloon-injured rat aorta

scientific article published in January 2002

Recombinant alphaviruses as vectors for anti-tumour and anti-microbial immunotherapy

scientific article

Reconstituted influenza virus envelopes as an efficient carrier system for cellular delivery of small-interfering RNAs.

scientific article published on March 2006

Replication-defective recombinant Semliki Forest virus encoding GM-CSF as a vector system for rapid and facile generation of autologous human tumor cell vaccines

scientific article published in October 2001

Reversible Acid-Induced Inactivation of the Membrane Fusion Protein of Semliki Forest Virus

scientific article (publication date: June 2005)

Role of T cell competition in the induction of cytotoxic T lymphocyte activity during viral vector-based immunization regimens

scientific article

Role of regulatory T-cells in immunization strategies involving a recombinant alphavirus vector system

scientific article published on 01 January 2011

Role of the M2 protein in influenza virus membrane fusion: effects of amantadine and monensin on fusion kinetics

scientific article published in August 1993

Safety and efficacy of influenza vaccination in systemic lupus erythematosus patients with quiescent disease

scientific article published on December 2005

Semliki Forest virus produced in the absence of the 6K protein has an altered spike structure as revealed by decreased membrane fusion capacity.

scientific article published on August 2004

Severity of acute Zika virus infection: A prospective emergency room surveillance study during the 2015-2016 outbreak in Suriname

scientific article published on 23 October 2017

Sphingolipid and cholesterol dependence of alphavirus membrane fusion. Lack of correlation with lipid raft formation in target liposomes

scientific article

Sphingolipid-dependent fusion of Semliki Forest virus with cholesterol-containing liposomes requires both the 3-hydroxyl group and the double bond of the sphingolipid backbone

scientific article

Sphingolipids Activate Membrane Fusion of Semliki Forest Virus in a Stereospecific Manner

scientific article published on August 22, 1995

Studies of cell-mediated immune responses to influenza vaccination in systemic lupus erythematosus.

scientific article published in August 2009

Studies on the mechanism of membrane fusion: kinetics of calcium ion induced fusion of phosphatidylserine vesicles followed by a new assay for mixing of aqueous vesicle contents

scientific article

Superior immunogenicity of inactivated whole virus H5N1 influenza vaccine is primarily controlled by Toll-like receptor signalling.

scientific article

Superior therapeutic efficacy of alphavirus-mediated immunization against human papilloma virus type 16 antigens in a murine tumour model: effects of the route of immunization.

scientific article

The effect of pre-existing immunity on the capacity of influenza virosomes to induce cytotoxic T lymphocyte activity

scientific article published on 19 March 2008

The role of ADP-ribosylation and G(M1)-binding activity in the mucosal immunogenicity and adjuvanticity of the Escherichia coli heat-labile enterotoxin and Vibrio cholerae cholera toxin

scientific article

The role of membrane fusion activity of a whole inactivated influenza virus vaccine in (re)activation of influenza-specific cytotoxic T lymphocytes

scientific article published on October 19, 2010

The virosome concept for influenza vaccines

scientific article

Therapeutic vaccination against chronic hepatitis C virus infection

scientific article published on 25 July 2012

Use of a dialyzable short-chain phospholipid for efficient solubilization and reconstitution of influenza virus envelopes.

scientific article published on 3 April 2006

Vectors based on Semliki Forest virus for rapid and efficient gene transfer into non-endothelial cardiovascular cells: comparison to adenovirus

scientific article published in September 1997

Viral vector-based prime-boost immunization regimens: a possible involvement of T-cell competition

scientific article published on 15 November 2007

Virosome-mediated delivery of protein antigens in vivo: efficient induction of class I MHC-restricted cytotoxic T lymphocyte activity.

scientific article

Virosome-mediated delivery of protein antigens to dendritic cells

scientific article published on 01 May 2002

Virosomes for antigen and DNA delivery

scientific article

Virosomes in vaccine development: induction of cytotoxic T lymphocyte activity with virosome-encapsulated protein antigens

scientific article

Whole inactivated virus influenza vaccine is superior to subunit vaccine in inducing immune responses and secretion of proinflammatory cytokines by DCs.

scientific article published on March 2008

[Reaction to 'What is a delusion?']

scientific article published on 01 January 2006