List of works by Giovanni Maga

2,3-Dihydro-1,2-Diphenyl-substituted 4H-Pyridinone derivatives as new anti Flaviviridae inhibitors

scientific article published on 17 March 2011

2-(Alkyl/aryl)amino-6-benzylpyrimidin-4(3H)-ones as inhibitors of wild-type and mutant HIV-1: enantioselectivity studies

scientific article

3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors

scientific article published on June 2009

5-Alkyl-2-alkylamino-6-(2,6-difluorophenylalkyl)-3,4-dihydropyrimidin-4(3H)-ones, a new series of potent, broad-spectrum non-nucleoside reverse transcriptase inhibitors belonging to the DABO family.

scientific article published on March 2005

5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile

scientific article published on 17 July 2008

8-Oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutS

scientific article

8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins

scientific article published in Nature

8-oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSalpha

scientific article

A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant

scientific article published on 18 June 2016

A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors

scientific article published on 01 June 2006

A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors.

scientific article published on March 2013

A motif unique to the human DEAD-box protein DDX3 is important for nucleic acid binding, ATP hydrolysis, RNA/DNA unwinding and HIV-1 replication

scientific article

A multicomponent pharmacophore fragment-decoration approach to identify selective LRRK2-targeting probes

A multidisciplinary approach for the identification of novel HIV-1 non-nucleoside reverse transcriptase inhibitors: S-DABOCs and DAVPs

scientific article

A new and efficient synthesis of substituted 6-[(2'-dialkylamino)ethyl] pyrimidine and 4-N,N-dialkyl-6-vinyl-cytosine derivatives and evaluation of their anti-rubella activity.

scientific article published in July 2002

A new proofreading mechanism for lesion bypass by DNA polymerase-λ.

scientific article published on 23 December 2011

AKAP149 binds to HIV-1 reverse transcriptase and is involved in the reverse transcription.

scientific article published on 29 August 2008

Accessory proteins assist exonuclease-deficient bacteriophage T4 DNA polymerase in replicating past an abasic site

scientific article published on March 2007

Antivirals at the mirror: the lack of stereospecificity of some viral and human enzymes offers novel opportunities in antiviral drug development.

scientific article

Arylthiopyrrole (AThP) derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis, structure-activity relationships, and docking studies (part 1).

scientific article published on December 2006

Arylthiopyrrole (AThP) derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis, structure-activity relationships, and docking studies (part 2).

scientific article published on December 2006

Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins

scientific article published on May 2002

Characterization of the 6-methyl isoxanthopterin (6-MI) base analog dimer, a spectroscopic probe for monitoring guanine base conformations at specific sites in nucleic acids

scientific article published on 18 October 2011

Chiral Indolylarylsulfone Non-Nucleoside Reverse Transcriptase Inhibitors as New Potent and Broad Spectrum Anti-HIV-1 Agents.

scientific article published on 19 June 2017

Combinations against combinations: associations of anti-HIV 1 reverse transcriptase drugs challenged by constellations of drug resistance mutations

scientific article

Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma

scientific article

Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT.

scientific article published in May 2005

Crystal structure of HIV-1 reverse transcriptase bound to a non-nucleoside inhibitor with a novel mechanism of action

scientific article

Current state-of-the-art in preclinical and clinical development of novel non-nucleoside HIV-1 reverse transcriptase inhibitors

article

Cytotoxicity of α-dicarbonyl compounds submitted to in vitro simulated digestion process

scientific article published on 10 November 2012

DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection

scientific article published on 21 February 2019

DNA Polymerases

DNA Polymerases λ and β: The Double-Edged Swords of DNA Repair

scientific article

DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A

scientific article

DNA polymerase beta bypasses in vitro a single d(GpG)-cisplatin adduct placed on codon 13 of the HRAS gene

scientific article

DNA polymerase epsilon interacts with proliferating cell nuclear antigen in primer recognition and elongation

scientific article published on January 1995

DNA polymerase lambda from calf thymus preferentially replicates damaged DNA

scientific article published on 08 March 2002

DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading

scientific article

DNA polymerase theta purified from human cells is a high-fidelity enzyme

scientific article

DNA polymerase δ-interacting protein 2 is a processivity factor for DNA polymerase λ during 8-oxo-7,8-dihydroguanine bypass

scientific article

DNA polymerases and mutagenesis in human cancers

scientific article published on January 2010

DNA polymerases beta and lambda bypass thymine glycol in gapped DNA structures

scientific article published in June 2010

DNA replication and repair bypass machines

scientific article published on September 2011

DNA replication machinery: functional characterization of a complex containing DNA polymerase alpha, DNA polymerase delta, and replication factor C suggests an asymmetric DNA polymerase dimer

scientific article published in May 1996

DNA replication: a complex matter

scientific article published on 18 July 2003

DNA replication: a complex matter.

scientific article

Design and synthesis of thiadiazoles and thiazoles targeting the Bcr-Abl T315I mutant: from docking false positives to ATP-noncompetitive inhibitors

scientific article published in August 2010

Design, Molecular Modeling, Synthesis, and Anti-HIV-1 Activity of New Indolyl Aryl Sulfones. Novel Derivatives of the Indole-2-carboxamide

article

Design, Synthesis and SAR of New Potent HIV-1 RT Inhibitors

article

Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant.

scientific article

Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents

scientific article

Design, synthesis, biological activity, and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study.

scientific article

Design, synthesis, biological evaluation, and molecular modeling studies of TIBO-like cyclic sulfones as non-nucleoside HIV-1 reverse transcriptase inhibitors

scientific article published on January 2006

Detection of a new HIV-1 reverse transcriptase mutation (Q145M) conferring resistance to nucleoside and non-nucleoside inhibitors in a patient failing highly active antiretroviral therapy.

scientific article

Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data

scientific article

Development and in Vitro Evaluation of a Microbicide Gel Formulation for a Novel Non-Nucleoside Reverse Transcriptase Inhibitor Belonging to the N-Dihydroalkyloxybenzyloxopyrimidines (N-DABOs) Family

scientific article published on 20 February 2016

Diarylpyrimidine-dihydrobenzyloxopyrimidine hybrids: new, wide-spectrum anti-HIV-1 agents active at (sub)-nanomolar level

scientific article published on 25 March 2011

Dihydro-alkylthio-benzyl-oxopyrimidines as inhibitors of reverse transcriptase: synthesis and rationalization of the biological data on both wild-type enzyme and relevant clinical mutants.

scientific article

Diketo hexenoic acid derivatives are novel selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases, with potent cytotoxic effect against leukemic cells

scientific article

Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents

scientific article

Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases

scientific article

Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases

scientific article published on 15 June 2015

Discovery of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase Competing with the Nucleotide Substrate

article

Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants

scientific article

Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains

scientific article published on 19 January 2007

Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase

scientific article published on 6 September 2010

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

scientific article published on 15 January 2016

Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors.

scientific article

Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its

scientific article

Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms

scientific article published on 18 April 2010

Dual mode of interaction of DNA polymerase epsilon with proliferating cell nuclear antigen in primer binding and DNA synthesis

scientific article

Effect of 8-oxoguanine and abasic site DNA lesions on in vitro elongation by human DNA polymerase in the presence of replication protein A and proliferating-cell nuclear antigen

scientific article

Effect of divalent and monovalent cations on calf thymus PCNA-independent DNA polymerase delta and its 3'----5' exonuclease.

scientific article published in January 1990

Effect of α-Methoxy Substitution on the Anti-HIV Activity of Dihydropyrimidin-4(3 H)-ones

scientific article published on 20 December 2018

Effects of drug resistance mutations L100I and V106A on the binding of pyrrolobenzoxazepinone nonnucleoside inhibitors to the human immunodeficiency virus type 1 reverse transcriptase catalytic complex

scientific article published on May 2004

Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment

scientific article published on 20 September 2018

Electron microscopic analysis reveals that replication factor C is sequestered by single-stranded DNA.

scientific article published on September 1999

Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants

article

Enzymes of DNA metabolism in a patient with the Wiedemann-Rautenstrauch progeroid syndrome

scientific article published in November 1992

Error-free bypass of 2-hydroxyadenine by human DNA polymerase lambda with Proliferating Cell Nuclear Antigen and Replication Protein A in different sequence contexts

scientific article

Eukaryotic DNA Polymerases

scientific article

Expansion of CAG triplet repeats by human DNA polymerases λ and β in vitro, is regulated by flap endonuclease 1 and DNA ligase 1.

scientific article

Exploiting the nucleotide substrate specificity of repair DNA polymerases to develop novel anticancer agents

scientific article

Exploring the chemical space around the privileged pyrazolo[3,4-d]pyrimidine scaffold: toward novel allosteric inhibitors of T315I-mutated Abl.

scientific article

Exploring the role of 2-chloro-6-fluoro substitution in 2-alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: effects in HIV-1-infected cells and in HIV-1 reverse transcriptase enzymes

scientific article

Foreword: "new targets and new drugs: from in silico planning to in vivo testing".

scientific article published in January 2013

From the magic bullet to the magic target: exploiting the diverse roles of DDX3X in viral infections and tumorigenesis

scientific article published on 28 February 2019

Genetic divergence of influenza A NS1 gene in pandemic 2009 H1N1 isolates with respect to H1N1 and H3N2 isolates from previous seasonal epidemics ⬇️

scientific article published on September 1, 2010

Gln145Met/Leu changes in human immunodeficiency virus type 1 reverse transcriptase confer resistance to nucleoside and nonnucleoside analogs and impair virus replication.

scientific article

HCV-targeted antivirals: current status and future challenges

scientific article published on January 2014

HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide Substrate

scientific article

HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other

scientific article published on 01 October 2001

HIV-1 reverse transcriptase inhibitors: current issues and future perspectives

scientific article published in August 2004

Hepatitis C virus NS3 ATPase/helicase: an ATP switch regulates the cooperativity among the different substrate binding sites

scientific article

Hepatitis C virus NS3 NTPase/helicase: different stereoselectivity in nucleoside triphosphate utilisation suggests that NTPase and helicase activities are coupled by a nucleotide-dependent rate limiting step

scientific article published in November 2001

High potency of indolyl aryl sulfone nonnucleoside inhibitors towards drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutants is due to selective targeting of different mechanistic forms of the enzyme.

scientific article

Homology Model-Based Virtual Screening for the Identification of Human Helicase DDX3 Inhibitors

scientific article published on 6 November 2015

How to win the HIV-1 drug resistance hurdle race: running faster or jumping higher?

scientific article

Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents

scientific article published on 26 April 2016

Human DEAD-box ATPase DDX3 shows a relaxed nucleoside substrate specificity

scientific article published in June 2007

Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study

scientific article

Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis

scientific article (publication date: 13 December 2002)

Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: implications for novel functions

scientific article published on 01 April 2003

Human DNA polymerase β, but not λ, can bypass a 2-deoxyribonolactone lesion together with proliferating cell nuclear antigen.

scientific article published on 7 November 2012

Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation

scientific article published in September 2004

Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins

scientific article published on 8 February 2007

Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners

scientific article (publication date: 10 October 2003)

Human replication protein A can suppress the intrinsic in vitro mutator phenotype of human DNA polymerase lambda

scientific article

Human terminal deoxynucleotidyl transferases as novel targets for anticancer chemotherapy

scientific article published on January 2006

Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents

scientific article

Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines

scientific article published on 18 July 2019

Identification of a novel antiviral micro-RNA targeting the NS1 protein of the H1N1 pandemic human influenza virus and a corresponding viral escape mutation

scientific article published on 27 August 2019

Identification of a novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice

scientific article

Identification of broad-spectrum dengue/Zika virus replication inhibitors by functionalization of quinoline and 2,6-diaminopurine scaffolds.

scientific article

Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma

scientific article published on 19 December 2016

Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells.

scientific article

Identification, partial purification and inhibition by guanine analogues of a novel enzymic activity which phosphorylates guanosine to GMP in the protozoan parasite Eimeria tenella

scientific article published on March 1994

Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair.

scientific article

Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases beta and lambda.

scientific article

Indolyl aryl sulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: role of two halogen atoms at the indole ring in developing new analogues with improved antiviral activity

scientific article published on 6 September 2007

Indolyl aryl sulphones as HIV-1 non-nucleoside reverse transcriptase inhibitors: synthesis, biological evaluation and binding mode studies of new derivatives at indole-2-carboxamide

scientific article published on January 2006

Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors

scientific article

Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide

scientific article

Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus

scientific article published on April 2009

Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors

scientific article published on 24 November 2014

Inhibition of Bcr-Abl phosphorylation and induction of apoptosis by pyrazolo[3,4-d]pyrimidines in human leukemia cells

scientific article published on March 2007

Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants.

scientific article published on July 2005

Inhibition of subgenomic hepatitis C virus RNA replication by acridone derivatives: identification of an NS3 helicase inhibitor

scientific article published on May 2009

Inhibitors of human immunodeficiency virus-1 replication targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase

Investigation of novel lipid-functionalized PNA monomers as potential HIV-1 non-nucleoside reverse transcriptase and/or integrase inhibitors

scientific article published in January 2007

Kinetic studies with N2-phenylguanines and with L-thymidine indicate that herpes simplex virus type-1 thymidine kinase and thymidylate kinase share a common active site

scientific article published on August 1994

L-thymidine is phosphorylated by herpes simplex virus type 1 thymidine kinase and inhibits viral growth.

scientific article published in October 1992

Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: molecular basis for the antiviral activity of unnatural L-beta-nucleosides.

scientific article published on January 1995

Lack of stereospecificity of suid pseudorabies virus thymidine kinase

scientific article published on September 1993

Living on the Edge: DNA Polymerase Lambda between Genome Stability and Mutagenesis.

scientific article

Mechanism of interaction of novel indolylarylsulfone derivatives with K103N and Y181I mutant HIV-1 reverse transcriptase in complex with its substrates.

scientific article published on 17 November 2011

Microhomology-mediated DNA strand annealing and elongation by human DNA polymerases λ and β on normal and repetitive DNA sequences.

scientific article

Molecular basis for the antiviral and anticancer activities of unnatural L-beta-nucleosides

scientific article published in August 1998

Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs

scientific article

Molecular characterization of c-Abl/c-Src kinase inhibitors targeted against murine tumour progenitor cells that express stem cell markers

scientific article

Molecular docking, design, synthesis and biological evaluation of novel 2,3-aryl-thiazolidin-4-ones as potent NNRTIs

scientific article published on 23 September 2019

Multitarget CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach †

scientific article published on 03 December 2019

Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities

scientific article

Mutant DNA polymerase delta from thermosensitive Schizosaccharomyces pombe strains display reduced stimulation by proliferating cell nuclear antigen

scientific article published on November 1998

Mutational analysis of the HIV-1 auxiliary protein Vif identifies independent domains important for the physical and functional interaction with HIV-1 reverse transcriptase

scientific article published on 13 March 2014

N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds

scientific article

N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a scaffold for the synthesis of inhibitors of Bcr-Abl.

scientific article published on 30 August 2011

N2-benzyloxycarbonylguan-9-yl acetic acid derivatives as HIV-1 reverse transcriptase non-nucleoside inhibitors with decreased loss of potency against common drug-resistance mutations

scientific article published in October 2007

NNRTI-selected mutations at codon 190 of human immunodeficiency virus type 1 reverse transcriptase decrease susceptibility to stavudine and zidovudine.

scientific article

Nevirapine resistance mutation at codon 181 of the HIV-1 reverse transcriptase confers stavudine resistance by increasing nucleotide substrate discrimination and phosphorolytic activity.

scientific article published on 24 February 2003

Nevirapine-selected mutations Y181I/C of HIV-1 reverse transcriptase confer cross-resistance to stavudine

scientific article

New in silico and conventional in vitro approaches to advance HIV drug discovery and design

scientific article

New indolylarylsulfones as highly potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors

scientific article published on 12 April 2014

New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors

scientific article

New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target

scientific article

Next generation of antiretroviral agents targeting the RNA binding site of the HIV-1 cellular cofactor DDX3: an innovative therapeutic approach.

scientific article published on 25 May 2012

Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: past, present, and future perspectives

scientific article

Non-nucleoside HIV-1 reverse transcriptase inhibitors di-halo-indolyl aryl sulfones achieve tight binding to drug-resistant mutants by targeting the enzyme-substrate complex

scientific article

Non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis and biological evaluation of novel quinoxalinylethylpyridylthioureas as potent antiviral agents

scientific article published in March 2000

Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies.

scientific article published on 14 February 2011

Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

scientific article

Novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. A structure-activity relationship investigation

scientific article published on June 2005

Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors

scientific article

Novel pyrazolo[3,4-d]pyrimidines as dual Src-Abl inhibitors active against mutant form of Abl and the leukemia K-562 cell line.

scientific article published on 19 July 2016

Nuclear import of the transcription factor SHOOT MERISTEMLESS depends on heterodimerization with BLH proteins expressed in discrete sub-domains of the shoot apical meristem of Arabidopsis thaliana

scientific article

Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase delta by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1.

scientific article

Overcoming the drug resistance problem with second-generation tyrosine kinase inhibitors: from enzymology to structural models

scientific article published on January 2011

Oxidative DNA damage bypass in Arabidopsis thaliana requires DNA polymerase λ and proliferating cell nuclear antigen 2

scientific article published on 15 February 2011

Parallel solution-phase and microwave-assisted synthesis of new S-DABO derivatives endowed with subnanomolar anti-HIV-1 activity

scientific article published on December 2005

Parallel solution-phase synthesis of 4-dialkylamino-2-methylsulfonyl-6-vinylpyrimidines

scientific article published in January 2005

Pharmacophore modeling and molecular docking led to the discovery of inhibitors of human immunodeficiency virus-1 replication targeting the human cellular aspartic acid-glutamic acid-alanine-aspartic acid box polypeptide 3.

scientific article published on 4 October 2008

Photoreactive DNA probes as a tool for studying the translesion synthesis system in Mammalian cell extracts

scientific article published in March 2008

Potentiation of inhibition of wild-type and mutant human immunodeficiency virus type 1 reverse transcriptases by combinations of nonnucleoside inhibitors and d- and L-(beta)-dideoxynucleoside triphosphate analogs

scientific article

Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides

scientific article published on 01 February 1999

Proliferating cell nuclear antigen (PCNA): a dancer with many partners

scientific article (publication date: August 2003)

Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors

scientific article published on 20 May 2013

Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation.

scientific article published on March 2006

Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase

scientific article

Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity

scientific article

Quantitative structure-activity relationships of N2-phenylguanines as inhibitors of herpes simplex virus thymidine kinases

scientific article

Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent.

scientific article

RFLP-based genetic relationships of Einkorn wheats

scientific article published in August 1994

Reconstitution of the base excision repair pathway for 7,8-dihydro-8-oxoguanine with purified human proteins

scientific article published in May 2002

Repair and translesion DNA polymerases as anticancer drug targets

scientific article published on May 2008

Replication of 2-hydroxyadenine-containing DNA and recognition by human MutSalpha.

scientific article

Replication protein A and proliferating cell nuclear antigen coordinate DNA polymerase selection in 8-oxo-guanine repair

scholarly article

Replication protein A as a "fidelity clamp" for DNA polymerase alpha

scientific article published on 08 February 2001

Resistance to nevirapine of HIV-1 reverse transcriptase mutants: loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions.

scientific article

Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity

scientific article

Selective interaction of the human immunodeficiency virus type 1 reverse transcriptase nonnucleoside inhibitor efavirenz and its thio-substituted analog with different enzyme-substrate complexes

scientific article

Selective interactions of human kin17 and RPA proteins with chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner

scientific article

Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the "primer grip" region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants

scientific article

Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint

scientific article published on 30 October 2012

Slow binding-tight binding interaction between benzimidazol-2-one inhibitors and HIV-1 reverse transcriptase containing the lysine 103 to asparagine mutation

scientific article published on 20 March 2010

Slow-, tight-binding HIV-1 reverse transcriptase non-nucleoside inhibitors highly active against drug-resistant mutants

scientific article published on 01 April 2007

Specific structural determinants are responsible for the antioxidant activity and the cell cycle effects of resveratrol.

scientific article published on 20 April 2001

Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity

scientific article published in November 2005

Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663.

scientific article published in July 2005

Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations

scientific article published in February 2009

Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5'-triphospha

scientific article published on August 1995

Structural determinants of HIV-1 reverse transcriptase stereoselectivity towards (beta)-L-deoxy- and dideoxy-pyrimidine nucleoside triphosphates: molecular basis for the combination of L-dideoxynucleoside analogs with non-nucleoside inhibitors [...]

scientific article

Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines.

scientific article published on 8 February 2008

Structure-based pharmacophore identification of new chemical scaffolds as non-nucleoside reverse transcriptase inhibitors

scientific article

Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors

scientific article published on 29 April 2015

Substrate-induced stable enzyme-inhibitor complex formation allows tight binding of novel 2-aminopyrimidin-4(3H)-ones to drug-resistant HIV-1 reverse transcriptase mutants

scientific article published in September 2008

Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X

scientific article published on 04 November 2019

Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors

scientific article published on 18 April 2006

Synthesis and biological properties of novel 2-aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains

scientific article

Synthesis, Biological Activity, and ADME Properties of Novel S-DABOs/N-DABOs as HIV Reverse Transcriptase Inhibitors

article

Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines

scientific article

Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases

scientific article published on January 1995

Targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase as a novel strategy to inhibit viral replication

scientific article published on January 2011

The 2009 influenza pandemic: promising lessons for antiviral therapy for future outbreaks

scientific article

The Arabidopsis STRESS RESPONSE SUPPRESSOR DEAD-box RNA helicases are nucleolar- and chromocenter-localized proteins that undergo stress-mediated relocalization and are involved in epigenetic gene silencing.

scientific article published on 27 May 2014

The PDZ-ligand and Src-homology type 3 domains of epidemic avian influenza virus NS1 protein modulate human Src kinase activity during viral infection.

scientific article

The RNA helicase, nucleotide 5'-triphosphatase, and RNA 5'-triphosphatase activities of Dengue virus protein NS3 are Mg2+-dependent and require a functional Walker B motif in the helicase catalytic core.

scientific article published on October 2004

The balance between the rates of incorporation and pyrophosphorolytic removal influences the HIV-1 reverse transcriptase bypass of an abasic site with deoxy-, dideoxy-, and ribonucleotides

scientific article published in May 2008

The block of DNA polymerase delta strand displacement activity by an abasic site can be rescued by the concerted action of DNA polymerase beta and Flap endonuclease 1.

scientific article published on 27 March 2009

The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta in long patch base excision repair

scientific article published on 10 April 2007

The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1.

scientific article

The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair

scientific article published on 22 June 2004

The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins

scientific article

The human tyrosine kinase Kit and its gatekeeper mutant T670I, show different kinetic properties: Implications for drug design.

scientific article published on 2 August 2016

The novel influenza A virus protein PA-X and its naturally deleted variant show different enzymatic properties in comparison to the viral endonuclease PA.

scientific article published on 17 September 2015

The power of enzyme kinetics in the drug development process

scientific article published on January 2013

The resveratrol analogue 4,4'-dihydroxy-trans-stilbene inhibits cell proliferation with higher efficiency but different mechanism from resveratrol

scientific article

The solution structure of functionally active human proliferating cell nuclear antigen determined by small-angle neutron scattering 1 1Edited by M. F. Moody

scientific article published on 01 January 1998

The stereoselective targeting of a specific enzyme-substrate complex is the molecular mechanism for the synergic inhibition of HIV-1 reverse transcriptase by (R)-(-)-PPO464: a novel generation of nonnucleoside inhibitors

scientific article published on 25 September 2001

Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation.

scientific article published on 22 June 2011

Towards novel S-DABOC inhibitors: synthesis, biological investigation, and molecular modeling studies

scientific article

Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents.

scientific article published on 8 August 2015

Vif is an auxiliary factor of the HIV-1 reverse transcriptase and facilitates abasic site bypass

scientific article

What makes y family pols potential candidates for molecular targeted therapies and novel biotechnological applications.

scientific article published on January 2014

p15PAF binding to PCNA modulates the DNA sliding surface

scientific article published on 01 October 2018

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