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List of works by Giuseppe Valacchi

13-HODE, 9-HODE and ALOX15 as potential players in Rett syndrome OxInflammation

scientific article published on 08 February 2019

17-β-Estradiol counteracts the effects of high frequency electromagnetic fields on trophoblastic connexins and integrins

scientific article published on 30 May 2013

4-hydroxynonenal protein adducts: Key mediator in Rett syndrome oxinflammation

scientific article published on 4 January 2017

A correlation between redox imbalance and altered mitochondrial quality control pathway in Autistic Spectrum Disorder

scholarly article by Francesca Ferrara et al published July 2017 in Free Radical Biology and Medicine

A plasma proteomic approach in Rett syndrome: classical versus preserved speech variant.

scientific article published on 23 December 2013

A proteomics approach to further highlight the altered inflammatory condition in Rett syndrome

scientific article published on 04 November 2020

ASD: biochemical mechanisms behind behavioral disorders

scientific article published on 27 March 2014

Abnormal N-glycosylation pattern for brain nucleotide pyrophosphatase-5 (NPP-5) in Mecp2-mutant murine models of Rett syndrome.

scientific article published on 14 October 2015

Additive effect of combined pollutants to UV induced skin OxInflammation damage. Evaluating the protective topical application of a cosmeceutical mixture formulation

scientific article published on 18 April 2020

Air particulate matter as enhancer of ozone-induced skin damage

Alaskan Bog Blueberry (Vaccinium uliginosum) Extract as an Innovative Topical Approach to Prevent UV-Induced Skin Damage

scientific article published in 2021

Alteration of serum lipid profile, SRB1 loss, and impaired Nrf2 activation in CDKL5 disorder

scientific article published on 22 May 2015

Alterations of mitochondrial bioenergetics, dynamics, and morphology support the theory of oxidative damage involvement in autism spectrum disorder

scientific article published on 04 April 2020

Altered erythrocyte membrane fatty acid profile in typical Rett syndrome: effects of omega-3 polyunsaturated fatty acid supplementation

scientific article

Altered inflammasome machinery as a key player in the perpetuation of Rett syndrome oxinflammation

scientific article published on 06 October 2019

Alternative Pathways of Cancer Cell Death by Rottlerin: Apoptosis versus Autophagy.

scientific article published on 20 December 2012

Antiangiogenic VEGF isoform in inflammatory myopathies

scientific article published on 12 June 2013

Antiglycative Activity and RAGE Expression in Rett Syndrome

scientific article published on 15 February 2019

Antiproliferative Effect of Rottlerin on Sk-Mel-28 Melanoma Cells

scientific article published on 28 May 2015

Antiproliferative effect of two novel COX-2 inhibitors on human keratinocytes

scientific article published on 26 February 2013

Antitubulinic effect of New Fluorazone Derivatives on Melanoma Cells

scientific article published on 9 September 2015

Are E-cigarettes a safe and good alternative to cigarette smoking?

scientific article

Association between circulatory levels of adipokines and bone mineral density in postmenopausal women.

scientific article published on 18 July 2016

Beta-actin deficiency with oxidative posttranslational modifications in Rett syndrome erythrocytes: insights into an altered cytoskeletal organization

scientific article

Blueberry Extracts as a Novel Approach to Prevent Ozone-Induced Cutaneous Inflammasome Activation

scientific article published on 13 August 2020

Bone status in relation to ambulatory performance in girls with Rett syndrome: a 10-year longitudinal study

scientific article published on 09 August 2018

Calorie Restriction with a High-Fat Diet Effectively Attenuated Inflammatory Response and Oxidative Stress-Related Markers in Obese Tissues of the High Diet Fed Rats ⬇️

scientific article published on June 19, 2012

Cholesterol metabolism is altered in Rett syndrome: a study on plasma and primary cultured fibroblasts derived from patients.

scientific article

Chondroprotective effect of three different classes of anti-inflammatory agents on human osteoarthritic chondrocytes exposed to IL-1β.

scientific article published on 17 August 2015

Cigarette Smoke Affects ABCAl Expression via Liver X Receptor Nuclear Translocation in Human Keratinocytes ⬇️

scientific article published on September 17, 2010

Cigarette smoke affects keratinocytes SRB1 expression and localization via H2O2 production and HNE protein adducts formation

scientific article

Cigarette smoke and ozone effect on murine inflammatory responses ⬇️

scientific article published on July 1, 2012

Cigarette smoke exposure causes changes in Scavenger Receptor B1 level and distribution in lung cells.

scientific article

Circadian Clock and OxInflammation: Functional Crosstalk in Cutaneous Homeostasis

scientific article published on 23 April 2020

Circadian clock as possible protective mechanism to pollution induced skin damage

article by Mascia Benedusi et al published July 2017 in Free Radical Biology and Medicine

Compromised aortic vasoreactivity in male estrogen receptor-alpha-deficient mice during acute lipopolysaccharide-induced inflammation

scientific article

Compromised immune/inflammatory responses in Rett syndrome

scientific article published on 28 February 2020

Correction: Cigarette Smoke Affects Keratinocytes SRB1 Expression and Localization via H2O2 Production and HNE Protein Adducts Formation

scientific article published on 30 January 2020

Correction: Wound healing properties of hyaluronan derivatives bearing ferulate residues

scientific article published on 20 August 2015

Cutaneous MMPs are differently modulated by environmental stressors in old and young mice

scientific article published on 16 June 2007

Cutaneous responses to environmental stressors ⬇️

scientific article published on October 1, 2012

Cytokines profile and peripheral blood mononuclear cells morphology in Rett and autistic patients

scientific article

Decreased arylesterase activity of paraoxonase-1 (PON-1) might be a common denominator of neuroinflammatory and neurodegenerative diseases

scientific article published on 13 June 2016

Defective proteasome biogenesis into skin fibroblasts isolated from Rett syndrome subjects with MeCP2 non-sense mutations

scientific article published on 07 April 2020

Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide,

scientific article published on 4 March 2016

Distribution of Paraoxonase-1 (PON-1) and Lipoprotein Phospholipase A2 (Lp-PLA2) across Lipoprotein Subclasses in Subjects with Type 2 Diabetes

scientific article published on 05 November 2018

Dysfunction of glutathione S-transferase leads to excess 4-hydroxy-2-nonenal and H(2)O(2) and impaired cytokine pattern in cultured keratinocytes and blood of vitiligo patients

scientific article

Effect of Dietary Conjugated Linoleic Acid Supplementation on Early Inflammatory Responses during Cutaneous Wound Healing ⬇️

scientific article published on August 17, 2010

Effect of apple extracts on NF-kappaB activation in human umbilical vein endothelial cells

scientific article published on May 2006

Effect of combined mulberry leaf and fruit extract on liver and skin cholesterol transporters in high fat diet-induced obese mice

scientific article published on 29 January 2014

Effect of nanostructured lipid vehicles on percutaneous absorption of curcumin

scientific article published on 20 December 2013

Effect of new curcumin-containing nanostructured lipid dispersions on human keratinocytes proliferative responses

scientific article

Effect of ozone oxidative stress on chloride current in human lung cells: Chemical mediators and protective role of catalase

Effects of dietary carotenoids on mouse lung genomic profiles and their modulatory effects on short-term cigarette smoke exposures

scientific article published on 18 December 2008

Effects of ω-3 polyunsaturated fatty acids on plasma proteome in Rett syndrome.

scientific article published on 09 December 2013

Emerging topics in cutaneous wound repair.

scientific article published on July 2012

Erythrocyte shape abnormalities, membrane oxidative damage, and β-actin alterations: an unrecognized triad in classical autism

scientific article published on 21 December 2013

Ethosomes and Transethosomes as Cutaneous Delivery Systems for Quercetin: A Preliminary Study on Melanoma Cells

scientific article published on 11 May 2022

Ethosomes for Coenzyme Q10 Cutaneous Administration: From Design to 3D Skin Tissue Evaluation

scientific article published on 03 June 2020

Evaluating the effect of Ozone in UV induced skin damage

scientific article published on 03 December 2020

Evaluating the link between Paraoxonase-1 levels and Alzheimer's disease development

scientific article published on 11 October 2018

Evaluation of Anti-Oxinflammatory and ACE-Inhibitory Properties of Protein Hydrolysates Obtained from Edible Non-Mulberry Silkworm Pupae (Antheraea assama and Philosomia ricinii)

scientific article published in 2023

Evaluation of oxidative damage and Nrf2 activation by combined pollution exposure in lung epithelial cells

scientific article published on 05 June 2020

Exploring the link between scavenger receptor B1 expression and chronic obstructive pulmonary disease pathogenesis

scientific article published on 12 March 2015

Exploring the possible link between MeCP2 and oxidative stress in Rett syndrome

scientific article published on 07 May 2015

F(2)-Dihomo-isoprostanes and brain white matter damage in stage 1 Rett syndrome.

scientific article published on 23 September 2012

F2-dihomo-isoprostanes as potential early biomarkers of lipid oxidative damage in Rett syndrome.

scientific article published on 13 September 2011

F4-neuroprostanes mediate neurological severity in Rett syndrome

scientific article published on 17 April 2011

Gallic acid loaded poloxamer gel as new adjuvant strategy for melanoma: A preliminary study

scientific article published on 31 October 2019

Genes related to mitochondrial functions, protein degradation, and chromatin folding are differentially expressed in lymphomonocytes of Rett syndrome patients

scientific article published on 12 December 2013

Glutathione peroxidase activity in the blood cells of psoriatic patients correlates with their responsiveness to Efalizumab

scientific article

HelixComplex snail mucus as a potential technology against O3 induced skin damage

scientific article published on 21 February 2020

Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/β-Catenin Pathway

scientific article

Impaired enzymatic defensive activity, mitochondrial dysfunction and proteasome activation are involved in RTT cell oxidative damage

scientific article

In vivo ozone exposure induces antioxidant/stress-related responses in murine lung and skin

scientific article published in March 2004

Incorporation of quercetin in respirable lipid microparticles: effect on stability and cellular uptake on A549 pulmonary alveolar epithelial cells

scientific article

Increased blood BACE1 activity as a potential common pathogenic factor of vascular dementia and late onset Alzheimer's disease

scientific article published on 11 September 2020

Increased levels of 4HNE-protein plasma adducts in Rett syndrome.

scientific article published on 26 January 2011

Inflammasome Activation in Pollution-Induced Skin Conditions

scientific article published on 01 January 2021

Inflammation in Neurological Disorders: The Thin Boundary Between Brain and Periphery

scientific article published on 09 April 2020

Inflammatory lung disease in Rett syndrome

scientific article published on 17 March 2014

Innovative approaches in environmental medicine: redox/detoxification biomarkers in environmental intolerances

scientific article published on 5 December 2013

Integrated Haematological Profiles of Redox Status, Lipid, and Inflammatory Protein Biomarkers in Benign Obesity and Unhealthy Obesity with Metabolic Syndrome

scientific article published on 18 May 2015

Involvement of 4-hydroxy-2-nonenal in pollution-induced skin damage

scientific article published on 14 May 2019

Involvement of cutaneous SR-B1 in skin lipid homeostasis

scientific article published on 13 March 2019

Involvement of the TREK-1 channel in human alveolar cell membrane potential and its regulation by inhibitors of the chloride current

scientific article published on 25 February 2019

Isoprostanes and 4-hydroxy-2-nonenal: markers or mediators of disease? Focus on Rett syndrome as a model of autism spectrum disorder

scientific article published on 13 June 2013

KRIT1 as a possible new player in melanoma aggressiveness

scientific article published on 28 July 2020

Lactonase Activity and Lipoprotein-Phospholipase A2 as Possible Novel Serum Biomarkers for the Differential Diagnosis of Autism Spectrum Disorders and Rett Syndrome: Results from a Pilot Study

scientific article

Lipid mediators in skin inflammation: updates and current views ⬇️

scientific article published on October 21, 2010

Lipid nanostructures for antioxidant delivery: a comparative preformulation study

scientific article published on 29 August 2019

Low-grade systemic inflammation is associated with functional disability in elderly people affected by dementia.

scientific article published on 10 February 2018

Mechanisms involved in the unbalanced redox homeostasis in osteoblastic cellular model of Alkaptonuria

scientific article published on 02 June 2020

Mixed Flavonoid Supplementation Attenuates Post-Exercise Plasma Levels of Protein Carbonyls and 4-Hydroxynonenal Protein Adducts Levels in Endurance Athletes (P23-009-19)

Mixed Flavonoid Supplementation Attenuates Postexercise Plasma Levels of 4-Hydroxynonenal and Protein Carbonyls in Endurance Athletes

scientific article published on 21 November 2019

Modulation of Chloride Currents in Human Lung Epithelial Cells Exposed to Exogenous Oxidative Stress

scientific article published on 25 November 2016

Modulation of cutaneous scavenger receptor B1 levels by exogenous stressors impairs "in vitro" wound closure.

scientific article published in November 2017

Modulation of cutaneous wound healing by ozone: differences between young and aged mice

scientific article published on 29 August 2005

Modulation of oxidative stress response in neurodevelopment disorders. The case of the Rett syndrome variants: MECP2 and CDKL5

Modulation of skin oxidative stress and inflammatory markers by environmental stressors. Differences between young and old

scientific article published on 18 November 2011

Monoolein aqueous dispersions as a delivery system for quercetin

scientific article

Morphological changes and oxidative damage in Rett Syndrome erythrocytes

scientific article published on 13 December 2011

Multiple mechanisms of Rottlerin toxicity in A375 melanoma cells

scientific article published on 13 August 2019

NADPH oxidase and mitochondria are relevant sources of superoxide anion in the oxinflammatory response of macrophages exposed to airborne particulate matter

scientific article published on 24 August 2020

NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells.

scientific article

Nanoparticulate Gels for Cutaneous Administration of Caffeic Acid

scientific article published on 18 May 2020

Nanostructured lipid carriers (NLC) for the delivery of natural molecules with antimicrobial activity: production, characterisation and in vitro studies

scientific article published on 18 January 2017

Nanostructured lipid systems modified with waste material of propolis for wound healing: Design, in vitro and in vivo evaluation

scientific article published on 10 July 2017

Non-protein-bound iron and 4-hydroxynonenal protein adducts in classic autism

scientific article

Novel PKCs activate ERK through PKD1 in MCF-7 cells

scientific article published on 13 November 2010

OxInflammation in Rett syndrome

scientific article

OxInflammation: From Subclinical Condition to Pathological Biomarker

scientific article published on 09 July 2018

Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome

scientific article

Oxidative challenge in Alzheimer's disease: state of knowledge and future needs.

scientific article

Oxidative stress in Rett syndrome: natural history, genotype, and variants.

scientific article published in January 2011

Ozonated Oils and Cutaneous Wound Healing

scientific article published on 01 January 2019

Ozonated sesame oil enhances cutaneous wound healing in SKH1 mice

scientific article published on 06 December 2010

Ozonation of human blood induces a remarkable upregulation of heme oxygenase-1 and heat stress protein-70.

scientific article published on January 2007

Ozone mediators effect on "in vitro" scratch wound closure

scientific article published on 3 August 2016

Ozone-induced damage in 3D-Skin Model is prevented by topical vitamin C and vitamin E compound mixtures application

scientific article published on 16 February 2016

Paraoxonase, arylesterase and lactonase activities of paraoxonase-1 (PON1) in obese and severely obese women.

scientific article published on 23 November 2017

Partial rescue of Rett syndrome by ω-3 polyunsaturated fatty acids (PUFAs) oil

scientific article

Particulate Matter Decreases Intestinal Barrier-Associated Proteins Levels in 3D Human Intestinal Model

scientific article published on 06 May 2020

Particulate matter induces tissues oxinflammation: From mechanism to damage

scientific article published on 22 May 2020

Postexercise Inflammasome Activation and IL-1β Production Mitigated by Flavonoid Supplementation in Cyclists

scientific article published on 15 September 2020

Potassium Ascorbate with Ribose: Promising Therapeutic Approach for Melanoma Treatment.

scientific article published on 24 September 2017

Preventive effects of protopanaxadiol and protopanaxatriol ginsenosides on liver inflammation and apoptosis in hyperlipidemic apoE KO mice

scientific article published on 19 August 2011

Production and Characterization of Nanoparticle Based Hyaluronate Gel Containing Retinyl Palmitate for Wound Healing

scientific article published on 01 January 2018

Proinflammatory properties and oxidative effects of atmospheric particle components in human keratinocytes

scientific article published on 13 September 2019

Protective Effects of Topical Vitamin C Compound Mixtures against Ozone-Induced Damage in Human Skin

scholarly article by Giuseppe Valacchi published in June 2017

Protective effect of palmitoylethanolamide in a rat model of cystitis

scientific article published on 18 November 2014

Proteome composition and profiling of bioactive peptides of edible Antheraea assamensis pupae by sequential enzymatic digestion and kinetic modeling of in vitro gastrointestinal digestion

scientific article published in 2021

Proteomic analysis of 4-hydroxynonenal and nitrotyrosine modified proteins in RTT fibroblasts

scientific article published on 2 August 2016

Proteomic profiling and post-translational modifications in human keratinocytes treated with Mucuna pruriens leaf extract

scientific article published on 5 December 2013

Proteomic profiling reveals mitochondrial alterations in Rett syndrome

scientific article published on 20 May 2020

ROLE OF NRF2 IN PREVENTING OXIDATIVE STRESS INDUCED CHLORIDE CURRENT ALTERATION IN HUMAN LUNG CELLS.

scientific article published on 22 December 2017

Reactivity of mouse alveolar macrophages to cigarette smoke is strain dependent

scientific article

Redox imbalance and morphological changes in skin fibroblasts in typical Rett syndrome

scientific article

Redox regulation of cutaneous inflammasome by ozone exposure

scientific article published on 26 November 2019

Redox regulation of inflammatory processes

scientific article published on 03 November 2016

Repeated Exposure of Native African Adansonia Digitata (Baobab) and Moringa Oleifera (Moringa) Modifies Caco-2 Cell Differentiation but Not Carotenoid Absorption (P10-025-19)

Resveratrol prevents cigarette smoke-induced keratinocytes damage

scientific article

Resveratrol: from diet to topical usage.

scientific article published on 16 October 2017

Retention of Mitochondria in Mature Human Red Blood Cells as the Result of Autophagy Impairment in Rett Syndrome.

scientific article published on 26 September 2017

Rottlerin and curcumin: a comparative analysis.

scientific article published on July 2012

Rottlerin exhibits antiangiogenic effects in vitro

scientific article published on 4 May 2011

Rottlerin inhibits ROS formation and prevents NFkappaB activation in MCF-7 and HT-29 cells

scientific article published on January 2009

Rottlerin: a multifaced regulator of keratinocyte cell cycle.

scientific article

Rottlerin: bases for a possible usage in psoriasis.

scientific article published on June 2010

SARS-CoV-2 infection, COVID-19 pathogenesis, and exposure to air pollution: What is the connection?

scientific article published on 06 October 2020

SRB1 as a new redox target of cigarette smoke in human sebocytes

scientific article published on 16 November 2016

Scavenger Receptor B1 oxidative post-translational modifications are responsible for its loss in Rett syndrome

scientific article

Scavenger receptor B1 post-translational modifications in Rett syndrome.

scientific article published on 24 May 2013

Scavenger receptor B1, a cutaneous sensor of pollution-induced oxidative damage

Scavenger receptor class B type I: a multifunctional receptor ⬇️

scientific article published on July 1, 2011

Serum beta-secretase 1 (BACE1) activity as candidate biomarker for late-onset Alzheimer's disease

scientific article published on 19 November 2019

Serum from patients affected by Alzheimer disease shows a paraoxonase-dependent pro-apoptotic effect on endothelial cells

Skin Damage Mechanisms Related to Airborne Particulate Matter Exposure

scientific article published on 26 October 2015

Skin Health from the Inside Out

scientific article published on 06 January 2020

Subclinical inflammatory status in Rett syndrome

scientific article published on 06 January 2014

Subclinical myocardial dysfunction in Rett syndrome.

scientific article published on 23 November 2011

Systemic oxidative stress and conversion to dementia of elderly patients with mild cognitive impairment

scientific article published on 12 January 2014

Systemic oxidative stress in classic Rett syndrome.

scientific article

TRAIL and Ceruloplasmin Inverse Correlation as a Representative Crosstalk between Inflammation and Oxidative Stress

scientific article published on 26 July 2018

Targeted lipidomics distinguishes patient subgroups in mild cognitive impairment (MCI) and late onset Alzheimer's disease (LOAD).

scientific article published on 14 November 2015

Testing a Combination of Markers of Systemic Redox Status as a Possible Tool for the Diagnosis of Late Onset Alzheimer's Disease

scientific article published on 09 September 2018

The Lesson Learned from the COVID-19 Pandemic: Can an Active Chemical Be Effective, Safe, Harmless-for-Humans and Low-Cost at a Time? Evidence on Aerosolized Hypochlorous Acid

scientific article published in 2022

The Magic Velvet Bean of Mucuna pruriens

scientific article published on October 2012

The PDE4 inhibitor CHF6001 affects keratinocyte proliferation via cellular redox pathways

scientific article published on 05 April 2020

The loss of cellular junctions in epithelial lung cells induced by cigarette smoke is attenuated by corilagin

scientific article

The physiological behaviour of IMR-32 neuroblastoma cells is affected by a 12-h hypoxia/24-h reoxygenation period.

scientific article published on 18 July 2010

The role of oxidative stress in Rett syndrome: an overview.

scientific article published on July 2012

Tissue-specific gene expression of prolactin receptor in the acute-phase response induced by lipopolysaccharides

scientific article published on 8 June 2004

Topical alpha-tocotrienol supplementation inhibits lipid peroxidation but fails to mitigate increased transepidermal water loss after benzoyl peroxide treatment of human skin

scientific article

Trehalose inhibits cell proliferation and amplifies long-term temozolomide- and radiation-induced cytotoxicity in melanoma cells: A role for autophagy and premature senescence

scientific article published on 29 November 2018

Unrecognized lung disease in classic Rett syndrome: a physiologic and high-resolution CT imaging study.

scientific article

Validity of Oxygen-Ozone Therapy as Integrated Medication Form in Chronic Inflammatory Diseases

scientific article

Vitamin C Compound Mixtures Prevent Ozone-Induced Oxidative Damage in Human Keratinocytes as Initial Assessment of Pollution Protection

scientific article

Walnuts reduce aortic ET-1 mRNA levels in hamsters fed a high-fat, atherogenic diet.

scientific article published in February 2006

Wound healing properties of hyaluronan derivatives bearing ferulate residues

scientific article published on 04 August 2015

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