List of works - Nanduri R Prabhakar

2019 Nobel Prize in Physiology or Medicine

scientific article published on 01 March 2020

Activation of tyrosine hydroxylase by intermittent hypoxia: involvement of serine phosphorylation ⬇️

scientific article published on April 11, 2003

Angiotensin II evokes sensory long-term facilitation of the carotid body via NADPH oxidase.

scientific article

CaV3.2 T-type Ca2+ channels mediate the augmented calcium influx in carotid body glomus cells by chronic intermittent hypoxia

scientific article published on 11 November 2015

CaV3.2 T-type Ca²⁺ channels in H₂S-mediated hypoxic response of the carotid body.

scientific article

Calpain activation by ROS mediates human ether-a-go-go-related gene protein degradation by intermittent hypoxia

scientific article published on 9 December 2015

Carbon monoxide (CO) and hydrogen sulfide (H(2)S) in hypoxic sensing by the carotid body

scientific article

Cardiovascular alterations by chronic intermittent hypoxia: importance of carotid body chemoreflexes.

scientific article

Cellular and molecular mechanisms associated with carotid body adaptations to chronic hypoxia

scientific article

DNA methylation in the central and efferent limbs of the chemo reflex requires carotid body neural activity

scientific article

Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha

scientific journal article

Enhanced neuropeptide Y synthesis during intermittent hypoxia in the rat adrenal medulla: role of reactive oxygen species-dependent alterations in precursor peptide processing

scientific article

Epigenetic Regulation of Carotid Body Oxygen Sensing: Clinical Implications

scientific article (publication date: 2015)

Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis

scientific article published on 9 January 2012

Gasotransmitter regulation of ion channels: a key step in O2 sensing by the carotid body

scientific article

H2S mediates O2 sensing in the carotid body

scientific article

H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea

scientific article

HIF-1α activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase

scientific article

HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium

scientific article

Hydrogen peroxide differentially affects activity in the pre-Bötzinger complex and hippocampus

scientific article published on 17 August 2011

Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension ⬇️

scientific article published on January 31, 2011

Hypoxia-inducible factors and hypertension: lessons from sleep apnea syndrome

scientific article

Hypoxia‐inducible factor 1 mediates increased expression of NADPH oxidase‐2 in response to intermittent hypoxia ⬇️

scientific article published on November 1, 2011

Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas

scientific article published on 7 August 2003

Intermittent hypoxia activates peptidylglycine alpha-amidating monooxygenase in rat brain stem via reactive oxygen species-mediated proteolytic processing

scientific journal article

Intermittent hypoxia augments acute hypoxic sensing via HIF-mediated ROS ⬇️

scientific article published on September 8, 2010

Is insulin the new intermittent hypoxia?

scientific article

Long-term facilitation of catecholamine secretion from adrenal chromaffin cells of neonatal rats by chronic intermittent hypoxia

scientific article published on 04 September 2019

Mechanisms of sympathetic activation and blood pressure elevation by intermittent hypoxia ⬇️

scientific article published on September 8, 2010

NADPH Oxidase-Derived H2O2Contributes to Angiotensin II-Induced Aldosterone Synthesis in Human and Rat Adrenal Cortical Cells ⬇️

scientific article published on March 2, 2012

NADPH oxidase 2 mediates intermittent hypoxia-induced mitochondrial complex I inhibition: relevance to blood pressure changes in rats

scientific article

Neonatal intermittent hypoxia impairs neuronal nicotinic receptor expression and function in adrenal chromaffin cells ⬇️

scientific article published on August 1, 2010

Neuromolecular mechanisms mediating the effects of chronic intermittent hypoxia on adrenal medulla

scientific article

Oxidative stress in the systemic and cellular responses to intermittent hypoxia

scientific article published on March 2004

Oxygen Sensing and Homeostasis

scientific article

Particulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels.

journal article published in 2012

Pattern-specific sustained activation of tyrosine hydroxylase by intermittent hypoxia: role of reactive oxygen species-dependent downregulation of protein phosphatase 2A and upregulation of protein kinases

scientific article

Peripheral chemoreception and arterial pressure responses to intermittent hypoxia

scientific article

Peripheral chemoreceptors in health and disease.

scientific article published on January 2004

Post‐translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of dopamine D1 receptor signaling ⬇️

scientific article published on November 19, 2010

Protein kinase G-regulated production of H2S governs oxygen sensing

scientific article published on 21 April 2015

Recent advances in understanding the physiology of hypoxic sensing by the carotid body

scientific article published on 06 December 2018

Regulation of carotid body oxygen sensing by hypoxia-inducible factors

scientific article published on 13 August 2015

Role of the carotid chemoreceptors in insulin-mediated sympathoexcitation in humans

scientific article published on 20 November 2019

Sensory plasticity of the carotid body: Role of reactive oxygen species and physiological significance ⬇️

scientific article published on May 18, 2011

Strategic plan for pediatric respiratory diseases research: an NHLBI working group report

scientific article

TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma

scientific article published on 15 May 2014

The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation

scientific journal article

The role of hypoxia-inducible factors in carotid body (patho) physiology.

scientific article published on 23 January 2018

Transcriptional responses to intermittent hypoxia

scientific article

Ventilatory changes during intermittent hypoxia: importance of pattern and duration.

scientific article

Xanthine oxidase mediates hypoxia-inducible factor-2α degradation by intermittent hypoxia ⬇️

scientific article

List of works by Nanduri R Prabhakar

2019 Nobel Prize in Physiology or Medicine

Activation of tyrosine hydroxylase by intermittent hypoxia: involvement of serine phosphorylation ⬇️

Angiotensin II evokes sensory long-term facilitation of the carotid body via NADPH oxidase.

CaV3.2 T-type Ca2+ channels mediate the augmented calcium influx in carotid body glomus cells by chronic intermittent hypoxia

CaV3.2 T-type Ca²⁺ channels in H₂S-mediated hypoxic response of the carotid body.

Calpain activation by ROS mediates human ether-a-go-go-related gene protein degradation by intermittent hypoxia

Carbon monoxide (CO) and hydrogen sulfide (H(2)S) in hypoxic sensing by the carotid body

Cardiovascular alterations by chronic intermittent hypoxia: importance of carotid body chemoreflexes.

Cellular and molecular mechanisms associated with carotid body adaptations to chronic hypoxia

DNA methylation in the central and efferent limbs of the chemo reflex requires carotid body neural activity

Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha

Enhanced neuropeptide Y synthesis during intermittent hypoxia in the rat adrenal medulla: role of reactive oxygen species-dependent alterations in precursor peptide processing

Epigenetic Regulation of Carotid Body Oxygen Sensing: Clinical Implications

Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis

Gasotransmitter regulation of ion channels: a key step in O2 sensing by the carotid body

H2S mediates O2 sensing in the carotid body

H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea

HIF-1α activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase

HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium

Hydrogen peroxide differentially affects activity in the pre-Bötzinger complex and hippocampus

Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension ⬇️

Hypoxia-inducible factors and hypertension: lessons from sleep apnea syndrome

Hypoxia‐inducible factor 1 mediates increased expression of NADPH oxidase‐2 in response to intermittent hypoxia ⬇️

Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas

Intermittent hypoxia activates peptidylglycine alpha-amidating monooxygenase in rat brain stem via reactive oxygen species-mediated proteolytic processing

Intermittent hypoxia augments acute hypoxic sensing via HIF-mediated ROS ⬇️

Is insulin the new intermittent hypoxia?

Long-term facilitation of catecholamine secretion from adrenal chromaffin cells of neonatal rats by chronic intermittent hypoxia

Mechanisms of sympathetic activation and blood pressure elevation by intermittent hypoxia ⬇️

NADPH Oxidase-Derived H2O2Contributes to Angiotensin II-Induced Aldosterone Synthesis in Human and Rat Adrenal Cortical Cells ⬇️

NADPH oxidase 2 mediates intermittent hypoxia-induced mitochondrial complex I inhibition: relevance to blood pressure changes in rats

Neonatal intermittent hypoxia impairs neuronal nicotinic receptor expression and function in adrenal chromaffin cells ⬇️

Neuromolecular mechanisms mediating the effects of chronic intermittent hypoxia on adrenal medulla

Oxidative stress in the systemic and cellular responses to intermittent hypoxia

Oxygen Sensing and Homeostasis

Particulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels.

Pattern-specific sustained activation of tyrosine hydroxylase by intermittent hypoxia: role of reactive oxygen species-dependent downregulation of protein phosphatase 2A and upregulation of protein kinases

Peripheral chemoreception and arterial pressure responses to intermittent hypoxia

Peripheral chemoreceptors in health and disease.

Post‐translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of dopamine D1 receptor signaling ⬇️

Protein kinase G-regulated production of H2S governs oxygen sensing

Recent advances in understanding the physiology of hypoxic sensing by the carotid body

Regulation of carotid body oxygen sensing by hypoxia-inducible factors

Role of the carotid chemoreceptors in insulin-mediated sympathoexcitation in humans

Sensory plasticity of the carotid body: Role of reactive oxygen species and physiological significance ⬇️

Strategic plan for pediatric respiratory diseases research: an NHLBI working group report

TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma

The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation

The role of hypoxia-inducible factors in carotid body (patho) physiology.

Transcriptional responses to intermittent hypoxia

Ventilatory changes during intermittent hypoxia: importance of pattern and duration.

Xanthine oxidase mediates hypoxia-inducible factor-2α degradation by intermittent hypoxia ⬇️