List of works - Liudmila Cebotaru

A Preclinical Study in Rhesus Macaques for Cystic Fibrosis to Assess Gene Transfer and Transduction by AAV1 and AAV5 with a Dual-Luciferase Reporter System.

scientific article published on 20 July 2017

A new role for heat shock factor 27 in the pathophysiology of Clostridium difficile toxin B

scientific article published on 11 November 2019

A potential strategy for reducing cysts in autosomal dominant polycystic kidney disease with a CFTR corrector

scientific article published on 06 June 2018

AN INHIBITOR OF HISTONE DEACETYLASE 6 ACTIVITY, ACY-1215, REDUCES cAMP and CYST GROWTH IN POLYCYSTIC KIDNEY DISEASE.

scientific article

Adeno-Associated Virus (AAV) gene therapy for cystic fibrosis: current barriers and recent developments

scientific article published on 28 June 2017

An Evaluation of Factors Associated With Pathogenic PRSS1, SPINK1, CTFR, and/or CTRC Genetic Variants in Patients With Idiopathic Pancreatitis

scientific article

C1q/TNF-related protein-12 (CTRP12), a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes

scientific journal article

CFTR Controls the Activity of NF-κB by Enhancing the Degradation of TRADD.

scientific article published on 14 December 2016

ClC-5: role in endocytosis in the proximal tubule.

scientific article published on 7 June 2005

Combination of Correctors Rescue ΔF508-CFTR by Reducing Its Association with Hsp40 and Hsp27.

scientific article

Combination of Correctors Rescues CFTR Transmembrane-Domain Mutants by Mitigating their Interactions with Proteostasis

scientific article published on 25 April 2017

Complement yourself: Transcomplementation rescues partially folded mutant proteins

scientific article

Correcting the cystic fibrosis disease mutant, A455E CFTR

scientific article published in 2014

Correctors Rescue CFTR Mutations in Nucleotide-Binding Domain 1 (NBD1) by Modulating Proteostasis.

scientific article published on 11 February 2016

Cystic fibrosis transmembrane conductance regulator modulators reduce the risk of recurrent acute pancreatitis among adult patients with pancreas sufficient cystic fibrosis

scientific article published on 28 September 2019

Cystic fibrosis transmembrane regulator missing the first four transmembrane segments increases wild type and DeltaF508 processing

scientific article published on 28 May 2008

Dexamethasone regulates CFTR expression in Calu-3 cells with the involvement of chaperones HSP70 and HSP90.

scientific article

Does the use of recombinant AAV2 in pulmonary gene therapy damage lung function?

scientific article published on 14 September 2007

Dual reporter comparative indexing of rAAV pseudotyped vectors in chimpanzee airway.

scientific article published on 13 October 2009

Enterohemorrhagic Escherichia coli infection stimulates Shiga toxin 1 macropinocytosis and transcytosis across intestinal epithelial cells

scientific article (publication date: November 2011)

Expression of a truncated cystic fibrosis transmembrane conductance regulator with an AAV5-pseudotyped vector in primates

scientific article published on 13 February 2007

Gene expression profile analysis of 4-phenylbutyrate treatment of IB3-1 bronchial epithelial cell line demonstrates a major influence on heat-shock proteins ⬇️

scientific article published on January 15, 2004

Gene therapy for cystic fibrosis paved the way for the use of AAV in gene therapy

scientific article published on 13 April 2020

Generation and genetic engineering of human induced pluripotent stem cells using designed zinc finger nucleases

scientific article published on 19 October 2012

Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca2+ in knock-out mouse models of polycystic kidney disease.

scientific article published on 8 September 2017

Inhibition of histone deacetylase 6 activity reduces cyst growth in polycystic kidney disease

scientific article published on 25 March 2016

Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier

scientific article published on 14 January 2014

Pharmacological reversal of renal cysts from secretion to absorption suggests a potential therapeutic strategy for managing autosomal dominant polycystic kidney disease

scientific article published on 30 September 2019

Polycystin-1 negatively regulates Polycystin-2 expression via the aggresome/autophagosome pathway.

scientific article published on 23 January 2014

Polycystin-1, 2, and STIM1 interact with IP(3)R to modulate ER Ca release through the PI3K/Akt pathway

scientific article published on 17 June 2011

Regulation of CFTR Expression and Arginine Vasopressin Activity Are Dependent on Polycystin-1 in Kidney-Derived Cells.

scientific article published on 8 January 2016

Rescue of CFTR NBD2 mutants N1303K and S1235R is influenced by the functioning of the autophagosome

scientific article published on 20 June 2018

Rescue of NBD2 mutants N1303K and S1235R of CFTR by small-molecule correctors and transcomplementation

scientific article

Rescuing Trafficking Mutants of the ATP-binding Cassette Protein, ABCA4, with Small Molecule Correctors as a Treatment for Stargardt Eye Disease.

scientific article published on 19 June 2015

Restoration of F508-del Function by Transcomplementation: The Partners Meet in the Endoplasmic Reticulum

scientific article published on 01 January 2019

Role of calcium in adult onset polycystic kidney disease

article

STIM1fl/fl Ksp-Cre Mouse has Impaired Renal Water Balance

scientific article published on 24 June 2016

Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator

scientific article

Syntaxin 8 and the Endoplasmic Reticulum Processing of ΔF508-CFTR

scientific article published on 28 November 2018

The CFTR Corrector, VX-809 (Lumacaftor), Rescues ABCA4 Trafficking Mutants: a Potential Treatment for Stargardt Disease

scientific article published on 01 January 2019

The CFTR-Associated Ligand Arrests the Trafficking of the Mutant ΔF508 CFTR Channel in the ER Contributing to Cystic Fibrosis

scientific article published on 29 January 2018

The Hypertonic Environment Differentially Regulates Wild-type CFTR and TNR-CFTR Chloride Channels ⬇️

scientific article published on October 29, 2010

Therapeutic Potential for CFTR Correctors in Autosomal Recessive Polycystic Kidney Disease

scientific article published on 27 July 2021

Transcomplementation by a truncation mutant of cystic fibrosis transmembrane conductance regulator (CFTR) enhances ΔF508 processing through a biomolecular interaction

scientific article published on 5 March 2013

Transcription factor MEF2C suppresses endothelial cell inflammation via regulation of NF-κB and KLF2

scientific article published in June 2015

Transcriptional adaptation to Clcn5 knockout in proximal tubules of mouse kidney.

scientific article

Transduction of Surface and Basal Cells in Rhesus Macaque Lung Following Repeat Dosing with AAV1CFTR

scientific article published on 01 September 2020

Translational research to enable personalized treatment of cystic fibrosis

scientific article published on 21 December 2017

Tubular and cellular localization of the cardiac L-type calcium channel in rat kidney

scientific article published on April 2002

WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway

scientific article

WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells

scientific article

List of works by Liudmila Cebotaru

A Preclinical Study in Rhesus Macaques for Cystic Fibrosis to Assess Gene Transfer and Transduction by AAV1 and AAV5 with a Dual-Luciferase Reporter System.

A new role for heat shock factor 27 in the pathophysiology of Clostridium difficile toxin B

A potential strategy for reducing cysts in autosomal dominant polycystic kidney disease with a CFTR corrector

AN INHIBITOR OF HISTONE DEACETYLASE 6 ACTIVITY, ACY-1215, REDUCES cAMP and CYST GROWTH IN POLYCYSTIC KIDNEY DISEASE.

Adeno-Associated Virus (AAV) gene therapy for cystic fibrosis: current barriers and recent developments

An Evaluation of Factors Associated With Pathogenic PRSS1, SPINK1, CTFR, and/or CTRC Genetic Variants in Patients With Idiopathic Pancreatitis

C1q/TNF-related protein-12 (CTRP12), a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes

CFTR Controls the Activity of NF-κB by Enhancing the Degradation of TRADD.

ClC-5: role in endocytosis in the proximal tubule.

Combination of Correctors Rescue ΔF508-CFTR by Reducing Its Association with Hsp40 and Hsp27.

Combination of Correctors Rescues CFTR Transmembrane-Domain Mutants by Mitigating their Interactions with Proteostasis

Complement yourself: Transcomplementation rescues partially folded mutant proteins

Correcting the cystic fibrosis disease mutant, A455E CFTR

Correctors Rescue CFTR Mutations in Nucleotide-Binding Domain 1 (NBD1) by Modulating Proteostasis.

Cystic fibrosis transmembrane conductance regulator modulators reduce the risk of recurrent acute pancreatitis among adult patients with pancreas sufficient cystic fibrosis

Cystic fibrosis transmembrane regulator missing the first four transmembrane segments increases wild type and DeltaF508 processing

Dexamethasone regulates CFTR expression in Calu-3 cells with the involvement of chaperones HSP70 and HSP90.

Does the use of recombinant AAV2 in pulmonary gene therapy damage lung function?

Dual reporter comparative indexing of rAAV pseudotyped vectors in chimpanzee airway.

Enterohemorrhagic Escherichia coli infection stimulates Shiga toxin 1 macropinocytosis and transcytosis across intestinal epithelial cells

Expression of a truncated cystic fibrosis transmembrane conductance regulator with an AAV5-pseudotyped vector in primates

Gene expression profile analysis of 4-phenylbutyrate treatment of IB3-1 bronchial epithelial cell line demonstrates a major influence on heat-shock proteins ⬇️

Gene therapy for cystic fibrosis paved the way for the use of AAV in gene therapy

Generation and genetic engineering of human induced pluripotent stem cells using designed zinc finger nucleases

Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca2+ in knock-out mouse models of polycystic kidney disease.

Inhibition of histone deacetylase 6 activity reduces cyst growth in polycystic kidney disease

Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier

Pharmacological reversal of renal cysts from secretion to absorption suggests a potential therapeutic strategy for managing autosomal dominant polycystic kidney disease

Polycystin-1 negatively regulates Polycystin-2 expression via the aggresome/autophagosome pathway.

Polycystin-1, 2, and STIM1 interact with IP(3)R to modulate ER Ca release through the PI3K/Akt pathway

Regulation of CFTR Expression and Arginine Vasopressin Activity Are Dependent on Polycystin-1 in Kidney-Derived Cells.

Rescue of CFTR NBD2 mutants N1303K and S1235R is influenced by the functioning of the autophagosome

Rescue of NBD2 mutants N1303K and S1235R of CFTR by small-molecule correctors and transcomplementation

Rescuing Trafficking Mutants of the ATP-binding Cassette Protein, ABCA4, with Small Molecule Correctors as a Treatment for Stargardt Eye Disease.

Restoration of F508-del Function by Transcomplementation: The Partners Meet in the Endoplasmic Reticulum

Role of calcium in adult onset polycystic kidney disease

STIM1fl/fl Ksp-Cre Mouse has Impaired Renal Water Balance

Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator

Syntaxin 8 and the Endoplasmic Reticulum Processing of ΔF508-CFTR

The CFTR Corrector, VX-809 (Lumacaftor), Rescues ABCA4 Trafficking Mutants: a Potential Treatment for Stargardt Disease

The CFTR-Associated Ligand Arrests the Trafficking of the Mutant ΔF508 CFTR Channel in the ER Contributing to Cystic Fibrosis

The Hypertonic Environment Differentially Regulates Wild-type CFTR and TNR-CFTR Chloride Channels ⬇️

Therapeutic Potential for CFTR Correctors in Autosomal Recessive Polycystic Kidney Disease

Transcomplementation by a truncation mutant of cystic fibrosis transmembrane conductance regulator (CFTR) enhances ΔF508 processing through a biomolecular interaction

Transcription factor MEF2C suppresses endothelial cell inflammation via regulation of NF-κB and KLF2

Transcriptional adaptation to Clcn5 knockout in proximal tubules of mouse kidney.

Transduction of Surface and Basal Cells in Rhesus Macaque Lung Following Repeat Dosing with AAV1CFTR

Translational research to enable personalized treatment of cystic fibrosis

Tubular and cellular localization of the cardiac L-type calcium channel in rat kidney

WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway

WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells