List of works - Jeffery G Saven

7 Computational protein design and discovery

A computationally designed water-soluble variant of a G-protein-coupled receptor: the human mu opioid receptor

scientific article

A focused antibody library for selecting scFvs expressed at high levels in the cytoplasm

scientific article

Advances in computational protein design

scientific article published in August 2004

All-Electronic Quantification of Neuropeptide-Receptor Interaction Using a Bias-Free Functionalized Graphene Microelectrode

scientific article published on 17 April 2018

An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity

scientific article

Binding Site and Affinity Prediction of General Anesthetics to Protein Targets Using Docking ⬇️

scientific article published on March 5, 2012

Characterization of a computationally designed water-soluble human μ-opioid receptor variant using available structural information

scientific article

Characterization of the cofactor-induced folding mechanism of a zinc-binding peptide using computationally designed mutants

scientific article published on 8 April 2009

Combinatorial protein design

scientific article

Combinatorial protein design strategies using computational methods

scientific article

Computational De Novo Design and Characterization of a Four-Helix Bundle Protein that Selectively Binds a Nonbiological Cofactor [J.Am. Chem. Soc.2005,127, 1346−1347]

article

Computational Design of Membrane Proteins ⬇️

scientific article published on January 11, 2012

Computational de novo design and characterization of a four-helix bundle protein that selectively binds a nonbiological cofactor

scientific article

Computational de novo design and characterization of a protein that selectively binds a highly hyperpolarizable abiological chromophore

scientific article published on 05 September 2013

Computational design and characterization of a monomeric helical dinuclear metalloprotein

scientific article published on December 2003

Computational design and elaboration of a de novo heterotetrameric alpha-helical protein that selectively binds an emissive abiological (porphinato)zinc chromophore

scientific article

Computational design and selections for an engineered, thermostable terpene synthase ⬇️

scientific article published on August 2, 2011

Computational design of a protein crystal ⬇️

scientific article published on April 25, 2012

Computational design of four-helix bundle proteins that bind nonbiological cofactors

scientific article published on 16 January 2008

Computational design of water-soluble analogues of the potassium channel KcsA

scholarly article

Computational protein design to reengineer stromal cell-derived factor-1α generates an effective and translatable angiogenic polypeptide analog

scientific article published in September 2011

Computational protein design: Advances in the design and redesign of biomolecular nanostructures ⬇️

scientific article published on April 1, 2010

Computational protein design: engineering molecular diversity, nonnatural enzymes, nonbiological cofactor complexes, and membrane proteins ⬇️

scientific article published on April 12, 2011

Computational protein design: structure, function and combinatorial diversity

scientific article

Computationally designed peptides for self-assembly of nanostructured lattices

scientific article published on 09 September 2016

Controlling Association and Separation of Gold Nanoparticles with Computationally Designed Zinc-Coordinating Proteins

scientific article

De novo design of a redox-active minimal rubredoxin mimic

scientific article

Design of functional ferritin-like proteins with hydrophobic cavities

scientific article published in May 2006

Designing gene libraries from protein profiles for combinatorial protein experiments

scientific article

Directing noble metal ion chemistry within a designed ferritin protein

scientific article

Engineering complementary hydrophobic interactions to control β-hairpin peptide self-assembly, network branching, and hydrogel properties

scientific article published on 17 October 2014

Evolutionary constraints on structural similarity in orthologs and paralogs

scientific article published on June 2009

Helical wrapping of single-walled carbon nanotubes by water soluble poly(p-phenyleneethynylene).

scientific article published in April 2009

Highly tunable photoluminescent properties of amphiphilic conjugated block copolymers

scientific article published on July 2010

Human μ Opioid Receptor Models with Evaluation of the Accuracy Using the Crystal Structure of the Murine μ Opioid Receptor

scientific article published on July 2012

Identification of the active form of endothelial lipase, a homodimer in a head-to-tail conformation

scientific article

Limitations of yeast surface display in engineering proteins of high thermostability

scientific article

Magneto-structural relationships for radical cation and neutral pyridinophane structures with intrabridgehead nitrogen atoms. An integrated experimental and quantum mechanical study.

scientific article

Modulating the DNA affinity of Elk-1 with computationally selected mutations

scientific article

Molecular Dynamics Simulation of WSK-3, a Computationally Designed, Water-Soluble Variant of the Integral Membrane Protein KcsA

scientific article

Molecular interactions between general anesthetics and the 5HT2B receptor.

scientific article published on 23 December 2013

Molecular recognition of ketamine by a subset of olfactory G protein-coupled receptors

scientific article published on 31 March 2015

Multiple hindered rotators in a gyroscope-inspired tribenzylamine hemicryptophane.

scientific article published on 27 January 2011

NMR structure and dynamics of a designed water-soluble transmembrane domain of nicotinic acetylcholine receptor

scientific article

Observing Changes in the Structure and Oligomerization State of a Helical Protein Dimer Using Solid-State Nanopores.

scientific article published on 17 August 2015

Opioid Binding Sites in Human Serum Albumin ⬇️

scientific article published on October 24, 2011

Photoinduced Electron Transfer Elicits a Change in the Static Dielectric Constant of a de Novo Designed Protein

scientific article published on 03 February 2016

Polyelectrolyte character of rigid rod peptide bundlemer chains constructed via hierarchical self-assembly

scientific article published on 01 December 2019

Polymers with controlled assembly and rigidity made with click-functional peptide bundles

scientific article published on 30 October 2019

Probabilistic approach to the design of symmetric protein quaternary structures

scientific article published in December 2003

Quantifying the effect of ionic screening with protein-decorated graphene transistors

scientific article published on 19 November 2015

Scalable Production of Molybdenum Disulfide Based Biosensors

scientific article

Scalable production of highly sensitive nanosensors based on graphene functionalized with a designed G protein-coupled receptor

scientific article

Simulation of pH-dependent edge strand rearrangement in human beta-2 microglobulin

scientific article

Single-handed helical wrapping of single-walled carbon nanotubes by chiral, ionic, semiconducting polymers

scientific article published on 21 October 2013

Statistical and molecular dynamics studies of buried waters in globular proteins

scientific article published in August 2005

Statistical theory for protein ensembles with designed energy landscapes

scientific article published in October 2005

Structural coupling between FKBP12 and buried water

scientific article

Structural-functional analysis of engineered protein-nanoparticle assemblies using graphene microelectrodes

scientific article published on 13 June 2017

Theoretical and Computational Protein Design ⬇️

scientific article published on January 1, 2011

Thermophilic Ferritin 24mer Assembly and Nanoparticle Encapsulation Modulated by Interdimer Electrostatic Repulsion

scientific article

Transition from disordered aggregates to ordered lattices: kinetic control of the assembly of a computationally designed peptide

scientific article published on 22 June 2017

Ultrafast folding of a computationally designed Trp-cage mutant: Trp2-cage

scientific article published on 01 March 2006

Using alpha-helical coiled-coils to design nanostructured metalloporphyrin arrays

scientific article published on 19 August 2008

Xe affinities of water-soluble cryptophanes and the role of confined water.

scientific article published on 22 September 2015

pH Sensing Properties of Flexible, Bias-Free Graphene Microelectrodes in Complex Fluids: From Phosphate Buffer Solution to Human Serum

scientific article published on 14 June 2017

List of works by Jeffery G Saven

7 Computational protein design and discovery

A computationally designed water-soluble variant of a G-protein-coupled receptor: the human mu opioid receptor

A focused antibody library for selecting scFvs expressed at high levels in the cytoplasm

Advances in computational protein design

All-Electronic Quantification of Neuropeptide-Receptor Interaction Using a Bias-Free Functionalized Graphene Microelectrode

An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity

Binding Site and Affinity Prediction of General Anesthetics to Protein Targets Using Docking ⬇️

Characterization of a computationally designed water-soluble human μ-opioid receptor variant using available structural information

Characterization of the cofactor-induced folding mechanism of a zinc-binding peptide using computationally designed mutants

Combinatorial protein design

Combinatorial protein design strategies using computational methods

Computational De Novo Design and Characterization of a Four-Helix Bundle Protein that Selectively Binds a Nonbiological Cofactor [J.Am. Chem. Soc.2005,127, 1346−1347]

Computational Design of Membrane Proteins ⬇️

Computational de novo design and characterization of a four-helix bundle protein that selectively binds a nonbiological cofactor

Computational de novo design and characterization of a protein that selectively binds a highly hyperpolarizable abiological chromophore

Computational design and characterization of a monomeric helical dinuclear metalloprotein

Computational design and elaboration of a de novo heterotetrameric alpha-helical protein that selectively binds an emissive abiological (porphinato)zinc chromophore

Computational design and selections for an engineered, thermostable terpene synthase ⬇️

Computational design of a protein crystal ⬇️

Computational design of four-helix bundle proteins that bind nonbiological cofactors

Computational design of water-soluble analogues of the potassium channel KcsA

Computational protein design to reengineer stromal cell-derived factor-1α generates an effective and translatable angiogenic polypeptide analog

Computational protein design: Advances in the design and redesign of biomolecular nanostructures ⬇️

Computational protein design: engineering molecular diversity, nonnatural enzymes, nonbiological cofactor complexes, and membrane proteins ⬇️

Computational protein design: structure, function and combinatorial diversity

Computationally designed peptides for self-assembly of nanostructured lattices

Controlling Association and Separation of Gold Nanoparticles with Computationally Designed Zinc-Coordinating Proteins

De novo design of a redox-active minimal rubredoxin mimic

Design of functional ferritin-like proteins with hydrophobic cavities

Designing gene libraries from protein profiles for combinatorial protein experiments

Directing noble metal ion chemistry within a designed ferritin protein

Engineering complementary hydrophobic interactions to control β-hairpin peptide self-assembly, network branching, and hydrogel properties

Evolutionary constraints on structural similarity in orthologs and paralogs

Helical wrapping of single-walled carbon nanotubes by water soluble poly(p-phenyleneethynylene).

Highly tunable photoluminescent properties of amphiphilic conjugated block copolymers

Human μ Opioid Receptor Models with Evaluation of the Accuracy Using the Crystal Structure of the Murine μ Opioid Receptor

Identification of the active form of endothelial lipase, a homodimer in a head-to-tail conformation

Limitations of yeast surface display in engineering proteins of high thermostability

Magneto-structural relationships for radical cation and neutral pyridinophane structures with intrabridgehead nitrogen atoms. An integrated experimental and quantum mechanical study.

Modulating the DNA affinity of Elk-1 with computationally selected mutations

Molecular Dynamics Simulation of WSK-3, a Computationally Designed, Water-Soluble Variant of the Integral Membrane Protein KcsA

Molecular interactions between general anesthetics and the 5HT2B receptor.

Molecular recognition of ketamine by a subset of olfactory G protein-coupled receptors

Multiple hindered rotators in a gyroscope-inspired tribenzylamine hemicryptophane.

NMR structure and dynamics of a designed water-soluble transmembrane domain of nicotinic acetylcholine receptor

Observing Changes in the Structure and Oligomerization State of a Helical Protein Dimer Using Solid-State Nanopores.

Opioid Binding Sites in Human Serum Albumin ⬇️

Photoinduced Electron Transfer Elicits a Change in the Static Dielectric Constant of a de Novo Designed Protein

Polyelectrolyte character of rigid rod peptide bundlemer chains constructed via hierarchical self-assembly

Polymers with controlled assembly and rigidity made with click-functional peptide bundles

Probabilistic approach to the design of symmetric protein quaternary structures

Quantifying the effect of ionic screening with protein-decorated graphene transistors

Scalable Production of Molybdenum Disulfide Based Biosensors

Scalable production of highly sensitive nanosensors based on graphene functionalized with a designed G protein-coupled receptor

Simulation of pH-dependent edge strand rearrangement in human beta-2 microglobulin

Single-handed helical wrapping of single-walled carbon nanotubes by chiral, ionic, semiconducting polymers

Statistical and molecular dynamics studies of buried waters in globular proteins

Statistical theory for protein ensembles with designed energy landscapes

Structural coupling between FKBP12 and buried water

Structural-functional analysis of engineered protein-nanoparticle assemblies using graphene microelectrodes

Theoretical and Computational Protein Design ⬇️

Thermophilic Ferritin 24mer Assembly and Nanoparticle Encapsulation Modulated by Interdimer Electrostatic Repulsion

Transition from disordered aggregates to ordered lattices: kinetic control of the assembly of a computationally designed peptide

Ultrafast folding of a computationally designed Trp-cage mutant: Trp2-cage

Using alpha-helical coiled-coils to design nanostructured metalloporphyrin arrays

Xe affinities of water-soluble cryptophanes and the role of confined water.

pH Sensing Properties of Flexible, Bias-Free Graphene Microelectrodes in Complex Fluids: From Phosphate Buffer Solution to Human Serum