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List of works by Jeffrey A Bluestone

A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells

scientific article published on 29 January 2019

A comprehensive review of interventions in the NOD mouse and implications for translation

scientific article

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism

scientific article published on 25 June 2018

A mimic of viral double-stranded RNA triggers fulminant type 1 diabetes-like syndrome in regulatory T cell-deficient autoimmune diabetic mouse

scientific article published on 03 October 2011

A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy.

scientific article published on 16 February 2009

A peptide of glutamic acid decarboxylase 65 can recruit and expand a diabetogenic T cell clone, BDC2.5, in the pancreas

scientific article published in September 2005

A resource for the conditional ablation of microRNAs in the mouse.

scientific article

A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes

scientific article

Aberrant innate immune activation following tissue injury impairs pancreatic regeneration

scientific article

Achieving antigen-specific tolerance in diabetes: regulating specifically

scientific article

Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala).

scientific article

Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment

scholarly article

Adoptive Regulatory T Cell Therapy in a Patient with Systemic Lupus Erythematosus

scientific article published on 24 January 2019

Altered balance between effector T cells and FOXP3+HELIOS+regulatory T cells after thymoglobulin induction in kidney transplant recipients ⬇️

scientific article published on September 21, 2012

Altered cutaneous immune parameters in transgenic mice overexpressing viral IL-10 in the epidermis

scientific article

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes

scientific article published on 09 June 2019

An important role of CD80/CD86-CTLA-4 signaling during photocarcinogenesis in mice

scientific article

Analysis of T-Cell Assays to Measure Autoimmune Responses in Subjects With Type 1 Diabetes

article

Anti-CD3 Therapy Promotes Tolerance by Selectively Depleting Pathogenic Cells while Preserving Regulatory T Cells ⬇️

scientific article published on July 8, 2011

Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs

scientific article

Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

scientific article published on May 2002

Antigen-specific regulatory T cells--ex vivo expansion and therapeutic potential

scientific article

Antithymocyte globulin therapy for patients with recent-onset type 1 diabetes: 2 year results of a randomised trial

scientific article published on 6 April 2016

Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial.

scientific article published on 28 August 2013

Author Correction: Discovery of stimulation-responsive immune enhancers with CRISPR activation

scientific article published in Nature

Autoimmunity

scientific article published on 30 October 2009

Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Receptors in Type 1 Diabetes

scientific article published on 26 October 2017

B cell depletion: a novel therapy for autoimmune diabetes?

scientific article published on December 2007

B7-independent inhibition of T cells by CTLA-4.

scientific article published in July 2005

Beta-cell replacement for type I diabetes

scientific article published on January 2004

Breakdown in peripheral tolerance in type 1 diabetes in mice and humans

scientific article published on March 2012

Bringing transplantation tolerance into the clinic: lessons from the ITN and RISET for the Establishment of Tolerance consortia

scientific article published on August 2010

CD28 Costimulation: From Mechanism to Therapy

scientific article published on May 2016

CD28 function: a balance of costimulatory and regulatory signals

scientific article (publication date: 2002)

CD28-inducible transcription factor DEC1 is required for efficient autoreactive CD4+ T cell response

scientific article published on 22 July 2013

CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo

scientific article published in February 2003

CD3-specific antibodies: a portal to the treatment of autoimmunity

scientific article

CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells

scientific article published on 27 April 2008

CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis.

scientific article published on 29 January 2016

CD4+Foxp3+ regulatory T cell therapy in transplantation ⬇️

scientific article published on December 14, 2011

CRISPR screen in regulatory T cells reveals modulators of Foxp3

scientific article published on 29 April 2020

CTLA-4 and tolerance: the biochemical point of view

scientific article published on January 2003

CTLA-4 regulates expansion and differentiation of Th1 cells following induction of peripheral T cell tolerance.

scientific article published in June 2004

CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment

scientific article published on 13 January 2003

CTLA-4: acting at the synapse

scientific article published in July 2002

CTLA-4Ig is finally making it: a personal perspective

scientific article published on 01 March 2005

CTLA4Ig: bridging the basic immunology with clinical application

scientific article published in March 2006

Cell-based therapeutics: the next pillar of medicine

scientific article published on April 2013

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

scientific article

Chance favours the prepared mind

scientific article published on 01 September 2018

Clinical application of regulatory T cells for treatment of type 1 diabetes and transplantation

scientific article published in April 2008

Clinical trials of transplant tolerance: slow but steady progress

scientific article

Clusterin synergizes with IL-2 for the expansion and IFN-γ production of natural killer cells ⬇️

scientific article published on August 20, 2010

Collateral Damage: Insulin-Dependent Diabetes Induced With Checkpoint Inhibitors

scientific article published on 24 June 2018

Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse.

scientific article published in July 2007

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

scientific article

Control of TH17 cells occurs in the small intestine.

scientific article

Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways.

scientific article published on August 2008

Correction: CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis

scientific article published on 01 May 2016

Corrigendum: Is autoimmunity the Achilles' heel of cancer immunotherapy?

scientific article published on 01 August 2017

Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells.

scientific article published on October 2004

Current and Future Immunomodulation Strategies to Restore Tolerance in Autoimmune Diseases ⬇️

scientific article published on November 1, 2012

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells ⬇️

scientific article published on October 1, 2003

Cutting Edge: IL-6-Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression

scientific article published on 10 January 2020

Cutting Edge: a novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28

scientific journal article

Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells

article

Cutting edge: vasostatin-1-derived peptide ChgA29-42 is an antigenic epitope of diabetogenic BDC2.5 T cells in nonobese diabetic mice

scientific article

Cytokines, Chemokines, and Other Biomarkers of Response for Checkpoint Inhibitor Therapy in Skin Cancer

DGCR8-Mediated Production of Canonical Micrornas Is Critical for Regulatory T Cell Function and Stability ⬇️

scientific article published on May 31, 2013

Differential roles of costimulatory signaling pathways in type 1 diabetes mellitus

scientific article published on January 2004

Directed evolution of a single-chain class II MHC product by yeast display

scientific article

Discovery of stimulation-responsive immune enhancers with CRISPR activation.

scientific article published on 30 August 2017

Distinct Roles of Dendritic Cells and B Cells in Va14Ja18 Natural T Cell Activation In Vivo

scientific article published on 01 April 2005

Distinct effector mechanisms in the development of autoimmune neuropathy versus diabetes in nonobese diabetic mice

scientific article published in November 2005

Distinct genetic control of autoimmune neuropathy and diabetes in the non-obese diabetic background

scientific article

Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function

scientific article published in November 2004

Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.

scientific article published on 20 May 2015

Engineering Therapeutic T Cells: From Synthetic Biology to Clinical Trials

scientific article published on 5 December 2016

Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy

scientific article published on 13 August 2018

Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice

scientific journal article

Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells

scientific article published on 02 August 2007

Expansion of Human Tregs from Cryopreserved Umbilical Cord Blood for GMP-Compliant Autologous Adoptive Cell Transfer Therapy

scientific article published on 24 December 2016

Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice

scientific article published in September 2005

Expansion of human regulatory T-cells from patients with type 1 diabetes

scientific article published on 15 December 2008

Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease.

scientific article published in May 2007

Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice ⬇️

scientific article published on November 22, 2010

FK506 causes cellular and functional defects in human natural killer cells.

scientific article published on 29 July 2010

FOXP3, the Transcription Factor at the Heart of the Rebirth of Immune Tolerance

scientific article

Functional CRISPR dissection of gene networks controlling human regulatory T cell identity

scientific article published on 28 September 2020

Future cancer research priorities in the USA: a Lancet Oncology Commission

scientific article published on 31 October 2017

Generation of knock-in primary human T cells using Cas9 ribonucleoproteins.

scientific article

Genetics, pathogenesis and clinical interventions in type 1 diabetes

scientific article

Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease

scientific article published on 15 February 2016

How do CD4+CD25+ regulatory T cells control autoimmunity?

scientific article

How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited

scientific article published on May 2011

Human Antigen-Specific Regulatory T Cells Generated by T Cell Receptor Gene Transfer ⬇️

scientific article published on July 22, 2010

Human regulatory T cells: role in autoimmune disease and therapeutic opportunities

scientific article published on June 2008

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

scientific article

IL-2: Change Structure … Change Function

scientific article published in May 2015

IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells.

scientific article

Immune Therapy and β-Cell Death in Type 1 Diabetes ⬇️

scientific article published on February 19, 2013

Immune response to enzyme replacement therapies in lysosomal storage diseases and the role of immune tolerance induction.

scientific article

Immunoregulatory pathways controlling progression of autoimmunity in NOD mice

scientific article

Immunotherapy of insulin-dependent diabetes mellitus

scientific article published on 01 October 2002

Immunotherapy: making the case for precision medicine

scientific article published in March 2015

Impairment of NK cell function by NKG2D modulation in NOD mice

scientific article published in January 2003

Importance of IL-10 for CTLA-4-mediated inhibition of tumor-eradicating immunity

scientific article published on February 2004

In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes

scientific article

Inability to induce tolerance through direct antigen presentation

scientific article

Inducing and Administering Tregs to Treat Human Disease

scientific article

Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.

scientific article

Inhibition of VEGFR-2 reverses type 1 diabetes in NOD mice by abrogating insulitis and restoring islet function

scientific article published on 08 July 2013

Innate antiviral host defense attenuates TGF-β function through IRF3-mediated suppression of Smad signaling

scientific article published on December 2014

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

scientific article

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

scientific article published on 26 July 2009

Insulin receptor substrate-2 in beta-cells decreases diabetes in nonobese diabetic mice

scientific article published on 02 July 2009

Insulin secretion in type 1 diabetes

scientific article published in February 2004

Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway.

scientific article

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.

scientific article

Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation

scientific article published on 16 June 2015

Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy.

scientific article

International trial of the Edmonton protocol for islet transplantation

scientific article

Intrinsic and extrinsic control of peripheral T‐cell tolerance by costimulatory molecules of the CD28/ B7 family ⬇️

scientific article published on May 1, 2011

Is antigen specificity of autoreactive T cells the key to islet entry?

scientific article published in October 2009

Is autoimmunity the Achilles' heel of cancer immunotherapy?

scientific article

Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade ⬇️

scientific article published on December 27, 2010

Lethal effect of CD3-specific antibody in mice deficient in TGF-beta1 by uncontrolled flu-like syndrome

scientific article

Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice

scientific article published on 12 August 2007

Mechanisms of PDL1-mediated regulation of autoimmune diabetes

scientific article published on 12 July 2007

Mechanisms of tolerance ⬇️

scientific article published on May 1, 2011

MicroRNA 10a marks regulatory T cells

scientific article

MicroRNA regulation of T‐cell differentiation and function ⬇️

scientific article published on May 1, 2013

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization

scientific article published in January 2017

Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial

article

Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19

scientific article published on 28 October 2020

Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories

scientific article published on 31 July 2020

Murine pancreatic islet isolation

scientific article published on 22 August 2007

NK cells are not required for spontaneous autoimmune diabetes in NOD mice

scientific article

NKG2D blockade prevents autoimmune diabetes in NOD mice

scientific article

Natural versus adaptive regulatory T cells

scientific article

Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4.

scientific article

Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo ⬇️

scientific article published on September 10, 2012

New Frontiers in the Treatment of Type 1 Diabetes

scientific article published on 12 December 2019

New reagents on the horizon for immune tolerance

scientific article published on January 2007

Next-generation regulatory T cell therapy

scientific article published on 20 September 2019

NextGen cell-based immunotherapies in cancer and other immune disorders

scientific article published on 06 May 2019

Notch 1 signaling regulates peripheral T cell activation

scientific article published on April 2004

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

scientific article published on 22 December 2013

Pathological conversion of regulatory T cells is associated with loss of allotolerance.

scientific article published on 4 May 2018

Peptide specific amelioration of T cell mediated pathogenesis in murine type 1 diabetes

scientific article published in October 2004

Peptide-MHC class II dimers as therapeutics to modulate antigen-specific T cell responses in autoimmune diabetes

scientific article published on November 2003

Peripherally Induced Tregs – Role in Immune Homeostasis and Autoimmunity ⬇️

scientific article published on 07 August 2013

Pillars article: CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1994. 1: 405-413

scientific article published on October 1, 2011

Plasmacytoid DCs and T(reg) cells: casual acquaintance or monogamous relationship?

scientific article published on 01 June 2006

Plasticity of CD4(+) FoxP3(+) T cells

scientific article published on 06 June 2009

Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes.

scientific article

Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency

scientific article published on 09 December 2019

Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies

scientific article published on 15 April 2020

Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance

scientific article published on 20 September 2021

Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs

scientific article

Production of α-galactosylceramide by a prominent member of the human gut microbiota ⬇️

scientific article (publication date: July 2013)

Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs β-Cell Function ⬇️

scientific article published on June 20, 2012

Recent advances in immunotherapies: from infection and autoimmunity, to cancer, and back again

scientific article published on 31 October 2018

Regulated beta-cell regeneration in the adult mouse pancreas.

scientific article published on 14 December 2007

Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells

scientific article published on May 2009

Regulatory T cell control of systemic immunity and immunotherapy response in liver metastasis

scientific article published on 01 October 2020

Regulatory T cell therapy for autoimmune and autoinflammatory diseases: the next frontier

scientific article published on 25 October 2018

Regulatory T cell therapy for type 1 diabetes: May the force be with you.

scientific article published on 28 April 2016

Regulatory T cells as therapeutic targets in rheumatoid arthritis

scientific article published on October 2009

Regulatory T cells directed to the site of the action

scientific article published on December 2009

Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy

scientific article published on October 2014

Regulatory T cells: recommendations to simplify the nomenclature.

scientific article published in April 2013

Regulatory T cells: stability revisited ⬇️

scientific article published on May 27, 2011

Regulatory T-cell physiology and application to treat autoimmunity

scientific article published on August 2006

Regulatory T-cell therapy: is it ready for the clinic?

scientific article

Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials

scientific article published on 01 May 2020

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation

scientific article published on 14 August 2011

Requirements for Prolongation of Allograft Survival with Regulatory T Cell Infusion in Lymphosufficient Hosts ⬇️

scientific article published on April 5, 2011

Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells

scientific article (publication date: 6 January 2011)

Revealing the specificity of regulatory T cells in murine autoimmune diabetes.

scientific article published on 30 April 2018

Revisiting IL-2: Biology and therapeutic prospects

scientific article published on 01 July 2018

Safer, longer-lasting regulatory T cells with beta-catenin

scientific article published on 01 February 2008

Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity

scientific article

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes.

scientific article

Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response

scientific article

Sensory neurons link the nervous system and autoimmune diabetes

scientific article published in December 2006

Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen

scientific article

Shifting the Evolving CAR T Cell Platform into Higher Gear

scientific article published in October 2015

Single step isolation and activation of primary CD3+ T lymphocytes using alcohol-dispersed electrospun magnetic nanofibers

scientific article

Small RNA regulators of T cell-mediated autoimmunity

scientific article published on May 2010

Solving the Puzzle of Immune Tolerance for β-Cell Replacement Therapy for Type 1 Diabetes

scientific article published on 01 October 2020

Spontaneous development of a pancreatic exocrine disease in CD28-deficient NOD mice

scientific article published on June 2008

Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges

scientific article published on 01 June 2018

Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells

scientific article

Suppression of human anti-porcine natural killer cell xenogeneic responses by combinations of monoclonal antibodies specific to CD2 and NKG2D and extracellular signal-regulated kinase kinase inhibitor

scientific article published on 6 April 2010

T cells in the control of organ-specific autoimmunity

scientific article published on 18 May 2015

T cells-the next frontier of cell therapy

scientific article

T regulatory cells in autoimmune diabetes: past challenges, future prospects

scientific article published on 21 August 2008

T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function

scientific article published on 17 June 2009

TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs

scientific article published on 15 September 2005

TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes

scientific article

Targeting ABL-IRE1α signaling spares ER-stressed pancreatic β cells to reverse autoimmune diabetes

scientific article published in April 2017

Targeting ABL-IRE1α signaling spares ER-stressed pancreatic β cells to reverse autoimmune diabetes

scientific article published on 01 May 2017

Targeting CD22 reprograms B-cells and reverses autoimmune diabetes

scientific article published on 08 August 2008

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity

scientific article published on 01 June 2018

Targeting Treg signaling for the treatment of autoimmune diseases

scientific article

Ten years of the Immune Tolerance Network: an integrated clinical research organization

scientific article published on February 2010

Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders

scientific article published on 08 July 2013

The B7-Independent Isoform of CTLA-4 Functions To Regulate Autoimmune Diabetes ⬇️

scientific article published on January 4, 2013

The Balancing Act between Cancer Immunity and Autoimmunity in Response to Immunotherapy

scientific article published on 01 December 2018

The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28

scientific article published on 23 March 2021

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

scientific article published on March 2008

The Future of Cancer Treatment: Will It Include Immunotherapy? ⬇️

scientific article published on July 10, 2012

The Immune Tolerance Network at 10 years: tolerance research at the bedside

scientific article

The NOD mouse: a model of immune dysregulation

scientific article

The Programmed Death-1 (pd-1) Pathway Regulates Peripheral T Cell Tolerance During Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice ⬇️

scholarly article

The Role of CD28 and CTLA4 in the Function and Homeostasis of CD4 + CD25 + Regulatory T Cells ⬇️

scientific article published on January 1, 2003

The Src family kinase Fyn mediates signals induced by TCR antagonists

scientific article published in May 2002

The Yin and Yang of Interleukin-2–Mediated Immunotherapy ⬇️

scientific article published on 01 December 2011

The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation.

scientific article

The functional plasticity of T cell subsets

scientific article

The immune system in Duchenne muscular dystrophy: Friend or foe.

scientific article

The immune tolerance network: a new paradigm for developing tolerance-inducing therapies

scientific article

The microRNA cluster miR-17∼92 promotes TFH cell differentiation and represses subset-inappropriate gene expression.

scientific article published on 30 June 2013

The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance

article by Todd N Eagar et al published April 2002 in European Journal of Immunology

The role of X-linked FOXP3 in the autoimmune susceptibility of Turner Syndrome patients

scientific article

The therapeutic potential of regulatory T cells for the treatment of autoimmune disease

scientific article published on 16 April 2015

Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells

scholarly article

Thymically-derived Foxp3+ regulatory T cells are the primary regulators of type 1 diabetes in the non-obese diabetic mouse model

scientific article published on 24 October 2019

Tolerance in the Age of Immunotherapy

scientific article published on 01 September 2020

Tolerance induction and reversal of diabetes in mice transplanted with human embryonic stem cell-derived pancreatic endoderm

scientific article

Transplantation of cultured islets from two-layer preserved pancreases in type 1 diabetes with anti-CD3 antibody

scientific article published in March 2004

Transplantation of pancreatic islets into the kidney capsule of diabetic mice

scientific article published on 31 October 2007

Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years

scientific article published on 14 May 2009

Treatment with nonmitogenic anti-CD3 monoclonal antibody induces CD4+ T cell unresponsiveness and functional reversal of established experimental autoimmune encephalomyelitis

scientific article published on 01 April 2005

Treg cell-based therapies: challenges and perspectives

scientific article published on 06 December 2019

Type 1 Diabetes Immunotherapy: Is the Glass Half Empty or Half Full? ⬇️

scientific article published on August 10, 2011

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

scientific article published on November 2015

Type 1 diabetes: translating mechanistic observations into effective clinical outcomes

scientific article

Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice

scholarly article

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

scientific article

What does the future hold for cell-based tolerogenic therapy?

scientific article published in August 2007

When ligand becomes receptor--tolerance via B7 signaling on DCs

microRNA-17-92 regulates IL-10 production by regulatory T cells and control of experimental autoimmune encephalomyelitis.

scientific article

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