List of works - Charles G Eberhart

Molecular subgroups of medulloblastoma: the current consensus

scientific article

Medulloblastoma comprises four distinct molecular variants

scientific article published on 07 September 2010

Medulloblastoma growth inhibition by hedgehog pathway blockade

scientific article published in August 2002

Altered telomeres in tumors with ATRX and DAXX mutations

scientific article

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

scientific article

Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma

scientific article (publication date: October 2007)

Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome

scientific article

Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors

scientific article published in August 2006

NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts

scientific article

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

scientific article

Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma

scientific article (publication date: April 2009)

Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation

scientific article

International Society Of Neuropathology--Haarlem consensus guidelines for nervous system tumor classification and grading

scientific article published on 10 September 2014

Clonal selection drives genetic divergence of metastatic medulloblastoma

scientific article published on 15 February 2012

Notch1 and notch2 have opposite effects on embryonal brain tumor growth

scientific article

Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes

scientific article

Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres

scientific article

Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples

scientific article published on 6 November 2011

Intertumoral Heterogeneity within Medulloblastoma Subgroups

scientific article published on June 2017

A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue

scientific article

Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma

scientific article published on 08 July 2013

c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype.

scientific article

Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma

scientific article

Notch3 gene amplification in ovarian cancer

scientific article

Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors

scientific article published on December 2009

Divergent clonal selection dominates medulloblastoma at recurrence

scientific article published on 13 January 2016

Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct

scientific article

A Mouse Model of Blast Injury to Brain: Initial Pathological, Neuropathological, and Behavioral Characterization

scientific article published on May 1, 2011

The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread

scientific article

Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer

scientific article

Histopathological and molecular prognostic markers in medulloblastoma: c-myc, N-myc, TrkC, and anaplasia.

scientific article published in May 2004

Cytogenetic prognostication within medulloblastoma subgroups

scientific article published on 03 February 2014

BRAF activation induces transformation and then senescence in human neural stem cells: a pilocytic astrocytoma model.

scientific article

The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance.

scientific article

Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1

scientific article published on 30 April 2013

BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants.

scientific article

Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition.

scientific article

Histopathologic grading of medulloblastomas: a Pediatric Oncology Group study

scientific article published on 01 January 2002

Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas.

scientific article

Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation

scientific article

The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation

scientific article

Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas

scientific article

A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors

scientific article published on March 1, 2011

PIK3CA gene mutations in pediatric and adult glioblastoma multiforme.

scientific article published in October 2006

5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft.

scientific article

Long interspersed element-1 protein expression is a hallmark of many human cancers

scientific article published on 06 March 2014

Three-dimensional amide proton transfer MR imaging of gliomas: Initial experience and comparison with gadolinium enhancement

scientific article

MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

scientific article

Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma.

scientific article published on 25 November 2012

Decreased 5-Hydroxymethylcytosine Is Associated with Neural Progenitor Phenotype in Normal Brain and Shorter Survival in Malignant Glioma

scientific article published on July 19, 2012

List of works by Charles G Eberhart

Molecular subgroups of medulloblastoma: the current consensus

Medulloblastoma comprises four distinct molecular variants

Medulloblastoma growth inhibition by hedgehog pathway blockade

Altered telomeres in tumors with ATRX and DAXX mutations

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma

Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome

Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors

NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma

Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation

International Society Of Neuropathology--Haarlem consensus guidelines for nervous system tumor classification and grading

Clonal selection drives genetic divergence of metastatic medulloblastoma

Notch1 and notch2 have opposite effects on embryonal brain tumor growth

Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes

Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres

Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples

Intertumoral Heterogeneity within Medulloblastoma Subgroups

A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue

Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma

c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype.

Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma

Notch3 gene amplification in ovarian cancer

Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors

Divergent clonal selection dominates medulloblastoma at recurrence

Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct

A Mouse Model of Blast Injury to Brain: Initial Pathological, Neuropathological, and Behavioral Characterization

The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread

Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer

Histopathological and molecular prognostic markers in medulloblastoma: c-myc, N-myc, TrkC, and anaplasia.

Cytogenetic prognostication within medulloblastoma subgroups

BRAF activation induces transformation and then senescence in human neural stem cells: a pilocytic astrocytoma model.

The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance.

Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1

BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants.

Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition.

Histopathologic grading of medulloblastomas: a Pediatric Oncology Group study

Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas.

Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation

The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation

Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas

A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors

PIK3CA gene mutations in pediatric and adult glioblastoma multiforme.

5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft.

Long interspersed element-1 protein expression is a hallmark of many human cancers

Three-dimensional amide proton transfer MR imaging of gliomas: Initial experience and comparison with gadolinium enhancement

MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma.

Decreased 5-Hydroxymethylcytosine Is Associated with Neural Progenitor Phenotype in Normal Brain and Shorter Survival in Malignant Glioma