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List of works by Alexander R Horswill

A coverslip-based technique for evaluating Staphylococcus aureus biofilm formation on human plasma

scientific article

A new mass spectrometry based bioassay for the direct assessment of hyaluronidase activity and inhibition

scientific article

A role for type I signal peptidase in Staphylococcus aureus quorum sensing

scientific article published on 03 July 2007

A systematic method for identifying small-molecule modulators of protein-protein interactions

scientific article

Accumulation-associated protein enhances Staphylococcus epidermidis biofilm formation under dynamic conditions and is required for infection in a rat catheter model

scientific article

Agr-mediated dispersal of Staphylococcus aureus biofilms

scientific article

Alpha-toxin induces programmed cell death of human T cells, B cells, and monocytes during USA300 infection

scientific article

An 18 kDa scaffold protein is critical for Staphylococcus epidermidis biofilm formation.

scientific article

An in vitro biofilm model to examine the effect of antibiotic ointments on biofilms produced by burn wound bacterial isolates ⬇️

scientific article published on December 3, 2010

Analysis of autoinducer-2 quorum sensing in Yersinia pestis

scientific article published on 19 August 2013

Bacteria activate sensory neurons that modulate pain and inflammation

scientific article published on 21 August 2013

Bacteriophage Transduction in Staphylococcus epidermidis

scientific article

Biofilm dispersal of community-associated methicillin-resistant Staphylococcus aureus on orthopedic implant material.

scientific article published in January 2010

Biosynthesis of Staphylococcus aureus autoinducing peptides by using the synechocystis DnaB mini-intein

scientific article

Biosynthesis of peptide signals in gram-positive bacteria.

scientific article published on 20 February 2010

Castanea sativa (European Chestnut) Leaf Extracts Rich in Ursene and Oleanene Derivatives Block Staphylococcus aureus Virulence and Pathogenesis without Detectable Resistance

scientific article published in 2015

Cefadroxil Comparable to Cephalexin: Minimum Inhibitory Concentrations among Methicillin-Susceptible Staphylococcus aureus Isolates from Pediatric Musculoskeletal Infections

scientific article published in 2022

Characterization of the propionyl-CoA synthetase (PrpE) enzyme of Salmonella enterica: residue Lys592 is required for propionyl-AMP synthesis

scientific article published in February 2002

Chronic ethanol feeding increases the severity of Staphylococcus aureus skin infections by altering local host defenses

scientific article

Coagulase-Negative Staphylococcal Strain Prevents Staphylococcus aureus Colonization and Skin Infection by Blocking Quorum Sensing

scientific article

Correction: Transcriptome Analysis of Acyl-Homoserine Lactone-Based Quorum Sensing Regulation in Yersinia pestis.

scientific article published on 10 September 2013

Corrigendum: Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice

scholarly article published in Frontiers in Microbiology

Cyclic peptides, a chemical genetics tool for biologists

scientific article

Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth

scientific article

Degradation of Nuclease-Stabilized RNA Oligonucleotides in Mycoplasma-Contaminated Cell Culture Media ⬇️

scientific article published on January 9, 2012

Development of a Staphylococcus aureus reporter strain with click beetle red luciferase for enhanced in vivo imaging of experimental bacteremia and mixed infections

scientific article published on 13 November 2019

Development of an in vitro colonization model to investigate Staphylococcus aureus interactions with airway epithelia

scientific article published on 13 November 2015

Differential regulation of staphylococcal virulence by the sensor kinase SaeS in response to neutrophil-derived stimuli.

scientific article

Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease

scientific article

Draft Genome Sequence of USA100 Methicillin-Resistant Staphylococcus aureus Strain 209.

scientific article

Effects of Low-Dose Amoxicillin on Staphylococcus aureus USA300 Biofilms

scientific article published on 8 February 2016

Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice

scientific article published in 2019

Epistatic relationships between sarA and agr in Staphylococcus aureus biofilm formation

scientific article

Extracellular proteases are key mediators of Staphylococcus aureus virulence via the global modulation of virulence-determinant stability

scientific article published on December 11, 2012

FamClash: a method for ranking the activity of engineered enzymes.

scientific article published on 23 February 2004

Flipping the switch: tools for detecting small molecule inhibitors of staphylococcal virulence

scientific article

Fluorescent reporters for Staphylococcus aureus

scientific article published on 03 March 2009

Heparin Mimics Extracellular DNA in Binding to Cell Surface-Localized Proteins and Promoting Staphylococcus aureus Biofilm Formation

scientific article

Host Nitric Oxide Disrupts Microbial Cell-to-Cell Communication to Inhibit Staphylococcal Virulence

scientific article

Host interception of bacterial communication signals

scientific article published on 01 December 2008

Hyaluronan Modulation Impacts Staphylococcus aureus Biofilm Infection

scientific article published on 11 April 2016

Hybrid Quadrupole-Orbitrap mass spectrometry for quantitative measurement of quorum sensing inhibition

scientific article published on 26 May 2016

Identification of Key Determinants of Staphylococcus aureus Vaginal Colonization

scientific article published on 24 December 2019

Identification of Staphylococcal Quorum Sensing Inhibitors by Quantification of õ-Hemolysin with High Performance Liquid Chromatography

scientific article published in January 2018

Identification of Staphylococcus aureus AgrD residues required for autoinducing peptide biosynthesis

scientific article

Identification of genes involved in polysaccharide-independent Staphylococcus aureus biofilm formation

scientific article

Identifying small-molecule modulators of protein-protein interactions

scientific article

Impact of Environmental Cues on Staphylococcal Quorum Sensing and Biofilm Development

scientific article published on 21 April 2016

Interconnections between Sigma B, agr, and proteolytic activity in Staphylococcus aureus biofilm maturation

scientific journal article

Low levels of β-lactam antibiotics induce extracellular DNA release and biofilm formation in Staphylococcus aureus

scientific article

Methionine sulfoxide reductases protect against oxidative stress in Staphylococcus aureus encountering exogenous oxidants and human neutrophils

scientific article

Modulation of eDNA release and degradation affects Staphylococcus aureus biofilm maturation

scientific article

New approaches for treating staphylococcal biofilm infections

scientific article published on December 2011

Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry

scientific article published on 27 February 2012

Nox2 modification of LDL is essential for optimal apolipoprotein B-mediated control of agr type III Staphylococcus aureus quorum-sensing.

scientific article

Nuclease expression by Staphylococcus aureus facilitates escape from neutrophil extracellular traps

scientific article

Nuclease modulates biofilm formation in community-associated methicillin-resistant Staphylococcus aureus

scientific article

Pentaerythritol propoxylate: a new crystallization agent and cryoprotectant induces crystal growth of 2-methylcitrate dehydratase

scientific article published on 24 January 2002

Peptide Signaling in the Staphylococci ⬇️

scientific article published on December 21, 2010

Phosphatidylinositol-specific phospholipase C contributes to survival of Staphylococcus aureus USA300 in human blood and neutrophils

scientific article published on 22 January 2014

Polyhydroxyanthraquinones as quorum sensing inhibitors from the guttates of Penicillium restrictum and their analysis by desorption electrospray ionization mass spectrometry ⬇️

scientific article

Processing, Export, and Identification of Novel Linear Peptides from Staphylococcus aureus

scientific article published on 14 April 2020

Proinflammatory exoprotein characterization of toxic shock syndrome Staphylococcus aureus

scientific article

Proteolytic cleavage inactivates the Staphylococcus aureus lipoteichoic acid synthase

scientific article

Quantification of confocal images of biofilms grown on irregular surfaces

scientific article

Quantitative analysis of autoinducing peptide I (AIP-I) from Staphylococcus aureus cultures using ultrahigh performance liquid chromatography-high resolving power mass spectrometry.

scientific article published on 19 April 2013

Quorum Quenching and Antimicrobial Activity of Goldenseal (Hydrastis canadensis) against Methicillin-Resistant Staphylococcus aureus (MRSA) ⬇️

scientific article published on July 18, 2012

Quorum Sensing, Virulence, and Antibiotic Resistance of USA100 Methicillin-Resistant Staphylococcus aureus Isolates

scientific article published on 14 August 2019

Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis

scientific article published on 01 May 2019

Random mutagenesis and topology analysis of the autoinducing peptide biosynthesis proteins in Staphylococcus aureus ⬇️

scientific article published on December 7, 2012

Rapid Aggregation of Staphylococcus aureus in Synovial Fluid Is Influenced by Synovial Fluid Concentration, Viscosity, and Fluid Dynamics, with Evidence of Polymer Bridging

scientific article published on 07 March 2022

Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung

scientific article

Reduced vancomycin susceptibility in an in vitro catheter-related biofilm model correlates with poor therapeutic outcomes in experimental endocarditis due to methicillin-resistant Staphylococcus aureus

scientific article published on 7 January 2013

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

scientific article

Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance

scientific article (publication date: June 2014)

Short chain fatty acids produced by Cutibacterium acnes inhibit biofilm formation by Staphylococcus epidermidis

scientific article published on 04 December 2020

Sialic Acid Catabolism in Staphylococcus aureus ⬇️

scientific article published on February 8, 2013

Small-molecule quorum quenchers to prevent Staphylococcus aureus infection

scientific article published in December 2013

Staphopains modulate Staphylococcus aureus biofilm integrity.

scientific article

Staphylococcal Biofilm Development: Structure, Regulation, and Treatment Strategies

scientific article published on 12 August 2020

Staphylococcal and streptococcal superantigen exotoxins

scientific article

Staphylococcal biofilm disassembly

scientific article

Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin

scientific article

Staphylococcus aureus Nuc2 is a functional, surface-attached extracellular nuclease

scientific article (publication date: 2014)

Staphylococcus aureus Osteomyelitis: Bad to the Bone ⬇️

scientific article published on June 12, 2013

Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis.

scientific article

Staphylococcus aureus adhesion in endovascular infections is controlled by the ArlRS-MgrA signaling cascade

scientific article published on 22 May 2019

Staphylococcus aureus biofilms: recent developments in biofilm dispersal

scientific article

Staphylococcus aureus hyaluronidase is a CodY-regulated virulence factor

scientific article

Staphylococcus aureus metalloprotease aureolysin cleaves complement C3 to mediate immune evasion

scientific article published on 18 April 2011

Staphylococcus aureus nuclease is an SaeRS-dependent virulence factor

scientific article published on 4 February 2013

Staphylococcus aureus regulates the expression and production of the staphylococcal superantigen-like secreted proteins in a Rot-dependent manner.

scientific article published on 16 June 2011

Staphylococcus aureus sarA regulates inflammation and colonization during central nervous system biofilm formation

scientific article

Staphylococcus aureus β-Toxin Mutants Are Defective in Biofilm Ligase and Sphingomyelinase Activity, and Causation of Infective Endocarditis and Sepsis

scientific article published on 25 March 2016

Staphylococcus aureusBiofilms Prevent Macrophage Phagocytosis and Attenuate Inflammation In Vivo ⬇️

scientific article published on April 27, 2011

Staphylococcus epidermidis-Skin friend or foe?

scientific article published on 12 November 2020

Stochastic Expression of Sae-Dependent Virulence Genes during Staphylococcus aureus Biofilm Development Is Dependent on SaeS

scientific article published on 14 January 2020

Structural Basis for Ligand Recognition and Discrimination of a Quorum-quenching Antibody ⬇️

scientific article published on March 23, 2011

Structure-Function Analyses of a Staphylococcus epidermidis Autoinducing Peptide Reveals Motifs Critical for AgrC-type Receptor Modulation

scientific article

Superantigens are critical for Staphylococcus aureus Infective endocarditis, sepsis, and acute kidney injury

scientific article

Swimming cells promote a dynamic environment within biofilms

scientific article

Synergistic interactions of Pseudomonas aeruginosa and Staphylococcus aureus in an in vitro wound model

scientific article

Temporal and stochastic control of Staphylococcus aureus biofilm development

scientific article

The 1.75 A crystal structure of acetyl-CoA synthetase bound to adenosine-5'-propylphosphate and coenzyme A

scientific article (publication date: 18 March 2003)

The ATP:Co(I)rrinoid adenosyltransferase (CobA) enzyme of Salmonella enterica requires the 2'-OH group of ATP for function and yields inorganic triphosphate as its reaction byproduct

scientific article

The Bordetella Bps Polysaccharide Is Required for Biofilm Formation and Enhances Survival in the Lower Respiratory Tract of Swine

scientific article published on 30 May 2017

The Spl Serine Proteases Modulate Staphylococcus aureus Protein Production and Virulence in a Rabbit Model of Pneumonia

scientific article published on September 2016

The Staphylococcal Biofilm: Adhesins, Regulation, and Host Response

scientific article

The Staphylococcus aureus ArlRS two-component system is a novel regulator of agglutination and pathogenesis

scientific article

The Staphylococcus aureus ArlRS two-component system regulates virulence factor expression through MgrA

scientific article published on 06 November 2019

The Staphylococcus aureus Global Regulator MgrA Modulates Clumping and Virulence by Controlling Surface Protein Expression

scientific article

The Tricarballylate utilization (tcuRABC) genes of Salmonella enterica serovar Typhimurium LT2.

scientific article published on March 2004

The effect of the chemical, biological, and physical environment on quorum sensing in structured microbial communities

scientific article published on 19 September 2006

The metalloprotease SepA governs processing of accumulation-associated protein and shapes intercellular adhesive surface properties in Staphylococcus epidermidis

scientific article published on 20 December 2016

The role of innate immunity in promoting SaeR/S-mediated virulence in Staphylococcus aureus.

scientific article published on 29 June 2013

The structure of LsrB from Yersinia pestis complexed with autoinducer-2 ⬇️

scientific article published on November 29, 2011

Transcriptome analysis of acyl-homoserine lactone-based quorum sensing regulation in Yersinia pestis [corrected]

scientific article

Triterpenoid acids isolated from Schinus terebinthifolia fruits reduce Staphylococcus aureus virulence and abate dermonecrosis

scientific article published on 15 May 2020

Truncated Autoinducing Peptides as Antagonists of Staphylococcus lugdunensis Quorum Sensing

scientific article published on September 2016

Use of Microfluidic Technology To Analyze Gene Expression during Staphylococcus aureus Biofilm Formation Reveals Distinct Physiological Niches ⬇️

scientific article published on March 22, 2013

Using incremental truncation to create libraries of hybrid enzymes

scientific article published in January 2004

Versatility of Biofilm Matrix Molecules in Staphylococcus epidermidis Clinical Isolates and Importance of Polysaccharide Intercellular Adhesin Expression during High Shear Stress

scientific article published on September 2016

Virulence Inhibitors from Brazilian Peppertree Block Quorum Sensing and Abate Dermonecrosis in Skin Infection Models

scientific article

agr-Dependent Interactions of Staphylococcus aureus USA300 with Human Polymorphonuclear Neutrophils ⬇️

scientific article published on September 10, 2010

coagulases are exploitable yet stable public goods in clinically relevant conditions

scientific article

sarA-mediated repression of protease production plays a key role in the pathogenesis of Staphylococcus aureus USA300 isolates.

scientific article

ω-Hydroxyemodin limits staphylococcus aureus quorum sensing-mediated pathogenesis and inflammation.

scientific article

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