List of works - Jeremy Burrows

A Divergent SAR Study Allows Optimization of a Potent 5-HT2c Inhibitor to a Promising Antimalarial Scaffold

scientific article

A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments

scientific article

A discovery and development roadmap for new endectocidal transmission-blocking agents in malaria

article

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

scientific article

A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria

scientific article (publication date: 9 December 2016)

An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes.

scientific article

Antimalarial Drug Discovery: Where Next? ⬇️

scientific article published on December 1, 2012

Antimalarial drug discovery - the path towards eradication.

scientific article published on 17 July 2013

Antimalarial drug discovery: progress and approaches

scientific article published on 31 August 2023

Arylmethylamino steroids as antiparasitic agents

scientific article published on 17 February 2017

Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus

scientific article published on 31 May 2017

Case Study of Small Molecules As Antimalarials: 2-Amino-1-phenylethanol (APE) Derivatives

scientific article published on 26 March 2014

Challenges in antimalarial drug discovery

scientific article published on September 2011

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling

scientific article

Concise syntheses of the natural products (+)-sylvaticin and (+)-cis-sylvaticin

scientific article published in September 2009

Correction to The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold

scientific article

Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone

scientific article published on 03 May 2019

Cyclopropyl carboxamides, a chemically novel class of antimalarial agents identified in a phenotypic screen

scientific article published on 3 October 2011

Defining the biology component of the drug discovery strategy for malaria eradication

scientific article

Designing the next generation of medicines for malaria control and eradication

scientific article

Development of medicines for the control and elimination of malaria

article

Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers

scientific article

ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria.

scientific article

Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity

scientific article published on October 2010

Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

scientific article

Erratum to: New developments in anti-malarial target candidate and product profiles

scientific article published on 18 April 2017

Evaluation of Current and Emerging Antimalarial Medicines for Inhibition of Toxoplasma gondii Growth in Vitro

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

scientific article

Fragment screening: an introduction

scientific article published on 01 September 2006

Hit and lead criteria in drug discovery for infectious diseases of the developing world

scientific article published on 05 October 2015

ICI 56,780 Optimization: Structure-Activity Relationship Studies of 7-(2-Phenoxyethoxy)-4(1H)-quinolones with Antimalarial Activity

scientific article

Identification and In-Vitro ADME Assessment of a Series of Novel Anti-Malarial Agents Suitable for Hit-to-Lead Chemistry

scientific article

Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria

scientific article published on 17 April 2018

In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models

scientific article

Injectable anti-malarials revisited: discovery and development of new agents to protect against malaria

article

Isoxazolopyrimidine-Based Inhibitors of Dihydroorotate Dehydrogenase with Antimalarial Activity

Killing the hypnozoite--drug discovery approaches to prevent relapse in Plasmodium vivax

scientific article

Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria

scientific article published on 06 April 2020

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

scientific article

Malaria

scholarly article by Margaret A. Phillips et al published 3 August 2017 in Nature Reviews Disease Primers

Microbiology: Malaria runs rings round artemisinin

scientific article published on 15 April 2015

Modelling mosquito infection at natural parasite densities identifies drugs targeting EF2, PI4K or ATP4 as key candidates for interrupting malaria transmission

scientific article published on 15 December 2017

Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas

scientific article published in January 2005

New developments in anti-malarial target candidate and product profiles

scientific article

New osmium-based reagent for the dihydroxylation of alkenes.

scientific article published on June 2006

Novel orally active antimalarial thiazoles

scientific article

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

scientific article (publication date: July 2016)

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

scientific article published on 14 September 2016

Open data in drug discovery and development: lessons from malaria

scientific article

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

scientific article published on 01 December 2018

Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium

scientific article

P. falciparum in vitro killing rates allow to discriminate between different antimalarial mode-of-action

scientific article

Parasite physiology: No longer lost in translation

scientific article published on 25 May 2017

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series

scientific article published on 20 April 2021

ProSAR: a new methodology for combinatorial library design

scientific article

Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum

scientific article

Quinolone-3-diarylethers: a new class of antimalarial drug.

scientific article published in March 2013

Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparum

scientific article

Shared Consensus Machine Learning Models for Predicting Blood Stage Malaria Inhibition

scientific article

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

scientific article

Studies on the total synthesis of lactonamycin: construction of model ABCD ring systems

scientific article published in March 2006

Studies on the total synthesis of lactonamycin: synthesis of the CDEF ring system

scientific article published on 01 October 2006

Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum

scientific article

Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome

scientific article published on 7 November 2018

Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination

scientific article published on 03 February 2010

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

scientific article published on 29 April 2016

The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold

scientific article published on 14 August 2017

The Malaria Box: a catalyst for drug discovery.

scientific article published on 9 November 2012

The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis

scientific article

The global pipeline of new medicines for the control and elimination of malaria

scientific article

The open access malaria box: a drug discovery catalyst for neglected diseases

scientific article (publication date: 2013)

The role of modern drug discovery in the fight against neglected and tropical diseases

The state of the art in anti-malarial drug discovery and development

scientific article published on January 2011

Total synthesis of (+)-cis-sylvaticin: double oxidative cyclization reactions catalyzed by osmium

scientific article published on 01 October 2006

List of works by Jeremy Burrows

A Divergent SAR Study Allows Optimization of a Potent 5-HT2c Inhibitor to a Promising Antimalarial Scaffold

A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments

A discovery and development roadmap for new endectocidal transmission-blocking agents in malaria

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria

An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes.

Antimalarial Drug Discovery: Where Next? ⬇️

Antimalarial drug discovery - the path towards eradication.

Antimalarial drug discovery: progress and approaches

Arylmethylamino steroids as antiparasitic agents

Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus

Case Study of Small Molecules As Antimalarials: 2-Amino-1-phenylethanol (APE) Derivatives

Challenges in antimalarial drug discovery

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling

Concise syntheses of the natural products (+)-sylvaticin and (+)-cis-sylvaticin

Correction to The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold

Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone

Cyclopropyl carboxamides, a chemically novel class of antimalarial agents identified in a phenotypic screen

Defining the biology component of the drug discovery strategy for malaria eradication

Designing the next generation of medicines for malaria control and eradication

Development of medicines for the control and elimination of malaria

Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers

ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria.

Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity

Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

Erratum to: New developments in anti-malarial target candidate and product profiles

Evaluation of Current and Emerging Antimalarial Medicines for Inhibition of Toxoplasma gondii Growth in Vitro

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

Fragment screening: an introduction

Hit and lead criteria in drug discovery for infectious diseases of the developing world

ICI 56,780 Optimization: Structure-Activity Relationship Studies of 7-(2-Phenoxyethoxy)-4(1H)-quinolones with Antimalarial Activity

Identification and In-Vitro ADME Assessment of a Series of Novel Anti-Malarial Agents Suitable for Hit-to-Lead Chemistry

Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria

In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models

Injectable anti-malarials revisited: discovery and development of new agents to protect against malaria

Isoxazolopyrimidine-Based Inhibitors of Dihydroorotate Dehydrogenase with Antimalarial Activity

Killing the hypnozoite--drug discovery approaches to prevent relapse in Plasmodium vivax

Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

Malaria

Microbiology: Malaria runs rings round artemisinin

Modelling mosquito infection at natural parasite densities identifies drugs targeting EF2, PI4K or ATP4 as key candidates for interrupting malaria transmission

Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas

New developments in anti-malarial target candidate and product profiles

New osmium-based reagent for the dihydroxylation of alkenes.

Novel orally active antimalarial thiazoles

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

Open data in drug discovery and development: lessons from malaria

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium

P. falciparum in vitro killing rates allow to discriminate between different antimalarial mode-of-action

Parasite physiology: No longer lost in translation

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series

ProSAR: a new methodology for combinatorial library design

Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum

Quinolone-3-diarylethers: a new class of antimalarial drug.

Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparum

Shared Consensus Machine Learning Models for Predicting Blood Stage Malaria Inhibition

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

Studies on the total synthesis of lactonamycin: construction of model ABCD ring systems

Studies on the total synthesis of lactonamycin: synthesis of the CDEF ring system

Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum

Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome

Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold

The Malaria Box: a catalyst for drug discovery.

The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis

The global pipeline of new medicines for the control and elimination of malaria

The open access malaria box: a drug discovery catalyst for neglected diseases

The role of modern drug discovery in the fight against neglected and tropical diseases

The state of the art in anti-malarial drug discovery and development

Total synthesis of (+)-cis-sylvaticin: double oxidative cyclization reactions catalyzed by osmium