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List of works by Matthew Bogyo

4-Bromophenacyl bromide specifically inhibits rhoptry secretion during Toxoplasma invasion

scientific article

A Bright Future for Precision Medicine: Advances in Fluorescent Chemical Probe Design and Their Clinical Application

scientific article

A Clinical Wide-Field Fluorescence Endoscopic Device for Molecular Imaging Demonstrating Cathepsin Protease Activity in Colon Cancer

scientific article published on 6 May 2016

A General Solid Phase Method for the Preparation of Diverse Azapeptide Probes Directed Against Cysteine Proteases

scientific article published on 01 December 2005

A Mild Chemically Cleavable Linker System for Functional Proteomic Applications

scientific article published on 01 January 2007

A Substrate-Inspired Probe Monitors Translocation, Activation, and Subcellular Targeting of Bacterial Type III Effector Protease AvrPphB

scientific article published on 01 February 2013

A biocompatible "split luciferin" reaction and its application for non-invasive bioluminescent imaging of protease activity in living animals

scientific article

A biocompatible in vivo ligation reaction and its application for noninvasive bioluminescent imaging of protease activity in living mice.

scientific article published on 29 March 2013

A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor

scientific journal article

A coupled protein and probe engineering approach for selective inhibition and activity-based probe labeling of the caspases

scientific article published on 06 June 2013

A fragmenting hybrid approach for targeted delivery of multiple therapeutic agents to the malaria parasite

scientific article published on 24 January 2011

A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites

scientific article

A nonpeptidic cathepsin S activity-based probe for noninvasive optical imaging of tumor-associated macrophages

scientific article

A proteolytic system that compensates for loss of proteasome function ⬇️

scientific article published on April 9, 1998

A role for the protease falcipain 1 in host cell invasion by the human malaria parasite

scientific article (publication date: 6 December 2002)

A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C.

scientific article published on May 2006

A small-molecule antivirulence agent for treating Clostridium difficile infection

scientific article published on 23 September 2015

AND-gate contrast agents for enhanced fluorescence-guided surgery

scientific article published on 28 September 2020

Acid-mediated tumor proteolysis: contribution of cysteine cathepsins

scientific article published on October 2013

Active cathepsins B, L, and S in murine and human pancreatitis

scientific article

Activity based probes for proteases: applications to biomarker discovery, molecular imaging and drug screening.

scientific article published on January 2007

Activity profiling of papain-like cysteine proteases in plants

scientific article

Activity profiling of vacuolar processing enzymes reveals a role for VPE during oomycete infection.

scientific article published on 28 December 2012

Activity-based probes as a tool for functional proteomic analysis of proteases.

scientific article published on October 2008

Activity-based probes for the multicatalytic proteasome

scientific article published on 20 January 2017

Activity-based probes for the ubiquitin conjugation-deconjugation machinery: new chemistries, new tools, and new insights

scientific article published on 14 February 2017

Activity-based probes that target diverse cysteine protease families

scientific article published on 24 May 2005

Activity-based profiling of proteases

scientific article

Activity-based protein profiling: applications to biomarker discovery, in vivo imaging and drug discovery

scientific article

Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors

scientific article

An Improved Preparation of the Activity-Based Probe JPM-OEt and In Situ Applications

An in vivo multiplexed small-molecule screening platform

scientific article

An optimized activity-based probe for the study of caspase-6 activation

scientific article published in March 2012

Application of activity-based probes to the study of enzymes involved in cancer progression

scientific article published on 21 February 2008

Applications for chemical probes of proteolytic activity

scientific article

Applications of small molecule probes in dissecting mechanisms of bacterial virulence and host responses

scientific article

Assessing subunit dependency of the Plasmodium proteasome using small molecule inhibitors and active site probes

scientific article

Autocatalytic processing of procathepsin B is triggered by proenzyme activity

scientific article

Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide

scientific article

Bifunctional Probes of Cathepsin Protease Activity and pH Reveal Alterations in Endolysosomal pH during Bacterial Infection

scientific article published on 13 July 2016

Biochemical analysis of the 20 S proteasome of Trypanosoma brucei

scientific article published on 24 February 2003

Biochemical characterization of Plasmodium falciparum dipeptidyl aminopeptidase 1

scientific article

Calcium Regulates the Activity and Structural Stability of Tpr, a Bacterial Calpain-like Peptidase

scientific article

Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection.

scientific article

Caspase-3 feeds back on caspase-8, Bid and XIAP in type I Fas signaling in primary mouse hepatocytes

scientific article published in May 2012

Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis

scientific article published on 21 April 2009

Cathepsin Activity-Based Probes and Inhibitor for Preclinical Atherosclerosis Imaging and Macrophage Depletion

scientific article (publication date: 2016)

Cathepsin B trafficking in thyroid carcinoma cells

scientific article published on 3 August 2011

Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones

scientific article published in June 2004

Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter.

scientific article

Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice

scientific article

Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages.

scientific article

Cathepsin X is secreted by human osteoblasts, digests CXCL-12 and impairs adhesion of hematopoietic stem and progenitor cells to osteoblasts

scientific article

Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis

scientific article

Characteristics of the caspase-like catalytic domain of human paracaspase.

scientific article

Chemical Strategies To Target Bacterial Virulence

scientific article published on 24 February 2017

Chemical Tools for Selective Activity Profiling of Endogenously Expressed MMP-14 in Multicellular Models

scientific article published on 11 September 2018

Chemical approaches for functionally probing the proteome

scientific article

Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion

scientific article

Chemical proteomics and its application to drug discovery

scientific article

Chemical proteomics and its application to drug discovery

Chemical proteomics applied to target identification and drug discovery

scientific article

Commonly used caspase inhibitors designed based on substrate specificity profiles lack selectivity

scientific article published on 01 December 2006

Comparative assessment of substrates and activity based probes as tools for non-invasive optical imaging of cysteine protease activity

scientific article published in 2009

Correction: Multiple Cathepsins Promote Pro-IL-1β Synthesis and NLRP3-Mediated IL-1β Activation

scientific article published in January 2016

Correction: Validation of near infrared fluorescence (NIRF) probes in vivo with dual laser NIRF endoscope

scientific article published in PLoS ONE

Coupling protein engineering with probe design to inhibit and image matrix metalloproteinases with controlled specificity

scientific article published on 06 June 2013

Covalent Modifiers of Botulinum Neurotoxin Counteract Toxin Persistence

scientific article published on 08 January 2019

Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents

scientific article published on 06 June 2019

Cysteine Cathepsin Inhibitors as Anti-Ebola Agents

scientific article

Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer

scientific article

Cysteine protease inhibitors block Toxoplasma gondii microneme secretion and cell invasion ⬇️

scientific article published on 4 December 2006

Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins

scientific article

Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors

scientific article published on 29 August 2018

Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites.

scientific article published on 18 September 2017

Design and Synthesis of Activity-Based Probes and Inhibitors for Bleomycin Hydrolase.

scientific article published on 3 August 2015

Design of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery

scientific article

Design of cell-permeable, fluorescent activity-based probes for the lysosomal cysteine protease asparaginyl endopeptidase (AEP)/legumain

scientific article

Design, syntheses, and evaluation of Taspase1 inhibitors

scientific article

Design, synthesis, and evaluation of in vivo potency and selectivity of epoxysuccinyl-based inhibitors of papain-family cysteine proteases

scientific article

Detection of Active Caspases During Apoptosis Using Fluorescent Activity-Based Probes

article published in 2016

Detection of intestinal cancer by local, topical application of a quenched fluorescence probe for cysteine cathepsins

scientific article

Development of activity-based probes for cathepsin X.

scientific article

Development of activity-based probes for trypsin-family serine proteases

scientific article published on 22 March 2006

Development of an activity-based probe for acyl-protein thioesterases

scientific article

Development of calpain-specific inactivators by screening of positional scanning epoxide libraries

scientific article

Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain

scientific article published on February 2010

Development of small molecule inhibitors and probes of human SUMO deconjugating proteases

scientific article published on June 2011

Disruption of gingipain oligomerization into non-covalent cell-surface attached complexes.

scientific article

Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death

scientific article published on 24 March 2016

Dissecting Protein Function Using Chemical Proteomic Methods

Dynamic imaging of protease activity with fluorescently quenched activity-based probes.

scientific article published on 14 August 2005

Engineered hybrid dimers: tracking the activation pathway of caspase-7.

scientific article published in August 2006

Enzyme activity--it's all about image

scientific article published on January 2004

Erratum for Foe et al., “The Toxoplasma gondii Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture”

scientific article published on 01 September 2018

Evaluation of alpha,beta-unsaturated ketone-based probes for papain-family cysteine proteases

scientific article published on 02 March 2008

Falstatin, a cysteine protease inhibitor of Plasmodium falciparum, facilitates erythrocyte invasion ⬇️

scientific article

Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment

scientific article published on 07 August 2011

Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivo

scientific article published on 21 October 2013

Finding enzymes that are actively involved in cancer

scientific article

Finding the needles in the haystack: mapping constitutive proteolytic events in vivo

scientific article published in October 2007

Fluorescent Triazole Urea Activity-Based Probes for the Single-Cell Phenotypic Characterization of Staphylococcus aureus

scientific article published on 22 March 2019

Friend or foe? Turning a host defense protein into a pathogen's accomplice.

scientific article

Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation.

scientific article published on 13 January 2017

Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors

scientific article (publication date: 24 June 2011)

Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase

scientific article

Functional imaging of legumain in cancer using a new quenched activity-based probe

scientific article published on 18 December 2012

Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes ⬇️

scientific article published on November 16, 2011

Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probes

scientific article

Genomics and proteomics

scientific article (publication date: February 2007)

Global Analysis of Palmitoylated Proteins in Toxoplasma gondii.

scientific article

Global profiling of proteolysis during rupture of Plasmodium falciparum from the host erythrocyte ⬇️

scientific article

Growth phase-dependent production of a cell wall-associated elastinolytic cysteine proteinase by Staphylococcus epidermidis

scientific article published on June 2004

Hemoglobin Digestion in Blood-Feeding Ticks: Mapping a Multipeptidase Pathway by Functional Proteomics

scientific article (publication date: 30 October 2009)

Highlight: the universe of proteolytic networks and mechanisms

scientific article published on 01 September 2012

Identification of a S. aureus virulence factor by activity-based protein profiling (ABPP)

scientific article published on 16 May 2018

Identification of a myeloid-derived suppressor cell cystatin-like protein that inhibits metastasis

scientific journal article

Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis.

scientific article published on 12 July 2013

Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes

scientific article

Identification of highly selective covalent inhibitors by phage display

scientific article published on 16 November 2020

Identification of potent and selective non-covalent inhibitors of the Plasmodium falciparum proteasome

scientific article

Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum

scientific article

Improved quenched fluorescent probe for imaging of cysteine cathepsin activity

scientific article published on 19 September 2013

In vivo imaging and biochemical characterization of protease function using fluorescent activity-based probes

scientific article published on January 2013

Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation.

scientific article published on September 2007

Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages

scientific journal article

Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.

scientific article

Influenza A virus elevates active cathepsin B in primary murine DC.

scientific article published on 19 April 2007

Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity

scientific article published on 25 October 2017

Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease

scientific article

Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer

scientific article published on 01 August 2007

Insulin-like growth factor II receptor-mediated intracellular retention of cathepsin B is essential for transformation of endothelial cells by Kaposi's sarcoma-associated herpesvirus

scientific article published on 16 May 2007

Introduction to the Special Issue on Proteases and Proteolysis in Health and Disease

scientific article published in May 2017

IrAE – An asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus

scientific article (publication date: June 2007)

Labeling of active proteases in fresh-frozen tissues by topical application of quenched activity-based probes

scientific article published on 30 December 2015

Legumain is activated in macrophages during pancreatitis

scientific article published on 11 August 2016

Leveraging Peptide Substrate Libraries to Design Inhibitors of Bacterial Lon Protease

scientific article published on 10 September 2019

Live Cell Imaging and Profiling of Cysteine Cathepsin Activity Using a Quenched Activity-Based Probe

scientific article published in January 2017

Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation

scientific article published on 03 February 2009

Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin

scientific article

Membrane skeletal association and post-translational allosteric regulation of Toxoplasma gondii GAPDH1.

scientific article

Metabolomics cuts to the chase to chase the cuts

scientific article published on 01 January 2009

Metalloproteases see the light

scientific article published on 01 May 2006

Microscopic detection of quenched activity-based optical imaging probes using an antibody detection system: localizing protease activity

scientific article

Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using 'click chemistry'.

scientific article

Multiple Cathepsins Promote Pro-IL-1β Synthesis and NLRP3-Mediated IL-1β Activation

scientific article published on 20 July 2015

Myoepithelial cell-specific expression of stefin A as a suppressor of early breast cancer invasion

scientific article

New Blood Test SEEKs To Detect and Localize Cancer before It's Too Late

scientific article published on 28 February 2018

New approaches for dissecting protease functions to improve probe development and drug discovery

scientific article

New technologies and their impact on 'omics' research

scientific article published in February 2013

Non-invasive Imaging of Idiopathic Pulmonary Fibrosis Using Cathepsin Protease Probes

scientific article published on 22 January 2016

Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probe

scientific article

Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes

scientific article

Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes.

scientific article

Novel aza peptide inhibitors and active-site probes of papain-family cysteine proteases

scientific article published in June 2006

Nuclear cysteine cathepsin variants in thyroid carcinoma cells

scientific article published on August 2010

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase.

scientific article

Optimization of a Protease Activated Probe for Optical Surgical Navigation.

scientific article published on 25 November 2017

PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells

article by Chaido Stathopoulou et al published 21 August 2018 in Immunity

Pathways accessory to proteasomal proteolysis are less efficient in major histocompatibility complex class I antigen production

scientific article

Phosphoramidates as Novel Activity-Based Probes for Serine Proteases

scholarly article by Ute R. Haedke published in May 2014

Plasmodium dipeptidyl aminopeptidases as malaria transmission-blocking drug targets

scientific article published on 08 July 2013

Pre-Trained Deep Convolutional Neural Network for Clostridioides Difficile Bacteria Cytotoxicity Classification Based on Fluorescence Images

scientific article published on 24 November 2020

Probes to monitor activity of the paracaspase MALT1.

scientific article

Probing structural determinants distal to the site of hydrolysis that control substrate specificity of the 20S proteasome.

scientific article published in May 2002

Procathepsin V Is Secreted in a TSH Regulated Manner from Human Thyroid Epithelial Cells and Is Accessible to an Activity-Based Probe

scientific article published on 30 November 2020

Proteases as regulators of pathogenesis: examples from the Apicomplexa.

scientific article published on 13 June 2011

Proteasome function is dispensable under normal but not under heat shock conditions in Thermoplasma acidophilum ⬇️

scientific article published on March 20, 1998

Proteasome inhibitors and antigen presentation ⬇️

scientific article published on January 1, 1997

Protein Degradation Systems as Antimalarial Therapeutic Targets

scientific article

Proteolytic processing and activation of gingipain zymogens secreted by T9SS of Porphyromonas gingivalis

scientific article published on 15 June 2019

Proteomic analysis of fractionated Toxoplasma oocysts reveals clues to their environmental resistance

scientific article

Proteomics evaluation of chemically cleavable activity-based probes

scientific article published on 5 July 2007

Proteomics meets microbiology: technical advances in the global mapping of protein expression and function

scientific article published in August 2005

Rab35 controls actin bundling by recruiting fascin as an effector protein.

scientific article

Rapid visualization of nonmelanoma skin cancer.

scientific article published on 19 November 2016

Rational Design of Inhibitors and Activity-Based Probes Targeting Clostridium difficile Virulence Factor TcdB

scientific article

Regulation of collagenase activities of human cathepsins by glycosaminoglycans

scientific article

Response to Comment on "A small-molecule antivirulence agent for treating Clostridium difficile infection".

scientific article published on December 2016

Screening for selective small molecule inhibitors of the proteasome using activity-based probes

scientific article published in January 2005

Sequential autolytic processing activates the zymogen of Arg-gingipain

scientific article published on 17 January 2003

Short-Wave Infrared Fluorescence Chemical Sensor for Detection of Otitis Media

scientific article published on 11 November 2020

Simplified, enhanced protein purification using an inducible, autoprocessing enzyme tag

scientific article (publication date: 2 December 2009)

Small Molecule-Induced Allosteric Activation of the Vibrio cholerae RTX Cysteine Protease Domain

scientific article

Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design

scientific article

Solid-phase methods for the preparation of epoxysuccinate-based inhibitors of cysteine proteases.

scientific article published in November 2006

Solid-phase synthesis of double-headed epoxysuccinyl activity-based probes for selective targeting of papain family cysteine proteases.

scientific article

Structural Basis for the Inhibitor and Substrate Specificity of the Unique Fph Serine Hydrolases of Staphylococcus aureus

scientific article published on 15 September 2020

Subclassification and biochemical analysis of plant papain-like cysteine proteases displays subfamily-specific characteristics.

scientific article

Subfamily-Specific Fluorescent Probes for Cysteine Proteases Display Dynamic Protease Activities during Seed Germination.

scientific article published on 5 June 2015

Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes ⬇️

scientific article published on June 1, 1998

Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities

scientific article

Substrate specificity of Staphylococcus aureus cysteine proteases--Staphopains A, B and C.

scientific article

Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries

scientific article

Substrate specificity of transthyretin: identification of natural substrates in the nervous system

scientific article

Successful Translation of Fluorescence Navigation During Oncologic Surgery: A Consensus Report

scientific article published on 8 October 2015

Synthesis and evaluation of aza-peptidyl inhibitors of the lysosomal asparaginyl endopeptidase, legumain ⬇️

scientific article published on December 21, 2011

Synthetic Fluorogenic Peptides Reveal Dynamic Substrate Specificity of Depalmitoylases

scientific article published on 01 November 2018

Synthetic and biological approaches to map substrate specificities of proteases

scientific article published on 01 December 2019

TGF-ß Regulates Cathepsin Activation during Normal and Pathogenic Development

scientific article published in March 2018

Tagging and detection strategies for activity-based proteomics.

scientific article published on 13 December 2006

Target deconvolution techniques in modern phenotypic profiling.

scientific article

Targeted disruption of Plasmodium falciparum cysteine protease, falcipain 1, reduces oocyst production, not erythrocytic stage growth

scientific article published in July 2004

The Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture

article by Ian T Foe et al published 19 September 2018 in mSphere

The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains

scientific article published on December 2012

The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells

scientific article published on 16 December 2013

The glucosyltransferase activity of C. difficile Toxin B is required for disease pathogenesis

scientific article published on 22 September 2020

The lysosomal protein cathepsin L is a progranulin protease

scientific article

The protease cathepsin L regulates Th17 cell differentiation

scientific article

The role of cathepsin X in the migration and invasiveness of T lymphocytes

scientific article published on 29 July 2008

Three-dimensional cultures modeling premalignant progression of human breast epithelial cells: role of cysteine cathepsins

scientific article published on December 2012

Topical application of activity-based probes for visualization of brain tumor tissue

scientific article (publication date: 2012)

Toxoplasma DJ-1 Regulates Organelle Secretion by a Direct Interaction with Calcium-Dependent Protein Kinase 1.

scientific article published on 28 February 2017

Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection

scientific article published on 19 June 2017

Toxoplasma gondii Cathepsin L Is the Primary Target of the Invasion-inhibitory Compound Morpholinurea-leucyl-homophenyl-vinyl Sulfone Phenyl ⬇️

scientific article

Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis-mediated therapy in a humanized death receptor mouse model

scientific article published on 13 October 2011

Treatment of rat thyrocytes in vitro with cathepsin B and L inhibitors results in disruption of primary cilia leading to redistribution of the trace amine associated receptor 1 to the endoplasmic reticulum

scientific article published on 11 July 2019

Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model.

scientific article published in August 2008

Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria

scientific article

Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.

scientific article published in May 2006

Ubiquitin-like modifiers and their deconjugating enzymes in medically important parasitic protozoa

scientific article

Use of activity-based probes to develop high throughput screening assays that can be performed in complex cell extracts.

scientific article

Using small molecules to dissect mechanisms of microbial pathogenesis

scientific article

VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation

scientific article published on 12 May 2009

Validation of near infrared fluorescence (NIRF) probes in vivo with dual laser NIRF endoscope

scientific article published in PLoS ONE

Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicity

scientific article

Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation.

scientific article

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