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List of works by Matthew R Redinbo

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin

scientific article

8-Oxoguanine rearranges the active site of human topoisomerase I

scientific article

A High Throughput Assay for Discovery of Bacterial β-Glucuronidase Inhibitors ⬇️

scientific article published on April 8, 2011

A Novel Fold in the TraI Relaxase–Helicase C-Terminal Domain Is Essential for Conjugative DNA Transfer

scientific article

A database method for automated map interpretation in protein crystallography

scholarly article by David J. Diller published in September 1999

A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'- 5' exonuclease and 5'-protruding strand endonuclease activities

scientific article published on 01 March 2002

A rapid method for positioning small flexible molecules, nucleic acids, and large protein fragments in experimental electron density maps

scholarly article by David J. Diller published in September 1999

Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity

scientific article published on 4 February 2016

Activated pregnenolone X-receptor is a target for ketoconazole and its analogs.

scientific article published on April 2007

Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase‐targeted anti‐HIV drug PNU‐142721 ⬇️

scientific article published on September 12, 2011

Active nuclear receptors exhibit highly correlated AF-2 domain motions

scientific article

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme ⬇️

scientific article published on November 5, 2010

An unusual CsrA family member operates in series with RsmA to amplify posttranscriptional responses in Pseudomonas aeruginosa

scientific article

Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds

scientific article published on 13 December 2006

Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics

scientific article published on 05 July 2013

Calcium binding properties of the Kingella kingae PilC1 and PilC2 proteins have differential effects on type IV pilus-mediated adherence and twitching motility.

scientific article published on 14 December 2012

Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR

scientific article

Characterization of the N-acetyl-α-D-glucosaminyl l-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis .

scientific article

Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor

scientific article

Correction: Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme

scientific article (publication date: 23 January 2012)

Crystal Structure of the HEAT Domain from the Pre-mRNA Processing Factor Symplekin

scientific article

Crystal Structure of the Plant Epigenetic Protein Arginine Methyltransferase 10 ⬇️

scientific article published on November 18, 2011

Crystal Structures of Human Carboxylesterase 1 in Covalent Complexes with the Chemical Warfare Agents Soman and Tabun † , ‡

scientific article

Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility

scientific article

Crystal structure of an ancient protein: evolution by conformational epistasis

scientific article

Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition

scientific article (publication date: April 2003)

Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism

scientific article

Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7

scientific article

Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity

scientific article

Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition

scientific article published on 27 February 2007

Disrupting antibiotic resistance propagation by inhibiting the conjugative DNA relaxase

scientific article

Electrostatic contribution of serine phosphorylation to the Drosophila SLBP--histone mRNA complex

scientific article

Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists

scientific article

Enhanced biofilm prevention activity of a SPLUNC1-derived antimicrobial peptide against Staphylococcus aureus

scientific article published in PLoS ONE

Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily

scientific article

Functional characterization of the multidomain F plasmid TraI relaxase-helicase.

scientific article

Glucuronides in the gut: Sugar-driven symbioses between microbe and host

scientific article

Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception

Human Carboxylesterase 1 Stereoselectively Binds the Nerve Agent Cyclosarin and Spontaneously Hydrolyzes the Nerve Agent Sarin

scientific article

Human PXR forms a tryptophan zipper-mediated homodimer

scientific article published on July 2006

Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways

scientific article

Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures

scientific article

Immobilization of active human carboxylesterase 1 in biomimetic silica nanoparticles ⬇️

scientific article published on April 20, 2011

Investigating the impact of bisphosphonates and structurally related compounds on bacteria containing conjugative plasmids ⬇️

scientific article published on July 13, 2012

Mammalian carboxylesterases: from drug targets to protein therapeutics

scientific article

Mammalian short palate lung and nasal epithelial clone 1 (SPLUNC1) in pH-dependent airway hydration

scientific article published on 13 March 2014

Mechanisms of camptothecin resistance by human topoisomerase I mutations

scientific article

Microbial Molecules from the Multitudes within Us.

scientific article

Microbial Unmasking of Plant Glycosides

scientific article

Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP

scientific article

Molecular Insights into Microbial β-Glucuronidase Inhibition to Abrogate CPT-11 Toxicity ⬇️

scientific article published on May 20, 2013

Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways

scientific article

Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus

scientific article

Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model

scientific article published in February 2004

Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1.

scientific article published on 15 August 2006

Mutation of the conserved calcium-binding motif in Neisseria gonorrhoeae PilC1 impacts adhesion but not piliation.

scientific article published on 03 September 2013

Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme ⬇️

scientific article published on March 18, 2011

Novel Yeast-based Strategy Unveils Antagonist Binding Regions on the Nuclear Xenobiotic Receptor PXR ⬇️

scientific article published on March 22, 2013

Orphan nuclear receptors adopted by crystallography

scientific article

PXR antagonists and implication in drug metabolism ⬇️

scientific article published on February 1, 2013

Pharmacologic Targeting of Bacterial β-Glucuronidase Alleviates Nonsteroidal Anti-Inflammatory Drug-Induced Enteropathy in Mice ⬇️

scientific article published on February 10, 2012

Post-translational Claisen Condensation and Decarboxylation en Route to the Bicyclic Core of Pantocin A

scientific article

Processing of Nonconjugative Resistance Plasmids by Conjugation Nicking Enzyme of Staphylococci.

scientific article

Promiscuity: what protects us, perplexes us.

scientific article published in May 2004

Pseudomonas aeruginosa PilY1 Binds Integrin in an RGD- and Calcium-Dependent Manner ⬇️

scientific article published on December 29, 2011

Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins

scientific article

Regulation of cyp3a gene transcription by the pregnane x receptor

scientific article

Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO).

scientific article published on February 2017

Rifampicin-Independent Interactions between the Pregnane X Receptor Ligand Binding Domain and Peptide Fragments of Coactivator and Corepressor Proteins ⬇️

scientific article published on December 20, 2011

SPLUNC1 is an allosteric modulator of the epithelial sodium channel

scientific article published on 2 January 2018

Short Palate, Lung, and Nasal Epithelial Clone 1 Has Antimicrobial and Antibiofilm Activities against the Burkholderia cepacia Complex

scientific article published on 25 July 2016

Stereoselective hydrolysis of pyrethroid-like fluorescent substrates by human and other mammalian liver carboxylesterases

scientific article

Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRα ⬇️

scientific article published on April 16, 2013

Structural basis for the regulation of β-glucuronidase expression by human gut Enterobacteriaceae

scientific article published on 21 December 2017

Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme

scientific article (publication date: May 2003)

Structural basis of human pregnane X receptor activation by the hops constituent colupulone

scientific article published on 02 September 2008

Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin

scientific article published on 10 February 2005

Structural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complex

scientific article

Structural insights into CPT-11 activation by mammalian carboxylesterases

scientific article

Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil

scientific article published in September 2005

Structural insights into the promiscuity and function of the human pregnane X receptor

scientific article (publication date: 2002)

Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity

scientific article

Structure and function of the human nuclear xenobiotic receptor PXR.

scientific article

Structure, function, and inhibition of drug reactivating human gut microbial β-glucuronidases

scientific article published in Scientific Reports

Substrate preference of Gen endonucleases highlights the importance of branched structures as DNA damage repair intermediates

scientific article

Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4.

scientific article

The crystal structure of human UDP-glucuronosyltransferase 2B7 C-terminal end is the first mammalian UGT target to be revealed: the significance for human UGTs from both the 1A and 2B families

scientific article published on February 2010

The human microbiome is a source of therapeutic drug targets ⬇️

scientific article published on May 13, 2013

The mechanism and control of DNA transfer by the conjugative relaxase of resistance plasmid pCU1

scientific article

The microbiota, chemical symbiosis, and human disease

scientific article

The nuclear xenobiotic receptor pregnane X receptor: recent insights and new challenges

scientific article

The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor

scientific article

The role of the microbiome in cancer development and therapy

scientific article published on 8 May 2017

Three structurally and functionally distinct β-glucuronidases from the human gut microbe Bacteroides uniformis

scientific article published in Journal of Biological Chemistry

Triggered Mycobacterium tuberculosis Heparin-Binding Hemagglutinin Adhesin Folding and Dimerization ⬇️

scientific article published on March 11, 2011

Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights

scientific article

Tyrosine partners coordinate DNA nicking by the Salmonella typhimurium plasmid pCU1 relaxase enzyme

scientific article

Understanding and modulating mammalian-microbial communication for improved human health

scientific article

Winning the asymmetric war: new strategies for combating antibacterial resistance

scientific article published on 01 April 2008

Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective ⬇️

scientific article published on 05 December 2012

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