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List of works by Bernhard Bettler

A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes

scientific article published on 5 December 2015

A modified RMCE-compatible Rosa26 locus for the expression of transgenes from exogenous promoters

scientific article (publication date: 2012)

A mouse model for visualization of GABA(B) receptors.

scientific article published in September 2009

A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor

scientific article

A tribute to Norman G Bowery

scientific article published on 18 May 2018

Activation of presynaptic GABA(B(1a,2)) receptors inhibits synaptic transmission at mammalian inhibitory cholinergic olivocochlear-hair cell synapses

scientific article

Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks

scientific article published on 24 December 2016

Acute behavioural responses to nicotine and nicotine withdrawal syndrome are modified in GABA(B1) knockout mice

scientific article published on 19 June 2012

Adenohypophyseal and hypothalamic GABA B receptor subunits are downregulated by estradiol in adult female rats

scientific article published on 3 March 2006

Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits.

scientific article published in February 2005

Altered emotionality and neuronal excitability in mice lacking KCTD12, an auxiliary subunit of GABAB receptors associated with mood disorders

scientific article published on 17 February 2015

Altered expression of GABAB receptors in the hippocampus after kainic-acid-induced seizures in rats

scientific article published on May 2003

Altered hippocampal expression of calbindin-D-28k and calretinin in GABA(B(1))-deficient mice.

scientific article published in October 2004

Altered peripheral myelination in mice lacking GABAB receptors

scientific article

Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice ⬇️

scientific article published on April 9, 1998

An Enzyme- and Serum-free Neural Stem Cell Culture Model for EMT Investigation Suited for Drug Discovery.

scientific article

Autism-like behavior in Pianp-deficient mice is associated with decreased neuronal Erdr1 expression and altered GABAB receptor signaling

scientific article published on 01 November 2020

Auxiliary GABAB receptor subunits uncouple G protein βγ subunits from effector channels to induce desensitization

scientific article published on 15 May 2014

Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines

scientific article

Behavioral evaluation of mice deficient in GABA(B(1)) receptor isoforms in tests of unconditioned anxiety.

scientific article published on 15 December 2006

Behavioural endophenotypes in mice lacking the auxiliary GABAB receptor subunit KCTD16.

scientific article published on 4 October 2016

Blunted 5-HT1A receptor-mediated responses and antidepressant-like behavior in mice lacking the GABAB1a but not GABAB1b subunit isoforms.

scientific article published on 9 January 2017

Ca2+ activity at GABAB receptors constitutively promotes metabotropic glutamate signaling in the absence of GABA.

scholarly article

Circuit specificity in the inhibitory architecture of the VTA regulates cocaine-induced behavior.

scientific article published on 23 January 2017

Cloning of a putative glutamate receptor: a low affinity kainate-binding subunit

scientific article published on February 1, 1992

Compartment-dependent colocalization of Kir3.2-containing K+ channels and GABAB receptors in hippocampal pyramidal cells.

scientific article

Compartmentalization of the GABAB receptor signaling complex is required for presynaptic inhibition at hippocampal synapses.

scientific article published in August 2011

Complex formation of APP with GABA receptors links axonal trafficking to amyloidogenic processing

scientific article published on 22 March 2019

Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons

scientific article

Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo

scientific article

Constitutive Notch2 signaling induces hepatic tumors in mice

scientific article published on 14 March 2013

Constitutive activation of Notch2 signalling confers chemoresistance to neural stem cells via transactivation of fibroblast growth factor receptor-1

scientific article published on 07 February 2019

Corrigendum: Circuit specificity in the inhibitory architecture of the VTA regulates cocaine-induced behavior.

scientific article published in July 2017

Deletion of GABA-B receptor in Schwann cells regulates remak bundles and small nociceptive C-fibers

scientific article published on 29 January 2014

Determination of the minimal functional ligand-binding domain of the GABAB1b receptor.

scientific article

Differential GABAB-receptor-mediated effects in perisomatic- and dendrite-targeting parvalbumin interneurons

scientific article published on May 2013

Differential association of GABAB receptors with their effector ion channels in Purkinje cells.

scientific article published on 25 November 2017

Differential compartmentalization and distinct functions of GABAB receptor variants

scientific article

Differential effects of GABAB receptor subtypes, {gamma}-hydroxybutyric Acid, and Baclofen on EEG activity and sleep regulation

scientific article published on October 2010

Differential roles of GABAB1 subunit isoforms on locomotor responses to acute and repeated administration of cocaine

scientific article

Distinct localization of GABA(B) receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus

scientific article published in January 2002

Distinct roles of GABAB1a- and GABAB1b-containing GABAB receptors in spontaneous and evoked termination of persistent cortical activity

scientific article published on 24 December 2012

Distribution of the auxiliary GABAB receptor subunits KCTD8, 12, 12b, and 16 in the mouse brain

scientific article published on 01 June 2011

Early-life stress induces visceral hypersensitivity in mice

scientific article published on 6 February 2012

Effect of androgens on sexual differentiation of pituitary gamma-aminobutyric acid receptor subunit GABA(B) expression

scientific article published on 7 December 2004

Effect of genetic and pharmacological blockade of GABA receptors on the 5-HT2C receptor function during stress

scientific article

Epilepsy and intellectual disability linked protein Shrm4 interaction with GABABRs shapes inhibitory neurotransmission

scientific article

Expression of gamma-aminobutyric acid B receptor subunits in hypothalamus of male and female developing rats

scientific article

Expression, Structure, and Function of the CD23 Antigen

scientific article published on January 1, 1991

Floxed allele for conditional inactivation of the GABAB(1) gene

scientific article published in November 2004

Functional mapping of GABA(B)-receptor subtypes in the thalamus

scientific article published on 19 September 2007

GABA blocks pathological but not acute TRPV1 pain signals

scientific article

GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors

scientific article published on 27 November 2013

GABA type B receptor signaling in proopiomelanocortin neurons protects against obesity, insulin resistance, and hypothalamic inflammation in male mice on a high-fat diet.

scientific article published in October 2013

GABA(B(1)) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories.

scientific article published in August 2006

GABA(B) receptors as potential therapeutic targets

scientific article

GABA(B) receptors: synaptic functions and mechanisms of diversity

scientific article published on 12 April 2007

GABA(B1) knockout mice reveal alterations in prolactin levels, gonadotropic axis, and reproductive function

scientific article published in January 2005

GABAB Receptor Signaling in the Mesolimbic System Suppresses Binge-like Consumption of a High-Fat Diet

scientific article published on 26 September 2019

GABAB receptor cell-surface export is controlled by an endoplasmic reticulum gatekeeper

scientific article

GABAB receptor deficiency causes failure of neuronal homeostasis in hippocampal networks

scientific article published on 8 June 2015

GABAB receptor phosphorylation regulates KCTD12-induced K⁺ current desensitization

scientific article

GABAB receptor subtypes differentially modulate synaptic inhibition in the dentate gyrus to enhance granule cell output

scientific article

GABAB receptor subtypes differentially regulate thalamic spindle oscillations.

scientific article published on 26 October 2017

GABAB receptors - the first 7TM heterodimers.

scientific article

GABAB receptors modulate morphine antinociception: Pharmacological and genetic approaches

scientific article published on 06 March 2019

GABAB receptors: physiological functions and mechanisms of diversity

scientific article published on January 2010

GABAB(1) receptor subunit isoforms differentially regulate stress resilience

scientific article

GABAB1 receptor subunit isoforms exert a differential influence on baseline but not GABAB receptor agonist-induced changes in mice.

scientific article published on 21 September 2006

GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness

scientific article

Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition.

scientific article published on 2 July 2006

Glioblastomas on the move

scientific article published on 13 April 2004

GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses

scholarly article

Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice.

scientific article

Heteromerization of GABAB Receptors: A New Principle for G Protein-Coupled Receptors. Satellite Symposium to the 28th Annual Meeting of the Society for Neuroscience Los Angeles, CA, November 5-7, 1998.

scientific article

Hyperdopaminergia and altered locomotor activity in GABAB1-deficient mice.

scientific article published on 5 April 2006

Impaired GABAB receptor signaling dramatically up-regulates Kiss1 expression selectively in nonhypothalamic brain regions of adult but not prepubertal mice.

scientific article

Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior

scientific article published on 16 March 2022

Independent maturation of the GABA(B) receptor subunits GABA(B1) and GABA(B2) during postnatal development in rodent brain

scientific article published in September 2004

Inhibition of Notch2 by Numb/Numblike controls myocardial compaction in the heart

scientific article published on 03 August 2012

Interneuron-specific signaling evokes distinctive somatostatin-mediated responses in adult cortical astrocytes.

scientific article published on 8 January 2018

Intracellular Retention of Recombinant GABABReceptors ⬇️

scientific article published on October 9, 1998

Involvement of GABAB receptors in biochemical alterations induced by anxiety-related responses to nicotine in mice: genetic and pharmacological approaches.

scientific article published on 30 January 2014

Ionotropic AMPA-type glutamate and metabotropic GABAB receptors: determining cellular physiology by proteomes

scientific article published on 7 March 2017

KCTD Hetero-oligomers Confer Unique Kinetic Properties on Hippocampal GABAB Receptor-Induced K+ Currents

scientific article published on 21 December 2016

KCTD12 Auxiliary Proteins Modulate Kinetics of GABAB Receptor-Mediated Inhibition in Cholecystokinin-Containing Interneurons

scientific article published on 12 April 2016

Lack of GABAB receptors modifies behavioural and biochemical alterations induced by precipitated nicotine withdrawal.

scientific article published on 3 December 2014

Lack of functional GABA(B) receptors alters GnRH physiology and sexual dimorphic expression of GnRH and GAD-67 in the brain

scientific article published on 15 December 2009

Lack of functional GABAB receptors alters Kiss1 , Gnrh1 and Gad1 mRNA expression in the medial basal hypothalamus at postnatal day 4.

scientific article published on 6 November 2013

Ligands for expression cloning and isolation of GABA(B) receptors

scientific article published on 01 March 2003

Loss of GABAB receptors in cochlear neurons: threshold elevation suggests modulation of outer hair cell function by type II afferent fibers

scientific article

Mechanisms of fast desensitization of GABA(B) receptor-gated currents

scientific article

Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics.

scientific article published on 21 December 2015

Molecular biology of the glutamate receptors

scientific article published on January 1, 1992

Molecular diversity, trafficking and subcellular localization of GABAB receptors

scientific article

Molecular organization and dynamics of the melatonin MT₁ receptor/RGS20/G(i) protein complex reveal asymmetry of receptor dimers for RGS and G(i) coupling

scientific article

Molecular structure and physiological functions of GABA(B) receptors

scientific article published in July 2004

Multiple failures in the lutenising hormone surge generating system in GABAB1KO female mice

scientific article published on 15 July 2019

NMDA receptor-dependent GABAB receptor internalization via CaMKII phosphorylation of serine 867 in GABAB1.

scientific article

Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits

scientific journal article

Native and recombinant soluble CD23 fragments with IgE suppressive activity ⬇️

scientific article published on 01 August 1992

Nicotine-induced molecular alterations are modulated by GABAB receptor activity

scientific article published on 17 April 2017

No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions.

scientific article

Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice

article

Opposite effects of KCTD subunit domains on GABA(B) receptor-mediated desensitization

scientific article

Organization and functions of mGlu and GABAB receptor complexes

scientific article published on December 2016

Parvalbumin-Interneuron Output Synapses Show Spike-Timing-Dependent Plasticity that Contributes to Auditory Map Remodeling

scientific article published on 02 August 2018

Pharmacological characterization of GABAB receptor subtypes assembled with auxiliary KCTD subunits

scientific article published on 6 September 2014

Pianp deficiency links GABAB receptor signaling and hippocampal and cerebellar neuronal cell composition to autism-like behavior

scientific article published on 11 September 2019

Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501

scientific article (publication date: November 2001)

Postnatal development of the endocrine pancreas in mice lacking functional GABAB receptors

scientific article published on 26 March 2013

Presynaptic Excitation via GABAB Receptors in Habenula Cholinergic Neurons Regulates Fear Memory Expression.

scientific article published on 14 July 2016

Presynaptic GABAB Receptors Regulate Hippocampal Synapses during Associative Learning in Behaving Mice

scientific article published on 5 February 2016

Presynaptic and postsynaptic localization of GABAB receptors in neurons of the rat retina ⬇️

scientific article published on 01 April 1998

Recognition molecule associated carbohydrate inhibits postsynaptic GABA(B) receptors: a mechanism for homeostatic regulation of GABA release in perisomatic synapses

scientific article published on October 2003

Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice.

scientific article published in July 2004

Reduction in the neuronal surface of post and presynaptic GABAB receptors in the hippocampus in a mouse model of Alzheimer's disease

scientific article published on 15 November 2019

Regulation of neuronal GABAB receptor functions by subunit composition ⬇️

scientific article published on May 18, 2012

Rimonabant, a potent CB1 cannabinoid receptor antagonist, is a Gαi/o protein inhibitor.

scientific article published on 27 January 2018

Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture.

scholarly article

Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice

scientific article

Specific roles of GABA(B(1)) receptor isoforms in cognition.

scientific article

Structural Basis of GABAB Receptor Regulation and Signaling

scientific article published on 19 August 2020

Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells.

scientific article published on 22 June 2009

Subtype-selective interaction with the transcription factor CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP) regulates cell surface expression of GABA(B) receptors.

scientific article

Symmetric signal transduction and negative allosteric modulation of heterodimeric mGlu1/5 receptors

scientific article published on 03 December 2020

Synapse loss in cortex of agrin-deficient mice after genetic rescue of perinatal death.

scientific article

TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity

scientific article

Targeting receptor complexes: a new dimension in drug discovery

scientific article published on 11 November 2020

Targeting the γ-Aminobutyric Acid Type B (GABAB) Receptor Complex: Development of Inhibitors Targeting the K+ Channel Tetramerization Domain (KCTD) Containing Proteins/GABAB Receptor Protein-Protein Interaction

scientific article published on 25 September 2019

The GABAB1a isoform mediates heterosynaptic depression at hippocampal mossy fiber synapses.

scientific article published in February 2009

The GABAB1b isoform mediates long-lasting inhibition of dendritic Ca2+ spikes in layer 5 somatosensory pyramidal neurons

scientific article published in May 2006

The RXR-type endoplasmic reticulum-retention/retrieval signal of GABAB1 requires distant spacing from the membrane to function

scientific article

The Sushi domains of GABAB receptors function as axonal targeting signals

scientific article published in January 2010

The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors.

scientific article published in June 2002

The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor

scientific article

The oligomeric state sets GABA(B) receptor signalling efficacy

scientific journal article

The organizing principle of GABAB receptor complexes: Physiological and pharmacological implications

scientific article published on 29 April 2019

The pros of not being competitive

scientific article published in September 2007

The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system

scientific article

The sushi domains of secreted GABA(B1) isoforms selectively impair GABA(B) heteroreceptor function

scientific journal article

Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers

scientific article

Trace amine-associated receptor 1 modulates dopaminergic activity

scientific article

Type B gamma-aminobutyric acid receptors modulate the function of the extracellular Ca2+-sensing receptor and cell differentiation in murine growth plate chondrocytes

scientific article published on 5 July 2007

Up-regulation of GABA(B) receptor signaling by constitutive assembly with the K+ channel tetramerization domain-containing protein 12 (KCTD12)

scientific article published on 10 July 2013

WITHDRAWN: Type B gamma-aminobutyric Acid Receptors Modulate the Expression and Function of the Extracellular Ca2+-sensing Receptor in Murine Growth Plate Chondrocytes

retracted scientific article published on 5 September 2006

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