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List of works by Saverio Minucci

A comprehensive review of lysine-specific demethylase 1 and its roles in cancer

scientific article

A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.

scientific article

A novel autophagy-independent, oncosuppressive function of BECN1: Degradation of MCL1.

scientific article

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.

scientific article

Abstract A28: Challenging new epigenetic vulnerabilities in human metastatic melanoma PDXs

Acetylation: a novel link between double-strand break repair and autophagy

scientific article published on March 2012

Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer

scientific article published on 23 January 2017

Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to arsenic trioxide

scientific article published on 17 September 2002

Assessment of histone acetylation levels in relation to cell cycle phase

scientific article published in October 2008

Author Correction: Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion

scientific article published on 06 August 2019

BLUEPRINT to decode the epigenetic signature written in blood.

scientific article

Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner.

scientific article published on 4 December 2014

Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2

scientific article

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

scientific article

Chiral resolution and pharmacological characterization of the enantiomers of the Hsp90 inhibitor 2-amino-7-[4-fluoro-2-(3-pyridyl)phenyl]-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime

scientific article published on 17 April 2014

Chromatin accessibility, p300, and histone acetylation define PML-RARα and AML1-ETO binding sites in acute myeloid leukemia

scientific article

Chromatin immunoprecipitation and high-throughput sequencing from paraffin-embedded pathology tissue

scientific article

Cinnamic anilides as new mitochondrial permeability transition pore inhibitors endowed with ischemia-reperfusion injury protective effect in vivo

scientific article published on 11 June 2014

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

scientific article published on 25 April 2019

Comparing apples with oranges: Studying LSD1 inhibitors in cellular assays

scientific article published on 08 July 2019

Corrigendum: Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer.

scientific article

Corrigendum: From Resistance to Sensitivity: Insights and Implications of Biphasic Modulation of Autophagy by Sunitinib

scientific article published on 12 February 2018

DNA binding modes of leukemia oncoproteins.

scientific article published in January 2016

Determinants of oncogenic transformation in acute promyelocytic leukemia: the hetero-union makes the force

scientific article published on July 2007

Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion

scientific article

Differentiation response of acute promyelocytic leukemia cells and PML/RARa leukemogenic activity studies by real-time RT-PCR.

scientific article published on July 2005

Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models

scientific article published on 13 February 2020

Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent

scientific article published on 24 December 2015

Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors

scientific article published on April 2011

Dual inhibition of mTOR pathway and VEGF signalling in neuroendocrine neoplasms: from bench to bedside.

scientific article published on 28 June 2015

Dual modulation of MCL-1 and mTOR determines the response to sunitinib

scientific article published on 28 November 2016

Efficient Inhibition of Activation-induced Fas Ligand Up-regulation and T Cell Apoptosis by Retinoids Requires Occupancy of both Retinoid X Receptors and Retinoic Acid Receptors ⬇️

scientific article published on 01 August 1995

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

article

Entinostat for the treatment of breast cancer.

scientific article published on 18 July 2017

Epigenetic alterations in acute myeloid leukemias

scientific article

Epigenetic therapies in haematological malignancies: searching for true targets

scientific article published on 05 April 2009

Epigenomic profiling of archived FFPE tissues by enhanced PAT-ChIP (EPAT-ChIP) technology

scientific article published on 16 November 2018

Extensive and systematic rewiring of histone post-translational modifications in cancer model systems.

scientific article published on 29 March 2018

Fish the ChIPs: a pipeline for automated genomic annotation of ChIP-Seq data ⬇️

scientific article published on October 6, 2011

Fragment-based identification of Hsp90 inhibitors

scientific article

From Resistance to Sensitivity: Insights and Implications of Biphasic Modulation of Autophagy by Sunitinib.

scientific article published on 10 October 2017

Functional characterization of a novel FGFR1OP-RET rearrangement in hematopoietic malignancies.

scientific article published on 19 November 2013

Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles.

scientific article published on 28 March 2014

HDACs link the DNA damage response, processing of double-strand breaks and autophagy

scientific article published on March 2011

Histone Modification Therapy of Cancer

scientific article published on January 1, 2010

Histone deacetylase inhibitors as a new weapon in the arsenal of differentiation therapies of cancer

scientific article published on 02 April 2009

Histone deacetylases and epigenetic therapies of hematological malignancies

scientific article published on 26 February 2010

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

scientific article

Identification of a Novel cis-Element Required for the Constitutive Activity and Osmotic Response of the Rat Aldose Reductase Promoter ⬇️

scientific article published on December 19, 1997

Identification of mutations associated with acquired resistance to sunitinib in renal cell cancer

scientific article published on 30 March 2019

Immunocell-array for molecular dissection of multiple signaling pathways in mammalian cells

scientific article published on 10 February 2007

Impairment of p53 acetylation, stability and function by an oncogenic transcription factor

scientific article published on 19 February 2004

In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype.

scientific article

In vitro and in vivo hematopoietic potential of human stem cells residing in muscle tissue

scientific article published on 01 August 2002

Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway

scientific article published on 26 December 2004

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer.

scientific article published on 20 February 2011

Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression

scientific article

MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks.

scientific article published on 21 July 2008

MOZ-TIF2 inhibits transcription by nuclear receptors and p53 by impairment of CBP function

scientific article

Mass-spectrometry analysis of histone post-translational modifications in pathology tissue using the PAT-H-MS approach.

scientific article published on 16 February 2016

Mechanisms of selective anticancer action of histone deacetylase inhibitors

scientific article

Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

scientific article (publication date: 8 February 2002)

Molecular Pathways: Old Drugs Define New Pathways: Non-Histone Acetylation at the Crossroads of the DNA Damage Response and Autophagy

article

Molecular and biologic analysis of histone deacetylase inhibitors with diverse specificities

scientific article published on 3 October 2013

NA-Seq: a discovery tool for the analysis of chromatin structure and dynamics during differentiation

scientific article published in March 2009

New method to detect histone acetylation levels by flow cytometry

scientific article

Next generation histone deacetylase inhibitors: the answer to the search for optimized epigenetic therapies? ⬇️

scientific article published on February 23, 2011

Novel potent inhibitors of the histone demethylase KDM1A (LSD1), orally active in a murine promyelocitic leukemia model

scientific article

Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice

scientific article

PAT-ChIP coupled with laser microdissection allows the study of chromatin in selected cell populations from paraffin-embedded patient samples.

scientific article

PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damage

PML-RAR induces promyelocytic leukemias with high efficiency following retroviral gene transfer into purified murine hematopoietic progenitors

scientific article published in October 2002

PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response

scientific article published on 12 June 2017

Pathology Tissue-quantitative Mass Spectrometry Analysis to Profile Histone Post-translational Modification Patterns in Patient Samples

scientific article published on 13 October 2015

Pathology tissue-chromatin immunoprecipitation, coupled with high-throughput sequencing, allows the epigenetic profiling of patient samples.

scientific article

Pharmacokinetic drug evaluation of ribociclib for the treatment of metastatic, hormone-positive breast cancer

scientific article published on 11 April 2017

Preclinical models of breast cancer: Two-way shuttles for immune checkpoint inhibitors from and to patient bedside

scientific article published on 10 October 2019

Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc

scientific article published on 01 February 2007

Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies.

scientific article

Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts

article

Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells

Quantitative chemical proteomics identifies novel targets of the anti-cancer multi-kinase inhibitor E-3810.

scientific article published on 2 April 2014

Recruitment of the histone methyltransferase SUV39H1 and its role in the oncogenic properties of the leukemia-associated PML-retinoic acid receptor fusion protein

scientific article

Redox-Mediated Suberoylanilide Hydroxamic Acid Sensitivity in Breast Cancer

scientific article published on 27 May 2015

Retinoic acid receptor alpha fusion to PML affects its transcriptional and chromatin-remodeling properties

scientific article published on December 2003

Retinoid-Induced Chromatin Structure Alterations in the Retinoic Acid Receptor β2 Promoter ⬇️

scientific article published on November 1, 1997

Role of the polycomb repressive complex 2 in acute promyelocytic leukemia

scientific article

SILAC-based proteomic analysis to dissect the "histone modification signature" of human breast cancer cells

scientific article published on 9 July 2010

Semantic and Geographical Analysis of COVID-19 Trials Reveals a Fragmented Clinical Research Landscape Likely to Impair Informativeness

scientific article published on 29 June 2020

Semantic and geographical analysis of Covid-19 trials reveals a fragmented clinical research landscape likely to impair informativeness.

scientific article published on 19 May 2020

Shiftworking keeps locked-down lab on track

scientific article published on 01 April 2020

Spiro[chromane-2,4'-piperidine]-based histone deacetylase inhibitors with improved in vivo activity

scientific article

Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors

scientific article published on 06 June 2018

Synthesis and biological characterization of amidopropenyl hydroxamates as HDAC inhibitors

scientific article published on August 2010

Synthesis and biological characterization of spiro[2H-(1,3)-benzoxazine-2,4'-piperidine] based histone deacetylase inhibitors

scientific article published on 10 April 2013

Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors

scientific article published in January 2010

Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A

scientific article

Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors

scientific article published on 11 November 2015

Targeting protein inactivation through an oligomerization chain reaction

scientific article

Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation

scientific article published on 08 April 2020

The DNA demethylating agent decitabine activates the TRAIL pathway and induces apoptosis in acute myeloid leukemia

scientific article

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

scientific article

The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome

scientific article (publication date: 13 February 2004)

The methyl-CpG binding protein MBD1 is required for PML-RARalpha function

scientific article

The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells

scientific article

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration.

scientific article published on 10 February 2017

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.

scientific article published on 10 February 2017

Tranylcypromine-Based LSD1 Inhibitors: Structure-Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation

scientific article published on 14 February 2020

Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis

scientific article published on 19 September 2017

Tuning mTORC1 activity dictates the response of acute myeloid leukemia to LSD1 inhibition

scientific article published on 19 September 2019

c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer.

scientific article

p66Shc-generated oxidative signal promotes fat accumulation

scientific article published on 06 October 2008

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