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List of works by George G Zhanel

2383. In Vitro Activity of Ceftolozane–Tazobactam in Comparison With Ceftazidime–Avibactam vs. Antimicrobial Non-Susceptible Pseudomonas aeruginosa Clinical Isolates, Including Multidrug-Resistant and Extensively Drug-Resistant Subsets: CANWARD,

254In Vitro Activity of Ceftazidime in Combination with Avibactam vs 1825 Pseudomonas aeruginosa Clinical Isolates Obtained from across Canada as Part of the CANWARD Study, 2009-2013.

scientific article

A One Health Genomic Investigation of Gentamicin Resistance in Escherichia coli from Human and Chicken Sources in Canada, 2014 to 2017

scientific article published in 2022

A Review of New Fluoroquinolones

article

A Review of New Fluoroquinolones : Focus on their Use in Respiratory Tract Infections

scientific article

A critical review of the fluoroquinolones: focus on respiratory infections

scientific article (publication date: 2002)

A review of clinical failures associated with macrolide-resistant Streptococcus pneumoniae

scientific article published in August 2004

AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity

scientific article published on June 2009

Abrupt emergence of a single dominant multidrug-resistant strain of Escherichia coli

scientific article published on 3 January 2013

Activity of Dapsone versus Community and Hospital Pathogens from the CANWARD Study

scientific article

Activity of Plazomicin against Gram-negative and Gram-positive Bacterial Pathogens Isolated from Patients in Canadian Hospitals from 2013 to 2017: CANWARD Surveillance Study

article

Adjuvants Based on Hybrid Antibiotics Overcome Resistance in Pseudomonas aeruginosa and Enhance Fluoroquinolone Efficacy

scientific article published on 26 November 2015

Amphiphilic tobramycins with immunomodulatory properties

scientific article published on April 2015

Analysis of 1560 Inpatient and OutpatientEscherichia coliIsolates from across Canada—Results from the CANWARD 2007 Study

article

Analysis of 3789 in- and outpatient Escherichia coli isolates from across Canada--results of the CANWARD 2007-2009 study.

scientific article published in March 2011

Annual macrolide prescription rates and the emergence of macrolide resistance among Streptococcus pneumoniae in Canada from 1995 to 2005.

scientific article published on 27 June 2009

Anti-infective research and development--problems, challenges, and solutions

scientific article published on January 2007

Antibacterial activities of aminoglycoside antibiotics-derived cationic amphiphiles. Polyol-modified neomycin B-, kanamycin A-, amikacin-, and neamine-based amphiphiles with potent broad spectrum antibacterial activity

scientific article published in May 2010

Antibacterial activity of amphiphilic tobramycin ⬇️

scientific article published on July 11, 2012

Antibacterial activity of guanidinylated neomycin B- and kanamycin A-derived amphiphilic lipid conjugates

scientific article published on 23 March 2010

Antibacterial activity of ultrashort cationic lipo-beta-peptides

scientific article published on 23 February 2009

Antibacterial drivers of resistance

scientific article

Antibiofilm activity of GlmU enzyme inhibitors against catheter-associated uropathogens

scientific article

Antibiotic Hybrids: the Next Generation of Agents and Adjuvants against Gram-Negative Pathogens?

scientific article published on 14 March 2018

Antibiotic activity against urinary tract infection (UTI) isolates of vancomycin-resistant enterococci (VRE): results from the 2002 North American Vancomycin Resistant Enterococci Susceptibility Study (NAVRESS).

scientific article published on 29 July 2003

Antibiotic resistance and expression of resistance-nodulation-division pump- and outer membrane porin-encoding genes in Acinetobacter species isolated from Canadian hospitals

scientific article published on January 2013

Antibiotic resistance in Escherichia coli outpatient urinary isolates: final results from the North American Urinary Tract Infection Collaborative Alliance (NAUTICA).

scientific article published on 18 May 2006

Antibiotic resistance in outpatient urinary isolates: final results from the North American Urinary Tract Infection Collaborative Alliance (NAUTICA).

scientific article published in November 2005

Antimicrobial Susceptibility of 6685 Organisms Isolated from Canadian Hospitals: CANWARD 2007

article

Antimicrobial resistance among clinical isolates of Streptococcus pneumoniae in Canada during 2000.

scientific article

Antimicrobial resistance in Haemophilus influenzae and Moraxella catarrhalis respiratory tract isolates: results of the Canadian Respiratory Organism Susceptibility Study, 1997 to 2002

scientific article

Antimicrobial resistance in hospital-acquired gram-negative bacterial infections

scientific article

Antimicrobial resistance in respiratory tract Streptococcus pneumoniae isolates: results of the Canadian Respiratory Organism Susceptibility Study, 1997 to 2002

scientific article

Antimicrobial resistance in urinary tract pathogens in Canada from 2007 to 2009: CANWARD surveillance study

scientific article

Antimicrobial susceptibility of 15,644 pathogens from Canadian hospitals: results of the CANWARD 2007–2009 study ⬇️

scientific article published on March 1, 2011

Antimicrobial susceptibility of 22746 pathogens from Canadian hospitals: results of the CANWARD 2007-11 study

scientific article published on May 2013

Antimicrobial susceptibility of 2906 Pseudomonasaeruginosa clinical isolates obtained from patients in Canadian hospitals over a period of 8 years: Results of the Canadian Ward surveillance study (CANWARD), 2008-2015.

scientific article published on 7 October 2016

Antimicrobial susceptibility of 3931 organisms isolated from intensive care units in Canada: Canadian National Intensive Care Unit Study, 2005/2006.

scientific article published on 29 May 2008

Antimicrobial susceptibility of Pseudomonas aeruginosa isolates obtained from patients in Canadian hospitals: CANWARD 2008–2011 ⬇️

scientific article published on June 12, 2012

Antimicrobial susceptibility of Pseudomonas aeruginosa isolates obtained from patients in Canadian intensive care units as part of the Canadian National Intensive Care Unit study

scientific article

Antimicrobial treatment in diabetic women with asymptomatic bacteriuria

scientific article

Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006.

scientific article

Are fluoroquinolone-susceptible isolates of Streptococcus pneumoniae really susceptible? A comparison of resistance mechanisms in Canadian isolates from 1997 and 2003.

scientific article published on 26 August 2005

Assessment of multidrug resistance, clonality and virulence in non-PCV-13 Streptococcus pneumoniae serotypes in Canada, 2011-13.

scientific article published on 11 March 2015

Assessment of the activity of ceftaroline against clinical isolates of penicillin-intermediate and penicillin-resistant Streptococcus pneumoniae with elevated MICs of ceftaroline using an in vitro pharmacodynamic model ⬇️

scientific article published on March 30, 2012

Association between fluoroquinolone usage and a dramatic rise in ciprofloxacin-resistant Streptococcus pneumoniae in Canada, 1997-2006.

scientific article

Baseline Epidemiology of Streptococcus pneumoniae Serotypes in Canada Prior to the Introduction of the 13-Valent Pneumococcal Vaccine ⬇️

scientific article published on December 28, 2011

Biocide Selective TolC-Independent Efflux Pumps in Enterobacteriaceae

scientific article published on 23 October 2017

Cadaverine Suppresses Persistence to Carboxypenicillins in Pseudomonas aeruginosa PAO1 ⬇️

scientific article published on September 20, 2010

Call for the international adoption of microbiological breakpoints for fluoroquinolones and Streptococcus pneumoniae

scientific article published on 9 August 2006

Canadian Practice Guidelines for Surgical Intra‐Abdominal Infections ⬇️

scientific article published on January 1, 2010

Cationic amphiphiles, a new generation of antimicrobials inspired by the natural antimicrobial peptide scaffold

scientific article published on 09 August 2010

Ceftaroline: a novel broad-spectrum cephalosporin with activity against meticillin-resistant Staphylococcus aureus.

scientific article

Ceftazidime-avibactam: a novel cephalosporin/β-lactamase inhibitor combination

scientific article

Ceftobiprole: a review of a broad-spectrum and anti-MRSA cephalosporin

scientific article

Ceftolozane/tazobactam: a novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant gram-negative bacilli.

scientific article

Changes in fluoroquinolone resistance over 5 years (CANWARD 2007-11) in bacterial pathogens isolated in Canadian hospitals

scientific article published in May 2013

Changing epidemiology of methicillin-resistant Staphylococcus aureus in Canada

scientific article published in May 2013

Characterization of Acinetobacter baumannii and meropenem-resistant Pseudomonas aeruginosa in Canada: results of the CANWARD 2007–2009 study ⬇️

scientific article published on 01 March 2011

Characterization of MDR and XDR Streptococcus pneumoniae in Canada, 2007-13.

scientific article published on 28 April 2015

Characterization of methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci and extended-spectrum beta-lactamase-producing Escherichia coli in intensive care units in Canada: Results of the Canadian National Intensive Care Unit

scientific article published on May 2008

Characterization of plasmids encoding CMY-2 AmpC beta-lactamases from Escherichia coli in Canadian intensive care units

scientific article published on 23 September 2009

Chicken as reservoir for extraintestinal pathogenic Escherichia coli in humans, Canada

scientific article published in March 2012

Clinical cure rates in subjects treated with azithromycin for community-acquired respiratory tract infections caused by azithromycin-susceptible or azithromycin-resistant Streptococcus pneumoniae: analysis of Phase 3 clinical trial data

scientific article

Clinical cure rates in subjects treated with azithromycin for community-acquired respiratory tract infections caused by azithromycin-susceptible or azithromycin-resistant Streptococcus pneumoniae: analysis of Phase 3 clinical trial data-authors' res

scientific article published on 4 August 2015

Clinical implications of macrolide resistance in community-acquired respiratory tract infections

scientific article published on December 2006

Clinical practice guidelines for hospital-acquired pneumonia and ventilator-associated pneumonia in adults

scientific article published on January 2008

Comparative in vitro activity of PGE 9262932 and fluoroquinolones against Canadian clinical Streptococcus pneumoniae isolates, including molecularly characterized ciprofloxacin-resistant isolates

scientific article published on 24 April 2006

Comparative pharmacodynamics of garenoxacin, gemifloxacin, and moxifloxacin in community-acquired pneumonia caused by Streptococcus pneumoniae: a Monte Carlo simulation analysis

scientific article

Comparative review of the carbapenems

scientific article published on January 2007

Comparison of Escherichia coli ST131 pulsotypes, by epidemiologic traits, 1967-2009.

scientific article published on April 2012

Comparison of antimicrobial resistance profiles among extended-spectrum-beta-lactamase-producing and acquired AmpC beta-lactamase-producing Escherichia coli isolates from Canadian intensive care units

scientific article published on 25 February 2008

Comparison of community-associated and health care-associated methicillin-resistant Staphylococcus aureus in Canada: results of the CANWARD 2007–2009 study

article

Comparison of gatifloxacin and levofloxacin administered at various dosing regimens to hospitalised patients with community-acquired pneumonia: pharmacodynamic target attainment study using North American surveillance data for Streptococcus pneumoni

scientific article

Comparison of in vivo and in vitro pharmacodynamics of a humanized regimen of 600 milligrams of Ceftaroline Fosamil every 12 hours against Staphylococcus aureus at initial inocula of 106 and 108 CFU per milliliter

scientific article

Comparison of pathogens and their antimicrobial resistance patterns in paediatric, adult and elderly patients in Canadian hospitals.

scientific article published in May 2013

Comparison of the next-generation aminoglycoside plazomicin to gentamicin, tobramycin and amikacin

scientific article

Correction to: Imipenem-Relebactam and Meropenem-Vaborbactam: Two Novel Carbapenem-β-Lactamase Inhibitor Combinations.

scientific article

Cost-Effectiveness Analysis of Fosfomycin for Treatment of Uncomplicated Urinary Tract Infections in Ontario

scientific article published on 20 February 2017

Cumulative clinical experience from over a decade of use of levofloxacin in community-acquired pneumonia: critical appraisal and role in therapy ⬇️

scientific article published on October 7, 2011

Dalbavancin and telavancin: novel lipoglycopeptides for the treatment of Gram-positive infections.

scientific article published on February 2008

Design, synthesis, and antibacterial activities of neomycin-lipid conjugates: polycationic lipids with potent gram-positive activity

scientific article published on 09 September 2008

Determination of the pharmacodynamic activity of clinically achievable tigecycline serum concentrations against clinical isolates of Escherichia coli with extended-spectrum beta-lactamases, AmpC beta-lactamases and reduced susceptibility to carbapen

scientific article published on 29 July 2009

Differences in antimicrobial susceptibility in Escherichia coli from Canadian intensive care units based on regional and demographic variables.

scientific article published on July 2008

Dual activity of fluoroquinolones against Streptococcus pneumoniae: the facts behind the claims

scientific article

ESBL genotypes in fluoroquinolone-resistant and fluoroquinolone-susceptible ESBL-producing Escherichia coli urinary isolates in Manitoba

scientific article published on March 2007

Emergence of Antimicrobial Resistance among Pseudomonas aeruginosa: Implications for Therapy

scientific article published on 4 June 2017

Emergence of antimicrobial resistance among Acinetobacter species: a global threat

scientific article

Emergence of fluoroquinolone resistance in Neisseria gonorrhoeae isolates from four clinics in three regions of Kenya

scientific article published in May 2012

Epidemic clonal groups of Escherichia coli as a cause of antimicrobial-resistant urinary tract infections in Canada, 2002 to 2004

scientific article published on 27 April 2009

Ertapenem: review of a new carbapenem

scientific article

Escalation of antimicrobial resistance among Streptococcus pneumoniae: implications for therapy

scientific article

Evaluation of amphiphilic aminoglycoside-peptide triazole conjugates as antibacterial agents

scientific article published on 3 April 2010

Evolution and molecular characterization of macrolide-resistant Streptococcus pneumoniae in Canada between 1998 and 2008.

scientific article published on 22 August 2013

Evolution of antimicrobial resistance among Enterobacteriaceae (focus on extended spectrum β-lactamases and carbapenemases) ⬇️

scientific article published on January 15, 2013

Expression of the mef(E) gene encoding the macrolide efflux pump protein increases in Streptococcus pneumoniae with increasing resistance to macrolides

scientific article

Faropenem: review of a new oral penem

scientific article published on April 2007

Fidaxomicin: A novel agent for the treatment of Clostridium difficile infection

scientific article

Fluoroquinolone AUIC break points and the link to bacterial killing rates: in vitro models

scientific article published on 01 September 2003

Fluoroquinolone resistance in Escherichia coli isolated from patients attending Canadian hospitals is associated with the ST131 clone.

scientific article

Fluoroquinolone-associated tendinopathy: a critical review of the literature

scientific article

Fluoroquinolone-resistant urinary isolates of Escherichia coli from outpatients are frequently multidrug resistant: results from the North American Urinary Tract Infection Collaborative Alliance-Quinolone Resistance study

scientific article

Fosfomycin: A First-Line Oral Therapy for Acute Uncomplicated Cystitis

scientific article

Frequency of MCR-1-mediated colistin resistance among Escherichia coli clinical isolates obtained from patients in Canadian hospitals (CANWARD 2008-2015).

scientific article published on 26 October 2016

Genetic relatedness of multidrug-resistant Escherichia coli cultured from geographically diverse outpatient, midstream urine specimens.

scientific article published on 26 March 2007

Genomic analyses of DNA transformation and penicillin resistance in Streptococcus pneumoniae clinical isolates.

scientific article

Guanidylation and tail effects in cationic antimicrobial lipopeptoids

scientific article

Horizontal transfer of antibiotic resistance from Enterococcus faecium of fermented meat origin to clinical isolates of E. faecium and Enterococcus faecalis

scientific article published on 21 January 2015

Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux

scientific article published on 13 August 2016

Imipenem-Relebactam and Meropenem-Vaborbactam: Two Novel Carbapenem-β-Lactamase Inhibitor Combinations

scientific article published on 12 December 2017

In Vitro Activity of Ceftolozane-Tazobactam vs. Antimicrobial Non-Susceptible Pseudomonas aeruginosa Clinical Isolates Obtained from Across Canada as Part of the CANWARD Study, 2008–2016.

scientific article published on 4 October 2017

In Vitro Activity of Colistin (Polymyxin E) Versus 2541 Pseudomonas aeruginosa Clinical Isolates Obtained From Patients in Canadian Hospitals: Results of the CANWARD Study, 2008–2014

article

In Vitro Activity of Newer Antimicrobials and Relevant Comparators Vs. 349 Stenotrophomonas maltophilia Clinical Isolates Obtained from Patients in Canadian Hospitals (CANWARD, 2011–2016).

scientific article published on 4 October 2017

In Vitro activity of fosfomycin against Escherichia coli isolated from patients with urinary tract infections in Canada as part of the CANWARD surveillance study.

scientific article published on 09 December 2013

In vitro activity of API-1252, a novel FabI inhibitor, against clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis

scientific article published on 12 January 2007

In vitro activity of Iclaprim against respiratory and bacteremic isolates of Streptococcus pneumoniae

scientific article published on 12 January 2009

In vitro activity of OPT-80 tested against clinical isolates of toxin-producing Clostridium difficile

scientific article published on 25 August 2008

In vitro activity of Oritavancin against gram-positive pathogens isolated in Canadian hospital laboratories from 2011 to 2015.

scientific article published on 20 January 2017

In vitro activity of ceftaroline against gram-positive and gram-negative pathogens isolated from patients in Canadian hospitals in 2009.

scientific article

In vitro activity of ceftaroline-avibactam against gram-negative and gram-positive pathogens isolated from patients in Canadian hospitals from 2010 to 2012: results from the CANWARD surveillance study

scientific article published on 26 August 2013

In vitro activity of ceftazidime-avibactam against 338 molecularly characterized gentamicin-nonsusceptible Gram-negative clinical isolates obtained from patients in Canadian hospitals

scientific article published on 30 March 2015

In vitro activity of ceftobiprole against clinical isolates of Pseudomonas aeruginosa obtained from Canadian intensive care unit (ICU) patients as part of the CAN-ICU Study

scientific article published in April 2008

In vitro activity of ceftobiprole against frequently encountered aerobic and facultative Gram-positive and Gram-negative bacterial pathogens: results of the CANWARD 2007–2009 study ⬇️

scientific article published on March 1, 2011

In vitro activity of ceftolozane/tazobactam versus antimicrobial non-susceptible Pseudomonas aeruginosa clinical isolates including MDR and XDR isolates obtained from across Canada as part of the CANWARD study, 2008-16.

scientific article published on 12 December 2017

In vitro activity of dalbavancin and telavancin against staphylococci and streptococci isolated from patients in Canadian hospitals: results of the CANWARD 2007–2009 study ⬇️

scientific article published on March 1, 2011

In vitro activity of eravacycline against 2213 Gram-negative and 2424 Gram-positive bacterial pathogens isolated in Canadian hospital laboratories: CANWARD surveillance study 2014-2015.

scientific article published on 22 December 2017

In vitro activity of nemonoxacin, a novel nonfluorinated quinolone, against 2,440 clinical isolates

scientific article published on 08 September 2009

In vitro activity of the investigational ketolide cethromycin against macrolide- and penicillin-resistant Streptococcus pneumoniae: review of the 1998 to 2006 Canadian Respiratory Organism Susceptibility Study (CROSS)

scientific article published on 16 January 2009

In vitro antimicrobial susceptibilities of Streptococcus pneumoniae clinical isolates obtained in Canada in 2002

scientific article published on September 2004

In vitro interactions of anidulafungin with azole antifungals, amphotericin B and 5-fluorocytosine against Candida species

scientific article published on 18 January 2006

Increasing genetic relatedness of ciprofloxacin-resistant Streptococcus pneumoniae isolated in Canada from 1997 to 2005.

scientific article

Infections Due to Acinetobacter baumannii in the ICU: Treatment Options

scientific article published on 4 June 2017

Influence of Pharmacokinetic and Pharmacodynamic Principles on Antibiotic Selection

scientific article published in February 2001

Integrating pharmacokinetics, pharmacodynamics and MIC distributions to assess changing antimicrobial activity against clinical isolates of Pseudomonas aeruginosa causing infections in Canadian hospitals (CANWARD)

article

Intravenous Fosfomycin: An Assessment of Its Potential for Use in the Treatment of Systemic Infections in Canada

scientific article published on 25 June 2018

Introduction to the CANWARD Study (2007–2009) ⬇️

scientific article published on March 1, 2011

Introduction to the CANWARD study (2007–11).

scientific article published in May 2013

Invasive Streptococcus pneumoniae in Canada, 2011-2014: Characterization of new candidate 15-valent pneumococcal conjugate vaccine serotypes 22F and 33F.

scientific article published on 13 April 2016

Investigating the antimicrobial peptide 'window of activity' using cationic lipopeptides with hydrocarbon and fluorinated tails

scientific article published on 10 May 2012

In vitro potency and combination testing of antimicrobial agents against Neisseria gonorrhoeae.

scientific article published on 18 November 2015

Ketolides in the treatment of respiratory infections

scientific article

Ketolides: an emerging treatment for macrolide-resistant respiratory infections, focusing on S. pneumoniae

scientific article

Key research issues in Clostridium difficile

scientific article

Kisameet Clay Isolated from the Central Coast of British Columbia, Canada, Demonstrates Broad-Spectrum Antimicrobial Activity

scientific article published on 8 March 2016

Launching of the CAN-R Web site -The official Web site of the Canadian Antimicrobial Resistance Alliance

scientific article published on March 2007

Lefamulin: A Novel Oral and Intravenous Pleuromutilin for the Treatment of Community-Acquired Bacterial Pneumonia

scientific article published on 28 November 2020

Levofloxacin for the treatment of community-acquired pneumonia

scientific article published on October 2006

Limitations of ceftriaxone compared with cefazolin against MSSA: an integrated pharmacodynamic analysis.

scientific article

Mature Pseudomonas aeruginosa biofilms prevail compared to young biofilms in the presence of ceftazidime

scientific article

Mechanisms of reduced susceptibility to ciprofloxacin in Escherichia coli isolates from Canadian hospitals

scientific article

Mechanisms of resistance and mobility among multidrug-resistant CTX-M-producing Escherichia coli from Canadian intensive care units: the 1st report of QepA in North America

scientific article published in March 2009

Mechanisms of resistance to telithromycin in Streptococcus pneumoniae

scientific article published on 8 July 2005

Microbiological Profile of Sarecycline: A Novel Targeted Spectrum Tetracycline for the Treatment of Acne Vulgaris

scientific article published in 2018

Modulation of the local neutrophil response by a novel hyaluronic acid-binding peptide reduces bacterial burden during staphylococcal wound infection.

scientific article published on 19 July 2010

Molecular characterisation of Canadian paediatric multidrug-resistant Streptococcus pneumoniae from 1998-2004

scientific article published on 16 October 2006

Molecular characterization of fluoroquinolone resistant Streptococcus pneumoniae clinical isolates obtained from across Canada

scientific article

Molecular characterization of increasing fluoroquinolone resistance in Streptococcus pneumoniae isolates in Canada, 1997 to 2005.

scientific article published on 6 November 2006

Molecular characterization of predominant Streptococcus pneumoniae serotypes causing invasive infections in Canada: the SAVE study, 2011-15

article

Molecular epidemiology and prevalence of macrolide efflux genes mef(A) and mef(E) in Streptococcus pneumoniae obtained in Canada from 1997 to 2002

scientific article

Molecular epidemiology of extended-spectrum β-lactamase-, AmpC β-lactamase- and carbapenemase-producing Escherichia coli and Klebsiella pneumoniae isolated from Canadian hospitals over a 5 year period: CANWARD 2007-11

scientific article

Molecular epidemiology of penicillin-resistant and ciprofloxacin-resistant Streptococcus pneumoniae in Canada

scientific article

Molecular epidemiology of urinary tract isolates of vancomycin-resistant Enterococcus faecium from North America

scientific article published on 18 April 2006

Monte Carlo simulation analysis of ceftobiprole, dalbavancin, daptomycin, tigecycline, linezolid and vancomycin pharmacodynamics against intensive care unit-isolated methicillin-resistant Staphylococcus aureus

scientific article

Multidrug-resistant North American pulsotype 2 Clostridium difficile was the predominant toxigenic hospital-acquired strain in the province of Manitoba, Canada, in 2006-2007

article

Multilocus sequence typing and virulence gene profiles associated with Escherichia coli from human and animal sources

scientific article published on 16 March 2015

Musculoskeletal injury associated with fluoroquinolone antibiotics

scientific article

Mutant prevention concentrations for single-step fluoroquinolone-resistant mutants of wild-type, efflux-positive, or ParC or GyrA mutation-containing Streptococcus pneumoniae isolates

scientific article published on October 2004

Mutant prevention concentrations of levofloxacin alone and in combination with azithromycin, ceftazidime, colistin (Polymyxin E), meropenem, piperacillin-tazobactam, and tobramycin against Pseudomonas aeruginosa

scientific article published on June 2006

Neomycin-phenolic conjugates: polycationic amphiphiles with broad-spectrum antibacterial activity, low hemolytic activity and weak serum protein binding

scientific article published on 14 January 2012

New biocide with both N-chloramine and quaternary ammonium moieties exerts enhanced bactericidal activity

scientific article published on 3 July 2012

New lipoglycopeptides: a comparative review of dalbavancin, oritavancin and telavancin

scientific article

Oral Fosfomycin for the Treatment of Acute and Chronic Bacterial Prostatitis Caused by Multidrug-Resistant Escherichia coli.

scientific article published on 30 January 2018

Oral and Intravenous Fosfomycin for the Treatment of Complicated Urinary Tract Infections

scientific article published on 28 March 2020

Oritavancin: Mechanism of Action ⬇️

scientific article published on April 1, 2012

Overview of seizure-inducing potential of doripenem

scientific article

PCR ribotyping and antimicrobial susceptibility testing of isolates of Clostridium difficile cultured from toxin-positive diarrheal stools of patients receiving medical care in Canadian hospitals: the Canadian Clostridium difficile Surveillance Stud

scientific article

Penicillin-binding protein 1A, 2B, and 2X alterations in Canadian isolates of penicillin-resistant Streptococcus pneumoniae

scientific article

Pharmacodynamic Profiling of Antimicrobials against Gram‐negative Respiratory Isolates from Canadian Hospitals ⬇️

scientific article published on January 1, 2011

Pharmacodynamic activity of azithromycin against macrolide-susceptible and -resistant Streptococcus pneumoniae simulating clinically achievable free serum, epithelial lining fluid and middle ear fluid concentrations

scientific article published on 29 May 2003

Pharmacodynamic activity of ceftobiprole compared with vancomycin versus methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate Staphylococcus aureus (VISA) and vancomycin-resistant Staphylococcus aureus (VRSA) using an in vitro

scientific article

Pharmacodynamic activity of ertapenem versus multidrug-resistant genotypically characterized extended-spectrum beta-lactamase-producing Escherichia coli using an in vitro model

scientific article published on 31 January 2008

Pharmacodynamic activity of ertapenem versus penicillin-susceptible and penicillin-non-susceptible Streptococcus pneumoniae using an in vitro model

scientific article published on 01 November 2006

Pharmacodynamic activity of fluoroquinolones against ciprofloxacin-resistant Streptococcus pneumoniae

scientific article

Pharmacodynamic activity of fosfomycin simulating urinary concentrations achieved after a single 3-g oral dose versus Escherichia coli using an in vitro model

scientific article published on 23 April 2017

Pharmacodynamic activity of garenoxacin against ciprofloxacin-resistant Streptococcus pneumoniae

scientific article published on 27 April 2006

Pharmacodynamic activity of telithromycin against macrolide-susceptible and macrolide-resistant Streptococcus pneumoniae simulating clinically achievable free serum and epithelial lining fluid concentrations

scientific article published on 5 November 2004

Pharmacodynamic activity of telithromycin at simulated clinically achievable free-drug concentrations in serum and epithelial lining fluid against efflux (mefE)-producing macrolide-resistant Streptococcus pneumoniae for which telithromycin MICs vary

scientific article published on May 2005

Pharmacodynamic modeling of clarithromycin against macrolide-resistant [PCR-positive mef(A) or erm(B)] Streptococcus pneumoniae simulating clinically achievable serum and epithelial lining fluid free-drug concentrations

scientific article published on December 2002

Pharmacodynamic target attainment analysis against Streptococcus pneumoniae using levofloxacin 500 mg, 750 mg and 1000 mg once daily in plasma (P) and epithelial lining fluid (ELF) of hospitalized patients with community acquired pneumonia (CAP).

scientific article published on November 2004

Pharmacodynamic target attainment potential of azithromycin, clarithromycin, and telithromycin in serum and epithelial lining fluid of community-acquired pneumonia patients with penicillin-susceptible, intermediate, and resistant Streptococcus pneum

scientific article

Pharmacodynamics of empirical antibiotic monotherapies for an intensive care unit (ICU) population based on Canadian surveillance data

scientific article

Pharmacokinetics/pharmacodynamics of levofloxacin 750 mg once daily in young women with acute uncomplicated pyelonephritis

scientific article published on 26 December 2007

Phylogenetic analysis of emergent Streptococcus pneumoniae serotype 22F causing invasive pneumococcal disease using whole genome sequencing

scientific article

Piperacillin-tazobactam: a beta-lactam/beta-lactamase inhibitor combination

scientific article published on June 2007

Polymyxin B3-Tobramycin Hybrids with Pseudomonas aeruginosa-Selective Antibacterial Activity and Strong Potentiation of Rifampicin, Minocycline, and Vancomycin

scientific article

Predictors of receipt of a fluoroquinolone versus trimethoprim-sulfamethoxazole for treatment of acute pyelonephritis in women in Manitoba, Canada

scientific article published in December 2004

Preferential emergence of reduced vancomycin susceptibility in health care-associated methicillin-resistant Staphylococcus aureus isolates during continuous-infusion vancomycin therapy in an in vitro dynamic model

scientific article published on 18 April 2011

Prevalence and Characterization of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae Isolated in Canadian Hospitals: Results from CANWARD 2007

article

Prevalence and characterization of extended-spectrum β-lactamase- and AmpC β-lactamase-producing Escherichia coli: results of the CANWARD 2007-2009 study.

scientific article published in March 2011

Prevalence of Antimicrobial Resistance among Clinical Isolates of Bacteroides fragilis Group in Canada in 2010-2011: CANWARD Surveillance Study ⬇️

scientific article published on December 27, 2011

Prevalence of Antimicrobial-Resistant Pathogens in Canadian Hospitals: Results of the Canadian Ward Surveillance Study (CANWARD 2007)

article

Prevalence of antimicrobial resistant pathogens from blood cultures from Canadian hospitals: results of the CANWARD 2007-2009 study.

scientific article published in March 2011

Prevalence of antimicrobial-resistant pathogens in Canadian hospitals: results of the Canadian Ward Surveillance Study (CANWARD 2008).

scientific article

Review of Eravacycline, a Novel Fluorocycline Antibacterial Agent

scientific article

Role of efflux mechanisms on fluoroquinolone resistance in Streptococcus pneumoniae and Pseudomonas aeruginosa

scientific article

Role of glycoside hydrolase genes in sinigrin degradation by E. coli O157:H7.

scientific article published on 9 April 2015

Scissors: a potential source of nosocomial infection

scientific article published in March 2002

Selection of a gyrA mutation and treatment failure with gatifloxacin in a patient with Streptococcus pneumoniae with a preexisting parC mutation

scientific article published on 01 February 2007

Serotype distribution of invasive Streptococcus pneumoniae in Canada after the introduction of the 13-valent pneumococcal conjugate vaccine, 2010–2012

article

Serotype distribution of invasive Streptococcus pneumoniae in Canada during the introduction of the 13-valent pneumococcal conjugate vaccine, 2010.

scientific article published on 24 July 2012

Serotype distribution of invasive Streptococcus pneumoniae in adults 65 years of age and over after the introduction of childhood 13-valent pneumococcal conjugate vaccination programs in Canada, 2010-2016

article

Short Antimicrobial Peptides and Peptide Scaffolds as Promising Antibacterial Agents

scientific article published on 15 September 2015

Short proline-rich lipopeptide potentiates minocycline and rifampicin against multidrug- and extensively drug-resistant Pseudomonas aeruginosa

scientific article published on 5 February 2018

Solithromycin: A Novel Fluoroketolide for the Treatment of Community-Acquired Bacterial Pneumonia

scientific article published on December 2016

Stability of fluoroquinolone resistance in Streptococcus pneumoniae clinical isolates and laboratory-derived mutants

scientific article

Status Report from the Scientific Panel on Antibiotic Use in Dermatology of the American Acne and Rosacea Society: Part 1: Antibiotic Prescribing Patterns, Sources of Antibiotic Exposure, Antibiotic Consumption and Emergence of Antibiotic Resistance

scientific article published on April 2016

Status Report from the Scientific Panel on Antibiotic Use in Dermatology of the American Acne and Rosacea Society: Part 3: Current Perspectives on Skin and Soft Tissue Infections with Emphasis on Methicillin-resistant Staphylococcus aureus, Commonly

scientific article published on June 2016

Streptococcus pneumoniae: does antimicrobial resistance matter?

scientific article published on 18 March 2009

Streptococcus pneumoniae: epidemiology and risk factors, evolution of antimicrobial resistance, and impact of vaccines

scientific article

Streptococcus pneumoniae: epidemiology, risk factors, and strategies for prevention

scientific article published on 18 March 2009

Stretching the mutant prevention concentration (MPC) beyond its limits

scientific article

Structure-activity relationships in ultrashort cationic lipopeptides: the effects of amino acid ring constraint on antibacterial activity

scientific article

Susceptibility of Clinical Isolates of Escherichia coli to Fosfomycin Measured by Four In Vitro Testing Methods

scientific article published on 12 August 2020

Synthesis and Antibacterial Activities of Amphiphilic Neomycin B-based Bilipid Conjugates and Fluorinated Neomycin B-based Lipids ⬇️

scientific article published on 02 August 2012

Synthesis and antibacterial activity of amphiphilic lysine-ligated neomycin B conjugates

scientific article published on 21 January 2011

Synthesis and antibacterial properties of carbohydrate-templated lysine surfactants ⬇️

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Synthesis of glucose-templated lysine analogs and incorporation into the antimicrobial dipeptide sequence kW-OBn

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Tedizolid: a novel oxazolidinone with potent activity against multidrug-resistant gram-positive pathogens.

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Telavancin: mechanisms of action, in vitro activity, and mechanisms of resistance

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The Use of Macrolides in Treatment of Upper Respiratory Tract Infections.

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