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List of works by Martin Hauer-Jensen

"Pelvic radiation disease": new understanding and new solutions for a new disease in the era of cancer survivorship

scientific article published on 29 December 2010

28Si total body irradiation injures bone marrow hematopoietic stem cells via induction of cellular apoptosis.

scientific article

A Quantitative Proteomic Analysis of Urine from Gamma-Irradiated Non-Human Primates

scientific article published on 28 December 2015

A priming dose of protons alters the early cardiac cellular and molecular response to (56)Fe irradiation

scientific article published on 14 December 2015

Activation of protease activated receptor 2 by exogenous agonist exacerbates early radiation injury in rat intestine

scientific article

Analysis of the ambient particulate matter-induced chromosomal aberrations using an in vitro system

journal article published in 2016

Animal models for medical countermeasures to radiation exposure

scientific article

BMS-345541 Sensitizes MCF-7 Breast Cancer Cells to Ionizing Radiation by Selective Inhibition of Homologous Recombinational Repair of DNA Double-Strand Breaks ⬇️

scientific article published on December 21, 2012

Bone marrow transplantation helps restore the intestinal mucosal barrier after total body irradiation in mice

scientific article

Bowel injury: current and evolving management strategies

scientific article

C/EBPδ deficiency sensitizes mice to ionizing radiation-induced hematopoietic and intestinal injury

scientific article (publication date: 2014)

C/EBPδ protects from radiation-induced intestinal injury and sepsis by suppression of inflammatory and nitrosative stress

scientific article published on 27 September 2019

Calcitonin gene-related peptide and substance P regulate the intestinal radiation response.

scientific article

Cardiac inflammation after local irradiation is influenced by the kallikrein-kinin system

scientific article

Cebpd Is Essential for Gamma-Tocotrienol Mediated Protection against Radiation-Induced Hematopoietic and Intestinal Injury

scientific article published on 6 April 2018

Changes in one-carbon metabolism and DNA methylation in the hearts of mice exposed to space environment-relevant doses of oxygen ions (16O)

scientific article published on 31 May 2019

Characterization of transgenic Gfrp knock-in mice: implications for tetrahydrobiopterin in modulation of normal tissue radiation responses

scientific article published on 03 May 2013

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

scientific article

Clinical significance of increased gelatinolytic activity in the rectal mucosa during external beam radiation therapy of prostate cancer

scientific article published on 01 July 2002

Combined exposure to protons and (56)Fe leads to overexpression of Il13 and reactivation of repetitive elements in the mouse lung

scientific article

Comparative expression profiling in primary and immortalized endothelial cells: changes in gene expression in response to hydroxy methylglutaryl-coenzyme A reductase inhibition

scientific article published on April 2006

Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin

scientific article

Deficiency of microvascular thrombomodulin and up-regulation of protease-activated receptor-1 in irradiated rat intestine: possible link between endothelial dysfunction and chronic radiation fibrosis

scientific journal article

Defining pelvic-radiation disease for the survivorship era.

scientific article published on 8 February 2010

Densely ionizing radiation affects DNA methylation of selective LINE-1 elements.

scientific article published on 12 July 2016

Detection of Inter-chromosomal Stable Aberrations by Multiple Fluorescence In Situ Hybridization (mFISH) and Spectral Karyotyping (SKY) in Irradiated Mice

scientific article published on 11 January 2017

Determination of sample sizes for demonstrating efficacy of radiation countermeasures

scientific article

Dietary Methionine Supplementation Exacerbates Gastrointestinal Toxicity in a Mouse Model of Abdominal Irradiation

scientific article published on 28 September 2020

EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair

scientific article published on 18 December 2015

Effects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation

scientific article

Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice

scientific article published on 15 January 2019

Effects of low-dose rate γ-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart

scientific article

Effects of radiation on the epidermal growth factor receptor pathway in the heart

scientific article published on 16 April 2013

Enhanced Survival in Mice Exposed to Ionizing Radiation by Combination of Gamma-Tocotrienol and Simvastatin

scientific article published on 01 March 2019

Epithelial to mesenchymal transition (EMT) induced by bleomycin or TFGb1/EGF in murine induced pluripotent stem cell-derived alveolar Type II-like cells ⬇️

scientific article published on May 18, 2011

Fibrinogen deficiency suppresses the development of early and delayed radiation enteropathy

scientific article

Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival

scientific article published on 11 August 2013

Gamma-Tocotrienol Modulates Radiation-Induced MicroRNA Expression in Mouse Spleen

scientific article published on 29 April 2016

Gamma-Tocotrienol Protects the Intestine from Radiation Potentially by Accelerating Mesenchymal Immune Cell Recovery

scientific article published on 06 March 2019

Gene expression profiling in non-human primate jejunum, ileum and colon after total-body irradiation: a comparative study of segment-specific molecular and cellular responses

scientific article published on 21 November 2015

Hyperbaric oxygen stimulates vasculogenic stem cell growth and differentiation in vivo

scientific article

Hyperhomocysteinemia leads to adverse cardiac remodeling in hypertensive rats

scientific article published on 29 August 2002

Hyperhomocysteinemia leads to pathological ventricular hypertrophy in normotensive rats ⬇️

scientific article published on May 1, 2003

IKKβ regulates the repair of DNA double-strand breaks induced by ionizing radiation in MCF-7 breast cancer cells

scientific article

Identification of novel breakpoints for locus- and region-specific translocations in 293 cells by molecular cytogenetics before and after irradiation

scientific article published on 22 July 2019

Impact of vascular endothelial growth factor on skin graft survival in irradiated rats

scientific article published in March 2009

In vitro toxicity and epigenotoxicity of different types of ambient particulate matter

journal article published in 2015

Inactivation of thrombomodulin by ionizing radiation in a cell-free system: possible implications for radiation responses in vascular endothelium

scientific article published in April 2008

Influence of endothelin 1 receptor inhibition on functional, structural and molecular changes in the rat heart after irradiation

scientific article published on September 2008

Influence of mast cells on outcome after heterotopic cardiac transplantation in rats

scientific article published on 01 March 2007

Influence of mast cells on structural and functional manifestations of radiation-induced heart disease

scientific article published on 01 April 2005

Influence of sublethal total-body irradiation on immune cell populations in the intestinal mucosa

scientific article

Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice.

scientific article published on 4 March 2017

Inhibition of Protease-activated Receptor 1 Ameliorates Intestinal Radiation Mucositis in a Preclinical Rat Model ⬇️

scientific article published on May 12, 2012

Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation

scientific article

Interval estimators of relative potency in toxicology and radiation countermeasure studies: comparing methods and experimental designs

article

Involvement of heat shock factor 1 in statin-induced transcriptional upregulation of endothelial thrombomodulin

scientific article published on 03 July 2008

Lactate stimulates vasculogenic stem cells via the thioredoxin system and engages an autocrine activation loop involving hypoxia-inducible factor 1.

scientific article published on 18 August 2008

Laser Capture Microdissected Mucosa versus Whole Tissue Specimens for Assessment of Radiation-Induced Dynamic Molecular and Pathway Changes in the Small Intestine ⬇️

scientific article published on January 14, 2013

Liver metabolomics reveals increased oxidative stress and fibrogenic potential in gfrp transgenic mice in response to ionizing radiation

scientific article

Local administration of interleukin-11 ameliorates intestinal radiation injury in rats

Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction.

scientific article

Low Doses of Oxygen Ion Irradiation Cause Acute Damage to Hematopoietic Cells in Mice

scientific article

M1 and M2 macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo expansion

scientific article published on 01 April 2018

Metabolomic changes in gastrointestinal tissues after whole body radiation in a murine model

scientific article published on 13 February 2013

Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome

scientific article published on 21 January 2020

Mobilization of progenitor cells into peripheral blood by gamma-tocotrienol: a promising radiation countermeasure

scientific article published on 12 February 2013

Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003

scientific article published on 01 December 2004

Modulation of Radiation Response by the Tetrahydrobiopterin Pathway

scientific article

Modulation of the intestinal response to ionizing radiation by anticoagulant and non-anticoagulant heparins

scientific article published on 01 November 2005

Molecular dynamics guided design of tocoflexol: a new radioprotectant tocotrienol with enhanced bioavailability

scientific article

NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity

scientific article published on 14 January 2019

Normal tissue effects: reporting and analysis

scientific article

Novel strategies to ameliorate radiation injury: a possible role for tetrahydrobiopterin

scientific article published in November 2010

One-carbon metabolism and ionizing radiation: a multifaceted interaction.

scientific article published on May 2017

Oral PEG 15-20 protects the intestine against radiation: role of lipid rafts

scientific article

Oral interleukin 11 as a countermeasure to lethal total-body irradiation in a murine model

scientific article

Orazipone, a locally acting immunomodulator, ameliorates intestinal radiation injury: a preclinical study in a novel rat model

scientific article published on 01 October 2006

Palmitoylethanolamide regulates development of intestinal radiation injury in a mast cell-dependent manner

scientific article

Pentoxifylline Enhances the Radioprotective Properties of γ-Tocotrienol: Differential Effects on the Hematopoietic, Gastrointestinal and Vascular Systems ⬇️

scientific article published on December 28, 2010

Pharmacological induction of transforming growth factor-beta1 in rat models enhances radiation injury in the intestine and the heart

scientific article

Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity

scientific article

Preclinical Evaluation of SOM230 as a Radiation Mitigator in a Mouse Model: Postexposure Time Window and Mechanisms of Action ⬇️

scientific article published on April 29, 2011

Prevention and treatment of functional and structural radiation injury in the rat heart by pentoxifylline and alpha-tocopherol

scientific article published on 14 July 2008

Protective role of mast cells in homocysteine-induced cardiac remodeling

scientific article published on 9 December 2004

Proteomic Changes in Mouse Spleen after Radiation-Induced Injury and its Modulation by Gamma-Tocotrienol

scientific article published on 02 August 2018

Radiation damage to the gastrointestinal tract: mechanisms, diagnosis, and management

scientific article published on April 2007

Radiation enteropathy--pathogenesis, treatment and prevention

scientific article (publication date: August 2014)

Radiation induced bowel injury: a neglected problem

scientific article

Radiation injury and the protein C pathway

scientific article published on May 2004

Radiation lethality potentiation in total body irradiated mice by a commonly prescribed proton pump inhibitor, Pantoprazole sodium

scientific article published on July 2014

Radiation responses in skin and connective tissues: effect on wound healing and surgical outcome

scientific article published on December 2006

Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart

scientific article published on 2 March 2016

Recombinant Thrombomodulin (Solulin) Ameliorates Early Intestinal Radiation Toxicity in a Preclinical Rat Model

scientific article published on 26 July 2016

Reduction of Radiation-Induced Vascular Nitrosative Stress by the Vitamin E Analog γ-Tocotrienol: Evidence of a Role for Tetrahydrobiopterin ⬇️

scientific article published on October 13, 2010

Regulation of early and delayed radiation responses in rat small intestine by capsaicin-sensitive nerves

scientific article published on 01 April 2006

Segmental Differences in Radiation-Induced Alterations of Tight Junction-Related Proteins in Non-Human Primate Jejunum, Ileum and Colon

scientific article

Selective deficiency of HIF-1alpha in myeloid cells influences secondary intention wound healing in mouse skin

scientific article published in November 2009

Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology

scientific article published on 6 September 2017

Short-term inhibition of ADP-induced platelet aggregation by clopidogrel ameliorates radiation-induced toxicity in rat small intestine.

scientific article published in January 2002

Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy.

scientific article

Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein C-independent mechanism

scientific article

Skin graft take rates, granulation, and epithelialization: dependence on myeloid cell hypoxia-inducible factor 1alpha

scientific article published on July 2010

Space radiation and cardiovascular disease risk

scientific article

Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome

scientific article

Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation

scientific article published in September 2003

Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model

scientific article published on 8 March 2018

Targets of potential radioprotective drugs

scientific article published on 01 November 2010

The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage

scientific article published on 23 May 2016

The Vitamin E Analog Gamma-Tocotrienol (GT3) and Statins Synergistically Up-Regulate Endothelial Thrombomodulin (TM).

scientific article

The radiotherapeutic injury--a complex 'wound'.

scientific article

The somatostatin analog SOM230 (pasireotide) ameliorates injury of the intestinal mucosa and increases survival after total-body irradiation by inhibiting exocrine pancreatic secretion

scientific article published on June 2009

Therapeutic potential of natural plant products and their metabolites in preventing radiation enteropathy resulting from abdominal or pelvic irradiation

scientific article published on 08 January 2019

Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice

scientific article

Time- and radiation-dose dependent changes in the plasma proteome after total body irradiation of non-human primates: Implications for biomarker selection.

scientific article

Timing of the loss of Pten protein determines disease severity in a mouse model of myeloid malignancy.

scientific article published on 13 January 2016

Total Body Irradiation in the "Hematopoietic" Dose Range Induces Substantial Intestinal Injury in Non-Human Primates.

scientific article

Up-regulation and Activation of Proteinase-Activated Receptor 2 in Early and Delayed Radiation Injury in the Rat Intestine: Influence of Biological Activators of Proteinase-Activated Receptor 2

scientific article published on November 1, 2003

Utilization of Vitamin E Analogs to Protect Normal Tissues While Enhancing Antitumor Effects

scientific article published on 01 January 2019

Whole-body proton irradiation causes long-term damage to hematopoietic stem cells in mice

scientific article published on 30 January 2015

gamma-Tocotrienol ameliorates intestinal radiation injury and reduces vascular oxidative stress after total-body irradiation by an HMG-CoA reductase-dependent mechanism

scientific article published on May 2009

γ-Tocotrienol Protects against Mitochondrial Dysfunction and Renal Cell Death ⬇️

scientific article published on October 31, 2011

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