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List of works by Karen L Mossman

A Comparison of Whole Genome Sequencing of SARS-CoV-2 Using Amplicon-Based Sequencing, Random Hexamers, and Bait Capture

scientific article published on 15 August 2020

A Lymphotoxin/Type I IFN Axis Programs CD8+ T Cells To Infiltrate a Self-Tissue and Propagate Immunopathology

scientific article

A critical role for IL-15 in TLR-mediated innate antiviral immunity against genital HSV-2 infection.

scientific article published on 22 February 2011

AHR signaling is induced by infection with coronaviruses

scientific article published on 26 August 2021

Activation and inhibition of virus and interferon: the herpesvirus story

scientific article

Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis

scientific article published on 23 August 2018

Adaptive antiviral immunity is a determinant of the therapeutic success of oncolytic virotherapy

scientific article

An accessory to the 'Trinity': SR-As are essential pathogen sensors of extracellular dsRNA, mediating entry and leading to subsequent type I IFN responses

scientific article

Analysis of anti-interferon properties of the herpes simplex virus type I ICP0 protein

scientific article

Anti-NMDA receptor encephalitis. The disorder, the diagnosis and the immunobiology.

scientific article

Antigen presentation by exosomes released from peptide-pulsed dendritic cells is not suppressed by the presence of active CTL.

scientific article

Bat Influenza Viruses: Making a Double Agent of MHC Class II

scientific article published on 20 April 2020

Bats and Coronaviruses

scientific article published in 2019

Cell fusion-induced activation of interferon-stimulated genes is not required for restriction of a herpes simplex virus VP16/ICP0 mutant in heterokarya formed between permissive and restrictive cells.

scientific article

Cellular Protein WDR11 Interacts with Specific Herpes Simplex Virus Proteins at the trans-Golgi Network To Promote Virus Replication

scientific article published on 15 July 2015

Cellular localization of the herpes simplex virus ICP0 protein dictates its ability to block IRF3-mediated innate immune responses

scientific article

Characterization of the interferon regulatory factor 3-mediated antiviral response in a cell line deficient for IFN production

scientific article

Cigarette smoke attenuation of poly I:C-induced innate antiviral responses in human PBMC is mainly due to inhibition of IFN-beta production.

scientific article published on 18 October 2008

Cigarette smoke suppresses type I interferon-mediated antiviral immunity in lung fibroblast and epithelial cells.

scientific article

Class A Scavenger Receptor-Mediated Double-Stranded RNA Internalization Is Independent of Innate Antiviral Signaling and Does Not Require Phosphatidylinositol 3-Kinase Activity

scientific article published on 11 September 2015

Combining oncolytic HSV-1 with immunogenic cell death-inducing drug mitoxantrone breaks cancer immune tolerance and improves therapeutic efficacy

scientific article published on 19 August 2013

Commentary: Phyllostomid bat microbiome composition is associated to host phylogeny and feeding strategies

article

Comparative functional evaluation of immunocompetent mouse breast cancer models established from PyMT-tumors using small animal PET with [(18)F]FDG and [(18)F]FLT ⬇️

scientific article published on December 15, 2011

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

scientific article published on 01 March 2020

Consensus guidelines for the detection of immunogenic cell death

scientific article published on October 2014

Critical Interactions between Immunogenic Cancer Cell Death, Oncolytic Viruses, and the Immune System Define the Rational Design of Combination Immunotherapies

scientific article published in January 2018

Cutting edge: FimH adhesin of type 1 fimbriae is a novel TLR4 ligand.

scientific article

Danger, diversity and priming in innate antiviral immunity.

scientific article published on 11 July 2014

De novo necroptosis creates an inflammatory environment mediating tumor susceptibility to immune checkpoint inhibitors

scientific article published on 04 November 2020

Detecting single cell interferon-beta production using a fluorescent reporter telomerase-immortalized human fibroblast cell line

scientific article published on 10 April 2021

Differential modification of interferon regulatory factor 3 following virus particle entry

scientific article

Direct binding and internalization of diverse extracellular nucleic acid species through the collagenous domain of class A scavenger receptors.

scientific article

Discovery and Use of Long dsRNA Mediated RNA Interference to Stimulate Antiviral Protection in Interferon Competent Mammalian Cells

scientific article published on 06 May 2022

Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression

scientific article

Enhanced efficacy with azacytidine and oncolytic BHV-1 in a tolerized cotton rat model of breast adenocarcinoma

scientific article published on 25 March 2015

Erratum: USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.

scientific article published in November 2016

Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses

Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses

scientific article published on 26 April 2021

Exposure to cigarette smoke suppresses IL-15 generation and its regulatory NK cell functions in poly I:C-augmented human PBMCs.

scientific article

Extracellular dsRNA: its function and mechanism of cellular uptake

scientific article

FimH adhesin of type 1 fimbriae is a potent inducer of innate antimicrobial responses which requires TLR4 and type 1 interferon signalling

scientific article

Functional inaccessibility of quiescent herpes simplex virus genomes

scientific article

Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue

scientific article published on 10 April 2020

Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue

scientific article published on 16 July 2020

Genetic modification of oncolytic viruses to enhance antitumor immunity

scientific article published on 11 June 2019

HIV-1 gp120 induces TLR2- and TLR4-mediated innate immune activation in human female genital epithelium

scientific article published on 16 September 2013

HSV cheats the executioner

scientific article published on February 2015

Handling of the cotton rat in studies for the pre-clinical evaluation of oncolytic viruses

scientific article

Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5

scientific article

Herpes simplex virus ICP0 and ICP34.5 counteract distinct interferon-induced barriers to virus replication

scientific article published on February 2002

Herpesviruses and the innate immune response.

scientific article

Hypoxia-Driven Immune Escape in the Tumor Microenvironment

scientific article published on 16 April 2020

ICP0 prevents RNase L-independent rRNA cleavage in herpes simplex virus type 1-infected cells

scientific article

IL-15 and IFN-γ signal through the ERK pathway to inhibit HCV replication, independent of type I IFN signaling

scientific article published on 19 June 2018

IL-15 and type I interferon are required for activation of tumoricidal NK cells by virus-infected dendritic cells

scientific article published on 9 February 2011

Identification of a novel pathway essential for the immediate-early, interferon-independent antiviral response to enveloped virions

scientific article published on January 2006

Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells

scientific article published on 12 July 2021

Immunogenic HSV-mediated oncolysis shapes the antitumor immune response and contributes to therapeutic efficacy

scientific article

Impairment of human NK cell cytotoxic activity and cytokine release by cigarette smoke.

scientific article published on 30 November 2007

Induction of innate immunity against herpes simplex virus type 2 infection via local delivery of Toll-like receptor ligands correlates with beta interferon production.

scientific article

Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection

scientific article published on 6 March 2017

Innate and Adaptive Immune Responses to Herpes Simplex Virus ⬇️

scientific article published on November 18, 2009

Innate cellular response to virus particle entry requires IRF3 but not virus replication

scientific article

Interferon-Dependent Induction of Clr-b during Mouse Cytomegalovirus Infection Protects Bystander Cells from Natural Killer Cells via NKR-P1B-Mediated Inhibition.

scientific article published on 14 March 2017

Isolation, Sequence, Infectivity, and Replication Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2

scientific article published on 19 June 2020

Long double-stranded RNA induces an antiviral response independent of IFN regulatory factor 3, IFN-beta promoter stimulator 1, and IFN

scientific article

MARCO is required for TLR2- and Nod2-mediated responses to Streptococcus pneumoniae and clearance of pneumococcal colonization in the murine nasopharynx.

scientific article

Mechanisms employed by herpes simplex virus 1 to inhibit the interferon response

scientific article published on September 2009

Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CL substrate degradome

scientific article

Membrane Perturbation Elicits an IRF3-Dependent, Interferon-Independent Antiviral Response ⬇️

scientific article published on 03 August 2011

Membrane Perturbation-Associated Ca2+ Signaling and Incoming Genome Sensing Are Required for the Host Response to Low-Level Enveloped Virus Particle Entry

scientific article published on 30 December 2015

Methods related to molecular virology

scientific article published in November 2015

Methods related to molecular virology

scientific article published on 01 October 2011

Molecular Pathogenesis of Middle East Respiratory Syndrome (MERS) Coronavirus

scientific article published on 5 July 2019

Novel Insights Into Immune Systems of Bats

scientific article published on 24 January 2020

Novel paradigms of innate immune sensing of viral infections

scientific article published on 22 June 2013

Novel roles of cytoplasmic ICP0: proteasome-independent functions of the RING finger are required to block interferon-stimulated gene production but not to promote viral replication

scientific article

Oncolytic bovine herpesvirus type 1 as a broad spectrum cancer therapeutic.

scientific article published on 02 April 2015

Oncolytic virotherapy and immunogenic cancer cell death: sharpening the sword for improved cancer treatment strategies

scientific article

Oncolytic viruses: how "lytic" must they be for therapeutic efficacy?

scientific article published on 28 March 2019

Open drug discovery of anti-virals critical for Canada’s pandemic strategy

scientific article published on 17 December 2020

Permissiveness of human cancer cells to oncolytic bovine herpesvirus 1 is mediated in part by KRAS activity ⬇️

scientific article

Positive Selection of a Serine Residue in Bat IRF3 Confers Enhanced Antiviral Protection

scientific article published on 02 March 2020

Pre-surgical neoadjuvant oncolytic virotherapy confers protection against rechallenge in a murine model of breast cancer

scientific article published in Scientific Reports

Predicting the recombination potential of severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome coronavirus

scientific article published on 09 September 2020

Proinflammatory Cytokines and Chemokines - But not Interferon-β - Produced in Response to HSV-2 in Primary Human Genital Epithelial Cells are Associated with Viral Replication and the Presence of the Virion Host Shutoff Protein ⬇️

scientific article published on April 29, 2013

Recent advances in understanding viral evasion of type I interferon ⬇️

scientific article published on March 1, 2013

Recognition of virus infection and innate host responses to viral gene therapy vectors

scientific article

Replication of subgenomic hepatitis C virus replicons in mouse fibroblasts is facilitated by deletion of interferon regulatory factor 3 and expression of liver-specific microRNA 122

scientific article

Restoration of vitamin C synthesis in transgenic Gulo-/- mice by helper-dependent adenovirus-based expression of gulonolactone oxidase

scientific article

Retroviral expression of MIR2 decreases both surface MHC class I and the alloimmune CTL response ⬇️

scientific article published on January 10, 2011

Rewiring cancer cell death to enhance oncolytic viro-immunotherapy

scientific article published on 9 December 2013

S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.

scientific article

Sequence, infectivity and replication kinetics of SARS-CoV-2 isolated from COVID-19 patients in Canada

scientific article published on 13 April 2020

Seroprevalence in Bats and Detection of Borrelia burgdorferi in Bat Ectoparasites

scientific article published on 20 March 2020

Studies of immunosuppressive poxviruses.

The IFN-independent response to virus particle entry provides a first line of antiviral defense that is independent of TLRs and retinoic acid-inducible gene I.

scientific article published in December 2006

The Importance of Physiologically Relevant Cell Lines for Studying Virus-Host Interactions

scientific article

The herpes simplex virus 1-encoded envelope glycoprotein B activates NF-κB through the Toll-like receptor 2 and MyD88/TRAF6-dependent signaling pathway

scientific article

The herpes simplex virus ICP0 RING finger domain inhibits IRF3- and IRF7-mediated activation of interferon-stimulated genes

scientific article

The nitric oxide pathway provides innate antiviral protection in conjunction with the type I interferon pathway in fibroblasts

scientific article

The role of ICP0-Null HSV-1 and interferon signaling defects in the effective treatment of breast adenocarcinoma.

scientific article published on September 2005

The role of oncolytic virus immunotherapies to subvert cancer immune evasion

scientific article

The role of palmitoylation for protein recruitment to the inner membrane complex of the malaria parasite

scientific article (publication date: 16 January 2015)

Treating viral exacerbations of chronic obstructive pulmonary disease: insights from a mouse model of cigarette smoke and H1N1 influenza infection

scientific article (publication date: 12 October 2010)

Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors

scientific article published on 27 August 2018

Type I Interferon Induced by Streptococcus suis Serotype 2 is Strain-Dependent and May Be Beneficial for Host Survival

scientific article published on 28 August 2017

Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells

scientific article

Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages.

scientific article

USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation

scientific article published on 10 October 2016

Unraveling the Zoonotic Origin and Transmission of SARS-CoV-2

scientific article published on 13 December 2020

Varicella-zoster virus immediate-early protein ORF61 abrogates the IRF3-mediated innate immune response through degradation of activated IRF3

scientific article (publication date: November 2011)

Virus-Intrinsic Differences and Heterogeneous IRF3 Activation Influence IFN-Independent Antiviral Protection

scientific article published on 27 November 2020

Widely Used Herpes Simplex Virus 1 ICP0 Deletion Mutant Strain dl1403 and Its Derivative Viruses Do Not Express Glycoprotein C Due to a Secondary Mutation in the gC Gene

scientific article published on 17 July 2015

Zooanthroponotic potential of SARS-CoV-2 and implications of reintroduction into human populations

publication published on 13 January 2021

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