List of works - Maria G Belvisi

5-Hydroxytryptamine facilitates cholinergic bronchoconstriction in human and guinea pig airways ⬇️

scientific article published on July 1, 1995

8-Epi-PGF2 alpha, a novel noncyclooxygenase-derived prostaglandin, constricts airways in vitro

scientific article published on 01 February 1996

Airway sensory innervation as a target for novel therapies: an outdated concept?

scientific article

Anti-inflammatory effects of PGE2 in the lung: role of the EP4 receptor subtype

scientific article published on 4 May 2015

Barriers to new drug development in respiratory disease

scientific article published in May 2015

Beta(2)-agonists block tussive responses in guinea pigs via an atypical cAMP-dependent pathway

scientific article published on 13 August 2009

Bronchodilating effects of the novel potassium channel opener HOE 234 in human airways in vitro

scientific article

Cholinergic control of human airways in vitro following extrinsic denervation of the human respiratory tract by heart-lung transplantation

scientific article published on 01 November 1990

Chronic systemic administration of salmeterol to rats promotes pulmonary beta(2)-adrenoceptor desensitization and down-regulation of G(s alpha)

scientific article

Cigarette smoke induced airway inflammation is independent of NF-κB signalling

scientific article

Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium

scientific article

Constitutive expressions of type I NOS in human airway smooth muscle cells: evidence for an antiproliferative role

scientific article published on 01 October 1999

Contraction of human airway smooth muscle by endothelin-1 and IRL 1620: effect of bosentan

scientific article published on 01 April 1997

Correction: Co-ordinated Role of TLR3, RIG-I and MDA5 in the Innate Response to Rhinovirus in Bronchial Epithelium.

scientific article published on 3 April 2012

Cough and airway disease: The role of ion channels

scientific article published on 29 June 2017

Cough sensors. III. Opioid and cannabinoid receptors on vagal sensory nerves

scientific article published on January 2009

Critical role for T cells in Sephadex-induced airway inflammation: pharmacological and immunological characterization and molecular biomarker identification

scientific journal article

DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease.

scientific article

Defining critical roles for NF-κB p65 and type I interferon in innate immunity to rhinovirus.

scientific article

Dissociation by steroids of eosinophilic inflammation from airway hyperresponsiveness in murine airways

scientific article

Distribution of human i-NANC bronchodilator and nitric oxide-immunoreactive nerves

scientific article published in August 1995

Downregulation of MicroRNA-126 Augments DNA Damage Response in Cigarette Smokers and COPD Patients.

scientific article published on 28 July 2017

E-ring 8-isoprostanes inhibit ACh release from parasympathetic nerves innervating guinea-pig trachea through agonism of prostanoid receptors of the EP3-subtype

scientific article

EP4 receptor as a new target for bronchodilator therapy

scientific article published on 23 May 2011

Effect of Ba 679 BR, a novel long-acting anticholinergic agent, on cholinergic neurotransmission in guinea pig and human airways

scientific article published in December 1994

Effect of dopamine receptor agonists on sensory nerve activity: possible therapeutic targets for the treatment of asthma and COPD.

scientific article

Effect of endothelin antagonists, including the novel ET(A) receptor antagonist LBL 031, on endothelin-1 and lipopolysaccharide-induced microvascular leakage in rat airways

scientific article

Effects of prostaglandin E2 and cAMP elevating drugs on GM-CSF release by cultured human airway smooth muscle cells. Relevance to asthma therapy

scientific article

Evidence for prejunctional muscarinic autoreceptors in human and guinea pig trachea ⬇️

scientific article published on 01 September 1995

Evidence for the involvement of cGMP in neural bronchodilator responses in humal trachea ⬇️

scientific article published on March 1, 1995

Evidence that the anti-spasmogenic effect of the beta-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase

scientific article

Expression of cyclo-oxygenase-2 in human airway smooth muscle is associated with profound reductions in cell growth

scientific article

Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids

scientific article

Functional characterization and biomarker identification in the Brown Norway model of allergic airway inflammation

scientific article

G-protein coupled receptors regulating cough

scientific article

High levels of nitric oxide synthase activity are associated with nasal polyp tissue from aspirin-sensitive asthmatics

scientific article (publication date: April 2002)

Human tissue models for a human disease: what are the barriers?

scientific article published on 28 January 2015

Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema

scientific article published in June 2015

Identification in human airways smooth muscle cells of the prostanoid receptor and signalling pathway through which PGE2 inhibits the release of GM-CSF.

scientific article

Identification of a missense variant in SPDL1 associated with idiopathic pulmonary fibrosis

scientific article published on 23 March 2021

In vivo bioimaging with tissue-specific transcription factor activated luciferase reporters.

scientific article published on 3 July 2015

Induction of cyclo-oxygenase-2 by cytokines in human cultured airway smooth muscle cells: novel inflammatory role of this cell type

scientific article

Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone

scientific article

Inhibition of cholinergic neurotransmission in human airways by opioids ⬇️

scientific article published on March 1, 1992

Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation

scientific article

Inhibitory NANC nerves in human tracheal smooth muscle: a quest for the neurotransmitter

scientific article published in December 1992

Inhibitory activity of the novel CB2 receptor agonist, GW833972A, on guinea-pig and human sensory nerve function in the airways

scientific article published on 11 August 2008

Mediator involvement in antigen-induced bronchospasm and microvascular leakage in the airways of ovalbumin sensitized Brown Norway rats

scientific article

Modulation of cholinergic neural bronchoconstriction by endogenous nitric oxide and vasoactive intestinal peptide in human airways in vitro

scientific article

Neurophenotypes in Airway Diseases. Insights from Translational Cough Studies.

scientific article

New Glucocorticosteroids with an improved therapeutic ratio?

scientific article

New advances and potential therapies for the treatment of asthma

scientific article published in January 2004

New anti-inflammatory therapies and targets for asthma and chronic obstructive pulmonary disease

scientific article published in August 2004

Nitric oxide is the endogenous neurotransmitter of bronchodilator nerves in humans

scientific article published on January 14, 1992

Nitric oxide synthase activity is elevated in inflammatory lung disease in humans

scientific article published on 01 September 1995

Novel therapies for the treatment of inflammatory airway disease

scientific article

Overview of the innervation of the lung

scientific article

P2X7 receptor and caspase 1 activation are central to airway inflammation observed after exposure to tobacco smoke

scientific article (publication date: 2011)

PPAR-gamma agonists as therapy for diseases involving airway neutrophilia

scientific article

Peroxisome proliferator-activated receptor gamma agonists as therapy for chronic airway inflammation

scientific article

Peroxisome proliferator-activated receptors as novel targets in lung disease

scientific article published in July 2008

Pharmacological characterization of the muscarinic receptor antagonist, glycopyrrolate, in human and guinea-pig airways

scientific article

Protein Phosphatase 2A Reduces Cigarette Smoke-induced Cathepsin S and Loss of Lung Function

scientific article published on 01 July 2019

RANTES release by human airway smooth muscle: effects of prostaglandin E(2) and fenoterol

scientific article published in December 2001

Regulation of inflammatory cell function by corticosteroids

scientific article

Release of granulocyte-macrophage colony stimulating factor by human cultured airway smooth muscle cells: suppression by dexamethasone

scientific article

Respiratory infections cause the release of extracellular vesicles: implications in exacerbation of asthma/COPD

scientific article

Role of EP2 and EP4 receptors in airway microvascular leak induced by prostaglandin E2.

scientific article published on 7 December 2015

Role of K+ channels in the modulation of cholinergic neural responses in guinea-pig and human airways ⬇️

scientific article published on September 1, 1992

Role of p38 MAP kinase in LPS-induced airway inflammation in the rat

scientific article

Role of potassium channels in bronchodilator responses in human airways

scientific article published on 01 July 1992

Role of the inflammasome-caspase1/11-IL-1/18 axis in cigarette smoke driven airway inflammation: an insight into the pathogenesis of COPD

scientific article

Selectivity profiling of the novel EP2 receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP2 receptor.

scientific article published on January 2013

Sensory nerves and airway inflammation: role of A delta and C-fibres

scientific article

Soft steroids: a new approach to the treatment of inflammatory airways diseases ⬇️

scientific article published on January 1, 2003

Steroid-resistant inflammation in a rat model of chronic obstructive pulmonary disease is associated with a lack of nuclear factor-kappaB pathway activation

scientific article

Summary: animal models for cough

scientific article

TLR4 activation induces IL-1β release via an IPAF dependent but caspase 1/11/8 independent pathway in the lung

scientific article

TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein

scientific article

TRPA1 agonists evoke coughing in guinea pig and human volunteers

scientific article

Targeting the NF-kappaB pathway in asthma and chronic obstructive pulmonary disease.

scientific article published on 06 October 2008

The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy

scientific article published in February 2001

The heterotopic tracheal allograft as an animal model of obliterative bronchiolitis ⬇️

scientific article published on April 5, 2001

The role of adenylyl cyclase isoform 6 in β-adrenoceptor signalling in murine airways

scientific article

Theobromine inhibits sensory nerve activation and cough

scientific article

Theophylline inhibits the cough reflex through a novel mechanism of action.

scientific article

Therapeutic benefit of a dissociated glucocorticoid and the relevance of in vitro separation of transrepression from transactivation activity

scientific article

Tiotropium bromide (Ba 679 BR), a novel long-acting muscarinic antagonist for the treatment of obstructive airways disease

scientific article published in January 1995

Transient receptor potential (TRP) channels in the airway: role in airway disease

scientific article

Transient receptor potential A1 channels: insights into cough and airway inflammatory disease

scientific article

Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin

scientific article

XEN-D0501, a Novel TRPV1 Antagonist, Does Not Reduce Cough in Refractory Cough Patients.

scientific article published on 26 June 2017

List of works by Maria G Belvisi

5-Hydroxytryptamine facilitates cholinergic bronchoconstriction in human and guinea pig airways ⬇️

8-Epi-PGF2 alpha, a novel noncyclooxygenase-derived prostaglandin, constricts airways in vitro

Airway sensory innervation as a target for novel therapies: an outdated concept?

Anti-inflammatory effects of PGE2 in the lung: role of the EP4 receptor subtype

Barriers to new drug development in respiratory disease

Beta(2)-agonists block tussive responses in guinea pigs via an atypical cAMP-dependent pathway

Bronchodilating effects of the novel potassium channel opener HOE 234 in human airways in vitro

Cholinergic control of human airways in vitro following extrinsic denervation of the human respiratory tract by heart-lung transplantation

Chronic systemic administration of salmeterol to rats promotes pulmonary beta(2)-adrenoceptor desensitization and down-regulation of G(s alpha)

Cigarette smoke induced airway inflammation is independent of NF-κB signalling

Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium

Constitutive expressions of type I NOS in human airway smooth muscle cells: evidence for an antiproliferative role

Contraction of human airway smooth muscle by endothelin-1 and IRL 1620: effect of bosentan

Correction: Co-ordinated Role of TLR3, RIG-I and MDA5 in the Innate Response to Rhinovirus in Bronchial Epithelium.

Cough and airway disease: The role of ion channels

Cough sensors. III. Opioid and cannabinoid receptors on vagal sensory nerves

Critical role for T cells in Sephadex-induced airway inflammation: pharmacological and immunological characterization and molecular biomarker identification

DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease.

Defining critical roles for NF-κB p65 and type I interferon in innate immunity to rhinovirus.

Dissociation by steroids of eosinophilic inflammation from airway hyperresponsiveness in murine airways

Distribution of human i-NANC bronchodilator and nitric oxide-immunoreactive nerves

Downregulation of MicroRNA-126 Augments DNA Damage Response in Cigarette Smokers and COPD Patients.

E-ring 8-isoprostanes inhibit ACh release from parasympathetic nerves innervating guinea-pig trachea through agonism of prostanoid receptors of the EP3-subtype

EP4 receptor as a new target for bronchodilator therapy

Effect of Ba 679 BR, a novel long-acting anticholinergic agent, on cholinergic neurotransmission in guinea pig and human airways

Effect of dopamine receptor agonists on sensory nerve activity: possible therapeutic targets for the treatment of asthma and COPD.

Effect of endothelin antagonists, including the novel ET(A) receptor antagonist LBL 031, on endothelin-1 and lipopolysaccharide-induced microvascular leakage in rat airways

Effects of prostaglandin E2 and cAMP elevating drugs on GM-CSF release by cultured human airway smooth muscle cells. Relevance to asthma therapy

Evidence for prejunctional muscarinic autoreceptors in human and guinea pig trachea ⬇️

Evidence for the involvement of cGMP in neural bronchodilator responses in humal trachea ⬇️

Evidence that the anti-spasmogenic effect of the beta-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase

Expression of cyclo-oxygenase-2 in human airway smooth muscle is associated with profound reductions in cell growth

Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids

Functional characterization and biomarker identification in the Brown Norway model of allergic airway inflammation

G-protein coupled receptors regulating cough

High levels of nitric oxide synthase activity are associated with nasal polyp tissue from aspirin-sensitive asthmatics

Human tissue models for a human disease: what are the barriers?

Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema

Identification in human airways smooth muscle cells of the prostanoid receptor and signalling pathway through which PGE2 inhibits the release of GM-CSF.

Identification of a missense variant in SPDL1 associated with idiopathic pulmonary fibrosis

In vivo bioimaging with tissue-specific transcription factor activated luciferase reporters.

Induction of cyclo-oxygenase-2 by cytokines in human cultured airway smooth muscle cells: novel inflammatory role of this cell type

Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone

Inhibition of cholinergic neurotransmission in human airways by opioids ⬇️

Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation

Inhibitory NANC nerves in human tracheal smooth muscle: a quest for the neurotransmitter

Inhibitory activity of the novel CB2 receptor agonist, GW833972A, on guinea-pig and human sensory nerve function in the airways

Mediator involvement in antigen-induced bronchospasm and microvascular leakage in the airways of ovalbumin sensitized Brown Norway rats

Modulation of cholinergic neural bronchoconstriction by endogenous nitric oxide and vasoactive intestinal peptide in human airways in vitro

Neurophenotypes in Airway Diseases. Insights from Translational Cough Studies.

New Glucocorticosteroids with an improved therapeutic ratio?

New advances and potential therapies for the treatment of asthma

New anti-inflammatory therapies and targets for asthma and chronic obstructive pulmonary disease

Nitric oxide is the endogenous neurotransmitter of bronchodilator nerves in humans

Nitric oxide synthase activity is elevated in inflammatory lung disease in humans

Novel therapies for the treatment of inflammatory airway disease

Overview of the innervation of the lung

P2X7 receptor and caspase 1 activation are central to airway inflammation observed after exposure to tobacco smoke

PPAR-gamma agonists as therapy for diseases involving airway neutrophilia

Peroxisome proliferator-activated receptor gamma agonists as therapy for chronic airway inflammation

Peroxisome proliferator-activated receptors as novel targets in lung disease

Pharmacological characterization of the muscarinic receptor antagonist, glycopyrrolate, in human and guinea-pig airways

Protein Phosphatase 2A Reduces Cigarette Smoke-induced Cathepsin S and Loss of Lung Function

RANTES release by human airway smooth muscle: effects of prostaglandin E(2) and fenoterol

Regulation of inflammatory cell function by corticosteroids

Release of granulocyte-macrophage colony stimulating factor by human cultured airway smooth muscle cells: suppression by dexamethasone

Respiratory infections cause the release of extracellular vesicles: implications in exacerbation of asthma/COPD

Role of EP2 and EP4 receptors in airway microvascular leak induced by prostaglandin E2.

Role of K+ channels in the modulation of cholinergic neural responses in guinea-pig and human airways ⬇️

Role of p38 MAP kinase in LPS-induced airway inflammation in the rat

Role of potassium channels in bronchodilator responses in human airways

Role of the inflammasome-caspase1/11-IL-1/18 axis in cigarette smoke driven airway inflammation: an insight into the pathogenesis of COPD

Selectivity profiling of the novel EP2 receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP2 receptor.

Sensory nerves and airway inflammation: role of A delta and C-fibres

Soft steroids: a new approach to the treatment of inflammatory airways diseases ⬇️

Steroid-resistant inflammation in a rat model of chronic obstructive pulmonary disease is associated with a lack of nuclear factor-kappaB pathway activation

Summary: animal models for cough

TLR4 activation induces IL-1β release via an IPAF dependent but caspase 1/11/8 independent pathway in the lung

TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein