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List of works by Owen J T McCarty

A Temporal Examination of Platelet Counts as a Predictor of Prognosis in Lung, Prostate, and Colon Cancer Patients.

scientific article published on 26 April 2018

A major role for Scar/WAVE-1 downstream of GPVI in platelets

scientific article published in March 2007

A non-circulating pool of factor XI associated with glycosaminoglycans in mice

scientific article published on 17 June 2019

A physical sciences network characterization of circulating tumor cell aggregate transport

scientific article published on 18 March 2015

A physical sciences network characterization of non-tumorigenic and metastatic cells

scientific article published on January 2013

A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo

scientific article (publication date: 11 November 2010)

A theme series on physical biology in cancer in AJP-Cell

scientific article published on 25 September 2013

Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor

scientific article

Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes

scientific article

Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo

scientific article published on 13 April 2017

Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells

scientific article

Antibody inhibition of contact factor XII reduces platelet deposition in a model of extracorporeal membrane oxygenator perfusion in nonhuman primates

scientific article published on 11 February 2020

Aspirin therapy reduces the ability of platelets to promote colon and pancreatic cancer cell proliferation: Implications for the oncoprotein c-MYC.

scientific article published on 30 November 2016

Assessment of neonatal, cord, and adult platelet granule trafficking and secretion

scientific article published on 27 February 2019

Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor Ly-GDI in platelet function: a spatial systems approach

scientific article published in February 2017

Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis.

scientific article

Biorheology of platelet activation in the bloodstream distal to thrombus formation

scientific article published on 26 May 2016

Bleeding TAPs out

scientific article published on 13 December 2018

Breakup feared after filamin leaves GPIb ⬇️

scientific article published on 01 March 2011

CXCR7 expression disrupts endothelial cell homeostasis and causes ligand-dependent invasion.

scientific article

Capture of flowing endothelial cells using surface-immobilized anti-kinase insert domain receptor antibody

scientific article published in June 2008

Cardiac Myosin Promotes Thrombin Generation and Coagulation In Vitro and In Vivo

scientific article published on 27 February 2020

Carpe low-dose aspirin: the new anti-cancer face of an old anti-platelet drug

scientific article published on 21 December 2017

Cell-cell interactions in inflammation and cancer metastasis

scientific article

Characterization of human platelet binding of recombinant T cell receptor ligand.

scientific article

Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in platelets

scientific article

Chronic liver disease, thrombocytopenia and procedural bleeding risk; are novel thrombopoietin mimetics the solution?

scientific article published on 13 November 2018

Coagulation Factor XI Promotes Distal Platelet Activation and Single Platelet Consumption in the Bloodstream Under Shear Flow.

scientific article published on 14 January 2016

Coated platelets function in platelet-dependent fibrin formation via integrin αIIbβ3 and transglutaminase factor XIII.

scientific article published on 31 December 2015

Colocalization of neutrophils, extracellular DNA and coagulation factors during NETosis: Development and utility of an immunofluorescence-based microscopy platform

scientific article published on 7 June 2016

Comparative efficacy between the glycoprotein IIb/IIIa antagonists roxifiban and orbofiban in inhibiting platelet responses in flow models of thrombosis

scientific article published in April 2002

Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial

scientific article published on 01 April 2019

Contact system sends defensins to the rescue

scientific article published on 01 January 2019

Critical behavior of subcellular density organization during neutrophil activation and migration

scientific article

Cytoskeletal structure regulates endothelial cell immunogenicity independent of fluid shear stress.

scientific article

Data detailing the platelet acetyl-lysine proteome

scientific article

Design of a Microfluidic Bleeding Chip to Evaluate Antithrombotic Agents for Use in COVID-19 Patients

scientific article published on 06 August 2020

Development of a Label-free Imaging Technique for the Quantification of Thrombus Formation ⬇️

scientific article published on December 1, 2012

Development of a method to quantify platelet adhesion and aggregation under static conditions

scientific article

Development of coagulation factor probes for the identification of procoagulant circulating tumor cells

scientific article published on 6 September 2012

Differential Roles for the Coagulation Factors XI and XII in Regulating the Physical Biology of Fibrin.

scientific article published on 8 December 2016

Dimensional analysis and scaling relevant to flow models of thrombus formation: communication from the SSC of the ISTH.

scientific article published on 29 December 2015

Distinct but critical roles for integrin ?IIb?3in platelet lamellipodia formation on fibrinogen, collagen-related peptide and thrombin

scientific article published on 09 October 2006

Distinct extracellular matrix microenvironments of progenitor and carotid endothelial cells.

scientific article published in November 2009

Do circulating tumor cells play a role in coagulation and thrombosis? ⬇️

scientific article published on September 10, 2012

Dynamics of blood flow and thrombus formation in a multi-bypass microfluidic ladder network

scientific article published on 20 October 2016

Effect of Pneumatic Tubing System Transport on Platelet Apheresis Units

scientific article published on 21 May 2018

Effect of ionizing radiation on the physical biology of head and neck squamous cell carcinoma cells

scientific article

Effect of sex difference on platelet adhesion, spreading and aggregate formation under flow

scientific article published in November 2009

Endothelial PAI-1 (Plasminogen Activator Inhibitor-1) Blocks the Intrinsic Pathway of Coagulation, Inducing the Clearance and Degradation of FXIa (Activated Factor XI)

scientific article published on 23 May 2019

Evaluation of platelet antagonists in in vitro flow models of thrombosis.

scientific article published on January 2004

Evaluation of the Antihemostatic and Antithrombotic Effects of Lowering Coagulation Factor VII Levels in a Non-human Primate

scientific article published on 23 March 2020

Evaluation of the Effect of Crosslinking Method of Poly(Vinyl Alcohol) Hydrogels on Thrombogenicity

scientific article published on 30 June 2020

Evaluation of the role of platelet integrins in fibronectin-dependent spreading and adhesion

scientific article published in October 2004

Exogenous eosinophil activation converts PSGL-1-dependent binding to CD18-dependent stable adhesion to platelets in shear flow

scientific article published on 15 January 2003

Exogenous modification of platelet membranes with the omega-3 fatty acids EPA and DHA reduces platelet procoagulant activity and thrombus formation ⬇️

scientific article published on November 21, 2012

Factor XI Deficiency Alters the Cytokine Response and Activation of Contact Proteases during Polymicrobial Sepsis in Mice

scientific article (publication date: 2016)

Factor XI contributes to myocardial ischemia-reperfusion injury in mice

scientific article published on 01 January 2018

Factor XII Activation Promotes Platelet Consumption in the Presence of Bacterial-Type Long-Chain Polyphosphate In Vitro and In Vivo

scientific article published on 01 August 2018

Factor XII inhibition reduces thrombus formation in a primate thrombosis model

scientific article published on 09 January 2014

Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates.

scientific article published on July 2013

Flow-dependent thrombin and fibrin generation in vitro: opportunities for standardization: communication from SSC of the ISTH.

scientific article published in January 2014

Fluid shear regulates the kinetics and molecular mechanisms of activation-dependent platelet binding to colon carcinoma cells

scientific article published on August 2002

Fondaparinux pentasaccharide reduces sepsis coagulopathy and promotes survival in the baboon model of Escherichia coli sepsis

scientific article published on 16 October 2019

GPVI and integrin alphaIIb beta3 signaling in platelets

scientific article

GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.

scientific article

Gammaherpesvirus latency induces antibody-associated thrombocytopenia in mice

scientific article

Heat shock protein 70 regulates platelet integrin activation, granule secretion and aggregation

scientific article published on 13 January 2016

Heparin Resistance Is Common in Patients Undergoing Extracorporeal Membrane Oxygenation but Is Not Associated with Worse Clinical Outcomes

scientific article published on 01 August 2021

Hepatic thrombopoietin gene silencing reduces platelet count and breast cancer progression in transgenic MMTV-PyMT mice

scientific article published on 01 October 2019

Histone deacetylase 6-mediated deacetylation of α-tubulin coordinates cytoskeletal and signaling events during platelet activation

scientific article published on 11 September 2013

Hyaluronan anchored to activated CD44 on central nervous system vascular endothelial cells promotes lymphocyte extravasation in experimental autoimmune encephalomyelitis

scientific article

Hyaluronan oligosaccharides perturb lymphocyte slow rolling on brain vascular endothelial cells: implications for inflammatory demyelinating disease

scientific article published on 16 January 2013

Identification of a novel, actin-rich structure, the actin nodule, in the early stages of platelet spreading

scientific article published in November 2008

Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2).

scientific article published on 06 August 2009

Identification, Quantification, and System Analysis of Protein N-ε Lysine Methylation in Anucleate Blood Platelets

scientific article published on 09 May 2019

Immobilized platelets support human colon carcinoma cell tethering, rolling, and firm adhesion under dynamic flow conditions.

scientific article published on September 2000

Inhibition of Factor XII-Mediated Activation of Factor XI Provides Protection Against Experimental Acute Ischemic Stroke in Mice.

scientific article published on September 2012

Inhibition of contact-mediated activation of factor XI protects baboons against S aureus–induced organ damage and death

scientific article published on 01 February 2019

Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis

scientific article

Laminin promotes coagulation and thrombus formation in a factor XII-dependent manner

scientific article

Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI.

scientific article published on 11 October 2005

Lysine acetyltransfer supports platelet function.

scientific article

Management of Anticoagulation in Pregnant Women With Mechanical Heart Valves

scientific article published on 01 March 2020

Measurement science in the circulatory system.

scientific article published on March 2014

Minimal regulation of platelet activity by PECAM-1.

scientific article published on February 2007

Modeling and Simulation of Procoagulant Circulating Tumor Cells in Flow ⬇️

scientific article published on September 14, 2012

Modeling the effect of blood vessel bifurcation ratio on occlusive thrombus formation

scientific article published on 08 May 2019

Molecular Imaging of Activated von Willebrand Factor to Detect High-Risk Atherosclerotic Phenotype ⬇️

scientific article published on September 1, 2010

Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition.

scientific article published on 13 December 2012

MyosinIIa contractility is required for maintenance of platelet structure during spreading on collagen and contributes to thrombus stability

scientific article

Network signatures of nuclear and cytoplasmic density alterations in a model of pre and postmetastatic colorectal cancer

scientific article

Nucleic acids as cofactors for factor XI and prekallikrein activation: Different roles for high-molecular-weight kininogen

scientific article published on 26 January 2017

Optical quantification of cellular mass, volume, and density of circulating tumor cells identified in an ovarian cancer patient

scientific article

Oral administration of Bruton's tyrosine kinase inhibitors impairs GPVI-mediated platelet function.

scientific article published on 09 December 2015

Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization.

scientific article

Pharmacological targeting of coagulation factor XI mitigates the development of experimental atherosclerosis in low-density lipoprotein receptor-deficient mice

scientific article published on 10 February 2021

Phosphatidylserine index as a marker of the procoagulant phenotype of acute myelogenous leukemia cells

scientific article published on 08 October 2013

Phosphoproteomic quantitation and causal analysis reveal pathways in GPVI/ITAM-mediated platelet activation programs

scientific article published on 08 July 2020

Physical biology in cancer. 2. The physical biology of circulating tumor cells

scientific article published on 16 October 2013

Physiological levels of blood coagulation factors IX and X control coagulation kinetics in anin vitromodel of circulating tissue factor ⬇️

scientific article published on April 15, 2013

Pilot study of novel lab methodology and testing of platelet function in adolescent women with heavy menstrual bleeding

scientific article published on 22 November 2017

Pivotal role for the mTOR pathway in the formation of neutrophil extracellular traps via regulation of autophagy ⬇️

scientific article published on May 29, 2013

Plasma contact factors as therapeutic targets

scientific article published on 12 April 2018

Platelet count as a predictor of metastasis and venous thromboembolism in patients with cancer

scientific article published on 17 May 2017

Platelet integrin activation surfs the calcium waves

scientific article published on 22 May 2020

Platelet miR-223 Delivery Rescues Vascular Cells in Kawasaki Disease

scientific article published on 10 September 2020

Platelet procoagulant phenotype is modulated by a p38 - MK2 axis regulating RTN4/Nogo proximal to the endoplasmic reticulum: utility of pathway analysis

scientific article published on 7 February 2018

Platelet shape change and spreading

scientific article published in January 2012

Platelet-Derived Short-Chain Polyphosphates Enhance the Inactivation of Tissue Factor Pathway Inhibitor by Activated Coagulation Factor XI.

scientific article

Polyphosphate nanoparticles on the platelet surface trigger contact system activation

scientific article

Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y12 signaling with MRS2395.

scientific article published on 19 May 2017

Preferential binding of platelets to monocytes over neutrophils under flow

scientific article

Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI

scientific article published on 22 October 2008

Promotion of experimental thrombus formation by the procoagulant activity of breast cancer cells.

scientific article published on 7 February 2011

Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions

scientific article published on 18 December 2018

Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2.

scientific article published in June 2008

Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va.

scientific article published on 15 July 2016

Quantification of cellular volume and sub-cellular density fluctuations: comparison of normal peripheral blood cells and circulating tumor cells identified in a breast cancer patient.

scientific article

Quantification of volume, mass, and density of thrombus formation using brightfield and differential interference contrast microscopy ⬇️

scientific article published on January 1, 2013

Quantitative optical microscopy: measurement of cellular biophysical features with a standard optical microscope

scientific article

Rac and Cdc42 team up for platelets.

scientific article

Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow.

scientific article

Regulation of immune cell signaling by activated protein C.

scientific article published on 30 March 2018

Regulation of the mTOR-Rac1 axis in platelet function

scientific article

Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates.

scientific article published on 16 January 2007

Removal of the C-Terminal Domains of ADAMTS13 by Activated Coagulation Factor XI induces Platelet Adhesion on Endothelial Cells under Flow Conditions.

scientific article published on 20 December 2017

Role of coagulation in the recruitment of colon adenocarcinoma cells to thrombus under shear.

scientific article

S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation.

scientific article

Safety and antithrombotic efficacy of moderate platelet count reduction by thrombopoietin inhibition in primates

scientific article published on June 2010

Single molecule characterization of P-selectin/ligand binding

scientific article published on 08 January 2003

Single particle quantum dot imaging achieves ultrasensitive detection capabilities for Western immunoblot analysis

scientific article

Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism

scholarly article

Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear

scientific article

TRPing out Platelet Calcium: TRPM7 (Transient Receptor Potential Melastatin-Like 7) Modulates Calcium Mobilization and Platelet Function via Phospholipase C Interactions.

scientific article published in February 2018

The BCR-ABL inhibitor ponatinib inhibits platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling, platelet activation and aggregate formation under shear

scientific article

The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation

scientific article published on 19 June 2013

The Predictive Value of Inflammation-Related Peripheral Blood Measurements in Cancer Staging and Prognosis

scientific article published on 21 March 2018

The Safety and Efficacy of Novel Agents Targeting Factors XI and XII in Early Phase Human Trials

scientific article published on 19 June 2019

The basement membrane protein nidogen-1 supports platelet adhesion and activation

scientific article published on 01 April 2020

The contact activation system as a potential therapeutic target in patients with COVID‐19

scientific article published on 18 April 2020

The contact pathway and sepsis

scientific article published on 23 May 2019

The hemostatic role of factor XI.

scientific article published on May 2016

The leech product saratin is a potent inhibitor of platelet integrin alpha2beta1 and von Willebrand factor binding to collagen

scientific article published in March 2007

The protein C activator AB002 rapidly interrupts thrombus development in baboons

scientific article published on 01 February 2020

The prothrombotic activity of cancer cells in the circulation

scientific article published on 14 July 2015

The role of carrier number on the procoagulant activity of tissue factor in blood and plasma ⬇️

scientific article published on November 2, 2011

The role of coagulation and platelets in colon cancer-associated thrombosis

scientific article published on 21 November 2018

The thrombotic potential of circulating tumor microemboli: computational modeling of circulating tumor cell-induced coagulation

scientific article

Thrombin generation and activity in multiple sclerosis

scientific article published on 07 January 2021

Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist.

scientific article published on 25 October 2007

Thrombin mutant W215A/E217A treatment improves neurological outcome and attenuates central nervous system damage in experimental autoimmune encephalomyelitis.

scientific article

Thrombin mutant W215A/E217A treatment improves neurological outcome and reduces cerebral infarct size in a mouse model of ischemic stroke

scientific article

Thrombosis and Bleeding in Extracorporeal Membrane Oxygenation (ECMO) Without Anticoagulation: A Systematic Review

scientific article published on 23 July 2020

Thrombosis in Cancer: Research Priorities Identified by a National Cancer Institute/National Heart, Lung, and Blood Institute Strategic Working Group

scientific article published on 20 June 2016

Thrombotic microangiopathy as a cause of cardiovascular toxicity from the BCR-ABL1 tyrosine kinase inhibitor ponatinib

scientific article published on 28 January 2019

Ticagrelor breaks up the tumor-platelet party

scientific article published on September 2017

Utility and development of microfluidic platforms for platelet research

scientific article published in July 2017

Utility of microfluidic devices to study the platelet-endothelium interface

scientific article published on 30 March 2017

Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3.

scientific article published on February 2007

gammaA/gamma' fibrinogen inhibits thrombin-induced platelet aggregation

scientific article published on 01 November 2008

p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear

scientific article published on 02 May 2013

p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils

scientific article

von Willebrand factor mediates platelet spreading through glycoprotein Ib and alphaIIbbeta3 in the presence of botrocetin and ristocetin, respectively

scientific article published on 01 June 2006

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