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List of works by Owen J T McCarty

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GPVI and integrin alphaIIb beta3 signaling in platelets

scientific article
A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo

scientific article (publication date: 11 November 2010)
Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow.

scientific article
Immobilized platelets support human colon carcinoma cell tethering, rolling, and firm adhesion under dynamic flow conditions.

scientific article published on September 2000
Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI

scientific article published on 22 October 2008
Pivotal role for the mTOR pathway in the formation of neutrophil extracellular traps via regulation of autophagy

scientific article published on May 29, 2013
Factor XII inhibition reduces thrombus formation in a primate thrombosis model

scientific article published on 09 January 2014
Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI.

scientific article published on 11 October 2005
Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells

scientific article
Single molecule characterization of P-selectin/ligand binding

scientific article published on 08 January 2003
A physical sciences network characterization of non-tumorigenic and metastatic cells

scientific article published on January 2013
S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation.

scientific article
Optical quantification of cellular mass, volume, and density of circulating tumor cells identified in an ovarian cancer patient

scientific article
Evaluation of the role of platelet integrins in fibronectin-dependent spreading and adhesion

scientific article published in October 2004
Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear

scientific article
Laminin promotes coagulation and thrombus formation in a factor XII-dependent manner

scientific article
Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition.

scientific article published on 13 December 2012
Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2.

scientific article published in June 2008
Molecular Imaging of Activated von Willebrand Factor to Detect High-Risk Atherosclerotic Phenotype

scientific article published on September 1, 2010
Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism

scholarly article
Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates.

scientific article published on 16 January 2007
The prothrombotic activity of cancer cells in the circulation

scientific article published on July 14, 2015
Fluid shear regulates the kinetics and molecular mechanisms of activation-dependent platelet binding to colon carcinoma cells

scientific article published on August 2002
Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis

scientific article
Polyphosphate nanoparticles on the platelet surface trigger contact system activation

scientific article
Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist.

scientific article published on 25 October 2007
Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates.

scientific article published on July 2013
Aspirin therapy reduces the ability of platelets to promote colon and pancreatic cancer cell proliferation: Implications for the oncoprotein c-MYC.

scientific article published on 30 November 2016
Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor

scientific article
Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2).

scientific article published on 06 August 2009
Platelet shape change and spreading

scientific article published in January 2012
Hyaluronan anchored to activated CD44 on central nervous system vascular endothelial cells promotes lymphocyte extravasation in experimental autoimmune encephalomyelitis

scientific article
p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear

scientific article published on 02 May 2013
Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis.

scientific article
MyosinIIa contractility is required for maintenance of platelet structure during spreading on collagen and contributes to thrombus stability

scientific article published on 23 July 2007
von Willebrand factor mediates platelet spreading through glycoprotein Ib and alphaIIbbeta3 in the presence of botrocetin and ristocetin, respectively

scientific article published on 01 June 2006
The BCR-ABL inhibitor ponatinib inhibits platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling, platelet activation and aggregate formation under shear

scientific article
Histone deacetylase 6-mediated deacetylation of α-tubulin coordinates cytoskeletal and signaling events during platelet activation

scientific article published on 11 September 2013
Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3.

scientific article published on February 2007
Factor XI Deficiency Alters the Cytokine Response and Activation of Contact Proteases during Polymicrobial Sepsis in Mice

scientific article (publication date: 2016)
Coagulation Factor XI Promotes Distal Platelet Activation and Single Platelet Consumption in the Bloodstream Under Shear Flow.

scientific article published on 14 January 2016
Quantification of cellular volume and sub-cellular density fluctuations: comparison of normal peripheral blood cells and circulating tumor cells identified in a breast cancer patient.

scientific article
Do circulating tumor cells play a role in coagulation and thrombosis?

scientific article published on September 10, 2012
The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation

scientific article published on 19 June 2013
Exogenous modification of platelet membranes with the omega-3 fatty acids EPA and DHA reduces platelet procoagulant activity and thrombus formation

scientific article published on November 21, 2012
Capture of flowing endothelial cells using surface-immobilized anti-kinase insert domain receptor antibody

scientific article published in June 2008
Inhibition of Factor XII-Mediated Activation of Factor XI Provides Protection Against Experimental Acute Ischemic Stroke in Mice.

scientific article published on September 2012
Physical biology in cancer. 2. The physical biology of circulating tumor cells

scientific article published on 16 October 2013
Preferential binding of platelets to monocytes over neutrophils under flow

scientific article
A physical sciences network characterization of circulating tumor cell aggregate transport

scientific article published on 18 March 2015

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