List of works - Benedikt Wefers

Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS

scientific article published on 19 June 2020

Control of gene editing by manipulation of DNA repair mechanisms

scientific article published on 3 April 2017

Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos.

scientific article

Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides

scientific article published on 20 February 2013

Gene Editing in One-Cell Embryos by Zinc-Finger and TAL Nucleases.

scientific article published in December 2012

Gene editing in mouse zygotes using the CRISPR/Cas9 system

scientific article published on 2 March 2017

Generating conditional knockout mice

scientific article published on 01 January 2011

Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA.

scientific article published on 31 October 2013

Generation of targeted mouse mutants by embryo microinjection of TALENs

scientific article published on 11 January 2014

Genome Editing in Mice Using TALE Nucleases

scientific article published in January 2016

Highly efficient targeted mutagenesis in mice using TALENs

scientific article published on 26 August 2013

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.

scientific article

Local knockdown of ERK2 in the adult mouse brain via adeno-associated virus-mediated RNA interference.

scientific article published on 04 December 2008

MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adults

scientific article

Rational correction of pathogenic conformational defects in HTRA1

scientific article published in 2024

The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.

scientific article published on 30 May 2017

The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

scholarly article by Xianyuan Xiang published in September 2018

List of works by Benedikt Wefers

Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS

Control of gene editing by manipulation of DNA repair mechanisms

Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos.

Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides

Gene Editing in One-Cell Embryos by Zinc-Finger and TAL Nucleases.

Gene editing in mouse zygotes using the CRISPR/Cas9 system

Generating conditional knockout mice

Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA.

Generation of targeted mouse mutants by embryo microinjection of TALENs

Genome Editing in Mice Using TALE Nucleases

Highly efficient targeted mutagenesis in mice using TALENs

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.

Local knockdown of ERK2 in the adult mouse brain via adeno-associated virus-mediated RNA interference.

MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adults

Rational correction of pathogenic conformational defects in HTRA1

The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.

The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans