List of works - Takashi Yokoyama

A novel anti-prion protein monoclonal antibody and its single-chain fragment variable derivative with ability to inhibit abnormal prion protein accumulation in cultured cells

scientific article published on February 2010

A solid-phase immunoassay of protease-resistant prion protein with filtration blotting involving sodium dodecyl sulfate

scientific article

Accumulation of L-type bovine prions in peripheral nerve tissues

scientific article published in July 2010

Acquired transmissibility of sheep-passaged L-type bovine spongiform encephalopathy prion to wild-type mice

scientific article published on 13 July 2015

All major prion types recognised by a multiplex immunofluorometric assay for disease screening and confirmation in sheep.

scientific article published on 29 March 2012

Alteration of the biological and biochemical characteristics of bovine spongiform encephalopathy prions during interspecies transmission in transgenic mice models

scientific article

An advantageous method utilizing new homogenizing device BioMasher and a sensitive ELISA to detect bovine spongiform encephalopathy accurately in brain tissue

scientific article

Anti-Prion Activity of Brilliant Blue G ⬇️

scientific article published on May 31, 2012

Anti-bovine prion protein RNA aptamer containing tandem GGA repeat interacts both with recombinant bovine prion protein and its beta isoform with high affinity

scientific article published on 17 April 2008

Applicability of current bovine spongiform encephalopathy (BSE) diagnostic procedures for chronic wasting disease (CWD).

scientific article published in January 2007

Assessment of prion inactivation by combined use of Bacillus-derived protease and SDS.

scientific article

Assessment of prion inactivation by fenton reaction using protein misfolding cyclic amplification and bioassay

scientific article published on 7 August 2007

Biological and biochemical characterization of L-type-like bovine spongiform encephalopathy (BSE) detected in Japanese black beef cattle.

scientific article published on 14 July 2008

Characterization and application of a novel RNA aptamer against the mouse prion protein

scientific article published on March 2006

Characterization of Syrian hamster adapted prions derived from L-type and C-type bovine spongiform encephalopathies

scientific article

Chicken antibody against a restrictive epitope of prion protein distinguishes normal and abnormal prion proteins

scientific article published on 23 March 2007

Coexistence of two forms of disease-associated prion protein in extracerebral tissues of cattle infected with H-type bovine spongiform encephalopathy

scientific article published on 24 March 2016

Comparative analysis of Japanese and foreign L-type BSE prions ⬇️

scientific article published on January 1, 2012

Comparison of the local structural stabilities of mammalian prion protein (PrP) by fragment molecular orbital calculations

scientific article published on 11 December 2012

Conformational change in hamster scrapie prion protein (PrP27-30) associated with proteinase K resistance and prion infectivity

scientific article published in February 2008

Cytochalasin D enhances the accumulation of a protease-resistant form of prion protein in ScN2a cells: involvement of PI3 kinase/Akt signalling pathway

scientific article

Detection of Disease-associated Prion Protein in the Optic Nerve and the Adrenal Gland of Cattle with Bovine Spongiform Encephalopathy by Using Highly Sensitive Immunolabeling Procedures ⬇️

scientific article published on January 19, 2012

Detection of structural changes of RNA aptamer containing GGA repeats under the ionic condition using the microchip electrophoresis

scientific article published on 01 January 2007

Development of recombinant chicken IgY from single chain fragment of variable region for diagnosis of BSE

scientific article published on 31 March 2006

Different antigenicities of the N-terminal region of cellular and scrapie prion proteins.

scientific article published in November 2013

Effect of tissue deterioration on postmortem BSE diagnosis by immunobiochemical detection of an abnormal isoform of prion protein

scientific article

Effective antigen-retrieval method for immunohistochemical detection of abnormal isoform of prion proteins in animals

scientific article published on 22 December 2004

Efficient in vitro amplification of a mouse-adapted scrapie prion protein

scientific article published on 14 December 2006

Efficient propagation of variant Creutzfeldt-Jakob disease prion protein using the cell-protein misfolding cyclic amplification technique with samples containing plasma and heparin

scientific article published on 8 September 2015

Emergence of a novel bovine spongiform encephalopathy (BSE) prion from an atypical H-type BSE.

scientific article

Enhanced enteric invasion of scrapie agents into the villous columnar epithelium via maternal immunoglobulin

scientific article published on 01 December 2010

Establishment and characterization of SV40 large T antigen-immortalized cell lines derived from fetal bovine brain tissues after prolonged cryopreservation

scientific article published on 10 September 2006

Establishment of a Cell Line Persistently Infected with Chronic Wasting Disease Prions ⬇️

scientific article published on June 5, 2012

Establishment of an SV40 large T antigen-immortalized bovine brain cell line and its neuronal differentiation by dibutyryl-cyclic AMP.

scientific article

Evaluation of rapid post-mortem test kits for bovine spongiform encephalopathy (BSE) screening in Japan: Their analytical sensitivity to atypical BSE prions

scientific article published on 30 March 2017

Examination of the offspring of a Japanese cow affected with L-type bovine spongiform encephalopathy

scientific article published on 25 August 2010

Experimental H-type bovine spongiform encephalopathy characterized by plaques and glial- and stellate-type prion protein deposits.

scientific article

Experimental Infection of Cattle With a Novel Prion Derived From Atypical H-Type Bovine Spongiform Encephalopathy

scientific article published on January 2017

Experimental transmission of two young and one suspended bovine spongiform encephalopathy (BSE) cases to bovinized transgenic mice

scientific article published on 01 September 2007

Expression of cellular prion-related protein by murine Langerhans cells and keratinocytes.

scientific article

Fragment molecular orbital calculations reveal that the E200K mutation markedly alters local structural stability in the human prion protein

scientific article

Fusion of Doppel to octapeptide repeat and N-terminal half of hydrophobic region of prion protein confers resistance to serum deprivation

scientific article published on January 2006

Glycosylphosphatidylinositol anchor-dependent stimulation pathway required for generation of baculovirus-derived recombinant scrapie prion protein

scientific article

Heparan Sulfate and Heparin Promote Faithful Prion Replication in Vitro by Binding to Normal and Abnormal Prion Proteins in Protein Misfolding Cyclic Amplification

scientific article published on 7 November 2016

Heparin enhances the cell-protein misfolding cyclic amplification efficiency of variant Creutzfeldt-Jakob disease

scientific article published on 5 May 2011

Heterogeneity of abnormal prion protein (PrP(Sc)) in murine scrapie prions determined by PrP(Sc)-specific monoclonal antibodies

scientific article published on 16 October 2013

Heterogeneity of the Abnormal Prion Protein (PrPSc) of the Chandler Scrapie Strain

scientific article

Identification of the first case of atypical scrapie in Japan

scientific article published on 11 September 2016

Immunohistochemical detection of disease-associated prion protein in the intestine of cattle naturally affected with bovine spongiform encephalopathy by using an alkaline-based chemical antigen retrieval method

scientific article

In situ detection of cellular and abnormal isoforms of prion protein in brains of cattle with bovine spongiform encephalopathy and sheep with scrapie by use of a histoblot technique

scientific article published in May 2002

In vitro selection of RNA aptamers against cellular and abnormal isoform of mouse prion protein

scientific article published on January 2005

Infectivity-associated PrP(Sc) and disease duration-associated PrP(Sc) of mouse BSE prions

scientific article

Inhibition of prion propagation in scrapie-infected mouse neuroblastoma cell lines using mouse monoclonal antibodies against prion protein

scientific article

Insect cell-derived cofactors become fully functional after proteinase K and heat treatment for high-fidelity amplification of glycosylphosphatidylinositol-anchored recombinant scrapie and BSE prion proteins

scientific article

Interspecies transmission to bovinized transgenic mice uncovers new features of a CH1641-like scrapie isolate

article

Intraspecies prion transmission results in selection of sheep scrapie strains

scientific article

Intraspecies transmission of L-type-like Bovine Spongiform Encephalopathy detected in Japan.

scientific article published in December 2009

Isolation of two distinct prion strains from a scrapie-affected sheep

scientific article published on 30 October 2009

Lactoferrin induces cell surface retention of prion protein and inhibits prion accumulation

scientific article published on 20 September 2008

Magnetic microparticle-based multimer detection system for the detection of prion oligomers in sheep

scientific article

Microglial cell line established from prion protein-overexpressing mice is susceptible to various murine prion strains

scientific article published on 22 November 2006

Multiple affinity purification of a baculovirus-derived recombinant prion protein with in vitro ability to convert to its pathogenic form.

scientific article

Neuroanatomical distribution of disease-associated prion protein in cases of bovine spongiform encephalopathy detected by fallen stock surveillance in Japan

scientific article published on 15 July 2011

Neuroanatomical distribution of disease-associated prion protein in experimental bovine spongiform encephalopathy in cattle after intracerebral inoculation

scientific article published on January 1, 2012

Novel assay with fluorescence‐labelled PrP peptides for differentiating L‐type atypical and classical BSEs, and scrapie ⬇️

scientific article published on January 25, 2012

Oral Transmission of L-Type Bovine Spongiform Encephalopathy Agent among Cattle

scientific article published on February 2017

Prion Protein Devoid of the Octapeptide Repeat Region Delays Bovine Spongiform Encephalopathy Pathogenesis in Mice

scientific article

Prion diseases and emerging prion diseases

scientific article published on January 2008

Prion in saliva of bovine spongiform encephalopathy-infected cattle

scientific article published in December 2012

Prion inactivation by the Maillard reaction

scientific article published in March 2007

Prion infection correlates with hypersensitivity of P2X7 nucleotide receptor in a mouse microglial cell line

scientific article published on 29 May 2007

Prion replication elicits cytopathic changes in differentiated neurosphere cultures

scientific article published on 05 June 2013

Prions in the peripheral nerves of bovine spongiform encephalopathy-affected cattle

scientific article

Protein misfolding cyclic amplification as a rapid test for assessment of prion inactivation

scientific article published on 31 July 2006

Proximity of SCG10 and prion protein in membrane rafts

scientific article

Quantitative analysis of wet-heat inactivation in bovine spongiform encephalopathy

scientific article published on 30 January 2013

Rapid PrP(Sc) detection in lymphoid tissue and application to scrapie surveillance of fallen stock in Japan: variable PrP(Sc) accumulation in palatal tonsil in natural scrapie

scientific article

Rapid assessment of bovine spongiform encephalopathy prion inactivation by heat treatment in yellow grease produced in the industrial manufacturing process of meat and bone meals

scientific article

Retrospective Analysis of Sheep Scrapie by Western Blotting with Formalin-Fixed Paraffin-Embedded (FFPE) Tissues ⬇️

scientific article published on May 15, 2012

Sc237 hamster PrPSc and Sc237-derived mouse PrPSc generated by interspecies in vitro amplification exhibit distinct pathological and biochemical properties in tga20 transgenic mice ⬇️

scientific article published on May 1, 2011

Selective propagation of mouse-passaged scrapie prions with long incubation period from a mixed prion population using GT1-7 cells

scientific article

Sensitive detection of scrapie prion protein in soil

scientific article published on 4 June 2010

Sensitivity and specificity of a commercial BSE kit for the detection of ovine scrapie

scientific article published on 27 January 2013

Strain-specific effects of reducing agents on the cell-free conversion of recombinant prion protein into a protease-resistant form ⬇️

scientific article published on September 1, 2011

Structural analysis of r(GGA)4 found in RNA aptamer for bovine prion protein

scientific article published on 01 January 2008

Subcritical Water Hydrolysis Effectively Reduces the In Vitro Seeding Activity of PrPSc but Fails to Inactivate the Infectivity of Bovine Spongiform Encephalopathy Prions

scientific article published on 16 December 2015

Sulfated dextrans enhance in vitro amplification of bovine spongiform encephalopathy PrP(Sc) and enable ultrasensitive detection of bovine PrP(Sc).

scientific article

Susceptibility of GT1-7 cells to mouse-passaged field scrapie isolates with a long incubation

scientific article

The N-terminal cleavage site of PrPSc from BSE differs from that of PrPSc from scrapie

scientific article published in March 2005

The N-terminal sequence of prion protein consists an epitope specific to the abnormal isoform of prion protein (PrP(Sc))

scientific article

The presence of disease-associated prion protein in skeletal muscle of cattle infected with classical bovine spongiform encephalopathy

scientific article published on 27 August 2013

Tracing conformational transition of abnormal prion proteins during interspecies transmission by using novel antibodies

scientific article

Transmissibility of H-Type Bovine Spongiform Encephalopathy to Hamster PrP Transgenic Mice

scientific article

Transmission of atypical scrapie to homozygous ARQ sheep

scientific article published on 20 June 2016

Two different scrapie prions isolated in Japanese sheep flocks

scientific article published in January 2003

Ultrasensitive detection of scrapie prion protein derived from ARQ and AHQ homozygote sheep by interspecies in vitro amplification ⬇️

scientific article published on August 1, 2012

Uptake dynamics of scrapie agent in the intestinal villous epithelium of suckling and weanling Syrian hamsters ⬇️

scientific article published on September 1, 2011

Urinary excretion and blood level of prions in scrapie-infected hamsters

scientific article published in October 2007

[Establishment and characterization of prion-infected microglial cells]

scientific article published on 01 July 2008

List of works by Takashi Yokoyama

A novel anti-prion protein monoclonal antibody and its single-chain fragment variable derivative with ability to inhibit abnormal prion protein accumulation in cultured cells

A solid-phase immunoassay of protease-resistant prion protein with filtration blotting involving sodium dodecyl sulfate

Accumulation of L-type bovine prions in peripheral nerve tissues

Acquired transmissibility of sheep-passaged L-type bovine spongiform encephalopathy prion to wild-type mice

All major prion types recognised by a multiplex immunofluorometric assay for disease screening and confirmation in sheep.

Alteration of the biological and biochemical characteristics of bovine spongiform encephalopathy prions during interspecies transmission in transgenic mice models

An advantageous method utilizing new homogenizing device BioMasher and a sensitive ELISA to detect bovine spongiform encephalopathy accurately in brain tissue

Anti-Prion Activity of Brilliant Blue G ⬇️

Anti-bovine prion protein RNA aptamer containing tandem GGA repeat interacts both with recombinant bovine prion protein and its beta isoform with high affinity

Applicability of current bovine spongiform encephalopathy (BSE) diagnostic procedures for chronic wasting disease (CWD).

Assessment of prion inactivation by combined use of Bacillus-derived protease and SDS.

Assessment of prion inactivation by fenton reaction using protein misfolding cyclic amplification and bioassay

Biological and biochemical characterization of L-type-like bovine spongiform encephalopathy (BSE) detected in Japanese black beef cattle.

Characterization and application of a novel RNA aptamer against the mouse prion protein

Characterization of Syrian hamster adapted prions derived from L-type and C-type bovine spongiform encephalopathies

Chicken antibody against a restrictive epitope of prion protein distinguishes normal and abnormal prion proteins

Coexistence of two forms of disease-associated prion protein in extracerebral tissues of cattle infected with H-type bovine spongiform encephalopathy

Comparative analysis of Japanese and foreign L-type BSE prions ⬇️

Comparison of the local structural stabilities of mammalian prion protein (PrP) by fragment molecular orbital calculations

Conformational change in hamster scrapie prion protein (PrP27-30) associated with proteinase K resistance and prion infectivity

Cytochalasin D enhances the accumulation of a protease-resistant form of prion protein in ScN2a cells: involvement of PI3 kinase/Akt signalling pathway

Detection of Disease-associated Prion Protein in the Optic Nerve and the Adrenal Gland of Cattle with Bovine Spongiform Encephalopathy by Using Highly Sensitive Immunolabeling Procedures ⬇️

Detection of structural changes of RNA aptamer containing GGA repeats under the ionic condition using the microchip electrophoresis

Development of recombinant chicken IgY from single chain fragment of variable region for diagnosis of BSE

Different antigenicities of the N-terminal region of cellular and scrapie prion proteins.

Effect of tissue deterioration on postmortem BSE diagnosis by immunobiochemical detection of an abnormal isoform of prion protein

Effective antigen-retrieval method for immunohistochemical detection of abnormal isoform of prion proteins in animals

Efficient in vitro amplification of a mouse-adapted scrapie prion protein

Efficient propagation of variant Creutzfeldt-Jakob disease prion protein using the cell-protein misfolding cyclic amplification technique with samples containing plasma and heparin

Emergence of a novel bovine spongiform encephalopathy (BSE) prion from an atypical H-type BSE.

Enhanced enteric invasion of scrapie agents into the villous columnar epithelium via maternal immunoglobulin

Establishment and characterization of SV40 large T antigen-immortalized cell lines derived from fetal bovine brain tissues after prolonged cryopreservation

Establishment of a Cell Line Persistently Infected with Chronic Wasting Disease Prions ⬇️

Establishment of an SV40 large T antigen-immortalized bovine brain cell line and its neuronal differentiation by dibutyryl-cyclic AMP.

Evaluation of rapid post-mortem test kits for bovine spongiform encephalopathy (BSE) screening in Japan: Their analytical sensitivity to atypical BSE prions

Examination of the offspring of a Japanese cow affected with L-type bovine spongiform encephalopathy

Experimental H-type bovine spongiform encephalopathy characterized by plaques and glial- and stellate-type prion protein deposits.

Experimental Infection of Cattle With a Novel Prion Derived From Atypical H-Type Bovine Spongiform Encephalopathy

Experimental transmission of two young and one suspended bovine spongiform encephalopathy (BSE) cases to bovinized transgenic mice

Expression of cellular prion-related protein by murine Langerhans cells and keratinocytes.

Fragment molecular orbital calculations reveal that the E200K mutation markedly alters local structural stability in the human prion protein

Fusion of Doppel to octapeptide repeat and N-terminal half of hydrophobic region of prion protein confers resistance to serum deprivation

Glycosylphosphatidylinositol anchor-dependent stimulation pathway required for generation of baculovirus-derived recombinant scrapie prion protein

Heparan Sulfate and Heparin Promote Faithful Prion Replication in Vitro by Binding to Normal and Abnormal Prion Proteins in Protein Misfolding Cyclic Amplification

Heparin enhances the cell-protein misfolding cyclic amplification efficiency of variant Creutzfeldt-Jakob disease

Heterogeneity of abnormal prion protein (PrP(Sc)) in murine scrapie prions determined by PrP(Sc)-specific monoclonal antibodies

Heterogeneity of the Abnormal Prion Protein (PrPSc) of the Chandler Scrapie Strain

Identification of the first case of atypical scrapie in Japan

Immunohistochemical detection of disease-associated prion protein in the intestine of cattle naturally affected with bovine spongiform encephalopathy by using an alkaline-based chemical antigen retrieval method

In situ detection of cellular and abnormal isoforms of prion protein in brains of cattle with bovine spongiform encephalopathy and sheep with scrapie by use of a histoblot technique

In vitro selection of RNA aptamers against cellular and abnormal isoform of mouse prion protein

Infectivity-associated PrP(Sc) and disease duration-associated PrP(Sc) of mouse BSE prions

Inhibition of prion propagation in scrapie-infected mouse neuroblastoma cell lines using mouse monoclonal antibodies against prion protein

Insect cell-derived cofactors become fully functional after proteinase K and heat treatment for high-fidelity amplification of glycosylphosphatidylinositol-anchored recombinant scrapie and BSE prion proteins

Interspecies transmission to bovinized transgenic mice uncovers new features of a CH1641-like scrapie isolate

Intraspecies prion transmission results in selection of sheep scrapie strains

Intraspecies transmission of L-type-like Bovine Spongiform Encephalopathy detected in Japan.

Isolation of two distinct prion strains from a scrapie-affected sheep

Lactoferrin induces cell surface retention of prion protein and inhibits prion accumulation

Magnetic microparticle-based multimer detection system for the detection of prion oligomers in sheep

Microglial cell line established from prion protein-overexpressing mice is susceptible to various murine prion strains

Multiple affinity purification of a baculovirus-derived recombinant prion protein with in vitro ability to convert to its pathogenic form.

Neuroanatomical distribution of disease-associated prion protein in cases of bovine spongiform encephalopathy detected by fallen stock surveillance in Japan

Neuroanatomical distribution of disease-associated prion protein in experimental bovine spongiform encephalopathy in cattle after intracerebral inoculation

Novel assay with fluorescence‐labelled PrP peptides for differentiating L‐type atypical and classical BSEs, and scrapie ⬇️

Oral Transmission of L-Type Bovine Spongiform Encephalopathy Agent among Cattle

Prion Protein Devoid of the Octapeptide Repeat Region Delays Bovine Spongiform Encephalopathy Pathogenesis in Mice

Prion diseases and emerging prion diseases

Prion in saliva of bovine spongiform encephalopathy-infected cattle

Prion inactivation by the Maillard reaction

Prion infection correlates with hypersensitivity of P2X7 nucleotide receptor in a mouse microglial cell line

Prion replication elicits cytopathic changes in differentiated neurosphere cultures

Prions in the peripheral nerves of bovine spongiform encephalopathy-affected cattle

Protein misfolding cyclic amplification as a rapid test for assessment of prion inactivation

Proximity of SCG10 and prion protein in membrane rafts

Quantitative analysis of wet-heat inactivation in bovine spongiform encephalopathy

Rapid PrP(Sc) detection in lymphoid tissue and application to scrapie surveillance of fallen stock in Japan: variable PrP(Sc) accumulation in palatal tonsil in natural scrapie

Rapid assessment of bovine spongiform encephalopathy prion inactivation by heat treatment in yellow grease produced in the industrial manufacturing process of meat and bone meals

Retrospective Analysis of Sheep Scrapie by Western Blotting with Formalin-Fixed Paraffin-Embedded (FFPE) Tissues ⬇️