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List of works by Carlo Toniatti

A functionally orthogonal estrogen receptor-based transcription switch specifically induced by a nonsteroid synthetic ligand

scientific article published in August 2005

A multiplexed siRNA screening strategy to identify genes in the PARP pathway.

scientific article published on 10 July 2012

A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies

scientific article

A zinc finger nuclease assay to rapidly quantitate homologous recombination proficiency in human cell lines.

scientific article

Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities

scientific article

Construction of an rtTA2(s)-m2/tts(kid)-based transcription regulatory switch that displays no basal activity, good inducibility, and high responsiveness to doxycycline in mice and non-human primates

scientific article published on February 2003

Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery

scientific article

Development of substituted 6-[4-fluoro-3-(piperazin-1-ylcarbonyl)benzyl]-4,5-dimethylpyridazin-3(2H)-ones as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors active in BRCA deficient cells

scientific article published on 22 November 2009

Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).

scientific article published on 4 December 2009

Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors

scientific article published on November 2009

Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models

scientific article published on 04 May 2016

Electro-gene-transfer: a new approach for muscle gene delivery

scientific article

Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1.

scientific article published on 23 April 2012

Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer

scientific article published on 3 March 2015

Helper-dependent adenovirus for the gene therapy of proliferative retinopathies: stable gene transfer, regulated gene expression and therapeutic efficacy

scientific article published in October 2007

IT-15DELTA-24-RGDOX: TARGETING CO-STIMULATORY IMMUNE CHECKPOINT PROTEINS WITH ONCOLYTIC ADENOVIRUSES.

scientific article published in November 2014

Identification and SAR of novel pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).

scientific article

Identification of aminoethyl pyrrolo dihydroisoquinolinones as novel poly(ADP-ribose) polymerase-1 inhibitors

scientific article published on 13 June 2009

Identification of potent and selective MTH1 inhibitors

scientific article

Identification of substituted pyrazolo[1,5-a]quinazolin-5(4H)-one as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors.

scientific article published on 2 June 2009

Inhibition of retinal and choroidal neovascularization by a novel KDR kinase inhibitor

scientific journal article

Long-term and tight control of gene expression in mouse skeletal muscle by a new hybrid human transcription factor

scientific article

MK-4827, a PARP-1/-2 inhibitor, strongly enhances response of human lung and breast cancer xenografts to radiation

scientific article published on 30 November 2011

Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells

scientific article

Niraparib: A Poly(ADP-ribose) Polymerase (PARP) Inhibitor for the Treatment of Tumors with Defective Homologous Recombination

article

Oncology drug discovery: planning a turnaround

scientific article published on April 2014

Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination

scientific article published on 31 May 2017

Preclinical evaluation of the WEE1 inhibitor MK-1775 as single-agent anticancer therapy

scientific article published on 22 May 2013

Stringent control of gene expression in vivo by using novel doxycycline-dependent trans-activators

scientific article

Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor

scientific article published on 10 June 2015

Synthesis and biological evaluation of substituted 2-phenyl-2H-indazole-7-carboxamides as potent poly(ADP-ribose) polymerase (PARP) inhibitors

scientific article published in December 2009

Synthetic lethality of PARP inhibition in BRCA-network disrupted tumor cells is associated with interferon pathway activation and enhanced by interferon-γ.

scientific article published in July 2012

The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies

scientific article published on 2 July 2015

The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial

scientific article

Treatment with the PARP inhibitor, niraparib, sensitizes colorectal cancer cell lines to irinotecan regardless of MSI/MSS status

scientific article published on 4 February 2015

Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition

scientific article

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