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List of works by P. Michael Conn

"Pharmacoperone": what's in a word?

scientific article

'Effective inefficiency': cellular control of protein trafficking as a mechanism of post-translational regulation

scientific article published in July 2006

3 Ligand dimerization: A technique for assessing receptor-receptor interactions

scientific article published on 01 January 1983

A Gαs mutation (D229S) differentially effects gonadotropin-releasing hormone receptor regulation by RGS10, RGS3 and RGS3T

scientific article published on 01 February 2003

A mathematical model for LH release in response to continuous and pulsatile exposure of gonadotrophs to GnRH

scientific article

A mathematical model quantifying GnRH-induced LH secretion from gonadotropes

scientific article published in February 2000

A mechanism for the differential regulation of gonadotropin subunit gene expression by gonadotropin-releasing hormone.

scientific article

A new receptor for growth hormone-release peptide

scientific article published on August 1996

A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation

scientific article published on 29 December 2004

A phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptor

scientific article

Activation of two different but complementary biochemical pathways stimulates release of hypothalamic luteinizing hormone-releasing hormone

scientific article published on July 1986

Age-related alterations in the stimulated release in vitro of catecholamines and luteinizing hormone-releasing hormone from the male rat hypothalamus

scientific article

An inhibitor of arachidonic acid metabolism stimulates luteinizing hormone (LH) release from cultured pituitary cells

scientific article published on 01 June 1980

Animal rights: reaching the public

scientific article published on 01 November 1998

Assay strategies for identification of therapeutic leads that target protein trafficking

scientific article published on 8 June 2015

Beyond the signal sequence: protein routing in health and disease

scientific article

Binding of gonadotropin releasing hormone agonist to rat ovarian granulosa cells ⬇️

scientific article published on 01 December 1980

Biochemical mechanism of pathogenesis of human gonadotropin-releasing hormone receptor mutants Thr104Ile and Tyr108Cys associated with familial hypogonadotropic hypogonadism ⬇️

scientific article published on January 26, 2011

Calnexin regulated gonadotropin-releasing hormone receptor plasma membrane expression

scientific journal article

Chaperoning G protein-coupled receptors: from cell biology to therapeutics

scientific article

Characterization of the LH surge in middle-aged female rats

scientific article published on 01 October 1980

Characterization of the receptor for gonadotropin-releasing hormone in the pituitary of the African catfish,Clarias gariepinus

scientific article published in May 1988

Cis- and trans-activation of hormone receptors: the LH receptor

scientific article

Conformational effects of Lys191 in the human GnRH receptor: mutagenesis and molecular dynamics simulations studies.

scientific article

Conserved mammalian gonadotropin-releasing hormone receptor carboxyl terminal amino acids regulate ligand binding, effector coupling and internalization

scientific article

Contour of the GnRH pulse independently modulates gonadotropin secretion in the human male

scientific article published in September 1996

Development of a phenotypic high-content assay to identify pharmacoperone drugs for the treatment of primary hyperoxaluria type 1 by high-throughput screening

scientific article published on January 2015

Differential effects of the charge variants of human follicle-stimulating hormone

scientific article published on 01 May 2000

Distribution of gonadrotropin releasing hormone agonist binding sites in the rat central nervous system

scientific article published on 01 June 1988

Dominant negative effects of human follicle-stimulating hormone receptor expression-deficient mutants on wild-type receptor cell surface expression. Rescue of oligomerization-dependent defective receptor expression by using cognate decoys

scientific article

Dominant-negative action of disease-causing gonadotropin-releasing hormone receptor (GnRHR) mutants: a trait that potentially coevolved with decreased plasma membrane expression of GnRHR in humans

scientific article published on July 2003

Drug Library Screening for the Identification of Ionophores That Correct the Mistrafficking Disorder Associated with Oxalosis Kidney Disease

scientific article published on 31 January 2017

Drug development and the cellular quality control system

scientific article published on 21 March 2009

Ectopic luteinizing hormone secretion and anovulation

scientific article published on 01 January 2003

Effect of late follicular phase administration of antide on ovulation and inhibin secretion in macaques ⬇️

scientific article published on 01 December 1991

Ethical research as the target of animal extremism: an international problem

scientific article published on 22 January 2010

Evidence for an association between calmodulin and membrane patches containing gonadotropin-releasing hormone--receptor complexes in cultured gonadotropes

scientific article

Evidence of differential control of FSH and LH secretion by gonadotropin-releasing hormone (GnRH) from the use of a GnRH antagonist

scientific article published on 01 September 1988

Evolved regulation of gonadotropin-releasing hormone receptor cell surface expression

scientific article

Four naturally occurring mutations in the human GnRH receptor affect ligand binding and receptor function

scientific article published in July 2003

Functional Rescue of Misfolded Receptor Mutants

Functional significance of the BBXXB motif reversed present in the cytoplasmic domains of the human follicle-stimulating hormone receptor

scientific article published on August 2004

G protein-coupled receptor trafficking in health and disease: lessons learned to prepare for therapeutic mutant rescue in vivo

scientific article published on September 2007

G-protein-coupled receptor trafficking: understanding the chemical basis of health and disease

scientific article published on November 2006

GNRHR mutations in a woman with idiopathic hypogonadotropic hypogonadism highlight the differential sensitivity of luteinizing hormone and follicle-stimulating hormone to gonadotropin-releasing hormone

scientific article published in July 2004

GnRH-stimulated LH release from rat anterior pituitary cells in culture: refractoriness and recovery

scientific article published in December 1985

Gonadotrope-specific deletion of Dicer results in severely suppressed gonadotropins and fertility defects.

scientific article

Gonadotropin releasing hormone binding sites in rat hippocampus: Different structure/binding relationships compared to the anterior pituitary.

scientific article

Gonadotropin-Releasing Hormone Action in Cultured Pituicytes: Independence of Luteinizing Hormone Release and Adenosine 3′,5′-Monophosphate Production ⬇️

scientific article published on February 1, 1979

Gonadotropin-releasing hormone (GnRH) antibodies formation in hypogonadotropic azoospermic men treated with pulsatile GnRH--diagnosis and possible alternative treatment

scientific article published on 01 October 1988

Gonadotropin-releasing hormone and its analogs

scientific article

Gonadotropin-releasing hormone and its analogues

scientific article published on January 1991

Gonadotropin-releasing hormone receptor activates GTPase RhoA and inhibits cell invasion in the breast cancer cell line MDA-MB-231

scientific article

Gonadotropin-releasing hormone receptor concentration differentially regulates intracellular signaling pathways in GGH3 cells

scientific article published on 01 November 1999

Gonadotropin-releasing hormone stimulation of luteinizing hormone release: A ligand-receptor-effector model ⬇️

scientific article published on December 1, 1982

Gonadotropin-releasing hormone: molecular and cell biology, physiology, and clinical applications

scientific article published on June 1, 1984

High-throughput screen for pharmacoperones of the vasopressin type 2 receptor

scientific article

Human loss-of-function gonadotropin-releasing hormone receptor mutants retain wild-type receptors in the endoplasmic reticulum: molecular basis of the dominant-negative effect

scientific article published on 22 April 2004

Human placental lactogen release in vitro: paradoxical effects of calcium

scientific article published on 01 May 1981

Identification of Potential Pharmacoperones Capable of Rescuing the Functionality of Misfolded Vasopressin 2 Receptor Involved in Nephrogenic Diabetes Insipidus

scientific article

Identification of new gonadotrophin-releasing hormone partial agonists

scientific article published on 01 June 2006

In situ hybridization for LHRH mRNA following estrogen treatment

scientific article published on 01 November 1989

In vitro coexpression and pharmacological rescue of mutant gonadotropin-releasing hormone receptors causing hypogonadotropic hypogonadism in humans expressing compound heterozygous alleles

scientific article published on 22 February 2005

Increased plasma membrane expression of human follicle-stimulating hormone receptor by a small molecule thienopyr(im)idine

scientific article published on 20 September 2008

Interpretation of dose-response curves for luteinizing hormone release by gonadotropin-releasing hormone, related peptides, and leukotriene C4 according to a hormone/receptor/effector model

scientific article published on August 1986

LHRH messenger RNA in neurons in the intact and castrate male rat forebrain, studied by in situ hybridization

scientific article published in January 1987

Luteal Desensitization: Hormonal Regulation of LH Receptors, Adenylate Cyclase and Steroidogenic Responses in the Luteal Cell ⬇️

scientific article published on January 1, 1979

Lysozyme (muramidase) in isolated chick oviduct nuclei ⬇️

scientific article published on May 19, 1975

Measurement of Blood Volume in Adult Rhesus Macaques (Macaca mulatta).

scientific article published in January 2015

Measurement of changes in fluorescence resonance energy transfer between gonadotropin-releasing hormone receptors in response to agonists

scientific article published on 01 August 2002

Mechanisms mediating multiple physiological responses to gonadotropin-releasing hormone

scientific article published on 01 September 1998

Methods in Cell Biology. Receptor-receptor interactions. Preface

scientific article published on 01 January 2013

Methods in Enzymology. G protein coupled receptors trafficking and oligomerization. Preface

scientific article published in January 2013

Methods in Enzymology. Preface

scientific article published on 01 January 2011

Methods in Enzymology. Preface

scientific article published on 01 January 2012

Methods to assess the mechanism of protein function. Preface

scientific article published on 01 January 2010

Mice harboring Gnrhr E90K, a mutation that causes protein misfolding and hypogonadotropic hypogonadism in humans, exhibit testis size reduction and ovulation failure

scientific article

Misrouted cell surface GnRH receptors as a disease aetiology for congenital isolated hypogonadotrophic hypogonadism

scientific article published on March 2004

Misrouted cell surface receptors as a novel disease aetiology and potential therapeutic target: the case of hypogonadotropic hypogonadism due to gonadotropin-releasing hormone resistance

scientific article

Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site

scientific article

Molecular mechanism of action of pharmacoperone rescue of misrouted GPCR mutants: the GnRH receptor

scientific article published on 18 December 2008

Molecular mechanism of gonadotropin releasing hormone action.

scientific article published in November 1985

Multiple G proteins compete for binding with the human gonadotropin releasing hormone receptor

scientific article published on 27 May 2008

Mutations at the consensus phosphorylation sites in the third intracellular loop of the rat gonadotropin-releasing hormone receptor: effects on receptor ligand binding and signal transduction

scientific article published on 01 December 1998

Mutations in G protein-coupled receptors that impact receptor trafficking and reproductive function.

scientific article published on 24 June 2013

Parallel regulation of membrane trafficking and dominant-negative effects by misrouted gonadotropin-releasing hormone receptor mutants

scientific article published on 10 May 2005

Participation of the endoplasmic reticulum protein chaperone thio-oxidoreductase in gonadotropin-releasing hormone receptor expression at the plasma membrane

scientific article published on February 2009

Pavlov’s dogs and Schrödinger’s cat: Scenes from the living laboratory.

scientific article published in July 2009

Perifusion of rat pituitaries: requirements for optimal GnRH-stimulated LH release ⬇️

scientific article published on 01 May 1981

Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease

scientific article published in November 2004

Pharmacological Chaperones for Misfolded Gonadotropin-Releasing Hormone Receptors ⬇️

scientific article published on January 1, 2011

Pharmacological chaperones correct misfolded GPCRs and rescue function: protein trafficking as a therapeutic target

scientific article published on January 2012

Pharmacological profile of a new, potent, and long-acting gonadotropin-releasing hormone antagonist: degarelix

scientific article published in April 2002

Pharmacoperone Identification for Therapeutic Rescue of Misfolded Mutant Proteins ⬇️

scientific article published on March 3, 2011

Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias.

scientific article published on 02 August 2017

Pharmacoperones as Novel Therapeutics for Diverse Protein Conformational Diseases

scientific article published in April 2018

Pharmacoperones as a New Therapeutic Approach: In Vitro Identification and In vivo Validation of Bioactive Molecules

scientific article published on 7 March 2016

Pharmacoperones: targeting therapeutics toward diseases caused by protein misfolding

scientific article published on January 2015

Physiologists embedded in the animal research war

scientific article published on 01 June 2008

Pituitary luteinizing hormone responses to intravenous and subcutaneous administration of gonadotropin-releasing hormone in men.

scientific article published in November 1985

Preface

scientific article published on 01 January 2012

Preface

Preface. Endosome signaling part B

scientific article published on 01 January 2014

Preface: Laboratory methods in cell biology

scientific article published on 01 January 2013

Protein disulfide isomerase chaperone ERP-57 decreases plasma membrane expression of the human GnRH receptor

scientific article published on January 2010

Protein folding as posttranslational regulation: evolution of a mechanism for controlled plasma membrane expression of a G protein-coupled receptor

scientific article

Protein origami: therapeutic rescue of misfolded gene products

scientific article published on September 2002

Quality control autophagy degrades soluble ERAD-resistant conformers of the misfolded membrane protein GnRHR

scientific article

Receptor antagonism/agonism can be uncoupled from pharmacoperone activity

scientific article

Receptor-mediated internalization of fluorescent gonadotropin-releasing hormone by pituitary gonadotropes ⬇️

scientific article published on November 1, 1980

Receptor-misrouting: an unexpectedly prevalent and rescuable etiology in gonadotropin-releasing hormone receptor-mediated hypogonadotropic hypogonadism

scientific article published in October 2002

Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function in mice

scientific article

Refolding of misfolded mutant GPCR: post-translational pharmacoperone action in vitro

scientific article

Regulation of FSHbeta and GnRH receptor gene expression in activin receptor II knockout male mice

scientific article

Regulation of G protein-coupled receptor trafficking by inefficient plasma membrane expression: molecular basis of an evolved strategy

scientific article published on 30 January 2006

Regulation of RGS3 and RGS10 palmitoylation by GnRH.

scientific article published in April 2002

Regulation of hippocampal gonadotropin releasing hormone (GnRH) receptor mRNA and GnRH-stimulated inositol phosphate production by gonadal steroid hormones

scientific article published on 01 October 1995

Regulation of the gonadotropin-releasing hormone receptor (GnRHR) by RGS proteins: role of the GnRHR carboxyl-terminus

scientific article

Regulation of the pituitary gonadotrope by gonadotropin-releasing hormone: multiple intracellular effectors

scientific article published on January 1991

Release of gonadotropin alpha subunit from rat pituitary cultures in response to GnRH

scientific article published on 01 March 1988

Rescue of Misrouted GnRHR Mutants Reveals Its Constitutive Activity ⬇️

scientific article published on May 17, 2012

Rescue of hypogonadotropic hypogonadism-causing and manufactured GnRH receptor mutants by a specific protein-folding template: misrouted proteins as a novel disease etiology and therapeutic target

scientific article published in July 2002

Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy

scientific article

Salt Bridges Overlapping the Gonadotropin-Releasing Hormone Receptor Agonist Binding Site Reveal a Coincidence Detector for G Protein-Coupled Receptor Activation ⬇️

scientific article published on April 28, 2011

Salt bridge integrates GPCR activation with protein trafficking

scientific article

Single-dose administration of the gonadotropin-releasing hormone antagonist, Nal-Lys (antide) to healthy men

scientific article published on 01 October 1993

Specializations of a G-protein-coupled receptor that appear to aid with detection of frequency-modulated signals from its ligand.

scientific article published on 15 December 2006

Species sequence differences determine the interaction of GnRH receptor with the cellular quality control system

scientific article published on 24 July 2013

Structural determinants in the second intracellular loop of the human follicle-stimulating hormone receptor are involved in G(s) protein activation

scientific journal article

Structure-activity relations of successful pharmacologic chaperones for rescue of naturally occurring and manufactured mutants of the gonadotropin-releasing hormone receptor

scientific article published on 11 February 2003

Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized derivatives

scientific article published on 3 April 2007

Subcellular localization of the receptor for gonadotropin-releasing hormone in pituitary and ovarian tissue

scientific journal article

Synthesis and characterization of calmodulin antagonistic drugs

scientific article published on 01 January 1983

Synthesis and use of colloidal gold-coupled receptor ligands

scientific article published on 01 January 1986

Targeting of G protein-coupled receptors to the plasma membrane in health and disease

scientific article published on January 2009

The Role of Scientists and Clinicians in Raising Public Support for Animal Research in Reproductive Biology and Medicine1

scientific article published on 07 February 2013

The animal research war

scientific article published on 01 May 2008

The calcium requirement in GnRH-stimulated LH release is not mediated through a specific action on receptor binding

scientific article published on 01 July 1980

The human gonadotropin releasing hormone type I receptor is a functional intracellular GPCR expressed on the nuclear membrane

scientific article published in 2010

The role of protein kinases A and C pathways in the regulation of mitogen-activated protein kinase activation in response to gonadotropin-releasing hormone receptor activation

scientific article published on May 1999

The unfolded protein response and cellular stress, Part A.. Preface

scientific article published on 01 January 2011

The unfolded protein response and cellular stress, Part C. Preface

scientific article published on 01 January 2011

Therapeutic Rescue of Misfolded Mutants: Validation of Primary High Throughput Screens for Identification of Pharmacoperone Drugs ⬇️

scientific article published on July 27, 2011

Therapeutic rescue of misfolded/mistrafficked mutants: automation-friendly high-throughput assays for identification of pharmacoperone drugs of GPCRs

scientific article published in January 2013

Trafficking and quality control of the gonadotropin releasing hormone receptor in health and disease

scientific article (publication date: 27 February 2009)

Trafficking of G-protein-coupled receptors to the plasma membrane: insights for pharmacoperone drugs

scientific article

Transcriptional activation of gonadotropin-releasing hormone (GnRH) receptor gene by GnRH: involvement of multiple signal transduction pathways

scientific article published on January 1999

Transcriptional regulation of the GnRH receptor gene by glucocorticoids

scientific article published on 01 February 2003

Transitioning pharmacoperones to therapeutic use: in vivo proof-of-principle and design of high throughput screens.

scientific article

Two defective heterozygous luteinizing hormone receptors can rescue hormone action

scientific article published on 21 February 2002

Unexpected effects of epitope and chimeric tags on gonadotropin-releasing hormone receptors: implications for understanding the molecular etiology of hypogonadotropic hypogonadism

scientific article published on December 2003

Use of Pharmacoperones to Reveal GPCR Structural Changes Associated with Constitutive Activation and Trafficking

scientific article published on January 1, 2010

Use of protein kinase C-depleted cells for investigation of the role of protein kinase C in stimulus-response coupling in the pituitary

scientific article published on 01 January 1989

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