List of works - Christopher E Dempsey

Acquisition of Native β-Strand Topology During the Rapid Collapse Phase of Protein Folding ⬇️

scientific article published on October 28, 1997

Action potential clamp characterization of the S631A hERG mutation associated with short QT syndrome

scientific article published on 01 September 2018

Amide-resolved hydrogen?deuterium exchange measurements from membrane-reconstituted polypeptides using exchange trapping and semiselective two-dimensional NMR ⬇️

scientific article published on 01 November 1994

Amphipathic Antimicrobial Peptides – from Biophysics to Therapeutics? ⬇️

scientific article published on November 1, 2010

An Update on the Structure of hERG

scientific article published on 01 January 2019

Analysis of α-Dystroglycan/LG Domain Binding Modes: Investigating Protein Motifs That Regulate the Affinity of Isolated LG Domains

scientific article published on 29 March 2019

Arginine side chain interactions and the role of arginine as a gating charge carrier in voltage sensitive ion channels.

scientific article published on 22 February 2016

Electrophysiological characterization of the modified hERGT potassium channel used to obtain the first cryo-EM hERG structure

scientific article published on 01 October 2020

Functional and pharmacological characterization of an S5 domain hERG mutation associated with short QT syndrome

scientific article published on 20 April 2019

Helical structure and dynamics in membrane polypeptides ⬇️

scientific article published on 01 August 1998

Helical structure and orientation of melittin in dispersed phospholipid membranes from amide exchange analysis in situ

scientific article published on 01 December 1992

Hydrogen Bonding in Helical Polypeptides from Molecular Dynamics Simulations and Amide Hydrogen Exchange Analysis: Alamethicin and Melittin in Methanol ⬇️

scientific article published on January 1, 1998

Identification of a proton sensor that regulates conductance and open time of single hERG channels

scientific article published on 27 December 2019

Inhibition of prostaglandin biosynthesis by the mast-cell-degranulating agent compound 48/80 but not by the mast-cell-degranulating peptide (peptide-401) from bee venom

scientific article published in 1985

Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant

scientific article published on 02 November 2021

Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking.

scientific article published on 30 May 2016

Interactions between voltage sensor and pore domains in a hERG K+ channel model from molecular simulations and the effects of a voltage sensor mutation.

scientific article

Molecular determinants of hERG potassium channel inhibition by disopyramide ⬇️

scientific article published on September 29, 2011

New methods of isolating bee venom peptides ⬇️

scientific article published on 01 September 1981

Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome

scientific article published on 27 July 2019

Quantitation of the effects of an internal proline residue on individual hydrogen bond stabilities in an alpha-helix: pH-dependent amide exchange in melittin and [Ala-14]melittin

scientific article published on May 19, 1992

Ranolazine inhibition of hERG potassium channels: drug-pore interactions and reduced potency against inactivation mutants

scientific article published on 27 May 2014

Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker.

scientific article

The Basis for Low-affinity hERG Potassium Channel Block by Sotalol.

scientific article published on July 2017

The antimicrobial effects of the alginate oligomer OligoG CF-5/20 are independent of direct bacterial cell membrane disruption.

scientific article

The hERG K+ channel S4 domain L532P mutation: Characterization at 37°C ⬇️

scientific article published on July 14, 2011

The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine

scientific article published on 01 March 2020

Topology, sequence evolution and folding dynamics of an immunoglobulin domain

scientific article published on 01 March 1998

hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine

scientific article

List of works by Christopher E Dempsey

Acquisition of Native β-Strand Topology During the Rapid Collapse Phase of Protein Folding ⬇️

Action potential clamp characterization of the S631A hERG mutation associated with short QT syndrome

Amide-resolved hydrogen?deuterium exchange measurements from membrane-reconstituted polypeptides using exchange trapping and semiselective two-dimensional NMR ⬇️

Amphipathic Antimicrobial Peptides – from Biophysics to Therapeutics? ⬇️

An Update on the Structure of hERG

Analysis of α-Dystroglycan/LG Domain Binding Modes: Investigating Protein Motifs That Regulate the Affinity of Isolated LG Domains

Arginine side chain interactions and the role of arginine as a gating charge carrier in voltage sensitive ion channels.

Electrophysiological characterization of the modified hERGT potassium channel used to obtain the first cryo-EM hERG structure

Functional and pharmacological characterization of an S5 domain hERG mutation associated with short QT syndrome

Helical structure and dynamics in membrane polypeptides ⬇️

Helical structure and orientation of melittin in dispersed phospholipid membranes from amide exchange analysis in situ

Hydrogen Bonding in Helical Polypeptides from Molecular Dynamics Simulations and Amide Hydrogen Exchange Analysis: Alamethicin and Melittin in Methanol ⬇️

Identification of a proton sensor that regulates conductance and open time of single hERG channels

Inhibition of prostaglandin biosynthesis by the mast-cell-degranulating agent compound 48/80 but not by the mast-cell-degranulating peptide (peptide-401) from bee venom

Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant

Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking.

Interactions between voltage sensor and pore domains in a hERG K+ channel model from molecular simulations and the effects of a voltage sensor mutation.

Molecular determinants of hERG potassium channel inhibition by disopyramide ⬇️

New methods of isolating bee venom peptides ⬇️

Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome

Quantitation of the effects of an internal proline residue on individual hydrogen bond stabilities in an alpha-helix: pH-dependent amide exchange in melittin and [Ala-14]melittin

Ranolazine inhibition of hERG potassium channels: drug-pore interactions and reduced potency against inactivation mutants

Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker.

The Basis for Low-affinity hERG Potassium Channel Block by Sotalol.

The antimicrobial effects of the alginate oligomer OligoG CF-5/20 are independent of direct bacterial cell membrane disruption.

The hERG K+ channel S4 domain L532P mutation: Characterization at 37°C ⬇️

The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine

Topology, sequence evolution and folding dynamics of an immunoglobulin domain

hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine