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List of works by Søren Riis Paludan

A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival

scientific article

Activation and Evasion of Innate Antiviral Immunity by Herpes Simplex Virus ⬇️

scientific article published on November 5, 2009

Activation and regulation of DNA-driven immune responses

scientific article published on June 2015

Activation of NF-kappa B in virus-infected macrophages is dependent on mitochondrial oxidative stress and intracellular calcium: downstream involvement of the kinases TGF-beta-activated kinase 1, mitogen-activated kinase/extracellular signal-regulat

scientific article published on June 2003

Activation of autophagy by α-herpesviruses in myeloid cells is mediated by cytoplasmic viral DNA through a mechanism dependent on stimulator of IFN genes

scientific article published on 12 October 2011

Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner

scientific article

Age-dependent role for CCR5 in antiviral host defense against herpes simplex virus type 2

scientific article

An innate antiviral pathway acting before interferons at epithelial surfaces

scientific article

An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication.

scientific article published on August 2016

Antiviral and immunological effects of tenofovir microbicide in vaginal herpes simplex virus 2 infection.

scientific article published on 25 September 2012

Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1.

scientific article published in March 2018

Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

scientific article published on 21 October 2020

Author Correction: STEEP mediates STING ER exit and activation of signaling

scientific article published on 14 September 2020

Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity

scientific article published on 12 January 2021

Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model

scientific article

Constitutive immune mechanisms: mediators of host defence and immune regulation

scientific article published on 11 August 2020

Corona's new coat: SARS-CoV-2 in Danish minks and implications for travel medicine

scientific article published on 20 November 2020

Crystal Structure of Interleukin-21 Receptor (IL-21R) Bound to IL-21 Reveals That Sugar Chain Interacting with WSXWS Motif Is Integral Part of IL-21R

scientific article

Cutting Edge: Genetic Association between IFI16 Single Nucleotide Polymorphisms and Resistance to Genital Herpes Correlates with IFI16 Expression Levels and HSV-2-Induced IFN-β Expression.

scientific article published on 11 September 2017

DNA recognition in immunity and disease ⬇️

scientific article published on 09 January 2013

DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer

scientific article published on 01 March 2019

Defects in <i>LC3B2</i> and <i>ATG4A</i> underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans

scientific article published on 01 December 2020

Differential impact of interferon regulatory factor 7 in initiation of the type I interferon response in the lymphocytic choriomeningitis virus-infected central nervous system versus the periphery

scientific article

Differential regulation of the OASL and OAS1 genes in response to viral infections

scientific article

Early innate recognition of herpes simplex virus in human primary macrophages is mediated via the MDA5/MAVS-dependent and MDA5/MAVS/RNA polymerase III-independent pathways

scientific article published on 25 August 2010

Expression and function of chemokines during viral infections: from molecular mechanisms to in vivo function

scientific article

Expression of genes for cytokines and cytokine-related functions in leukocytes infected with Herpes simplex virus: comparison between resistant and susceptible mouse strains

scientific article published in July 2002

Expression of type III interferon (IFN) in the vaginal mucosa is mediated primarily by dendritic cells and displays stronger dependence on NF-kappaB than type I IFNs

scientific article

Functional IRF3 deficiency in a patient with herpes simplex encephalitis.

scientific article

Genomic HIV RNA induces innate immune responses through RIG-I-dependent sensing of secondary-structured RNA

scientific article (publication date: 2012)

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6

scientific article

HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression

scientific article published on 27 May 2016

HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0

scientific article published on 02 December 2019

Herpes simplex virus selectively induces expression of the CC chemokine RANTES/CCL5 in macrophages through a mechanism dependent on PKR and ICP0

scientific article

Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis

scientific article published on 05 December 2019

IFI16 is an innate immune sensor for intracellular DNA

scientific article

IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication.

scientific article published on 23 October 2013

IFI16: At the interphase between innate DNA sensing and genome regulation

scientific article published on 21 June 2014

IFN-lambda: novel antiviral cytokines

scientific article

Immune sensing of DNA

scientific article published on May 2013

Important role for Toll-like receptor 9 in host defense against meningococcal sepsis

scientific article published on 15 September 2008

Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections

scientific article published on 07 August 2017

Induction of RANTES/CCL5 by herpes simplex virus is regulated by nuclear factor kappa B and interferon regulatory factor 3.

scientific article published in September 2003

Induction of cytokine expression by herpes simplex virus in human monocyte-derived macrophages and dendritic cells is dependent on virus replication and is counteracted by ICP27 targeting NF-kappaB and IRF-3.

scientific article published in May 2006

Induction of interferon-stimulated genes by Chlamydia pneumoniae in fibroblasts is mediated by intracellular nucleotide-sensing receptors.

scientific article

Inflammation kinase PKR phosphorylates α-synuclein and causes α-synuclein-dependent cell death.

scientific article

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses.

scientific article published on 19 February 2016

Innate Antiviral Defenses Independent of Inducible IFNα/β Production

scientific article published on 23 June 2016

Innate antiviral signalling in the central nervous system

scientific article published on 06 December 2013

Innate immune recognition and activation during HIV infection

scientific article

Innate recognition of alphaherpesvirus DNA.

scientific article

Innate recognition of intracellular pathogens: detection and activation of the first line of defense.

scientific article published on May 2009

Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses

scientific article

Interferon-  Is Functionally an Interferon but Structurally Related to the Interleukin-10 Family

scientific article

Interleukin-21 receptor signalling is important for innate immune protection against HSV-2 infections.

scientific article

Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling

scientific article published on 25 February 2019

Lambda interferon (IFN-lambda), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo

scientific article

Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic

scientific article published on 20 April 2022

Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway

scientific article

Live and let die: ZBP1 senses viral and cellular RNAs to trigger necroptosis.

scientific article

Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation

scientific article published on 22 May 2020

Mechanisms of type III interferon expression

scientific article published on August 2010

Molecular requirements for sensing of intracellular microbial nucleic acids by the innate immune system.

scientific article

Mucosal IFNλ1 mRNA-based immunomodulation effectively reduces SARS-CoV-2 induced mortality in mice

scientific article published in 2024

Mutations in RNA Polymerase III genes and defective DNA sensing in adults with varicella-zoster virus CNS infection.

scientific article

Pattern recognition receptor responses in children with chronic hepatitis B virus infection ⬇️

scientific article published on May 11, 2012

Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors

scientific article published on 23 January 2013

RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.

scientific article published on 18 February 2009

Reading the viral signature by Toll-like receptors and other pattern recognition receptors

scientific article

Recognition of herpesviruses by the innate immune system

scientific article published on February 2011

SAM68 directs STING signaling to apoptosis in macrophages

scientific article published in 2024

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

scientific article published on 02 October 2020

STEEP mediates STING ER exit and activation of signaling

scientific article published on 20 July 2020

STING agonists enable antiviral cross-talk between human cells and confer protection against genital herpes in mice.

scientific article

Sensing the hybrid--a novel PAMP for TLR9.

scientific article published on 12 February 2014

Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4

scientific article published on 22 January 2020

Streptococcus pneumoniae stabilizes tumor necrosis factor alpha mRNA through a pathway dependent on p38 MAPK but independent of Toll-like receptors

scientific article

Suppression of proinflammatory cytokine expression by herpes simplex virus type 1.

scientific article

T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication

scientific article published on 3 January 2014

TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection

scientific article published on 01 March 2022

TLR3 deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in mice

scientific article published on 19 March 2012

TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adults

scientific article published on August 2012

TRAM is required for TLR2 endosomal signaling to type I IFN induction

scientific article

Targeting herpes simplex virus with CRISPR-Cas9 cures herpetic stromal keratitis in mice

scientific article published on 11 January 2021

Tenofovir selectively regulates production of inflammatory cytokines and shifts the IL-12/IL-10 balance in human primary cells

scientific article published on August 2011

The herpesviral antagonist m152 reveals differential activation of STING-dependent IRF and NF-κB signaling and STING's dual role during MCMV infection

scientific article published on 29 January 2019

The p38 MAPK regulates IL-24 expression by stabilization of the 3' UTR of IL-24 mRNA.

scientific article

Type I interferon production during herpes simplex virus infection is controlled by cell-type-specific viral recognition through Toll-like receptor 9, the mitochondrial antiviral signaling protein pathway, and novel recognition systems.

scientific article

Type III IFNs: new layers of complexity in innate antiviral immunity

scientific article published on January 2009

Viral activation of macrophages through TLR-dependent and -independent pathways

scientific article

Viral evasion of DNA-stimulated innate immune responses

scientific article published on 14 March 2016

[Toll-like receptors, a new way of treatment?]

scientific article published on 01 June 2007

cGAS is activated by DNA in a length-dependent manner.

scientific article published on 10 August 2017

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