List of works - Ross C Overman

A Chemical-Genetic Approach to Generate Selective Covalent Inhibitors of Protein Kinases

scientific article

Biochemical and biophysical characterization of four EphB kinase domains reveals contrasting thermodynamic, kinetic and inhibition profiles.

scientific article

Completing the structural family portrait of the human EphB tyrosine kinase domains

scientific article

Development of Specific, Irreversible Inhibitors for a Receptor Tyrosine Kinase EphB3

scientific article

Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumors

scientific article published on 01 April 2020

Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors

scientific article published on 24 September 2018

Endosomal escape enhancing compounds facilitate functional delivery of extracellular vesicle cargo

scientific article published on 14 November 2019

Introduction of a C-terminal hexa-lysine tag increases thermal stability of the LacDiNac binding adhesin (LabA) exodomain from Helicobacter pylori

scientific article published on 01 July 2019

KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe

scientific article published on 13 June 2019

Quantitative investigation of the affinity of human respiratory syncytial virus phosphoprotein C-terminus binding to nucleocapsid protein

scientific article published on 19 November 2014

Rapid isolation and enrichment of extracellular vesicle preparations using anion exchange chromatography.

scientific article published on 10 April 2018

Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis.

scientific article published on 4 December 2015

Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation ⬇️

scientific article

Stability and solubility engineering of the EphB4 tyrosine kinase catalytic domain using a rationally designed synthetic library ⬇️

scientific article published on July 8, 2013

Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange. ⬇️

scientific article

Structural basis of Lewis(b) antigen binding by the Helicobacter pylori adhesin BabA.

scientific article

Structural insights into FGFR kinase isoform selectivity: diverse binding modes of AZD4547 and ponatinib in complex with FGFR1 and FGFR4

scientific article

List of works by Ross C Overman

A Chemical-Genetic Approach to Generate Selective Covalent Inhibitors of Protein Kinases

Biochemical and biophysical characterization of four EphB kinase domains reveals contrasting thermodynamic, kinetic and inhibition profiles.

Completing the structural family portrait of the human EphB tyrosine kinase domains

Development of Specific, Irreversible Inhibitors for a Receptor Tyrosine Kinase EphB3

Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumors

Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors

Endosomal escape enhancing compounds facilitate functional delivery of extracellular vesicle cargo

Introduction of a C-terminal hexa-lysine tag increases thermal stability of the LacDiNac binding adhesin (LabA) exodomain from Helicobacter pylori

KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe

Quantitative investigation of the affinity of human respiratory syncytial virus phosphoprotein C-terminus binding to nucleocapsid protein

Rapid isolation and enrichment of extracellular vesicle preparations using anion exchange chromatography.

Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis.

Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation ⬇️

Stability and solubility engineering of the EphB4 tyrosine kinase catalytic domain using a rationally designed synthetic library ⬇️

Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange. ⬇️

Structural basis of Lewis(b) antigen binding by the Helicobacter pylori adhesin BabA.

Structural insights into FGFR kinase isoform selectivity: diverse binding modes of AZD4547 and ponatinib in complex with FGFR1 and FGFR4