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List of works by Xander H T Wehrens

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FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death

scientific article (publication date: 27 June 2003)
Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor

scientific article published on 11 March 2004
Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation

scientific article
Impact of noncardiac comorbidities on morbidity and mortality in a predominantly male population with heart failure and preserved versus reduced ejection fraction.

scientific article
Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2.

scientific article
Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

scientific article
Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice

scientific article
Intracellular calcium release and cardiac disease

scientific article
Defective cardiac ryanodine receptor regulation during atrial fibrillation

scientific article published in April 2005
Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression

scientific article
Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure

scientific article
Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation.

scientific article
Circadian rhythms govern cardiac repolarization and arrhythmogenesis

scientific journal article
Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak

scientific article
Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure.

scientific article published on 12 May 2003
Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice

scientific article
Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation.

scientific article
Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias

scientific journal article
Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification

scientific article
Role of RyR2 phosphorylation at S2814 during heart failure progression

scientific article
Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure

scientific article
Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans

scientific article
Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy.

scholarly article
Calmodulin kinase II is required for fight or flight sinoatrial node physiology

scholarly article
Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1.

scientific article
Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.

scientific article
Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation.

scientific article published on 27 March 2008
Transverse aortic constriction in mice

scientific article published on 21 April 2010
Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia

scientific article published on 14 April 2003
Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice

scientific article published on 8 December 2011
Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation

scientific article
PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1.

scientific article
Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization.

scientific article published on 21 August 2013
Role of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease

scientific article
Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling

scientific article published on 7 January 2011
Altered function and regulation of cardiac ryanodine receptors in cardiac disease

scientific article published on December 2003
The mitochondrial uniporter controls fight or flight heart rate increases.

scientific article
Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development

scientific article
Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure.

scientific article published on 11 February 2014
The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis

scientific article published on 23 December 2015
Atrial identity is determined by a COUP-TFII regulatory network.

scientific article published on May 2013
Novel therapeutic approaches for heart failure by normalizing calcium cycling

scientific article published in July 2004
Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation

scientific article published on 08 January 2009
Calcium Signaling and Cardiac Arrhythmias

scientific article
Junctophilin-2 is necessary for T-tubule maturation during mouse heart development.

scientific article published on 27 May 2013
Critical roles of junctophilin-2 in T-tubule and excitation-contraction coupling maturation during postnatal development

scientific article published on 16 July 2013
Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation

scientific article
Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice

scientific article
Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model

scientific article
Molecular evolution of the junctophilin gene family

scientific article

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