Search filters

List of works by Xander H T Wehrens

A Single Protein Kinase A or Calmodulin Kinase II Site Does Not Control the Cardiac Pacemaker Ca2+ Clock

scientific article published on February 2016

A novel mutation L619F in the cardiac Na+ channel SCN5A associated with long-QT syndrome (LQT3): a role for the I-II linker in inactivation gating

scientific article published on May 2003

Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model

scientific article

Alterations in ryanodine receptors and related proteins in heart failure

scientific article published on 14 June 2013

Alterations in the interactome of serine/threonine protein phosphatase type-1 in atrial fibrillation patients.

scientific article

Altered function and regulation of cardiac ryanodine receptors in cardiac disease

scientific article published on December 2003

Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development

scientific article

Alternative splicing: a key mechanism for ankyrin-B functional diversity?

scientific article

Ambulatory ECG recording in mice

scientific article published on 27 May 2010

Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice

scientific article

Analysis of enriched rare variants in JPH2-encoded junctophilin-2 among Greater Middle Eastern individuals reveals a novel homozygous variant associated with neonatal dilated cardiomyopathy.

scientific article

Angiogenesis-independent cardioprotection in FGF-1 transgenic mice

scientific article published in September 2002

Animal models of arrhythmogenic cardiomyopathy

scientific article

Association of systolic blood pressure with mortality in patients with heart failure with reduced ejection fraction: a complex relationship.

scientific article

Atrial identity is determined by a COUP-TFII regulatory network.

scientific article published on May 2013

Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure.

scientific article published on 12 May 2003

CRISPR -Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias

scientific article published on 01 October 2018

Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor

scientific article published on 11 March 2004

CaMKII effects on inotropic but not lusitropic force frequency responses require phospholamban

scientific article published on 11 July 2012

CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome.

scientific article

CaMKII regulation of the cardiac ryanodine receptor and sarcoplasmic reticulum calcium release ⬇️

scientific article published on September 29, 2010

CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift

scientific article published on 15 June 2016

CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury

scientific article

CaMKIIδ mediates β-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic β-adrenergic stimulation.

scientific article published on 14 June 2015

Calcium Signaling and Cardiac Arrhythmias

scientific article

Calcium dysregulation in atrial fibrillation: the role of CaMKII

scientific article

Calcium-calmodulin dependent protein kinase II (CaMKII): A main signal responsible for early reperfusion arrhythmias ⬇️

scientific article published on August 19, 2011

Calcium-calmodulin-dependent protein kinase mediates the intracellular signalling pathways of cardiac apoptosis in mice with impaired glucose tolerance

scientific article published on 20 January 2017

Calcium-mediated cellular triggered activity in atrial fibrillation

scientific article published on 9 February 2017

Calmodulin kinase II is required for fight or flight sinoatrial node physiology

scholarly article

Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillation

scientific article published on January 2010

Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice

scientific article

Calstabin deficiency, ryanodine receptors, and sudden cardiac death

scientific article published in October 2004

Cardiac rupture complicating myocardial infarction

scientific article published in June 2004

Cardiac ryanodine receptor function and regulation in heart disease

scientific article published on May 2004

Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation.

scientific article

Chronic exercise: a contributing factor to atrial fibrillation?

scientific article published on 09 April 2013

Chronic kidney disease promotes atrial fibrillation via inflammasome pathway activation

scientific article published in 2023

Circadian rhythms govern cardiac repolarization and arrhythmogenesis

scientific journal article

Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy

scientific article published on October 2016

Critical roles of junctophilin-2 in T-tubule and excitation-contraction coupling maturation during postnatal development

scientific article published on 16 July 2013

Crosstalk between RyR2 oxidation and phosphorylation contributes to cardiac dysfunction in mice with Duchenne muscular dystrophy.

scientific article

Defective cardiac ryanodine receptor regulation during atrial fibrillation

scientific article published in April 2005

Defective ryanodine receptor interdomain interactions may contribute to intracellular Ca2+ leak: a novel therapeutic target in heart failure

scientific article published in June 2005

Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation

scientific article

Diagnosing atrial fibrillation: Can we do better than the ECG?

scientific article published in 2022

Digoxin treatment in heart failure--unveiling risk by cluster analysis of DIG data

scientific article

Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice

scientific article

Distinct Cellular Basis for Early Cardiac Arrhythmias, the Cardinal Manifestation of Arrhythmogenic Cardiomyopathy, and the Skin Phenotype of Cardiocutaneous Syndromes

scientific article

Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes

scientific article published on 25 May 2016

EL20, A Potent Antiarrhythmic Compound, Selectively Inhibits Calmodulin Deficient Ryanodine Receptor Type 2.

scientific article published on 14 December 2017

Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance

scientific article

Emerging role of junctophilin-2 as a regulator of calcium handling in the heart.

scientific article published on 09 August 2010

Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases

scientific article

Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation

Enhanced impact of SCN5A mutation associated with long QT syndrome in fetal splice isoform

scientific article published on 30 November 2011

Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation

scientific article

Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure

scientific article

Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.

scientific article

Especially polymorphonuclear leukocytes, but also monomorphonuclear leukocytes, roll spontaneously in venules of intact rat skin: involvement of E-selectin

scientific article published in February 2002

Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation

scientific article published on 08 January 2009

Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation.

scientific article

Extinguishing intracellular calcium leak: a promising antiarrhythmic approach

scientific article published on 17 October 2012

FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death

scientific article (publication date: 27 June 2003)

Fetal cardiovascular response to large placental chorioangiomas

scientific article published on January 2004

Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling.

scientific article

Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy

scientific article

Genetics of atrial fibrillation: an update

scientific article published on 15 February 2018

Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1.

scientific article

Hemodynamic and Pathologic Characterization of the TASK-1-/- Mouse Does Not Demonstrate Pulmonary Hypertension

scientific article published on 23 October 2017

Human stanniocalcin-1 suppresses angiotensin II-induced superoxide generation in cardiomyocytes through UCP3-mediated anti-oxidant pathway

scientific article

Identification of microRNA-mRNA dysregulations in paroxysmal atrial fibrillation.

scientific article published on 28 January 2015

Impact of noncardiac comorbidities on morbidity and mortality in a predominantly male population with heart failure and preserved versus reduced ejection fraction.

scientific article

In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia.

scientific article published on 30 October 2015

Increased Reliance on Muscle-based Thermogenesis upon Acute Minimization of Brown Adipose Tissue Function

scientific article published on 13 June 2016

Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα

scientific article

Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy.

scientific article published on 12 December 2012

Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice

scientific article published on 8 December 2011

Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation.

scientific article published on 27 March 2008

Intracellular calcium release and cardiac disease

scientific article

It's not the heart: autonomic nervous system predisposition to lethal ventricular arrhythmias

scientific article published on 8 July 2015

Junctophilin-2 at the intersection of arrhythmia and pathologic cardiac remodeling

scientific article published on 17 November 2015

Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis

scientific article published on 20 June 2019

Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling

scientific article published on 7 January 2011

Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release

scientific article published on 8 October 2016

Junctophilin-2 is necessary for T-tubule maturation during mouse heart development.

scientific article published on 27 May 2013

K+ channel structure-activity relationships and mechanisms of drug-induced QT prolongation.

scientific article

Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death

scientific article published on 25 October 2014

Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death

scientific article

Leaky ryanodine receptors cause delayed afterdepolarizations and ventricular arrhythmias

scientific article published on 25 April 2007

Long-term simulated microgravity causes cardiac RyR2 phosphorylation and arrhythmias in mice

scientific article

Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation.

scientific article published on 15 November 2016

Loss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release.

scientific article

Loss-of-Function SCN5A Mutations Associated With Sinus Node Dysfunction, Atrial Arrhythmias, and Poor Pacemaker Capture

scientific article

Mechanisms of human arrhythmia syndromes: abnormal cardiac macromolecular interactions

scientific article published on October 2007

Methyl-CpG binding-protein 2 function in cholinergic neurons mediates cardiac arrhythmogenesis

scientific article published in November 2016

Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy.

scholarly article

Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure.

scientific article published on 11 February 2014

Molecular determinants of altered contractility in heart failure

scientific article published on January 2004

Molecular evolution of the junctophilin gene family

scientific article

Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization.

scientific article published on 21 August 2013

Mutation-specific effects of lidocaine in Brugada syndrome

scientific article published on 29 August 2007

Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans

scientific article

Nanoscale Changes in the Organisation of Junctional Proteins in JPH2 Transgenic Mice

Nanoscale organization of junctophilin-2 and ryanodine receptors within peripheral couplings of rat ventricular cardiomyocytes

scientific article published on 6 March 2012

Neuronally released vasoactive intestinal polypeptide alters atrial electrophysiological properties and may promote atrial fibrillation

scientific article

Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia

scientific article published on 14 April 2003

Novel insights in the congenital long QT syndrome

scientific article published in December 2002

Novel junctophilin-2 mutation A405S is associated with basal septal hypertrophy and diastolic dysfunction

scientific article published on February 2017

Novel therapeutic approaches for heart failure by normalizing calcium cycling

scientific article published in July 2004

Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice

scientific article published on 16 November 2011

Oxidative stress and ca(2+) release events in mouse cardiomyocytes

scientific article

Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation.

scientific article

PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban.

scientific article

PITX2: a master regulator of cardiac channelopathy in atrial fibrillation?

scientific article published on 17 January 2016

PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1.

scientific article

Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia

scientific article published on 04 November 2020

Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: implication for therapy in Rett syndrome

scientific article

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

scientific article

Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure

scientific article published on 13 July 2007

Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification

scientific article

Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation

scientific article

Prevention of connexin-43 remodeling protects against Duchenne muscular dystrophy cardiomyopathy

scientific article published on 01 April 2020

Profibrotic, Electrical, and Calcium-Handling Remodeling of the Atria in Heart Failure Patients With and Without Atrial Fibrillation

article by Cristina E Molina et al published 2018 in Frontiers in Physiology

Programmed electrical stimulation in mice

scientific article published on 26 May 2010

Progress toward the prevention and treatment of atrial fibrillation: A summary of the Heart Rhythm Society Research Forum on the Treatment and Prevention of Atrial Fibrillation, Washington, DC, December 9-10, 2013.

scientific article published on 18 November 2014

Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2.

scientific article

Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice.

scientific article

Regulating the regulator: Insights into the cardiac protein phosphatase 1 interactome

scientific article published on 20 September 2016

Reply from Pei-Chi Yang, Jonathan D. Moreno, Mao-Tsuen Jeng, Xander H. T. Wehrens, Sergei Noskov and Colleen E. Clancy

scientific article published in November 2016

Role of RyR2 phosphorylation at S2814 during heart failure progression

scientific article

Role of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease

scientific article

Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure

scientific article

Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides

scientific article published on 08 October 2013

Ryanodine receptor phosphorylation, calcium/calmodulin-dependent protein kinase II, and life-threatening ventricular arrhythmias

scientific article published on February 2011

Ryanodine receptor-targeted anti-arrhythmic therapy

scientific article

Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression

scientific article

Ryanodine receptors as pharmacological targets for heart disease

scientific article

SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity

scientific article published on 11 October 2016

SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice

scientific article

STAT3: a link between CaMKII-βIV-spectrin and maladaptive remodeling?

scientific article published on 12 November 2018

Serine/Threonine Phosphatases in Atrial Fibrillation

scientific article published on 7 January 2017

Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias

scientific journal article

Stress synchronizes calcium release and promotes SR calcium leak

scientific article published in February 2010

Subcellular targeting of phosphatases: a novel function of ankyrins

scientific article published on 20 April 2007

Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak

scientific article

Sudden infant death syndrome in mice with an inherited mutation in RyR2.

scientific article published on December 2009

Sudden unexplained death caused by cardiac ryanodine receptor (RyR2) mutations

scientific article

TWIK-2 channel deficiency leads to pulmonary hypertension through a rho-kinase-mediated process

scientific article published on 22 September 2014

Targeting ryanodine receptors for anti-arrhythmic therapy

scientific article published on June 2011

The mitochondrial uniporter controls fight or flight heart rate increases.

scientific article

The molecular basis of catecholaminergic polymorphic ventricular tachycardia: what are the different hypotheses regarding mechanisms?

scientific article published on 15 December 2006

The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications

scientific article published on 12 October 2010

The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis

scientific article published on 23 December 2015

Transthoracic echocardiography in mice

scientific article published on 28 May 2010

Transverse aortic constriction in mice

scientific article published on 21 April 2010

Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs.

scientific article

Treatment of catecholaminergic polymorphic ventricular tachycardia in mice using novel RyR2-modifying drugs

scientific article published on 29 October 2016

Unraveling the Mechanisms by Which Calpain Inhibition Prevents Heart Failure Development

article

Worsening renal function is not associated with response to treatment in acute heart failure.

scientific article

microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription.

scientific article

Paulina is supported by:

About Paulina

Help