Search filters

List of works by John Unitt

1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as potent GR antagonists with reduced hERG inhibition and an improved pharmacokinetic profile.

scientific article published on 31 October 2015

An evaluation of fluorescence polarization and lifetime discriminated polarization for high throughput screening of serine/threonine kinases

scientific article published in September 2002

Development and Validation of a Simple Cell-Based Fluorescence Assay for Dipeptidyl Peptidase 1 (DPP1) Activity ⬇️

scientific article published on November 18, 2010

Development of a high-throughput human rhinovirus infectivity cell-based assay for identifying antiviral compounds

scientific article published on 15 February 2011

Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists.

scientific article

Discovery of pyrazoles as novel FPR1 antagonists ⬇️

scientific article published on 06 September 2011

Discovery of small molecule human C5a receptor antagonists

scientific article published on 31 December 2008

Discovery of small molecule human FPR1 receptor antagonists ⬇️

scientific article published on March 21, 2011

Dynamic analysis of STAT6 signalling in living cells.

scientific article published on December 2002

Effect of lipophilicity modulation on inhibition of human rhinovirus capsid binders

scientific article published on 24 August 2011

FKBP5 mRNA Expression Is a Biomarker for GR Antagonism.

scientific article

Hit-to-Lead studies: the discovery of potent, orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists

scientific article published on 15 November 2005

Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors

scientific article published on June 2004

Hit-to-lead studies: the discovery of potent, orally bioavailable triazolethiol CXCR2 receptor antagonists

scientific article published in August 2003

Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Re

scientific article

Multi-parameter analysis of the kinetics of NF-kappaB signalling and transcription in single living cells.

scientific article published in March 2002

NF-kappaB signalling is inhibited by glucocorticoid receptor and STAT6 via distinct mechanisms

scientific article published on 06 May 2003

Plant lectins are novel Toll-like receptor agonists ⬇️

scientific article published on March 21, 2011

Potent Reversible Inhibition of Myeloperoxidase by Aromatic Hydroxamates

scientific article

Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription

scientific article

Thermal Shift as an Entropy-Driven Effect.

scientific article published on 7 November 2017

Paulina is supported by:

About Paulina

Help