Search filters

List of works by John B A G Haanen

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

A Phase I study of recombinant human interleukin-21 (rIL-21) in combination with sunitinib in patients with metastatic renal cell carcinoma (RCC) ⬇️

scientific article published on January 1, 2011

A Phase II, single-arm trial of neoadjuvant axitinib plus avelumab in patients with localized renal cell carcinoma who are at high risk of relapse after nephrectomy (NEOAVAX)

scientific article published on 26 April 2019

A large pooled analysis refines gene expression-based molecular subclasses in cutaneous melanoma

article

A phase II study of presurgical sunitinib in patients with metastatic clear-cell renal carcinoma and the primary tumor in situ

scientific article published on 29 July 2011

A phase-II study of pegylated interferon alfa-2b for patients with metastatic renal cell carcinoma and removal of the primary tumor

scientific article published on 31 December 2004

A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen expression

scientific article published on 19 June 2005

A systematic literature review and network meta-analysis of effectiveness and safety outcomes in advanced melanoma

scientific article published on 25 October 2019

Acquired and intrinsic resistance in cancer immunotherapy

scientific article

Adjuvant treatment of in-transit melanoma: Addressing the knowledge gap left by clinical trials.

scientific article published in 2022

Adoptive cellular therapies: the current landscape

scientific article published on 23 November 2018

Adoptive transfer of tumor-infiltrating lymphocytes in melanoma: a viable treatment option

scientific article published on 03 October 2018

Advanced Melanoma: Current Treatment Options, Biomarkers, and Future Perspectives.

scientific article published on 21 November 2017

Age Does Matter in Adolescents and Young Adults versus Older Adults with Advanced Melanoma; A National Cohort Study Comparing Tumor Characteristics, Treatment Pattern, Toxicity and Response

scientific article published on 27 July 2020

Alternating Treatment With Pazopanib and Everolimus vs Continuous Pazopanib to Delay Disease Progression in Patients With Metastatic Clear Cell Renal Cell Cancer: The ROPETAR Randomized Clinical Trial

scientific article published on December 2016

An inducible caspase 9 safety switch can halt cell therapy-induced autoimmune disease

scientific article

Antiangiogenic therapy combined with immune checkpoint blockade in renal cancer

scientific article published on 11 April 2017

Antigen-specific TIL therapy for melanoma: A flexible platform for personalized cancer immunotherapy

scientific article published on 23 March 2016

Association of Anti-TNF with Decreased Survival in Steroid Refractory Ipilimumab and Anti-PD1-Treated Patients in the Dutch Melanoma Treatment Registry

scientific article published on 27 January 2020

Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8 + T cells

Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma

scientific article published on 16 February 2019

Avelumab plus axitinib versus sunitinib in advanced renal cell carcinoma: biomarker analysis of the phase 3 JAVELIN Renal 101 trial

scientific article published on 07 September 2020

Baseline tumor volume in assessing prognosis of patients with intermediate-risk synchronous metastatic renal cell carcinoma

scientific article published on 25 January 2016

Cancer immunotherapy – revisited ⬇️

scientific article published on August 1, 2011

Case Report of a Fatal Serious Adverse Event Upon Administration of T Cells Transduced With a MART-1-specific T-cell Receptor

scientific article published on 21 April 2015

Characterization of the tumor immune microenvironment in human papillomavirus-positive and -negative head and neck squamous cell carcinomas

scientific article published on 30 October 2020

Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma

scientific article

Comparison of Immediate vs Deferred Cytoreductive Nephrectomy in Patients With Synchronous Metastatic Renal Cell Carcinoma Receiving Sunitinib: The SURTIME Randomized Clinical Trial

scientific article published on 01 February 2019

Comparison of pre-treatment MSKCC and IMDC prognostic risk models in patients with synchronous metastatic renal cell carcinoma treated in the era of targeted therapy

scientific article published in February 2016

Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma

scientific article published on 08 September 2020

Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma

scientific article published on 05 December 2020

Corrigendum: High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma

scientific article published on 01 October 2016

Cytokine therapy response as a selection criterion for cytoreductive nephrectomy in metastatic renal clear-cell carcinoma of intermediate prognosis. Results and conclusions from a combined analysis

scientific article published on 27 June 2008

Cytomegalovirus in Steroid-Refractory Immune Checkpoint Inhibition-Related Colitis

scientific article published on 01 January 2020

DNA vaccination in oncology: current status, opportunities and perspectives

scientific article published on August 2010

Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: a multicentre, double-blind, phase 3 randomised controlled trial

scientific article

Deferred Cytoreductive Nephrectomy Following Presurgical Vascular Endothelial Growth Factor Receptor-targeted Therapy in Patients with Primary Metastatic Clear Cell Renal Cell Carcinoma: A Pooled Analysis of Prospective Trial Data

scientific article published on 16 January 2020

Design and use of conditional MHC class I ligands

scientific article

Detection of Early Onset of Hypophysitis by 18F-FDG PET-CT in a Patient With Advanced Stage Melanoma Treated With Ipilimumab ⬇️

scientific article published on April 1, 2013

Development of Ocular Rosacea following Combined Ipilimumab and Nivolumab Treatment for Metastatic Malignant Skin Melanoma

scientific article published on 2 February 2017

Do targeted agents offer clinical benefit as presurgical therapy?

scientific article published on 26 February 2013

Dutch Melanoma Treatment Registry: Quality assurance in the care of patients with metastatic melanoma in the Netherlands.

scientific article published on 25 December 2016

Dutch Oncology COVID-19 consortium: Outcome of COVID-19 in patients with cancer in a nationwide cohort study

scientific article published on 07 October 2020

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

scientific article published on 27 December 2018

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

scientific article published on 01 April 2020

EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors

scientific article published on 23 April 2020

Early cost-effectiveness of tumor infiltrating lymphocytes (TIL) for second line treatment in advanced melanoma: a model-based economic evaluation

Evaluating different adoption scenarios for TIL-therapy and the influence on its (early) cost-effectiveness

scientific article published on 31 July 2020

Five-Year Outcomes with Dabrafenib plus Trametinib in Metastatic Melanoma.

scientific article

Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

scientific article published on 28 September 2019

Fixed Dosing of Monoclonal Antibodies in Oncology

scientific article published on 28 July 2017

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

scientific article published on 09 August 2018

Genetic polymorphisms associated with a prolonged progression-free survival in patients with metastatic renal cell cancer treated with sunitinib

scientific article published on 19 November 2010

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy

scientific article published on 04 March 2019

HPV16 E7 DNA tattooing: safety, immunogenicity, and clinical response in patients with HPV-positive vulvar intraepithelial neoplasia.

scientific article

Healthcare Costs of Metastatic Cutaneous Melanoma in the Era of Immunotherapeutic and Targeted Drugs

scientific article published on 18 April 2020

High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma

scientific article published on 22 December 2014

High-throughput identification of antigen-specific TCRs by TCR gene capture

scientific article

How I treat MSI cancers with advanced disease.

scientific article published on 21 May 2019

Human telomerase reverse transcriptase-transduced human cytotoxic T cells suppress the growth of human melanoma in immunodeficient mice.

scientific article published on March 2004

Identification of the optimal combination dosing schedule of neoadjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma (OpACIN-neo): a multicentre, phase 2, randomised, controlled trial

scientific article published on 31 May 2019

Identification of two new serum protein profiles for renal cell carcinoma.

scientific article

Immune Checkpoint Inhibitors

scientific article published on 04 September 2015

Immune checkpoint inhibition-related colitis: symptoms, endoscopic features, histology and response to management.

scientific article

Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial

scientific article published on 13 May 2019

Immune-escape markers in relation to clinical outcome of advanced melanoma patients following immunotherapy.

scientific article

Immunological and antitumor effects of IL-23 as a cancer vaccine adjuvant

scientific article

Immunotherapeutic strategies: the melanoma example

scientific article published on July 2009

Immunotherapy of melanoma

article

Improved HIV-1 specific T-cell responses by short-interval DNA tattooing as compared to intramuscular immunization in non-human primates

article

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

scientific article

In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigens

scientific article published on 01 April 2002

In situ visualization of antigen-specific T cells in cryopreserved human tissues

scientific article

In vivo antigen stability affects DNA vaccine immunogenicity

scientific article published in August 2007

Increased numbers of small circulating endothelial cells in renal cell cancer patients treated with sunitinib

scientific article published on 11 February 2009

Intradermal vaccination by DNA tattooing

scientific article published in January 2014

Intravital imaging of fluorescent markers and FRET probes by DNA tattooing

scientific article published on 3 January 2007

Ipilimumab in pretreated metastastic uveal melanoma patients. Results of the Dutch Working group on Immunotherapy of Oncology (WIN-O).

scientific article published on 23 April 2013

Ipilimumab-Induced Sarcoidosis in a Patient With Metastatic Melanoma Undergoing Complete Remission ⬇️

scientific article published on November 28, 2011

Lactate dehydrogenase as a selection criterion for ipilimumab treatment in metastatic melanoma.

scientific article published on 8 March 2014

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy

scientific article published on 18 April 2010

Letter Regarding Editorial by Samuel Zagarella

scientific article published on 01 December 2020

Lipopolysaccharide contamination in intradermal DNA vaccination: toxic impurity or adjuvant?

scientific article published on 02 July 2009

Local administration of PF-3512676 CpG-B instigates tumor-specific CD8+ T-cell reactivity in melanoma patients

scientific article published on 01 July 2008

Long-term Survival and Clinical Benefit from Adoptive T-cell Transfer in Stage IV Melanoma Patients Is Determined by a Four-Parameter Tumor Immune Signature.

scientific article published on 10 January 2017

Long-term functionality of TCR-transduced T cells in vivo

scientific article published in May 2008

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

scientific article published on 15 December 2014

Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers

scientific article published on 03 December 2018

Lower risk of severe checkpoint inhibitor toxicity in more advanced disease

scientific article published on 01 November 2020

Manufacture of gene-modified human T-cells with a memory stem/central memory phenotype.

scientific article

Melanoma and immunotherapy bridge 2015 : Naples, Italy. 1-5 December 2015

scientific article

Metabolic Biomarker-Based BRAFV600 Mutation Association and Prediction in Melanoma

scientific article published on 03 September 2019

Metastatic Uveal Melanoma: Treatment Strategies and Survival-Results from the Dutch Melanoma Treatment Registry

scientific article published on 18 July 2019

Metronomic cyclophosphamide attenuates mTOR-mediated expansion of regulatory T cells, but does not impact clinical outcome in patients with metastatic renal cell cancer treated with everolimus

scientific article published on 11 February 2019

Microbead-assisted retroviral transduction for clinical application

scientific article published on 01 October 2010

Modest improvement in 20 years of kidney cancer care in the Netherlands

scientific article

NHS-IL2 combined with radiotherapy: preclinical rationale and phase Ib trial results in metastatic non-small cell lung cancer following first-line chemotherapy

scientific article

Naked plasmid DNA formulation: effect of different disaccharides on stability after lyophilisation

scientific article

Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers

scientific article published on 06 April 2020

Neoadjuvant immunotherapy with nivolumab and ipilimumab induces major pathological responses in patients with head and neck squamous cell carcinoma

scientific article published on 22 December 2021

Neoadjuvant nivolumab, ipilimumab, and celecoxib in MMR-proficient and MMR-deficient colon cancers: Final clinical analysis of the NICHE study.

scientific article published on 06 June 2022

Neoadjuvant sunitinib for surgically complex advanced renal cell cancer of doubtful resectability: initial experience with downsizing to reconsider cytoreductive surgery

scientific article published on 15 January 2009

Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma

scientific article published on 08 October 2018

Neoantigen landscape dynamics during human melanoma-T cell interactions

scientific article published on 27 June 2016

Normal values of serum S-100B predict prolonged survival for stage IV melanoma patients

scientific article published in February 2005

Observation after Cytoreductive Nephrectomy in Patients with Synchronous Not Completely Resected Metastases of Renal Cell Carcinoma

scientific article published on 02 August 2017

On the role of melanoma-specific CD8+ T-cell immunity in disease progression of advanced-stage melanoma patients

scientific article published on 01 July 2004

Optimization of intradermal vaccination by DNA tattooing in human skin

scientific article

Optimizing the efficacy of epitope-directed DNA vaccination

scientific article published on 01 May 2002

Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma.

scientific article published on 11 September 2017

Pembrolizumab in Small-Cell Lung Cancer: In Search of the Best Biomarker

scientific article published on 10 October 2017

Peripheral Blood TCR Repertoire Profiling May Facilitate Patient Stratification for Immunotherapy against Melanoma

scientific article published on 13 November 2018

Personalized response-directed surgery and adjuvant therapy after neoadjuvant ipilimumab and nivolumab in high-risk stage III melanoma: the PRADO trial

Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity

scientific article published on 10 September 2009

Phase I clinical study with multiple peptide vaccines in combination with tetanus toxoid and GM-CSF in advanced-stage HLA-A*0201-positive melanoma patients

scientific article

Phase Ib/II trial testing combined radiofrequency ablation and ipilimumab in uveal melanoma (SECIRA-UM)

scientific article published on 21 January 2020

Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

scientific article published on 15 August 2019

Postapproval trials versus patient registries: comparability of advanced melanoma patients with brain metastases

scientific article published on 01 February 2021

Preclinical development of T cell receptor gene therapy

scientific article published on 25 March 2009

Progression of a caval vein thrombus in two patients with primary renal cell carcinoma on pretreatment with sunitinib

scientific article published in May 2010

Publisher Correction: Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial

scientific article published on 01 July 2019

Re: Surgical resection of renal cell carcinoma after targeted therapyA. A. Thomas, B. I. Rini, A. J. Stephenson, J. A. Garcia, A. Fergany, V. Krishnamurthi, A. C. Novick, I. S. Gill, E. A. Klein, M. Zhou and S. C. Campbell J Urol 2009; 182: 881-886

scientific article published on 21 February 2010

Real-world Data of Nivolumab for Patients With Advanced Renal Cell Carcinoma in the Netherlands: An Analysis of Toxicity, Efficacy, and Predictive Markers

scientific article published on 14 October 2020

Real-world Outcomes of First-line Anti-PD-1 Therapy for Advanced Melanoma: A Nationwide Population-based Study

scientific article published on 14 August 2020

Real-world healthcare costs of ipilimumab in patients with advanced cutaneous melanoma in The Netherlands

scientific article published on 01 July 2018

Real-world use, safety, and survival of ipilimumab in metastatic cutaneous melanoma in The Netherlands.

scientific article published on 13 April 2018

Rechallenge patients with immune checkpoint inhibitors following severe immune-related adverse events: review of the literature and suggested prophylactic strategy

scientific article published on 01 June 2020

Reconsidering the management of patients with cancer with viral hepatitis in the era of immunotherapy

scientific article published on 01 October 2020

Relevance of Tumor-Infiltrating Immune Cell Composition and Functionality for Disease Outcome in Breast Cancer.

scientific article published on 13 October 2016

Requirements for effective antitumor responses of TCR transduced T cells

scientific article published on October 2008

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

scientific article

Safety and efficacy of nivolumab in challenging subgroups with advanced melanoma who progressed on or after ipilimumab treatment: A single-arm, open-label, phase II study (CheckMate 172)

scientific article published on 30 September 2019

Safety and efficacy of nivolumab in patients with rare melanoma subtypes who progressed on or after ipilimumab treatment: a single-arm, open-label, phase II study (CheckMate 172)

scientific article published on 21 August 2019

Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: an expanded-access trial

scientific article

Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study

scientific article

Selecting highly affine and well-expressed TCRs for gene therapy of melanoma

scientific article published on 27 July 2007

Sensorineural Hearing Loss After Adoptive Cell Immunotherapy for Melanoma Using MART-1 Specific T Cells: A Case Report and Its Pathophysiology

scientific article published on 01 August 2019

Serous Retinopathy Associated with Mitogen-Activated Protein Kinase Kinase Inhibition (Binimetinib) for Metastatic Cutaneous and Uveal Melanoma

scientific article published on 26 June 2015

Shielding the cationic charge of nanoparticle-formulated dermal DNA vaccines is essential for antigen expression and immunogenicity

scientific article published on 12 September 2009

Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice.

scholarly article

Skewing the T-cell repertoire by combined DNA vaccination, host conditioning, and adoptive transfer

scientific article published on 01 April 2008

Subtle CXCR3-Dependent Chemotaxis of CTLs within Infected Tissue Allows Efficient Target Localization.

scientific article published on 2 November 2015

Successful treatment of metastatic melanoma by adoptive transfer of blood-derived polyclonal tumor-specific CD4+ and CD8+ T cells in combination with low-dose interferon-alpha

scientific article

Sunitinib Alone or after Nephrectomy in Renal Cancer

Sunitinib for treatment of advanced renal cell cancer: primary tumor response

scientific article published in April 2008

Sunitinib pretreatment improves tumor-infiltrating lymphocyte expansion by reduction in intratumoral content of myeloid-derived suppressor cells in human renal cell carcinoma

scientific article

Sunitinib-induced changes in circulating endothelial cell-related proteins in patients with metastatic renal cell cancer

scientific article published on 08 November 2011

Sunitinib-induced myeloid lineage redistribution in renal cell cancer patients: CD1c+ dendritic cell frequency predicts progression-free survival

scientific article

Surgery for Unresectable Stage IIIC and IV Melanoma in the Era of New Systemic Therapy

scientific article published on 07 May 2020

Survival outcomes of patients with advanced mucosal melanoma diagnosed from 2013 to 2017 in the Netherlands - A nationwide population-based study

scientific article published on 04 August 2020

Susceptible loci associated with autoimmune disease as potential biomarkers for checkpoint inhibitor-induced immune-related adverse events

scientific article published on 21 July 2019

Switch to checkpoint inhibition after targeted therapy at time of progression or during ongoing response: A retrospective single-centre experience in patients with BRAF-mutated melanoma

scientific article published on 23 October 2019

Switching to Immune Checkpoint Inhibitors upon Response to Targeted Therapy; The Road to Long-Term Survival in Advanced Melanoma Patients with Highly Elevated Serum LDH?

scientific article published on 04 December 2019

Synthetic vehicles for DNA vaccination

scientific article published on January 2010

T-Cell Immune Function in Tumor, Skin, and Peripheral Blood of Advanced Stage Melanoma Patients: Implications for Immunotherapy

scientific article published on 12 July 2011

T-cell receptor gene therapy of established tumors in a murine melanoma model

scientific article

TIL therapy broadens the tumor-reactive CD8(+) T cell compartment in melanoma patients.

scientific article

Targeting CD4(+) T-helper cells improves the induction of antitumor responses in dendritic cell-based vaccination

scientific article published on 18 October 2012

Targeting self-antigens through allogeneic TCR gene transfer

scientific article published on 01 August 2006

Targeting the MAPK and PI3K pathways in combination with PD1 blockade in melanoma.

scientific article published on 14 October 2016

The Use of Dried Blood Spots for Pharmacokinetic Monitoring of Vemurafenib Treatment in Melanoma Patients

scientific article published on 26 February 2016

The effect of seasonal variation and secretion of sunitinib in sweat on the development of hand-foot syndrome

scientific article published on 31 August 2013

The outcome of ex vivo TIL expansion is highly influenced by spatial heterogeneity of the tumor T-cell repertoire and differences in intrinsic in vitro growth capacity between T-cell clones

scientific article published on 17 April 2020

The outcome of patients treated with sunitinib prior to planned nephrectomy in metastatic clear cell renal cancer

scientific article

Three-year pooled analysis of factors associated with clinical outcomes across dabrafenib and trametinib combination therapy phase 3 randomised trials

scientific article

Tilting the AXIS towards therapeutic limits in renal cancer

scientific article published on 04 November 2011

Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen.

scientific article

Toxicity patterns with immunomodulating antibodies and their combinations

scientific article published on 14 February 2015

Treatment guidance for lung cancer patients during the COVID-19 pandemic

scientific article published on 13 May 2020

Treatment of older patients with immune checkpoint inhibitors in routine clinical care as compared to inclusion in pivotal registration trials

Tumor infiltrating lymphocytes (TIL) therapy in metastatic melanoma: boosting of neoantigen-specific T cell reactivity and long-term follow-up

scientific article published on 01 August 2020

Tumor-specific CD8+ T cell reactivity in the sentinel lymph node of GM-CSF-treated stage I melanoma patients is associated with high myeloid dendritic cell content

scientific article published on 01 May 2006

Vaccine leads to memory loss

scientific article published on 01 March 2007

Validation of SELDI-TOF MS serum protein profiles for renal cell carcinoma in new populations

scientific article published in February 2007

Vemurafenib as neoadjuvant treatment for unresectable regional metastatic melanoma

scientific article published on 8 April 2013

Vemurafenib in BRAF-mutant metastatic melanoma patients in real-world clinical practice: prognostic factors associated with clinical outcomes

scientific article published on 01 August 2018

Vemurafenib plus cobimetinib in unresectable stage IIIc or stage IV melanoma: response monitoring and resistance prediction with positron emission tomography and tumor characteristics (REPOSIT): study protocol of a phase II, open-label, multicenter s

scientific article published on 15 September 2017

[Recent treatment results for metastatic melanoma: data from the Dutch Melanoma Treatment Registry]

scientific article published on 15 June 2018

γδ T cells are effectors of immunotherapy in cancers with HLA class I defects

scientific article published in 2023

Paulina is supported by:

About Paulina

Help