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List of works by James Spicer

"I Can Breathe Again!" Patients' Self-Management Strategies for Episodic Breathlessness in Advanced Disease, Derived From Qualitative Interviews.

scientific article published on 21 May 2016

A phase 1 study of AS1409, a novel antibody-cytokine fusion protein, in patients with malignant melanoma or renal cell carcinoma

scientific article published on 29 March 2011

A phase I study of afatinib combined with paclitaxel and bevacizumab in patients with advanced solid tumors.

scientific article

A phase I study of intravenous and oral rucaparib in combination with chemotherapy in patients with advanced solid tumours

scientific article

A phase I study to assess afatinib in combination with carboplatin or with carboplatin plus paclitaxel in patients with advanced solid tumors

scientific article published on 07 August 2018

A phase I/II study of epertinib plus trastuzumab with or without chemotherapy in patients with HER2-positive metastatic breast cancer

scientific article published on 31 December 2019

A phase II, open-label study of ramucirumab in combination with paclitaxel and carboplatin as first-line therapy in patients with stage IIIB/IV non-small-cell lung cancer

scientific article

A randomized phase II study of ganetespib, a heat shock protein 90 inhibitor, in combination with docetaxel in second-line therapy of advanced non-small cell lung cancer (GALAXY-1).

scientific article published on 21 May 2015

AllergoOncology - the impact of allergy in oncology: EAACI position paper.

scientific article published on 29 December 2016

AllergoOncology: Expression platform development and functional profiling of an anti-HER2 IgE antibody

scientific article published on 27 May 2019

An exploratory, open-label, randomized, multicenter study to investigate the pharmacodynamics of a glycoengineered antibody (imgatuzumab) and cetuximab in patients with operable head and neck squamous cell carcinoma.

scientific article published on 11 September 2017

An extended phase Ib study of epertinib, an orally active reversible dual EGFR/HER2 tyrosine kinase inhibitor, in patients with solid tumours

scientific article published on 06 September 2018

An immunologically relevant rodent model demonstrates safety of therapy using a tumour-specific IgE.

scientific article published on 13 April 2018

Anti-Folate Receptor Alpha-Directed Antibody Therapies Restrict the Growth of Triple-negative Breast Cancer

scientific article published on 01 August 2018

Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling

scientific article published on 17 January 2017

Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs).

scientific article published on 20 November 2017

Arginine Deprivation With Pegylated Arginine Deiminase in Patients With Argininosuccinate Synthetase 1-Deficient Malignant Pleural Mesothelioma: A Randomized Clinical Trial.

scientific article published on September 2016

BRAF inhibitors: resistance and the promise of combination treatments for melanoma

scientific article published on 3 August 2017

Beta-glucan contamination of pharmaceutical products: How much should we accept?

scientific article

CAR T-cell immunotherapy of MET-expressing malignant mesothelioma

scientific article published on 14 August 2017

Carboplatin versus two doses of cisplatin in combination with gemcitabine in the treatment of advanced non-small-cell lung cancer: Results from a British Thoracic Oncology Group randomised phase III trial

scientific article

Clinical pharmacokinetics of tyrosine kinase inhibitors: implications for therapeutic drug monitoring

scientific article

Combining Immune Checkpoint Inhibitors: Established and Emerging Targets and Strategies to Improve Outcomes in Melanoma

article

Comparative reactivity of human IgE to cynomolgus monkey and human effector cells and effects on IgE effector cell potency.

scientific article published on 14 January 2014

Design of a phase I clinical trial to evaluate intratumoral delivery of ErbB-targeted chimeric antigen receptor T-cells in locally advanced or recurrent head and neck cancer

scientific article

Development of downstream processing to minimize beta-glucan impurities in GMP-manufactured therapeutic antibodies.

scientific article published on 7 September 2016

Differential Survival characteristics of sarcomatoid subtype biphasic pleural mesothelioma

scientific article published on 30 October 2018

EGFR inhibition and more: a new generation growing up ⬇️

scientific article published on December 1, 2012

EGFR-mutated lung cancer in Li-Fraumeni syndrome.

scientific article published on 30 June 2014

Embracing model-based designs for dose-finding trials. ⬇️

scientific article

Episodic and continuous breathlessness: a new categorization of breathlessness.

scientific article

Evaluation of Antigen-Conjugated Fluorescent Beads to Identify Antigen-Specific B Cells.

scientific article published on 23 March 2018

Exome array analysis of adverse reactions to fluoropyrimidine-based therapy for gastrointestinal cancer.

scientific article published in May 2018

Extra-pleural pneumonectomy versus no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: clinical outcomes of the Mesothelioma and Radical Surgery (MARS) randomised feasibility study

scientific article

First-in-Human Study of PF-05212384 (PKI-587), a Small-Molecule, Intravenous, Dual Inhibitor of PI3K and mTOR in Patients with Advanced Cancer.

scientific article published on 4 February 2015

First-in-human study of CH5132799, an oral class I PI3K inhibitor, studying toxicity, pharmacokinetics, and pharmacodynamics, in patients with metastatic cancer

scientific article

Functionally Active Fc Mutant Antibodies Recognizing Cancer Antigens Generated Rapidly at High Yields.

scientific article published on 11 September 2017

Geographical variations in the use of cancer treatments are associated with survival of lung cancer patients.

scientific article published on 6 March 2018

HOX transcription factors are potential targets and markers in malignant mesothelioma

scientific article published in January 2015

IDEAL-CRT: A Phase 1/2 Trial of Isotoxic Dose-Escalated Radiation Therapy and Concurrent Chemotherapy in Patients With Stage II/III Non-Small Cell Lung Cancer.

scientific article published on 28 March 2016

IgE immunotherapy: a novel concept with promise for the treatment of cancer

scientific article published on January 2014

IgE re-programs alternatively-activated human macrophages towards pro-inflammatory anti-tumoural states

scientific article published on 05 April 2019

IgG subclass switching and clonal expansion in cutaneous melanoma and normal skin

scientific article published on 14 July 2016

Immune mediator expression signatures are associated with improved outcome in ovarian carcinoma

scientific article published on 28 March 2019

Induction chemotherapy, cytoreductive surgery and intraoperative hyperthermic pleural irrigation in patients with stage IVA thymoma ⬇️

scientific article published on December 20, 2010

Intracavitary 'T4 immunotherapy' of malignant mesothelioma using pan-ErbB re-targeted CAR T-cells.

scientific article published on 18 February 2017

LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1 ⬇️

scientific article published on December 1, 2001

MTL-CEBPA, a small activating RNA therapeutic up-regulating C/EBP-α, in patients with advanced liver cancer: a first-in-human, multi-centre, open-label, phase I trial

scientific article published on 01 May 2020

Microdroplet digital PCR: detection and quantitation of biomarkers in archived tissue and serial plasma samples in patients with lung cancer

scientific article published on January 2015

Nedaplatin: a new platinum for squamous lung cancer?

scientific article published on 27 October 2015

PATRIOT: A phase I study to assess the tolerability, safety and biological effects of a specific ataxia telangiectasia and Rad3-related (ATR) inhibitor (AZD6738) as a single agent and in combination with palliative radiation therapy in patients with

scientific article published on 08 June 2018

Patterns of disease progression on 18F-fluorodeoxyglucose positron emission tomography-computed tomography in patients with malignant pleural mesothelioma undergoing multimodality therapy with pleurectomy/decortication

scientific article published on 01 November 2013

Pharmacogenetics of pemetrexed combination therapy in lung cancer: pathway analysis reveals novel toxicity associations

scientific article published on 15 April 2014

Phase 1 Dose-Escalation Study of Pegylated Arginine Deiminase, Cisplatin, and Pemetrexed in Patients With Argininosuccinate Synthetase 1-Deficient Thoracic Cancers

scientific article published on 07 April 2017

Phase II, open-label trial to assess QTcF effects, pharmacokinetics and antitumor activity of afatinib in patients with relapsed or refractory solid tumors

scientific article published on 2 October 2013

Pleurectomy/decortication, hyperthermic pleural lavage with povidone-iodine, prophylactic radiotherapy, and systemic chemotherapy in patients with malignant pleural mesothelioma: A 10-year experience

scientific article published in February 2015

Randomized Prospective Biomarker Trial of ERCC1 for Comparing Platinum and Nonplatinum Therapy in Advanced Non-Small-Cell Lung Cancer: ERCC1 Trial (ET).

scientific article published on 28 November 2016

Repurposing tin mesoporphyrin as an immune checkpoint inhibitor shows therapeutic efficacy in preclinical models of cancer

scientific article published on 16 January 2018

Routine EGFR and KRAS Mutation analysis using COLD-PCR in non-small cell lung cancer ⬇️

scientific article published on August 1, 2012

Screening for EGFR and KRAS mutations in endobronchial ultrasound derived transbronchial needle aspirates in non-small cell lung cancer using COLD-PCR.

scientific article

Survival of patients with small cell lung cancer undergoing lung resection in England, 1998-2009.

scientific article published on 30 October 2013

Targeting folate receptor alpha for cancer treatment

scientific article

The impact of socioeconomic status on access to cancer clinical trials

scientific article

The role of the HGF/Met axis in mesothelioma.

scientific article published on April 2016

Therapeutic targets and new directions for antibodies developed for ovarian cancer.

scientific article published on 05 August 2016

Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1-2 trial

scientific article published on 08 February 2019

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