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List of works by Diomedes E Logothetis

A Critical Gating Switch at a Modulatory Site in Neuronal Kir3 Channels

scientific article

A computational model predicts that Gβγ acts at a cleft between channel subunits to activate GIRK1 channels.

scientific article published on 13 August 2013

A sodium-mediated structural switch that controls the sensitivity of Kir channels to PtdIns(4,5)P(2).

scientific article published on 14 September 2008

A unique alkaline pH-regulated and fatty acid-activated tandem pore domain potassium channel (K₂P) from a marine sponge.

scientific article

Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia

scientific article

Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies

scientific article

An analytical tool for elucidating ion-channel molecular mechanisms from macroscopic current traces

scientific article published on 20 July 2010

An inactivation gate in the selectivity filter of KCNQ1 potassium channels

scientific article

Assaying Phosphatidylinositol Bisphosphate Regulation of Potassium Channels ⬇️

scientific article published on January 1, 2002

Ca(2+)-Calmodulin and PIP2 interactions at the proximal C-terminus of Kv7 channels

scientific article published on 4 October 2017

Channelopathies linked to plasma membrane phosphoinositides.

scientific article published on 16 April 2010

Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators

scientific article published on 20 May 2004

Cholesterol sensitivity of KIR2.1 depends on functional inter-links between the N and C termini.

scientific article published on 27 June 2013

Cholesterol sensitivity of KIR2.1 is controlled by a belt of residues around the cytosolic pore

scientific article

Comparative analysis of cholesterol sensitivity of Kir channels: role of the CD loop

scientific article published on 20 January 2010

Competition of calcified calmodulin N lobe and PIP2 to an LQT mutation site in Kv7.1 channel

scientific article published on 17 January 2017

Correction: Elucidation of molecular kinetic schemes from macroscopic traces using system identification

article

Critical determinants of the G protein gamma subunits in the Gbetagamma stimulation of G protein-activated inwardly rectifying potassium (GIRK) channel activity

scientific article published on 15 September 2003

Cross-signaling in metabotropic glutamate 2 and serotonin 2A receptor heteromers in mammalian cells

scientific article

D3 dopamine autoreceptors do not activate G-protein-gated inwardly rectifying potassium channel currents in substantia nigra dopamine neurons.

scientific article published on July 2003

Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs.

scientific article

Direct modulation of P2X1 receptor-channels by the lipid phosphatidylinositol 4,5-bisphosphate

scientific article published on 3 June 2008

Distant cytosolic residues mediate a two-way molecular switch that controls the modulation of inwardly rectifying potassium (Kir) channels by cholesterol and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)).

scientific article

Distinct sites on G protein beta gamma subunits regulate different effector functions

scientific article

Dual Regulation of Voltage-Sensitive Ion Channels by PIP(2).

scientific article published on 25 September 2012

Elucidation of molecular kinetic schemes from macroscopic traces using system identification.

scientific article

Endocytosis and degradative sorting of NMDA receptors by conserved membrane-proximal signals.

scientific article

Epilepsy-Related Slack Channel Mutants Lead to Channel Over-Activity by Two Different Mechanisms

scientific article

Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine A2A-Dopamine D2 Receptor Heterotetramers and Adenylyl Cyclase.

scientific article published on 9 April 2018

G beta gamma and KACh: old story, new insights

scientific article

G protein {beta}{gamma} gating confers volatile anesthetic inhibition to Kir3 channels ⬇️

scientific article published on November 2, 2010

G protein-coupled receptor signaling to Kir channels in Xenopus oocytes

scientific article published on January 2014

Gating of a G protein-sensitive mammalian Kir3.1 prokaryotic Kir channel chimera in planar lipid bilayers

scientific article

Gβ Residues That Do Not Interact with Gα Underlie Agonist-independent Activity of K+ Channels ⬇️

scientific article published on November 13, 2001

Hydrogen sulfide inhibits Kir2 and Kir3 channels by decreasing sensitivity to the phospholipid PIP2.

scientific article published on 9 January 2018

Hydrogen-bonding dynamics between adjacent blades in G-protein beta-subunit regulates GIRK channel activation

scientific article

Hypercholesterolemia induces up-regulation of KACh cardiac currents via a mechanism independent of phosphatidylinositol 4,5-bisphosphate and Gβγ

scientific article published on 15 December 2011

Identification of Critical Residues Controlling G Protein-gated Inwardly Rectifying K+ Channel Activity through Interactions with the βγ Subunits of G Proteins ⬇️

scientific article (publication date: 22 February 2002)

Identification of a C-terminus domain critical for the sensitivity of Kir2.1 to cholesterol

scholarly article

Identification of novel cholesterol-binding regions in Kir2 channels

scientific article published on 09 September 2013

Identification of the Conformational transition pathway in PIP2 Opening Kir Channels

scientific article published on 11 June 2015

Mechanism of PLC-mediated Kir3 current inhibition

scientific article

Molecular characteristics of phosphoinositide binding

scientific article published on 23 June 2007

Molecular determinants responsible for differential cellular distribution of G protein-gated inwardly rectifying K+ channels

scientific article

Molecular overlap in the regulation of SK channels by small molecules and phosphoinositides

scientific article

Mutations in Nature Conferred a High Affinity Phosphatidylinositol 4,5-Bisphosphate-binding Site in Vertebrate Inwardly Rectifying Potassium Channels

scientific article published on 8 May 2015

New roles for a key glycine and its neighboring residue in potassium channel gating

scientific article

On the mechanism of GIRK2 channel gating by phosphatidylinositol bisphosphate, sodium, and the Gβγ dimer

scientific article published on 28 October 2019

PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain

scientific article published on 24 April 2005

PIP 2 controls voltage-sensor movement and pore opening of Kv channels through the S4–S5 linker ⬇️

scientific article published on August 13, 2012

PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents

scientific article published in March 2003

PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels.

scientific article

Phosphatidylinositol 4,5-bisphosphate activates Slo3 currents and its hydrolysis underlies the epidermal growth factor-induced current inhibition

scientific article

Phosphatidylinositol-4,5-bisphosphate regulates NMDA receptor activity through alpha-actinin

scientific article

Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation ⬇️

scientific article published on November 24, 2010

Phosphoinositide control of membrane protein function: a frontier led by studies on ion channels.

scientific article published on 2 October 2014

Phosphoinositide-mediated gating of inwardly rectifying K(+) channels

scientific article published on 23 May 2007

Phosphoinositides regulate P2X4 ATP-gated channels through direct interactions

scientific article

Positive allosteric modulators of metabotropic glutamate 2 receptors in schizophrenia treatment

scientific article

Potassium channel gating in the absence of the highly conserved glycine of the inner transmembrane helix

scientific article published on 23 May 2007

Protein Binding Pocket Optimization for Virtual High-Throughput Screening (vHTS) Drug Discovery

scientific article published on 10 June 2020

Protein kinase A modulates PLC-dependent regulation and PIP2-sensitivity of K+ channels

scientific article

Reformulating a Pharmacophore for 5-HT2A Serotonin Receptor Antagonists.

scientific article published on 6 July 2016

Regulation of ATP-gated P2X receptors by phosphoinositides

scientific article published on 4 May 2007

Regulation of Kv2.1 channel inactivation by phosphatidylinositol 4,5-bisphosphate.

scientific article

SLO-2 isoforms with unique Ca2+- and voltage-dependence characteristics confer sensitivity to hypoxia inC. elegans ⬇️

scientific article published on April 16, 2013

Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex

scientific article published on 10 August 2014

Specificity of Gbetagamma signaling to Kir3 channels depends on the helical domain of pertussis toxin-sensitive Galpha subunits

scientific article published on 14 September 2007

Specificity of activation by phosphoinositides determines lipid regulation of Kir channels

scholarly article

Stoichiometry of Kir channels with phosphatidylinositol bisphosphate

scientific article published on 01 January 2008

Structural determinants of phosphatidylinositol 4,5-bisphosphate (PIP2) regulation of BK channel activity through the RCK1 Ca2+ coordination site

scientific article

Subtype-specific regulation of P2X3 and P2X2/3 receptors by phosphoinositides in peripheral nociceptors.

scientific article published on 11 August 2009

The (beta)gamma subunits of G proteins gate a K(+) channel by pivoted bending of a transmembrane segment

scientific article published on September 2002

The Cytosolic GH Loop Regulates the Phosphatidylinositol 4,5-Bisphosphate-induced Gating Kinetics of Kir2 Channels ⬇️

scientific article published on October 2, 2012

The ICl,swell inhibitor DCPIB blocks Kir channels that possess weak affinity for PIP2.

scientific article published on 02 February 2016

The Molecular Mechanism by which PIP2 Opens the Intracellular G-Loop Gate of a Kir3.1 Channel ⬇️

scientific article published on May 2, 2012

The Molecular Mechanism of Opening the Helix Bundle Crossing (HBC) Gate of a Kir Channel

scientific article published on 21 July 2016

The RCK2 domain uses a coordination site present in Kir channels to confer sodium sensitivity to Slo2.2 channels

scientific article published on June 2010

The small molecule GAT1508 activates brain-specific GIRK1/2 channel heteromers and facilitates conditioned fear extinction in rodents

scientific article published on 17 January 2020

Three pairs of weak interactions precisely regulate the G-loop gate of Kir2.1 channel

scientific article

Unifying Mechanism of Controlling Kir3 Channel Activity by G Proteins and Phosphoinositides

scientific article published on 22 June 2015

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