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List of works by Chunzhang Yang

A Transgenic Mouse Model of Pacak⁻Zhuang Syndrome with An Epas1 Gain-of-Function Mutation

scientific article published on 14 May 2019

A novel EPAS1/HIF2A germline mutation in a congenital polycythemia with paraganglioma ⬇️

scientific article published on October 23, 2012

A novel splicing site IRP1 somatic mutation in a patient with pheochromocytoma and JAK2V617F positive polycythemia vera: a case report.

scientific article published on 13 March 2018

Acetylation within the N- and C-terminal domains of Src regulate distinct roles of STAT3-mediated tumorigenesis.

scientific article published on 12 March 2018

Activation of hypoxia signaling induces phenotypic transformation of glioma cells: implications for bevacizumab antiangiogenic therapy

scientific article published in May 2015

An innovative approach to the treatment of Gaucher disease and possibly other metabolic disorders of the brain ⬇️

scientific article published on July 20, 2012

Anthracyclines suppress pheochromocytoma cell characteristics, including metastasis, through inhibition of the hypoxia signaling pathway

scientific article

Application of Peptide Nucleic Acid-based Assays Toward Detection of Somatic Mosaicism

scientific article published on 26 April 2016

Blockade of Glutathione Metabolism in IDH1-Mutated Glioma

scientific article published on 23 September 2019

Brusatol, an NRF2 inhibitor for future cancer therapeutic.

scientific article published on 6 June 2019

Carbon dioxide influence on nitric oxide production in endothelial cells and astrocytes: Cellular mechanisms ⬇️

scientific article published on February 26, 2011

Celastrol increases glucocerebrosidase activity in Gaucher disease by modulating molecular chaperones.

scientific article published on 18 December 2013

Characterization of the blood-brain barrier of metastatic and primary malignant neoplasms.

scientific article published on 26 April 2013

Chemosensitivity of IDH1-Mutated Gliomas Due to an Impairment in PARP1-Mediated DNA Repair

scientific article published on 15 February 2017

Combination of PARP inhibitor and temozolomide to suppress chordoma progression

scientific article published on 14 June 2019

De novo VHL germline mutation detected in a patient with mild clinical phenotype of von Hippel-Lindau disease

scientific article published on 28 March 2014

Evaluating In Vitro DNA Damage Using Comet Assay

scientific article published on 11 October 2017

First report of bilateral pheochromocytoma in the clinical spectrum of HIF2A-related polycythemia-paraganglioma syndrome.

scientific article published on 28 March 2013

HIF2A gain-of-function mutations detected in duodenal gangliocytic paraganglioma.

scientific article published on 29 April 2016

Histone deacetylase inhibitors are neuroprotective and preserve NGF-mediated cell survival following traumatic brain injury ⬇️

scientific article published on June 10, 2013

Histone deacetylase inhibitors increase glucocerebrosidase activity in Gaucher disease by modulation of molecular chaperones ⬇️

scientific article published on December 31, 2012

Histone deacetylase inhibitors prevent the degradation and restore the activity of glucocerebrosidase in Gaucher disease ⬇️

scientific article published on December 12, 2011

Hypoxia-Inducible Factor Signaling in Pheochromocytoma: Turning the Rudder in the Right Direction ⬇️

scientific article published on August 12, 2013

Inhibition of protein phosphatase 2A with the small molecule LB100 overcomes cell cycle arrest in osteosarcoma after cisplatin treatment.

scientific article

Isocitrate Dehydrogenase Mutations in Glioma: Genetics, Biochemistry, and Clinical Indications

scientific article published on 20 August 2020

LB100, a small molecule inhibitor of PP2A with potent chemo- and radio-sensitizing potential

scientific article

Missense mutations in the human SDHB gene increase protein degradation without altering intrinsic enzymatic function ⬇️

scientific article published on July 26, 2012

Mutant glucocerebrosidase in Gaucher disease recruits Hsp27 to the Hsp90 chaperone complex for proteasomal degradation

scientific article

New developments in the pathogenesis and therapeutic targeting of the IDH1 mutation in glioma

scientific article

New syndrome of paraganglioma and somatostatinoma associated with polycythemia

scientific article published on 18 March 2013

Nonmosaic somatic HIF2A mutations associated with late onset polycythemia-paraganglioma syndrome: Newly recognized subclass of polycythemia-paraganglioma syndrome

scientific article published on 15 January 2019

Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas ⬇️

scientific article published on January 29, 2013

Novel Targeting of Transcription and Metabolism in Glioblastoma

scientific article published on 18 December 2017

Novel compound VHL heterozygosity (VHL T124A/L188V) associated with congenital polycythaemia ⬇️

scientific article published on June 17, 2013

Novel homozygous VHL mutation in exon 2 is associated with congenital polycythemia but not with cancer.

scientific article published on 28 March 2013

Novel insights into the polycythemia-paraganglioma-somatostatinoma syndrome

scientific article

Pheochromocytomas and Paragangliomas: From Genetic Diversity to Targeted Therapies

scientific article published on 28 March 2019

Protein Phosphatase 2A Inhibition with LB100 Enhances Radiation-Induced Mitotic Catastrophe and Tumor Growth Delay in Glioblastoma.

scientific article published on 4 May 2015

Proteostasis Modulators Prolong Missense VHL Protein Activity and Halt Tumor Progression ⬇️

scientific article published on January 10, 2013

Regulation and dysregulation of astrocyte activation and implications in tumor formation ⬇️

scientific article published on February 19, 2013

Somatic HIF2A gain-of-function mutations in paraganglioma with polycythemia

scientific article

Somatic IDH1 mutation in a pituitary adenoma of a patient with Maffucci syndrome

scientific article published on 16 October 2015

Targeting IDH1-Mutated Malignancies with NRF2 Blockade

scientific article published on 01 October 2019

Targeting NAD+/PARP DNA repair pathway as a novel therapeutic approach to SDHB-mutated cluster I pheochromocytoma and paraganglioma.

scientific article published on 10 April 2018

Targeting NRF2-Governed Glutathione Synthesis for SDHB-Mutated Pheochromocytoma and Paraganglioma

scientific article published on 23 January 2020

The p38 signaling pathway mediates quiescence of glioma stem cells by regulating epidermal growth factor receptor trafficking

scientific article

Therapeutic targeting of SDHB-mutated pheochromocytoma/paraganglioma with pharmacologic ascorbic acid

scientific article published on 09 March 2020

Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism

scientific article published on 20 April 2020

Tumor derived vasculogenesis in von Hippel-Lindau disease-associated tumors.

scientific article published on 17 February 2014

Vorinostat suppresses hypoxia signaling by modulating nuclear translocation of hypoxia inducible factor 1 alpha.

scientific article published on 23 May 2017

ZEB1 expression is increased in IDH1-mutant lower-grade gliomas.

scientific article published on 27 August 2016

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