List of works - Shoshana Yakar

Autologous bone marrow stromal cells genetically engineered to secrete an igf-I receptor decoy prevent the growth of liver metastases

scientific article

Biological effects of growth hormone on carbohydrate and lipid metabolism.

scientific article

Central effects of humanin on hepatic triglyceride secretion

scientific article published on 9 June 2015

Circulating IGF-1 and its role in cancer: lessons from the IGF-1 gene deletion (LID) mouse.

scientific article

Circulating levels of IGF-1 directly regulate bone growth and density

scientific article

Clinical relevance of systemic and local IGF-I.

scientific article

Does the GH/IGF-1 axis contribute to skeletal sexual dimorphism? Evidence from mouse studies.

scientific article

Effects of GH/IGF on the Aging Mitochondria

scientific article published on 02 June 2020

Elevated circulating IGF-I promotes mammary gland development and proliferation

scientific article

Elevated levels of insulin-like growth factor (IGF)-I in serum rescue the severe growth retardation of IGF-I null mice

scientific article

Elevated serum IGF-1 levels synergize PTH action on the skeleton only when the tissue IGF-1 axis is intact.

scientific article

Elevated serum levels of IGF-1 are sufficient to establish normal body size and skeletal properties even in the absence of tissue IGF-1.

scientific article

Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy

scientific article published on December 2011

From mouse to man: redefining the role of insulin-like growth factor-I in the acquisition of bone mass.

scientific article

Genetic reduction of circulating insulin-like growth factor-1 inhibits azoxymethane-induced colon tumorigenesis in mice

scientific article

Growth hormone protects against ovariectomy-induced bone loss in states of low circulating insulin-like growth factor (IGF-1).

scientific article

Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice

scientific article

Growth hormone regulates the balance between bone formation and bone marrow adiposity

scientific article

High-efficient FLPo deleter mice in C57BL/6J background

scientific article

Hyperinsulinemia enhances c-Myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse model of type 2 diabetes ⬇️

scientific article published on January 7, 2012

Hyperinsulinemia promotes metastasis to the lung in a mouse model of Her2-mediated breast cancer

scientific article

IGF-1 and bone: New discoveries from mouse models

scientific article

Increased serum IGF-1 levels protect the musculoskeletal system but are associated with elevated oxidative stress markers and increased mortality independent of tissue igf1 gene expression

scientific article

Induction of somatopause in adult mice compromises bone morphology and exacerbates bone loss during aging

scientific article published on 23 November 2021

Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice

scientific article

Insulin-like growth factor 1 physiology: lessons from mouse models

scientific article

Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation

scientific journal article

Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis

scientific article

Insulin-like growth factor-I: compartmentalization within the somatotropic axis?

scientific article

Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes

scientific article

Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression

scientific article

Low IGF-I Bioavailability Impairs Growth and Glucose Metabolism in a Mouse Model of Human PAPPA2 p.Ala1033Val Mutation

scientific article published on 01 June 2019

Mammalian target of rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes

scientific article

Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I.

scientific article

Osteocyte Apoptosis Caused by Hindlimb Unloading is Required to Trigger Osteocyte RANKL Production and Subsequent Resorption of Cortical and Trabecular Bone in Mice Femurs

scientific article

Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis ⬇️

scientific article published on January 23, 2013

Reductions in serum IGF-1 during aging impair health span.

scientific article

Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models.

scientific article published on 28 September 2015

Serum IGF-1 affects skeletal acquisition in a temporal and compartment-specific manner

scientific article

Sex-specific regulation of body size and bone slenderness by the acid labile subunit

scientific article

Skeletal growth and bone mineral acquisition in type 1 diabetic children; abnormalities of the GH/IGF-1 axis.

scientific article published on 28 April 2017

Skeletal muscle growth hormone receptor signaling regulates basal, but not fasting-induced, lipid oxidation

scientific article

TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival

scientific article

Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression

scientific article

Targeted loss of GHR signaling in mouse skeletal muscle protects against high-fat diet-induced metabolic deterioration

scientific article published on January 2012

The effect of dipeptidyl peptidase-IV inhibition on bone in a mouse model of type 2 diabetes

scientific article

The growth hormone-insulin like growth factor axis revisited: lessons from IGF-1 and IGF-1 receptor gene targeting

scientific article

The insulin-like growth factor-1 binding protein acid-labile subunit alters mesenchymal stromal cell fate

scientific article

The intricate role of growth hormone in metabolism.

scientific article

The role of circulating IGF-I: lessons from human and animal models

scientific article

The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models

scientific article

Type 2 diabetic mice demonstrate slender long bones with increased fragility secondary to increased osteoclastogenesis

scientific article

Unbound (bioavailable) IGF1 enhances somatic growth.

scientific article

List of works by Shoshana Yakar

Autologous bone marrow stromal cells genetically engineered to secrete an igf-I receptor decoy prevent the growth of liver metastases

Biological effects of growth hormone on carbohydrate and lipid metabolism.

Central effects of humanin on hepatic triglyceride secretion

Circulating IGF-1 and its role in cancer: lessons from the IGF-1 gene deletion (LID) mouse.

Circulating levels of IGF-1 directly regulate bone growth and density

Clinical relevance of systemic and local IGF-I.

Does the GH/IGF-1 axis contribute to skeletal sexual dimorphism? Evidence from mouse studies.

Effects of GH/IGF on the Aging Mitochondria

Elevated circulating IGF-I promotes mammary gland development and proliferation

Elevated levels of insulin-like growth factor (IGF)-I in serum rescue the severe growth retardation of IGF-I null mice

Elevated serum IGF-1 levels synergize PTH action on the skeleton only when the tissue IGF-1 axis is intact.

Elevated serum levels of IGF-1 are sufficient to establish normal body size and skeletal properties even in the absence of tissue IGF-1.

Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy

From mouse to man: redefining the role of insulin-like growth factor-I in the acquisition of bone mass.

Genetic reduction of circulating insulin-like growth factor-1 inhibits azoxymethane-induced colon tumorigenesis in mice

Growth hormone protects against ovariectomy-induced bone loss in states of low circulating insulin-like growth factor (IGF-1).

Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice

Growth hormone regulates the balance between bone formation and bone marrow adiposity

High-efficient FLPo deleter mice in C57BL/6J background

Hyperinsulinemia enhances c-Myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse model of type 2 diabetes ⬇️

Hyperinsulinemia promotes metastasis to the lung in a mouse model of Her2-mediated breast cancer

IGF-1 and bone: New discoveries from mouse models

Increased serum IGF-1 levels protect the musculoskeletal system but are associated with elevated oxidative stress markers and increased mortality independent of tissue igf1 gene expression

Induction of somatopause in adult mice compromises bone morphology and exacerbates bone loss during aging

Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice

Insulin-like growth factor 1 physiology: lessons from mouse models

Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation

Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis

Insulin-like growth factor-I: compartmentalization within the somatotropic axis?

Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes

Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression

Low IGF-I Bioavailability Impairs Growth and Glucose Metabolism in a Mouse Model of Human PAPPA2 p.Ala1033Val Mutation

Mammalian target of rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes

Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I.

Osteocyte Apoptosis Caused by Hindlimb Unloading is Required to Trigger Osteocyte RANKL Production and Subsequent Resorption of Cortical and Trabecular Bone in Mice Femurs

Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis ⬇️

Reductions in serum IGF-1 during aging impair health span.

Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models.

Serum IGF-1 affects skeletal acquisition in a temporal and compartment-specific manner

Sex-specific regulation of body size and bone slenderness by the acid labile subunit

Skeletal growth and bone mineral acquisition in type 1 diabetic children; abnormalities of the GH/IGF-1 axis.

Skeletal muscle growth hormone receptor signaling regulates basal, but not fasting-induced, lipid oxidation

TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival

Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression

Targeted loss of GHR signaling in mouse skeletal muscle protects against high-fat diet-induced metabolic deterioration

The effect of dipeptidyl peptidase-IV inhibition on bone in a mouse model of type 2 diabetes

The growth hormone-insulin like growth factor axis revisited: lessons from IGF-1 and IGF-1 receptor gene targeting

The insulin-like growth factor-1 binding protein acid-labile subunit alters mesenchymal stromal cell fate

The intricate role of growth hormone in metabolism.

The role of circulating IGF-I: lessons from human and animal models

The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models

Type 2 diabetic mice demonstrate slender long bones with increased fragility secondary to increased osteoclastogenesis

Unbound (bioavailable) IGF1 enhances somatic growth.