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List of works by Ruth Palmer

A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster

scientific article published on 4 July 2003

A nonphosphorylated 14-3-3 binding motif on exoenzyme S that is functional in vivo

scientific article

ALK and NSCLC: Targeted therapy with ALK inhibitors ⬇️

scientific article published on January 1, 2011

ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation

scientific article published on 07 January 2021

Activating ALK mutations found in neuroblastoma are inhibited by Crizotinib and NVP-TAE684 ⬇️

scientific article published on December 15, 2011

Activation of the MAP kinase pathway by c-Kit is PI-3 kinase dependent in hematopoietic progenitor/stem cell lines

scientific article published on 2 March 2004

Analysis of ALK, MYCN, and the ALK ligand ALKAL2 (FAM150B/AUGα) in neuroblastoma patient samples with chromosome arm 2p rearrangements

scientific article published on 24 July 2019

Anaplastic Lymphoma Kinase in Human Cancer ⬇️

scientific article published on January 1, 2012

Anaplastic lymphoma kinase L1198F and G1201E mutations identified in anaplastic thyroid cancer patients are not ligand-independent.

scientific article published on 24 December 2016

Anaplastic lymphoma kinase: signalling in development and disease

scientific article

Appearance of the novel activating F1174S ALK mutation in neuroblastoma correlates with aggressive tumor progression and unresponsiveness to therapy

scientific article published on 8 November 2010

Brigatinib, an anaplastic lymphoma kinase inhibitor, abrogates activity and growth in ALK-positive neuroblastoma cells, Drosophila and mice

scientific article

Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma.

scientific article published on 25 October 2012

Characterization of Drosophila Nidogen/entactin reveals roles in basement membrane stability, barrier function and nervous system patterning

scientific article published on 16 January 2019

Characterization of the expression of the ALK receptor tyrosine kinase in mice

scientific article published on 2 February 2006

Clinical response of the novel activating ALK-I1171T mutation in neuroblastoma to the ALK inhibitor ceritinib

scientific article published on 01 August 2018

Crizotinib--latest champion in the cancer wars? ⬇️

scientific article published on October 28, 2010

Delineation of exoenzyme S residues that mediate the interaction with 14-3-3 and its biological activity

scientific article published in February 2006

Electrostatic interactions play a minor role in the binding of ExoS to 14-3-3 proteins

scientific article

Exoenzyme S of Pseudomonas aeruginosa is not able to induce apoptosis when cells express activated proteins, such as Ras or protein kinase B/Akt

scientific article published on May 2006

Exoenzyme S shows selective ADP-ribosylation and GTPase-activating protein (GAP) activities towards small GTPases in vivo

scientific article published on November 2002

FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase

scientific journal article

Goliath family E3 ligases regulate the recycling endosome pathway via VAMP3 ubiquitylation.

scientific article published on 25 January 2013

Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation.

scientific article published on 30 November 2006

Identification of the Wallenda JNKKK as an Alk suppressor reveals increased competitiveness of Alk-expressing cells

scientific article published on 11 September 2020

Intragenic anaplastic lymphoma kinase (ALK) rearrangements: translocations as a novel mechanism of ALK activation in neuroblastoma tumors.

scientific article published on 23 September 2014

Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion.

scientific article published in October 2003

Jeb/Alk signalling regulates the Lame duck GLI family transcription factor in the Drosophila visceral mesoderm.

scientific article

MEK inhibitor trametinib does not prevent the growth of anaplastic lymphoma kinase (ALK)-addicted neuroblastomas

scientific article published on 28 November 2017

Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology

scientific article

Novel Mechanisms of ALK Activation Revealed by Analysis of the Y1278S Neuroblastoma Mutation

scientific article published on 30 October 2017

Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways

article

Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells.

scientific article published on 22 August 2013

Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis

scientific article

Targeted Disruption of ALK Reveals a Potential Role in Hypogonadotropic Hypogonadism

scientific article

The Neuroblastoma ALK(I1250T) Mutation Is a Kinase-Dead RTK In Vitro and In Vivo ⬇️

scientific article published on August 1, 2011

The Zic family homologue Odd-paired regulates Alk expression in Drosophila

scientific article

The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma

scientific article published on 28 October 2014

The ligand Jelly Belly (Jeb) activates the Drosophila Alk RTK to drive PC12 cell differentiation, but is unable to activate the mouse ALK RTK.

scientific article published in May 2007

The scaffolding protein Cnk binds to the receptor tyrosine kinase Alk to promote visceral founder cell specification in Drosophila.

scientific article

model of myosin myopathy rescued by overexpression of a TRIM-protein family member

scientific article published on 26 June 2018

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