List of works by Diana van Heemst

A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots

scientific article published on 23 February 2015

A Workflow for Missing Values Imputation of Untargeted Metabolomics Data

scientific article published on 26 November 2020

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

scientific article published on 02 August 2019

A meta-analysis of genome-wide association studies identifies multiple longevity genes

scientific article published on 14 August 2019

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function

scientific article

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

scientific article published on 20 August 2019

Accuracy of Continuous Glucose Monitoring Measurements in Normo-Glycemic Individuals

scientific article published on 7 October 2015

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

scientific article published on 22 September 2016

Ambulant 24-h glucose rhythms mark calendar and biological age in apparently healthy individuals

scientific article published on 06 February 2013

An Internet-Based Physical Activity Intervention to Improve Quality of Life of Inactive Older Adults: A Randomized Controlled Trial.

scientific article published on 27 April 2016

ApoE plasma levels and risk of cardiovascular mortality in old age

scientific article

Are skin senescence and immunosenescence linked within individuals?

scientific article published on 06 May 2019

Assessment of the contribution of APOE gene variants to metabolic phenotypes associated with familial longevity at middle age.

scientific article published on 15 August 2016

Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study

scientific article

Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes.

scientific article

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

scientific article published on 04 September 2019

Association of liver enzymes and computed tomography markers of liver steatosis with familial longevity

scientific article (publication date: 2014)

Associations between Lifestyle Factors and Vitamin E Metabolites in the General Population

scientific article published on 15 December 2020

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

article

Blood lipids influence DNA methylation in circulating cells

scientific article published on 27 June 2016

C-reactive protein and glucose regulation in familial longevity

scientific article published on 19 January 2011

C. elegans DAF-12, Nuclear Hormone Receptors and human longevity and disease at old age.

scientific article

Characterization of the Hypothalamic-Pituitary-Adrenal-Axis in Familial Longevity under Resting Conditions

scientific article published on 20 July 2015

Chronic inhibition of the respiratory chain in human fibroblast cultures: differential responses related to subject chronological and biological age.

scientific article published on 10 November 2011

Circulating Thyroid Hormone Profile in Response to a Triiodothyronine Challenge in Familial Longevity

scientific article published on 20 August 2020

Classification for Longevity Potential: The Use of Novel Biomarkers ⬇️

scientific article published on 28 October 2016

Colony formation and colony size do not reflect the onset of replicative senescence in human fibroblasts

scientific article published in July 2008

Correction: Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R.

scientific article published on 10 May 2012

Cortisol serum levels in familial longevity and perceived age: the Leiden longevity study.

scientific article

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Disease variants alter transcription factor levels and methylation of their binding sites

scientific article published on 5 December 2016

Do senescence markers correlate in vitro and in situ within individual human donors?

scientific article published in February 2018

Dose-response effects of a Web-based physical activity program on body composition and metabolic health in inactive older adults: additional analyses of a randomized controlled trial.

scientific article

Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals

scientific article published on 01 June 2019

Effects of a web-based intervention on physical activity and metabolism in older adults: randomized controlled trial.

scientific article

Effects of intranasal insulin application on the hypothalamic BOLD response to glucose ingestion

scientific article published on 17 October 2017

Employing biomarkers of healthy ageing for leveraging genetic studies into human longevity

scientific article published on 29 June 2016

Facial appearance reflects human familial longevity and cardiovascular disease risk in healthy individuals.

scientific article published on 9 August 2012

Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship.

scientific article published on 31 July 2015

Familial Longevity Is Not Associated with Major Differences in the Hypothalamic-Pituitary-Gonadal Axis in Healthy Middle-Aged Men.

scientific article

Familial longevity is associated with decreased thyroid function

scientific article published on 25 August 2010

Familial longevity is marked by better cognitive performance at middle age: the Leiden Longevity Study

scientific article

Familial longevity is marked by enhanced insulin sensitivity

scientific article

Familial longevity is marked by lower diurnal salivary cortisol levels: the Leiden Longevity Study.

scientific article

Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study

scientific article published in March 2010

Gene expression analysis of mTOR pathway: association with human longevity

scientific article published on 23 November 2012

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways

scientific article

Genes encoding longevity: from model organisms to humans

scientific article published on 15 January 2008

Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study

scientific article published on 05 May 2006

Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes

scientific article published on 30 October 2017

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

scientific article published in November 2018

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

scientific article published in Nature Communications

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

scientific article

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

scientific article

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

scientific article published on 17 January 2018

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

scientific article published on February 2016

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits ⬇️

scientific article published on 21 June 2016

Genomics of human longevity.

scientific article

Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity

scientific article published on 7 September 2016

Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age

article

High Liver Enzyme Concentrations are Associated with Higher Glycemia, but not with Glycemic Variability, in Individuals without Diabetes Mellitus

scientific article published on 13 September 2017

High serum glucose levels are associated with a higher perceived age.

scientific article published on 20 November 2011

Homocysteine and familial longevity: the Leiden Longevity Study

scientific article

Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis

scientific article published on 9 October 2017

Human in vivo longevity is reflected in vitro by differential metabolism as measured by 1H-NMR profiling of cell culture supernatants

article

Human insulin/IGF-1 and familial longevity at middle age.

scientific article

Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism

scientific article published on 19 June 2015

IL7R gene expression network associates with human healthy ageing

scientific article

Identification of context-dependent expression quantitative trait loci in whole blood

scientific article published on 5 December 2016

IgG glycosylation and DNA methylation are interconnected with smoking

scientific article

Impact of genetic variations in the WRN gene on age related pathologies and mortality

scientific article published on 06 January 2006

Influence of the TP53 codon 72 polymorphism on the cellular responses to X-irradiation in fibroblasts from nonagenarians

scientific article

Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug-metabolite atlas

scientific article published on 13 January 2020

Interrelationships Between Pituitary Hormones as Assessed From 24-hour Serum Concentrations in Healthy Older Subjects

scientific article published on 01 April 2020

Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study

scientific article

Lifestyle and youthful looks.

scientific article published on 15 April 2015

Lipid metabolism in long-lived families: the Leiden Longevity Study

scientific article

Liver X receptor alpha associates with human life span

scientific article published on 01 April 2007

Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study

scientific article published on 16 December 2009

Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood

scientific article published on 07 May 2020

Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors.

scientific article published on 29 November 2006

Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium

scientific article published on 12 August 2019

Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts.

scientific article published on 18 June 2012

Morphometric skin characteristics dependent on chronological and biological age: the Leiden Longevity Study.

scientific article

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

article

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

scientific article published in Nature Communications

No causal association between 25-hydroxyvitamin D and features of skin aging: evidence from a bidirectional Mendelian Randomization Study

scientific article

Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study.

scientific article published on 17 July 2009

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age.

scientific article published on 18 August 2015

Parameters of glucose metabolism and the aging brain: a magnetization transfer imaging study of brain macro- and micro-structure in older adults without diabetes

scientific article published on 17 July 2015

Persistence of high-replicative capacity in cultured fibroblasts from nonagenarians

scientific article published on February 2007

Plasma apolipoprotein CI protects against mortality from infection in old age.

scientific article published in February 2008

Plasma levels of apolipoprotein E and cognitive function in old age.

scientific article published in April 2007

Plasma levels of apolipoprotein E and risk of stroke in old age.

scientific article published in April 2007

Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study

scientific article

Pro-inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength

scientific article published on 27 May 2013

Proton magnetic resonance spectroscopy shows lower intramyocellular lipid accumulation in middle-aged subjects predisposed to familial longevity.

scientific article published on 15 November 2011

Rapid flow cytometric method for measuring senescence associated beta-galactosidase activity in human fibroblasts

scientific article published in November 2009

Reduced insulin/IGF-1 signalling and human longevity.

scientific article

Relation between body height and replicative capacity of human fibroblasts in nonagenarians

scientific article

Relation between maximum replicative capacity and oxidative stress-induced responses in human skin fibroblasts in vitro.

scientific article

Renal function in familial longevity: the Leiden Longevity Study.

scientific article published on 2 January 2014

Repeat UVA exposure of human skin fibroblasts induces both a transitionary and recovery DNA methylation response

scientific article published on 09 June 2020

SIRT1 gene, age-related diseases, and mortality: the Leiden 85-plus study.

scientific article published in September 2007

Serum insulin-like growth factor 1 and facial ageing: high levels associate with reduced skin wrinkling in a cross-sectional study

scientific article

Serum triiodothyronine levels and inflammatory cytokine production capacity

scientific article published on 25 February 2011

Stress-induced responses of human skin fibroblasts in vitro reflect human longevity.

scientific article published on 4 August 2009

Targeted biomarker discovery by high throughput glycosylation profiling of human plasma alpha1-antitrypsin and immunoglobulin A.

scientific article

The Association between Adult Weight Gain and Insulin Resistance at Middle Age: Mediation by Visceral Fat and Liver Fat

scientific article published on 28 September 2019

The Association between Habitual Sleep Duration and Sleep Quality with Glycemic Traits: Assessment by Cross-Sectional and Mendelian Randomization Analyses

scientific article published on 15 May 2019

The MC1R Gene and Youthful Looks

scientific article published on 27 April 2016

The Relation Between Thyroid Function and Anemia: A Pooled Analysis of Individual Participant Data

article

The effect of standardized food intake on the association between BMI and 1H-NMR metabolites.

scientific article published on 14 December 2016

The number of p16INK4a positive cells in human skin reflects biological age.

scientific article published on 11 June 2012

Thyroid status and mortality in nonagenarians from long-lived families and the general population

scientific article published on 25 October 2017

Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R

scientific article (publication date: 2012)

VDR gene variants associate with cognitive function and depressive symptoms in old age.

scientific article

Variation in the SHC1 gene and longevity in humans

scientific article (publication date: February 2004)

Variation in the human TP53 gene affects old age survival and cancer mortality.

scientific article

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