List of works by Anton J M de Craen

A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels

scientific article

A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration

scientific article

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function

scientific article

Accuracy of Continuous Glucose Monitoring Measurements in Normo-Glycemic Individuals

scientific article published on 7 October 2015

Accuracy of direct segmental multi-frequency bioimpedance analysis in the assessment of total body and segmental body composition in middle-aged adult population

scientific article published on 8 May 2011

Activation of hemostasis and decline in cognitive function in older people

scientific article published on 23 December 2009

Ambulant 24-h glucose rhythms mark calendar and biological age in apparently healthy individuals

scientific article published on 06 February 2013

An Internet-Based Physical Activity Intervention to Improve Quality of Life of Inactive Older Adults: A Randomized Controlled Trial.

scientific article published on 27 April 2016

An in vivo study on brain microstructure in biological and chronological ageing

scientific article

ApoE plasma levels and risk of cardiovascular mortality in old age

scientific article

Are markers of inflammation more strongly associated with risk for fatal than for nonfatal vascular events?

scientific article published on 23 June 2009

Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study

scientific article

Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants

scientific article

Association of visit-to-visit variability in blood pressure with cognitive function in old age: prospective cohort study

scientific article published on 29 July 2013

Biological correlates of blood pressure variability in elderly at high risk of cardiovascular disease

scientific article published on 8 October 2014

Blood Pressure Lowering Medication, Visit-to-Visit Blood Pressure Variability, and Cognitive Function in Old Age.

scientific article published on 8 July 2015

Blood pressure trends and mortality: the Leiden 85-plus Study.

scientific article published in January 2013

Blood pressure variability and cardiovascular risk in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER).

scientific article

Brain tissue volumes in familial longevity: the Leiden Longevity Study

scientific article published on 4 September 2012

C-reactive protein and genetic variants and cognitive decline in old age: the PROSPER study

scientific article (publication date: 2011)

C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects

scientific article published on 7 October 2011

CCR4+ Regulatory T Cells Accumulate in the Very Elderly and Correlate With Superior 8-Year Survival

scientific article published on 7 April 2015

Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies

scientific article

Cerebral Microbleeds and Lacunar Infarcts Are Associated with Walking Speed Independent of Cognitive Performance in Middle-Aged to Older Adults.

scientific article published on 15 March 2016

Circulating Interleukin-10 and Risk of Cardiovascular Events

scholarly article by Paul Welsh et al published October 2011 in Arteriosclerosis, Thrombosis, and Vascular Biology

Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women

scholarly article by Diana G Taekema et al published February 2011 in European Journal of Endocrinology

Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study

scientific article

Contrasting associations of insulin resistance with diabetes, cardiovascular disease and all-cause mortality in the elderly: PROSPER long-term follow-up

scientific article published on 30 September 2014

Copy number variation associates with mortality in long-lived individuals: a genome-wide assessment

scientific article

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

Correction: Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R.

scientific article published on 10 May 2012

Cortisol serum levels in familial longevity and perceived age: the Leiden longevity study.

scientific article

Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study

scientific article

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

scientific article

Dose-response effects of a Web-based physical activity program on body composition and metabolic health in inactive older adults: additional analyses of a randomized controlled trial.

scientific article

Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium

scientific article

Effect of anemia and comorbidity on functional status and mortality in old age: results from the Leiden 85-plus Study.

scientific article published on 27 July 2009

Effects of a web-based intervention on physical activity and metabolism in older adults: randomized controlled trial.

scientific article

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

scientific article published on 21 December 2016

Evaluation of the Use of Home Blood Pressure Measurement Using Mobile Phone-Assisted Technology: The iVitality Proof-of-Principle Study.

scientific article published on 13 June 2016

Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity

scientific article published on 12 January 2012

Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study.

scientific article published in January 2006

Executive function, but not memory, associates with incident coronary heart disease and stroke

scientific article published on 5 August 2015

Facial appearance reflects human familial longevity and cardiovascular disease risk in healthy individuals.

scientific article published on 9 August 2012

Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality

scientific article

Familial longevity is marked by better cognitive performance at middle age: the Leiden Longevity Study

scientific article

Familial longevity is marked by lower diurnal salivary cortisol levels: the Leiden Longevity Study.

scientific article

Familial resemblance for serum metabolite concentrations

scientific article published on 28 August 2013

Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study

scientific article published in March 2010

Gene expression analysis of mTOR pathway: association with human longevity

scientific article published on 23 November 2012

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways

scientific article

Genetic predictors of fibrin D-dimer levels in healthy adults

scientific article

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies

article

Genetic variation in galectin-3 gene associates with cognitive function at old age.

scientific article

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

scientific article published in November 2018

Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

scientific article

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

scientific article

Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity

scientific article

Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.

scientific article

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

scientific article

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

scientific article

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

scientific article published on 06 February 2013

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

scientific article

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

scientific article published on February 2016

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.

scientific article published on 23 March 2016

Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy

scientific article (publication date: 2012)

Hallmark features of immunosenescence are absent in familial longevity

scientific article published on 20 September 2010

Handgrip strength and mortality in the oldest old population: the Leiden 85-plus study

scientific article

Handgrip strength as a predictor of functional, psychological and social health. A prospective population-based study among the oldest old.

scientific article

Handgrip strength at midlife and familial longevity : The Leiden Longevity Study

scientific article

Hematopoietic capacity and exceptional survival: the Leiden Longevity Study

scientific article published on 01 November 2008

High Innate Production Capacity of Proinflammatory Cytokines Increases Risk for Death from Cancer: Results of the PROSPER Study

scientific article published on 01 December 2009

High blood pressure and resilience to physical and cognitive decline in the oldest old: the Leiden 85-plus Study

scientific article published on 5 November 2012

High serum glucose levels are associated with a higher perceived age.

scientific article published on 20 November 2011

High-sensitivity cardiac troponin T is associated with cognitive decline in older adults at high cardiovascular risk

scientific article published on 16 February 2016

Homocysteine and familial longevity: the Leiden Longevity Study

scientific article

Human cytokine response to ex vivo amyloid-beta stimulation is mediated by genetic factors.

scientific article

Human insulin/IGF-1 and familial longevity at middle age.

scientific article

Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies

scientific article

Identification of seven loci affecting mean telomere length and their association with disease

scientific article published on April 2013

Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study

scientific article published on 01 September 2004

In search for genetic determinants of clinically meaningful differential cardiovascular event reduction by pravastatin in the PHArmacogenetic study of Statins in the Elderly at risk (PHASE)/PROSPER study.

scientific article published on 26 April 2014

Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans

scientific article published on 3 August 2011

Inflammation underlying cardiovascular mortality is a late consequence of evolutionary programming

scientific article

Influence of Small Vessel Disease and Microstructural Integrity on Neurocognitive Functioning in Older Individuals: The DANTE Study Leiden.

scientific article published on 22 September 2016

LDL cholesterol still a problem in old age? A Mendelian randomization study

Leptin predicts diabetes but not cardiovascular disease: results from a large prospective study in an elderly population

scientific article

Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers

scientific article

Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study

scientific article

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

scientific article

Low blood pressure predicts increased mortality in very old age even without heart failure: the Leiden 85-plus Study.

scientific article published on 17 December 2012

Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study

scientific article published on 16 December 2009

Lower Susceptibility to Cerebral Small Vessel Disease in Human Familial Longevity

article published in 2013

Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people

scientific article published on 04 June 2012

Men Have a Stronger Monocyte-Derived Cytokine Production Response upon Stimulation with the Gram-Negative Stimulus Lipopolysaccharide than Women: A Pooled Analysis Including 15 Study Populations

scientific article published on 21 June 2019

Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance

scientific article published on 23 July 2014

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

scientific article

Meta-analysis of genome-wide association studies of HDL cholesterol response to statins

scientific article

Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect

scientific article published on 16 January 2013

Microstructural brain tissue damage in metabolic syndrome

scientific article published on 2 October 2013

Morphometric skin characteristics dependent on chronological and biological age: the Leiden Longevity Study.

scientific article

Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI

scientific article published on 7 February 2015

N-terminal pro-brain natriuretic peptide and cognitive decline in older adults at high cardiovascular risk

scientific article published on 9 July 2014

No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects

scientific article

No increased mortality risk in older persons with unexplained anaemia

scientific article published on 14 March 2012

Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study.

scientific article published on 17 July 2009

Novel genetic loci associated with hippocampal volume

scientific article published on 18 January 2017

Novel genetic loci underlying human intracranial volume identified through genome-wide association

scientific article (publication date: 3 October 2016)

PCSK9 SNP rs11591147 is associated with low cholesterol levels but not with cognitive performance or noncardiovascular clinical events in an elderly population

scientific article published on February 2013

Parental longevity correlates with offspring's optimism in two cohorts of community-dwelling older subjects

scientific article published on 7 April 2011

Patterns of muscle strength loss with age in the general population and patients with a chronic inflammatory state

scientific article published on 27 May 2010

Performance of Cockcroft-Gault, MDRD, and CKD-EPI in estimating prevalence of renal function and predicting survival in the oldest old

scientific article

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

scientific article

Pharmacogenetics of statins: achievements, whole-genome analyses and future perspectives

scientific article published on May 2012

Plasma apolipoprotein CI protects against mortality from infection in old age.

scientific article published in February 2008

Plasma levels of apolipoprotein E and cognitive function in old age.

scientific article published in April 2007

Plasma levels of apolipoprotein E and risk of stroke in old age.

scientific article published in April 2007

Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study

scientific article

Predictive value of low ferritin in older persons with anemia with and without inflammation: the Leiden 85-plus Study

scientific article published on 01 August 2010

Preserved white matter integrity is a marker of familial longevity

scientific article published in December 2013

Pro-inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength

scientific article published on 27 May 2013

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

scientific journal article

Relative validity of the food frequency questionnaire used to assess dietary intake in the Leiden Longevity Study.

scientific article published on 07 June 2013

Renal function in familial longevity: the Leiden Longevity Study.

scientific article published on 2 January 2014

Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses

scientific article

Resting heart rate and incident heart failure and cardiovascular mortality in older adults: role of inflammation and endothelial dysfunction: the PROSPER study

scientific article published on 18 December 2012

Resting heart rate, heart rate variability and functional decline in old age.

scientific article

Serum triiodothyronine levels and inflammatory cytokine production capacity

scientific article published on 25 February 2011

Subclinical Thyroid Dysfunction and Depressive Symptoms among the Elderly: A Prospective Cohort Study.

scientific article published on 14 July 2015

Subclinical Thyroid Dysfunction and the Risk of Heart Failure in Older Persons at High Cardiovascular Risk

scholarly article by David Nanchen et al published March 2012 in The Journal of Clinical Endocrinology and Metabolism

Subclinical thyroid dysfunction and cognitive decline in old age

scientific article

Temporal relationship between handgrip strength and cognitive performance in oldest old people

scientific article published on 27 February 2012

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

The MC1R Gene and Youthful Looks

scientific article published on 27 April 2016

The development, implementation and evaluation of a transitional care programme to improve outcomes of frail older patients after hospitalisation

scientific article published on 13 June 2016

The impact of low-frequency and rare variants on lipid levels

scientific article published on 11 May 2015

The inverse relationship between alanine aminotransferase in the normal range and adverse cardiovascular and non-cardiovascular outcomes

scientific article published on 17 November 2011

The number of p16INK4a positive cells in human skin reflects biological age.

scientific article published on 11 June 2012

Total joint replacement in the past does not relate to a deteriorated functional level and health status in the oldest old.

scientific article published on 8 May 2012

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

scientific article published on 12 September 2016

Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R

scientific article (publication date: 2012)

Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2.

scientific article published on 29 January 2016

Unraveling the Directional Link between Adiposity and Inflammation: A Bidirectional Mendelian Randomization Approach.

scientific article published in December 2009

Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach

scientific article

Use of Framingham risk score and new biomarkers to predict cardiovascular mortality in older people: population based observational cohort study.

scientific article published on 08 January 2009

Variation in the CBP gene involved in epigenetic control associates with cognitive function

scientific article

Variation in the human TP53 gene affects old age survival and cancer mortality.

scientific article

White Matter Lesion Progression: Genome-Wide Search for Genetic Influences

scientific article

White matter hyperintensities and cognitive impairment during electroconvulsive therapy in severely depressed elderly patients

scientific article

White matter hyperintensities, medial temporal lobe atrophy, cortical atrophy, and response to electroconvulsive therapy in severely depressed elderly patients

scientific article published on 24 August 2010

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