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List of works by Anton J M de Craen

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Genetic studies of body mass index yield new insights for obesity biology

scientific article
Identification of seven loci affecting mean telomere length and their association with disease

scientific article published on April 2013
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

scientific article published on 21 December 2016
Handgrip strength as a predictor of functional, psychological and social health. A prospective population-based study among the oldest old.

scientific article
Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies

scientific article
Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

scientific journal article
Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect

scientific article published on 16 January 2013
Use of Framingham risk score and new biomarkers to predict cardiovascular mortality in older people: population based observational cohort study.

scientific article published on 08 January 2009
Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study

scientific article published in January 2006
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

scientific article
The impact of low-frequency and rare variants on lipid levels

scientific article published on 11 May 2015
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

scientific article
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.

scientific article published on 23 March 2016
Handgrip strength and mortality in the oldest old population: the Leiden 85-plus study

scientific article
Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study.

scientific article published on 17 July 2009
Accuracy of direct segmental multi-frequency bioimpedance analysis in the assessment of total body and segmental body composition in middle-aged adult population

scientific article published on 8 May 2011
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

scientific article published on 12 September 2016
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

scientific article
Variation in the human TP53 gene affects old age survival and cancer mortality.

scientific article
Novel genetic loci underlying human intracranial volume identified through genome-wide association

scientific article (publication date: 3 October 2016)
Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

scientific article
Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans

scientific article published on 3 August 2011
Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity

scientific article
Novel genetic loci associated with hippocampal volume

scientific article published on 18 January 2017
The number of p16INK4a positive cells in human skin reflects biological age.

scientific article published on 11 June 2012
Hallmark features of immunosenescence are absent in familial longevity

scientific article published on 20 September 2010
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function

scientific article
Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

scientific article published on 06 February 2013
Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers

scientific article
Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

scientific article
Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI

scientific article published on 7 February 2015
Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study

scientific article published in March 2010
Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach

scientific article
Relative validity of the food frequency questionnaire used to assess dietary intake in the Leiden Longevity Study.

scientific article published on 07 June 2013
Gene expression analysis of mTOR pathway: association with human longevity

scientific article published on 23 November 2012
Effect of anemia and comorbidity on functional status and mortality in old age: results from the Leiden 85-plus Study.

scientific article published on 27 July 2009
Subclinical Thyroid Dysfunction and the Risk of Heart Failure in Older Persons at High Cardiovascular Risk

scholarly article by David Nanchen et al published March 2012 in The Journal of Clinical Endocrinology and Metabolism
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

scientific article
Effects of a web-based intervention on physical activity and metabolism in older adults: randomized controlled trial.

scientific article
Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways

scientific article
Association of visit-to-visit variability in blood pressure with cognitive function in old age: prospective cohort study

scientific article published on 29 July 2013
Patterns of muscle strength loss with age in the general population and patients with a chronic inflammatory state

scientific article published on 27 May 2010
Human insulin/IGF-1 and familial longevity at middle age.

scientific article
ApoE plasma levels and risk of cardiovascular mortality in old age

scientific article published on 9 May 2006
Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity

scientific article published on 12 January 2012
High blood pressure and resilience to physical and cognitive decline in the oldest old: the Leiden 85-plus Study

scientific article published on 5 November 2012
Are markers of inflammation more strongly associated with risk for fatal than for nonfatal vascular events?

scientific article published on 23 June 2009
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

scientific article published on February 2016
Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study

scientific article published on 01 September 2004

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