List of works - Takaomi Sanda

ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis

scientific article

ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry

scientific article published on 09 December 2019

ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification

scientific article

Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia

scientific article published on 28 December 2016

Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia

scientific article

Activating mutations in ALK provide a therapeutic target in neuroblastoma

scientific article

Anti-leukaemic activity of the TYK2 selective inhibitor NDI-031301 in T-cell acute lymphoblastic leukaemia.

scientific article published on 14 March 2017

Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia

scientific article

Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.

scientific article

Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.

scientific article

Correction: Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma

scientific article published on 14 July 2020

Cyclin-dependent kinase 9 as a potential specific molecular target in NK cell leukemia/lymphoma

scientific article published on 03 August 2018

Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma

scientific article published on 21 August 2018

Discovery of a selective irreversible BMX inhibitor for prostate cancer.

scientific article published on 26 April 2013

Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression.

scientific article published on 24 August 2009

Enhancer profiling identifies critical cancer genes and characterizes cell identity in adult T-cell leukemia

scientific article published on 4 October 2017

Growth inhibition of multiple myeloma cells by a novel IkappaB kinase inhibitor

scientific article

HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia

scientific article

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

scientific article published on 20 May 2009

IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma

scientific article published on 03 May 2022

Identification of novel lncRNAs regulated by the TAL1 complex in T-cell acute lymphoblastic leukemia.

scientific article published on 26 March 2018

Inactivation of LEF1 in T-cell acute lymphoblastic leukemia

scientific article

Induction of class II major histocompatibility complex expression in human multiple myeloma cells by retinoid

scientific article published on January 2007

Inhibition of Wild-Type p53-Expressing AML by the Novel Small Molecule HDM2 Inhibitor CGM097

scientific article

Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia

scientific article

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.

scientific article published on 25 June 2018

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.

scientific article published on 04 February 2013

Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics

scientific article published on 5 January 2012

Knock down of hSNF5/Ini1 causes cell cycle arrest and apoptosis in a p53-dependent manner

scientific article published on 25 July 2007

Leukemia-Initiating Cells in T-Cell Acute Lymphoblastic Leukemia

scientific article published on 25 September 2017

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma

scientific article published on September 2014

NF-kappa B signaling and carcinogenesis

scientific article published on January 2007

Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

scientific article

Oncogenic transcriptional program driven by TAL1 in T-cell acute lymphoblastic leukemia

scientific article published on 25 August 2018

Overexpression of carboxylesterase-2 results in enhanced efficacy of topoisomerase I inhibitor, irinotecan (CPT-11), for multiple myeloma

scientific article published on September 2008

PIDD Death-Domain Phosphorylation by ATM Controls Prodeath versus Prosurvival PIDDosome Signaling ⬇️

scientific article published on July 30, 2012

Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis

scientific article published on May 2010

RNA helicase A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator

scientific article

RUNX1 in T-ALL: tumor suppressive or oncogenic?

scientific article

RUNX1 point mutations potentially identify a subset of early immature T-cell acute lymphoblastic leukaemia that may originate from differentiated T-cells

scientific article published on 2 May 2014

RelA-associated inhibitor blocks transcription of human immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1 actions

scientific article

Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL ⬇️

scientific article published on April 4, 2011

Ribonucleoprotein HNRNPA2B1 interacts with and regulates oncogenic KRAS in pancreatic ductal adenocarcinoma cells.

scientific article

Roles of the RUNX1 Enhancer in Normal Hematopoiesis and Leukemogenesis

scientific article published on January 2017

Severe hypercholesterolemia associated with decreased hepatic triglyceride lipase activity and pseudohyponatremia in patients after allogeneic stem cell transplantation

scientific article

Successful treatment of nasal T-cell lymphoma with a combination of local irradiation and high-dose chemotherapy

scientific article

T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.

scientific article

TAL1 as a master oncogenic transcription factor in T-cell acute lymphoblastic leukemia

scientific article published on 23 June 2017

TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia

scientific article published on 7 March 2013

Targeting General Transcriptional Machinery as a Therapeutic Strategy for Adult T-Cell Leukemia.

scientific article published on 2 May 2018

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

scientific article

The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma

scientific article published in July 2012

The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia

scientific article

The KDM3A-KLF2-IRF4 axis maintains myeloma cell survival

scientific article published on 5 January 2016

The Requirement for Cyclin D Function in Tumor Maintenance ⬇️

scientific article published on October 16, 2012

The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia

scientific article published on 15 July 2013

The enhancer RNA ARIEL activates the oncogenic transcriptional program in T-cell acute lymphoblastic leukemia

scientific article published on 10 May 2019

Transcription factors as therapeutic targets in lymphoid malignancies

scientific article published on September 2007

List of works by Takaomi Sanda

ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis

ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry

ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification

Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia

Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia

Activating mutations in ALK provide a therapeutic target in neuroblastoma

Anti-leukaemic activity of the TYK2 selective inhibitor NDI-031301 in T-cell acute lymphoblastic leukaemia.

Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia

Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.

Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.

Correction: Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma

Cyclin-dependent kinase 9 as a potential specific molecular target in NK cell leukemia/lymphoma

Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma

Discovery of a selective irreversible BMX inhibitor for prostate cancer.

Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression.

Enhancer profiling identifies critical cancer genes and characterizes cell identity in adult T-cell leukemia

Growth inhibition of multiple myeloma cells by a novel IkappaB kinase inhibitor

HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma

Identification of novel lncRNAs regulated by the TAL1 complex in T-cell acute lymphoblastic leukemia.

Inactivation of LEF1 in T-cell acute lymphoblastic leukemia

Induction of class II major histocompatibility complex expression in human multiple myeloma cells by retinoid

Inhibition of Wild-Type p53-Expressing AML by the Novel Small Molecule HDM2 Inhibitor CGM097

Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.

Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics

Knock down of hSNF5/Ini1 causes cell cycle arrest and apoptosis in a p53-dependent manner

Leukemia-Initiating Cells in T-Cell Acute Lymphoblastic Leukemia

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma

NF-kappa B signaling and carcinogenesis

Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

Oncogenic transcriptional program driven by TAL1 in T-cell acute lymphoblastic leukemia

Overexpression of carboxylesterase-2 results in enhanced efficacy of topoisomerase I inhibitor, irinotecan (CPT-11), for multiple myeloma

PIDD Death-Domain Phosphorylation by ATM Controls Prodeath versus Prosurvival PIDDosome Signaling ⬇️

Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis

RNA helicase A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator

RUNX1 in T-ALL: tumor suppressive or oncogenic?

RUNX1 point mutations potentially identify a subset of early immature T-cell acute lymphoblastic leukaemia that may originate from differentiated T-cells

RelA-associated inhibitor blocks transcription of human immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1 actions

Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL ⬇️

Ribonucleoprotein HNRNPA2B1 interacts with and regulates oncogenic KRAS in pancreatic ductal adenocarcinoma cells.

Roles of the RUNX1 Enhancer in Normal Hematopoiesis and Leukemogenesis

Severe hypercholesterolemia associated with decreased hepatic triglyceride lipase activity and pseudohyponatremia in patients after allogeneic stem cell transplantation

Successful treatment of nasal T-cell lymphoma with a combination of local irradiation and high-dose chemotherapy

T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.

TAL1 as a master oncogenic transcription factor in T-cell acute lymphoblastic leukemia

TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia

Targeting General Transcriptional Machinery as a Therapeutic Strategy for Adult T-Cell Leukemia.

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma

The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia

The KDM3A-KLF2-IRF4 axis maintains myeloma cell survival

The Requirement for Cyclin D Function in Tumor Maintenance ⬇️

The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia

The enhancer RNA ARIEL activates the oncogenic transcriptional program in T-cell acute lymphoblastic leukemia

Transcription factors as therapeutic targets in lymphoid malignancies