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List of works by Tianlei Ying

A Potent Germline-like Human Monoclonal Antibody Targets a pH-Sensitive Epitope on H7N9 Influenza Hemagglutinin.

scientific article published on 27 September 2017

A Route to Novel Functional Metalloproteins via Hybrids of Cytochrome P450 and Cytochrome c ⬇️

scientific article published on 03 February 2011

A Single Dose of Anti-HBsAg Antibody-Encoding mRNA-LNPs Suppressed HBsAg Expression: a Potential Cure of Chronic Hepatitis B Virus Infection

scientific article published on 07 July 2022

A Unique Human Immunoglobulin Heavy Chain Variable Domain-Only CD33 CAR for the Treatment of Acute Myeloid Leukemia

scientific article published on 22 November 2018

A broadly neutralizing germline-like human monoclonal antibody against dengue virus envelope domain III

scientific article published in June 2019

A defucosylated bispecific multivalent molecule exhibits broad HIV-1-neutralizing activity and enhanced antibody-dependent cellular cytotoxicity against reactivated HIV-1 latently infected cells

article

A native-like bispecific antibody suppresses the inflammatory cytokine response by simultaneously neutralizing tumor necrosis factor-alpha and interleukin-17A.

scientific article published on 3 August 2017

A novel coronavirus (2019-nCoV) causing pneumonia-associated respiratory syndrome

scientific article published on 05 February 2020

A novel insight into the heme and NO/CO binding mechanism of the alpha subunit of human soluble guanylate cyclase ⬇️

scientific article published on July 2, 2011

A systems approach to HIV-1 vaccines.

scientific article published on January 2016

An immunogen containing four tandem 10E8 epitope repeats with exposed key residues induces antibodies that neutralize HIV-1 and activates an ADCC reporter gene

scientific article published on 22 June 2016

Antibody-based candidate therapeutics against HIV-1: implications for virus eradication and vaccine design.

scientific article published on 07 January 2013

Bispecific Engineered Antibody Domains (Nanoantibodies) That Interact Noncompetitively with an HIV-1 Neutralizing Epitope and FcRn ⬇️

scientific article published on August 7, 2012

Conformational Toggling of Yeast Iso-1-Cytochrome c in the Oxidized and Reduced States ⬇️

scientific article published on November 8, 2011

Development of Small-Molecule Inhibitors Against Zika Virus Infection

scientific article published on 06 December 2019

Development of Small-Molecule MERS-CoV Inhibitors

article

Development of human neutralizing monoclonal antibodies for prevention and therapy of MERS-CoV infections

scientific article

Development of small-molecule inhibitors against hantaviruses

scientific article published on 20 May 2020

Development of therapeutics for treatment of Ebola virus infection.

scientific article

Discovery of T-Cell Infection and Apoptosis by Middle East Respiratory Syndrome Coronavirus

scientific article published on 22 July 2015

Discovery of novel candidate therapeutics and diagnostics based on engineered human antibody domains.

scientific article

Editorial: Antibody Fc Engineering: Towards Better Therapeutics

scientific article published on 24 October 2018

Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets.

scientific article published on 4 April 2017

Engineered Fc based antibody domains and fragments as novel scaffolds

scientific article

Engineered Soluble Monomeric IgG1 Fc with Significantly Decreased Non-Specific Binding.

scientific article published on 13 November 2017

Engineered antibody domains with significantly increased transcytosis and half-life in macaques mediated by FcRn

scientific article

Engineered soluble monomeric IgG1 CH3 domain: generation, mechanisms of function, and implications for design of biological therapeutics.

scientific article published on 18 July 2013

Engineering a Novel Antibody-Peptide Bispecific Fusion Protein Against MERS-CoV

scientific article published on 04 November 2019

Escape from humoral immunity is associated with treatment failure in HIV-1-infected patients receiving long-term antiretroviral therapy.

scientific article

Establishment of Novel Monoclonal Fabs Specific for Epstein-Barr Virus Encoded Latent Membrane Protein 1

scientific article published on 04 April 2019

Evaluation of antiviral - passive - active immunization ("sandwich") therapeutic strategy for functional cure of chronic hepatitis B in mice

scientific article published on 01 November 2019

Exceptionally potent and broadly cross-reactive, bispecific multivalent HIV-1 inhibitors based on single human CD4 and antibody domains.

scientific article

Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies.

scientific article

Fc Engineering: Tailored Synthetic Human IgG1-Fc Repertoire for High-Affinity Interaction with FcRn at pH 6.0

scientific article published on 01 January 2018

From therapeutic antibodies to chimeric antigen receptors (CARs): making better CARs based on antigen-binding domain.

scientific article published on 12 September 2016

Fucoidan Extracted from the New Zealand -Physicochemical Comparison against Five Other Fucoidans: Unique Low Molecular Weight Fraction Bioactivity in Breast Cancer Cell Lines

article

Functional mapping of B-cell linear epitopes of SARS-CoV-2 in COVID-19 convalescent population

scientific article published on 26 August 2020

Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein

scientific article published on 11 February 2020

Generation of novel functional metalloproteins via hybrids of cytochrome c and peroxidase ⬇️

scientific article published on March 20, 2013

Germlining of the HIV-1 broadly neutralizing antibody domain m36

scientific article

Human monoclonal antibodies as candidate therapeutics against emerging viruses

scientific article published on 20 November 2017

Immune Repertoire Diversity Correlated with Mortality in Avian Influenza A (H7N9) Virus Infected Patients.

scientific article published on 27 September 2016

Improving the CH1-CK heterodimerization and pharmacokinetics of 4Dm2m, a novel potent CD4-antibody fusion protein against HIV-1.

scientific article

Interactions of IgG1 CH2 and CH3 Domains with FcRn

scientific article published on 02 April 2014

Investigation of Different Molecular Weight Fucoidan Fractions Derived from New Zealand in Combination with GroA Therapy in Prostate Cancer Cell Lines

article

Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody.

scientific article

Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients

scientific article published on 07 September 2020

Manganese superoxide dismutase from human pathogen Clostridium difficile.

scientific article published on 6 February 2015

Middle East respiratory syndrome coronavirus (MERS-CoV) entry inhibitors targeting spike protein.

scientific article

Monomeric IgG1 Fc molecules displaying unique Fc receptor interactions that are exploitable to treat inflammation-mediated diseases.

scientific article

N-Butanol Subfraction of Brassica Rapa L. Promotes Reactive Oxygen Species Production and Induces Apoptosis of A549 Lung Adenocarcinoma Cells via Mitochondria-Dependent Pathway.

scientific article

N-terminal truncation of an isolated human IgG1 CH2 domain significantly increases its stability and aggregation resistance

scientific article published on 29 May 2013

Neutralization of Zika virus by germline-like human monoclonal antibodies targeting cryptic epitopes on envelope domain III.

scientific article published on 11 October 2017

New Directions for Half-Life Extension of Protein Therapeutics: The Rise of Antibody Fc Domains and Fragments.

scientific article published on 23 August 2016

No evidence for a superior platform to develop therapeutic antibodies rapidly in response to MERS-CoV and other emerging viruses.

scientific article published on 28 August 2015

One-domain CD4 Fused to Human Anti-CD16 Antibody Domain Mediates Effective Killing of HIV-1-Infected Cells.

scientific article

Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus Infection

scientific article published on 19 August 2016

Pharmacodynamics of long-acting folic acid-receptor targeted ritonavir-boosted atazanavir nanoformulations

scientific article

Potent In Vivo NK Cell-mediated Elimination of HIV-1-Infected Cells Mobilized by a gp120-bispecific and Hexavalent Broadly Neutralizing Fusion Protein.

scientific article published on 9 August 2017

Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody

scientific article published on 17 February 2020

Potential Nutraceutical Use of Tribulus terrestris L. in Human Health

scientific article published on 19 April 2022

Precision immunomedicine

scientific article

Preparation, Characterization, and Immuno-Enhancing Activity of Polysaccharides from Glycyrrhiza uralensis

scientific article published on 19 January 2020

Probing the role of the bridging C509 between the [Fe4S4] cubane and the [NipNid] centre in the A-cluster of acetyl-coenzyme A synthase ⬇️

scientific article published on November 22, 2010

Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)-Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection

scientific article published on 3 March 2016

Purification, characterization and bioactivities of polysaccharides from Pleurotus ferulae.

scientific article published on 24 April 2017

Rapid Elimination of Broadly Neutralizing Antibodies Correlates with Treatment Failure in the Acute Phase of Simian-Human Immunodeficiency Virus Infection

scientific article published on 30 September 2019

Recent Progress on Neutralizing Antibodies against Hepatitis B Virus and its Implications

scientific article published on 01 January 2019

Recent advances in developing small-molecule inhibitors against SARS-CoV-2

scientific article

Receptor-binding domain-specific human neutralizing monoclonal antibodies against SARS-CoV and SARS-CoV-2

scientific article published on 22 September 2020

Soluble Monomeric IgG1 Fc ⬇️

scientific article published on April 19, 2012

Structural basis for cytochrome c Y67H mutant to function as a peroxidase

scientific article

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