List of works - Peng Yang

A novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy

scientific article published on 14 May 2019

A quantitative chemical proteomics approach to profile the specific cellular targets of andrographolide, a promising anticancer agent that suppresses tumor metastasis

scientific article

Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes ⬇️

scientific article published on May 15, 2011

Blocking the ZZ domain of sequestosome1/p62 suppresses myeloma growth and osteoclast formation in vitro and induces dramatic bone formation in myeloma-bearing bones in vivo.

scientific article published on 19 August 2015

Design, synthesis, and cholesterol-lowering efficacy for prodrugs of berberrubine ⬇️

scientific article published on July 30, 2010

Discovery of Novel Ligands for TNF-α and TNF Receptor-1 through Structure-Based Virtual Screening and Biological Assay.

scientific article

Discovery of novel and selective CDK4/6 inhibitors by pharmacophore and structure-based virtual screening

scientific article published on 13 May 2020

Examining the critical roles of human CB2 receptor residues Valine 3.32 (113) and Leucine 5.41 (192) in ligand recognition and downstream signaling activities

scientific article published on 19 August 2014

Integrated In Silico Fragment-Based Drug Design: Case Study with Allosteric Modulators on Metabotropic Glutamate Receptor 5.

scientific article published on 30 May 2017

LiCABEDS II. Modeling of ligand selectivity for G-protein-coupled cannabinoid receptors

scientific article published on 15 January 2013

Modeling, molecular dynamics simulation, and mutation validation for structure of cannabinoid receptor 2 based on known crystal structures of GPCRs.

scientific article

Multi-Functional Diarylurea Small Molecule Inhibitors of TRPV1 with Therapeutic Potential for Neuroinflammation

scientific article published on 21 March 2016

PTPN2, A Key Predictor of Prognosis for Pancreatic Adenocarcinoma, Significantly Regulates Cell Cycles, Apoptosis, and Metastasis

scientific article published on 27 January 2022

Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells

scientific article published on 18 February 2015

Synthesis, Biological Evaluation, and Autophagy Mechanism of 12N-Substituted Sophoridinamines as Novel Anticancer Agents.

scientific article published on 5 January 2017

Targeted inhibition of the type 2 cannabinoid receptor is a novel approach to reduce renal fibrosis

scientific article published on 06 August 2018

Trisubstituted Sulfonamides: a New Chemotype for Development of Potent and Selective CB2 Receptor Inverse Agonists

scientific article

p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis

scientific article published on 24 July 2017

List of works by Peng Yang

A novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy

A quantitative chemical proteomics approach to profile the specific cellular targets of andrographolide, a promising anticancer agent that suppresses tumor metastasis

Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes ⬇️

Blocking the ZZ domain of sequestosome1/p62 suppresses myeloma growth and osteoclast formation in vitro and induces dramatic bone formation in myeloma-bearing bones in vivo.

Design, synthesis, and cholesterol-lowering efficacy for prodrugs of berberrubine ⬇️

Discovery of Novel Ligands for TNF-α and TNF Receptor-1 through Structure-Based Virtual Screening and Biological Assay.

Discovery of novel and selective CDK4/6 inhibitors by pharmacophore and structure-based virtual screening

Examining the critical roles of human CB2 receptor residues Valine 3.32 (113) and Leucine 5.41 (192) in ligand recognition and downstream signaling activities

Integrated In Silico Fragment-Based Drug Design: Case Study with Allosteric Modulators on Metabotropic Glutamate Receptor 5.

LiCABEDS II. Modeling of ligand selectivity for G-protein-coupled cannabinoid receptors

Modeling, molecular dynamics simulation, and mutation validation for structure of cannabinoid receptor 2 based on known crystal structures of GPCRs.

Multi-Functional Diarylurea Small Molecule Inhibitors of TRPV1 with Therapeutic Potential for Neuroinflammation

PTPN2, A Key Predictor of Prognosis for Pancreatic Adenocarcinoma, Significantly Regulates Cell Cycles, Apoptosis, and Metastasis

Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells

Synthesis, Biological Evaluation, and Autophagy Mechanism of 12N-Substituted Sophoridinamines as Novel Anticancer Agents.

Targeted inhibition of the type 2 cannabinoid receptor is a novel approach to reduce renal fibrosis

Trisubstituted Sulfonamides: a New Chemotype for Development of Potent and Selective CB2 Receptor Inverse Agonists

p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis