List of works by Alessandra Boletta

2-Deoxy-d-Glucose Ameliorates PKD Progression

scientific article

A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus.

scientific article

A regulatory role of polycystin-1 on cystic fibrosis transmembrane conductance regulator plasma membrane expression

scientific article published on 14 August 2006

Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8.

scientific article published on 14 March 2018

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

scientific article

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.

scientific article

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

scientific article (publication date: December 2000)

Deciphering Variability of PKD1 and PKD2 in an Italian Cohort of 643 Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD).

scientific article published on 8 August 2016

Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy.

scientific article published on 24 March 2013

Defective glycolysis and the use of 2-deoxy-D-glucose in polycystic kidney disease: from animal models to humans.

scientific article published on 7 April 2017

Defective metabolism in polycystic kidney disease: potential for therapy and open questions.

scientific article published on 23 January 2014

Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways

scientific article published on 16 November 2018

Double inhibition of cAMP and mTOR signalling may potentiate the reduction of cell growth in ADPKD cells.

scientific article published on 9 June 2016

Emerging evidence of a link between the polycystins and the mTOR pathways

scientific article published on 28 October 2009

Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1.

scientific article

Impaired glomerulogenesis and endothelial cell migration in Pkd1-deficient renal organ cultures.

scientific article

Increased mitochondrial fragmentation in polycystic kidney disease acts as a modifier of disease progression

scientific article published on 02 April 2020

Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium.

scientific article published in August 2015

Metabolic reprogramming and the role of mitochondria in polycystic kidney disease

scientific article published on 06 December 2019

Metabolic reprogramming in polycystic kidney disease explained by super-enhancers and CDK7: new therapeutic targets?

scientific article published on 13 July 2020

Metabolism and mitochondria in polycystic kidney disease research and therapy

scientific article published on 01 November 2018

Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals

scientific article

Novel functional complexity of polycystin-1 by GPS cleavage in vivo: role in polycystic kidney disease

scientific article

PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function

scientific article

PI3K class II α: a novel regulator of vesicular trafficking at the base of the primary cilium.

scientific article published on 16 November 2012

PI3K-C2α regulates Polycystin-2 ciliary entry to prevent kidney cyst formation.

scientific article published on 13 July 2015

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

scientific journal article

Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation

scientific article published on 13 August 2015

Polycystin-1 Regulates Actomyosin Contraction and the Cellular Response to Extracellular Stiffness

scientific article published on 12 November 2019

Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis

scientific article published on January 2013

Polycystin-1 induces cell migration by regulating phosphatidylinositol 3-kinase-dependent cytoskeletal rearrangements and GSK3beta-dependent cell cell mechanical adhesion

scientific article

Polycystin-1 induces resistance to apoptosis through the phosphatidylinositol 3-kinase/Akt signaling pathway.

scientific article

Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells

scientific article

Polycystin-1 negatively regulates Polycystin-2 expression via the aggresome/autophagosome pathway.

scientific article published on 23 January 2014

Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1.

scientific article published on 2 March 2009

Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1

scientific article

Prospects for mTOR inhibitor use in patients with polycystic kidney disease and hamartomatous diseases

scientific article published on 24 May 2010

Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration

scientific article

Renal-retinal ciliopathy gene Sdccag8 regulates DNA damage response signaling

scientific article

Role of polycystins in renal tubulogenesis

scientific article (publication date: September 2003)

Role of the KEAP1-NRF2 Axis in Renal Cell Carcinoma

scientific article published on 20 November 2020

Role of the Polycystins in Cell Migration, Polarity, and Tissue Morphogenesis

scientific article

Slowing Polycystic Kidney Disease by Fasting

scientific article published on 4 November 2015

The N-Terminal Domain of NPHP1 Folds into a Monomeric Left-Handed Antiparallel Three-Stranded Coiled Coil with Anti-apoptotic Function

scientific article published on 05 August 2019

The centrosomal OFD1 protein interacts with the translation machinery and regulates the synthesis of specific targets

scientific article

The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function

scientific article

[The ciliopathies--Polycystic Kidney Disease].

scientific article published in January 2015

mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis

scientific article

mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis

scientific article published in 2017

mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression

scientific article published on 20 November 2018

mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex

scientific article published on 2 March 2016

mTORC1 Upregulation Leads to Accumulation of the Oncometabolite Fumarate in a Mouse Model of Renal Cell Carcinoma

scientific article published on 01 July 2018

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