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List of works by Said Hassounah

Addition of E138K to R263K in HIV integrase increases resistance to dolutegravir, but fails to restore activity of the HIV integrase enzyme and viral replication capacity.

scientific article

Antiviral Activity of Bictegravir and Cabotegravir Against Integrase Inhibitor Resistant SIVmac239 and HIV-1.

scientific article published on 18 September 2017

Biochemical Analysis of the Role of G118R-Linked Dolutegravir Drug Resistance Substitutions in HIV-1 Integrase.

scientific article published in January 2014

Biochemical Analysis of the Role of G118R-Linked Dolutegravir Drug Resistance Substitutions in HIV-1 Integrase.

scientific article published in June 2014

Biochemical analysis of the role of G118R-linked dolutegravir drug resistance substitutions in HIV-1 integrase

scientific article published on 30 September 2013

Cenicriviroc blocks HIV entry but does not lead to redistribution of HIV into extracellular space like maraviroc

scientific article published on 2 November 2014

Characterization of the Drug Resistance Profiles of Integrase Strand Transfer Inhibitors in Simian Immunodeficiency Virus SIVmac239.

scientific article

Differential effects of the G118R, H51Y, and E138K resistance substitutions in different subtypes of HIV integrase

scientific article

Dolutegravir monotherapy of simian immunodeficiency virus-infected macaques selects for several patterns of resistance mutations with variable virological outcomes

scientific article published on 04 January 2019

Durable suppression of HIV-1 with resistance mutations to integrase inhibitors by dolutegravir following drug washout

article

Effect of HIV-1 integrase resistance mutations when introduced into SIVmac239 on susceptibility to integrase strand transfer inhibitors

scientific article

Evaluation of Sofosbuvir (β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine) as an inhibitor of Dengue virus replication

scientific article published on 24 July 2017

Identification of a Pyridoxine-Derived Small-Molecule Inhibitor Targeting Dengue Virus RNA-Dependent RNA Polymerase

scientific article published on 16 November 2015

Insertion as a Resistance Mechanism Against Integrase Inhibitors in Several Retroviruses

scientific article published on 01 September 2019

Monotherapy with either dolutegravir or raltegravir fails to durably suppress HIV viraemia in humanized mice.

scientific article published on 13 June 2017

Purification of Zika virus RNA-dependent RNA polymerase and its use to identify small-molecule Zika inhibitors

scientific article (publication date: 8 January 2017)

Simian-tropic HIV as a model to study drug resistance against integrase inhibitors.

scientific article

Structural Studies of the HIV-1 Integrase Protein: Compound Screening and Characterization of a DNA-Binding Inhibitor

scientific article

The R262K substitution combined with H51Y in HIV-1 subtype B integrase confers low-level resistance against dolutegravir

scientific article published on 27 October 2014

The R263K substitution in HIV-1 subtype C is more deleterious for integrase enzymatic function and viral replication than in subtype B.

scientific article published on July 2015

The S230R Integrase Substitution Associated with Viral Rebound during DTG Monotherapy Confers Low Levels INSTI Drug Resistance.

scientific article published on 29 March 2018

The dual CCR5 and CCR2 inhibitor cenicriviroc does not redistribute HIV into extracellular space: implications for plasma viral load and intracellular DNA decline.

scientific article

Where are we with injectables against HIV infection and what are the remaining challenges?

scientific article published on 19 January 2018

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