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List of works by James A Hoxie

A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein

scientific article

A single amino acid mutation in the envelope cytoplasmic tail restores the ability of an attenuated simian immunodeficiency virus mutant to deplete mucosal CD4+ T cells

scientific article published on 11 September 2013

Adaptive mutations in a human immunodeficiency virus type 1 envelope protein with a truncated V3 loop restore function by improving interactions with CD4.

scientific article

An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serum

scientific article

Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individuals

scientific article

Antigenic conservation and immunogenicity of the HIV coreceptor binding site

scientific article

Blockade of Lymphocyte Chemotaxis in Visceral Graft-versus-Host Disease ⬇️

scientific article published on July 12, 2012

CCR5 interaction with HIV-1 Env contributes to Env-induced depletion of CD4 T cells in vitro and in vivo.

scientific article published on 29 March 2016

CD4 + T Cells Support Production of Simian Immunodeficiency Virus Env Antibodies That Enforce CD4-Dependent Entry and Shape Tropism In Vivo ⬇️

scientific article published on 03 July 2013

Characterization of a human immunodeficiency virus type 1 V3 deletion mutation that confers resistance to CCR5 inhibitors and the ability to use aplaviroc-bound receptor

scientific article published on 04 February 2009

Circulating human CD4 and CD8 T cells do not have large intracellular pools of CCR5

scientific article

DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets

scientific article

DC-SIGN increases the affinity of HIV-1 envelope glycoprotein interaction with CD4.

scientific article

Derivation and Characterization of a CD4-Independent, Non-CD4-Tropic Simian Immunodeficiency Virus

scientific article published on 2 March 2016

Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR

scientific article

Distinct molecular pathways to X4 tropism for a V3-truncated human immunodeficiency virus type 1 lead to differential coreceptor interactions and sensitivity to a CXCR4 antagonist

scientific article

Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption

scientific article

Effects of partial deletions within the human immunodeficiency virus type 1 V3 loop on coreceptor tropism and sensitivity to entry inhibitors

scientific article

Elite Control, Gut CD4 T Cell Sparing, and Enhanced Mucosal T Cell Responses in Macaca nemestrina Infected by a Simian Immunodeficiency Virus Lacking a gp41 Trafficking Motif

scientific article

Elite control of HIV is associated with distinct functional and transcriptional signatures in lymphoid tissue CD8+ T cells

scientific article published on 01 December 2019

Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases

scientific article

Enhanced exposure of the CD4-binding site to neutralizing antibodies by structural design of a membrane-anchored human immunodeficiency virus type 1 gp120 domain

scientific article published on 04 March 2009

Envelope glycoprotein incorporation, not shedding of surface envelope glycoprotein (gp120/SU), Is the primary determinant of SU content of purified human immunodeficiency virus type 1 and simian immunodeficiency virus

scientific article

Extended CCR5 Blockade for Graft-Versus-Host Disease Prophylaxis Improves Outcomes of Reduced Intensity Unrelated Donor Hematopoietic Cell Transplantation: A Phase II Clinical Trial

scientific article published on 10 October 2018

High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses

scientific article (publication date: August 2011)

Human immunodeficiency virus (HIV) envelope binds to CXCR4 independently of CD4, and binding can be enhanced by interaction with soluble CD4 or by HIV envelope deglycosylation.

scientific article

Human immunodeficiency virus type 2 (HIV-2)/HIV-1 envelope chimeras detect high titers of broadly reactive HIV-1 V3-specific antibodies in human plasma

scientific article

Identification of gp120 binding sites on CXCR4 by using CD4-independent human immunodeficiency virus type 2 Env proteins

scientific article

Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression

scientific article

Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structure

scientific article (publication date: 2010)

Mutations in HIV-1 envelope that enhance entry with the macaque CD4 receptor alter antibody recognition by disrupting quaternary interactions within the trimer.

scientific article

Mutations that destabilize the gp41 core are determinants for stabilizing the simian immunodeficiency virus-CPmac envelope glycoprotein complex

scientific article

Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor

scientific article

Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus

scientific article

Public health. A sound rationale needed for phase III HIV-1 vaccine trials

scientific article

Regulation of human immunodeficiency virus type 1 envelope glycoprotein fusion by a membrane-interactive domain in the gp41 cytoplasmic tail

scientific article

Relationship of HIV-1 and SIV envelope glycoprotein trimer occupation and neutralization

scientific article published on 9 June 2008

Replication-competent variants of human immunodeficiency virus type 2 lacking the V3 loop exhibit resistance to chemokine receptor antagonists

scientific article

Selection Pressure on HIV-1 Envelope by Broadly Neutralizing Antibodies to the Conserved CD4-Binding Site ⬇️

scientific article published on March 14, 2012

Simian immunodeficiency virus (SIV)/immunoglobulin G immune complexes in SIV-infected macaques block detection of CD16 but not cytolytic activity of natural killer cells

scientific article

Structure-based identification and neutralization mechanism of tyrosine sulfate mimetics that inhibit HIV-1 entry

scientific article

Three-dimensional structures of soluble CD4-bound states of trimeric simian immunodeficiency virus envelope glycoproteins determined by using cryo-electron tomography

scientific article

Translating social and behavioral science research to the AIDS epidemic: a center for AIDS research perspective

scientific article

Truncation of the cytoplasmic domain induces exposure of conserved regions in the ectodomain of human immunodeficiency virus type 1 envelope protein

scientific article

V3 loop truncations in HIV-1 envelope impart resistance to coreceptor inhibitors and enhanced sensitivity to neutralizing antibodies

scientific article

Vaccine-delivered HIV envelope inhibits CD4(+) T-cell activation, a mechanism for poor HIV vaccine responses

scientific article published on 7 December 2006

Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy-treated macaques

scientific article published on 9 March 2015

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