List of works - Nathalie Grandvaux

1st Workshop of the Canadian Society for Virology

scientific article published on 20 March 2017

2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV.

scientific article published on 12 December 2012

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3.

scientific article published on 24 January 2016

ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities

scientific article published on 09 November 2020

Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity

scientific article

Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression

scientific article

CSV2018: The 2nd Symposium of the Canadian Society for Virology

article

Cell-specific regulation of TRBP1 promoter by NF-Y transcription factor in lymphocytes and astrocytes

scientific article

Convergence of the NF-kappaB and interferon signaling pathways in the regulation of antiviral defense and apoptosis

scientific article published on December 2003

Cryptic O2- -generating NADPH oxidase in dendritic cells

scientific article

DUSP1 regulates apoptosis and cell migration, but not the JIP1-protected cytokine response, during Respiratory Syncytial Virus and Sendai Virus infection

scientific article published on 14 July 2017

DUSP1 regulates apoptosis and cell migration, but not the JIP1-protected cytokine response, during Respiratory Syncytial Virus and Sendai Virus infection.

scientific article published on 12 December 2017

Defective influenza A virus RNA products mediate MAVS-dependent upregulation of human leukocyte antigen class I proteins

scientific article published on 22 April 2020

Detection of IKKε by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis.

scientific article

Distinct antiviral signaling pathways in primary human hepatocytes and their differential disruption by HCV NS3 protease

scientific article published on 27 November 2009

Dual role of NOX2 in respiratory syncytial virus- and sendai virus-induced activation of NF-kappaB in airway epithelial cells

scientific article published in May 2008

Fludarabine downregulates indoleamine 2,3-dioxygenase in tumors via a proteasome-mediated degradation mechanism

scientific article

Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses.

scientific article

HIV-1 selectively targets gut-homing CCR6+CD4+ T cells via mTOR-dependent mechanisms.

scientific article published on 3 August 2017

Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients

scientific article published on 23 August 2007

IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH Oxidase-mediated airway antiviral response

scientific article

IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH oxidase-mediated airway antiviral response.

scientific article published on 2 April 2013

IRF-4 activities in HTLV-I-induced T cell leukemogenesis

scientific article (publication date: 2002)

Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA.

scientific article published on 10 January 2003

Impact of microRNA in normal and pathological respiratory epithelia.

scientific article published in January 2011

Individual interferon regulatory factor-3 thiol residues are not critical for its activation following virus infection

scientific article

Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon

scientific article

Inhibition of transcription of the beta interferon gene by the human herpesvirus 6 immediate-early 1 protein

scientific article published on 21 March 2007

Innate host defense: Nox and Duox on phox's tail

scientific article published on 21 April 2007

Interleukin (IL)-6 Inhibits IL-27- and IL-30-Mediated Inflammatory Responses in Human Monocytes.

scientific article

Involvement of TBK1 and IKKepsilon in lipopolysaccharide-induced activation of the interferon response in primary human macrophages.

scientific article published in February 2007

Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation

scientific article published on October 2006

Lung epithelial NOX/DUOX and respiratory virus infections.

scientific article published on March 2015

Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin β7.

scientific article published on 11 March 2011

Multiple signaling pathways leading to the activation of interferon regulatory factor 3.

scientific article

Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon

scientific article published on August 2006

Pathogen recognition receptor crosstalk in respiratory syncytial virus sensing: a host and cell type perspective.

scientific article published on 9 October 2013

Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association

scientific article published on 13 February 2008

Recognition of the measles virus nucleocapsid as a mechanism of IRF-3 activation

scientific article published on April 2002

Redox-modulating agents target NOX2-dependent IKKε oncogenic kinase expression and proliferation in human breast cancer cell lines

scientific article published on 23 June 2015

Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells

scientific article (publication date: 15 September 2002)

Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response

scientific article published in June 2005

Regulation of human immunodeficiency virus type 1 gene expression by clade-specific Tat proteins.

scientific article

Regulation of normal and cystic fibrosis airway epithelial repair processes by TNF-α after injury.

scientific article published on 9 September 2011

Repression of IRF-4 target genes in human T cell leukemia virus-1 infection

scientific article

Requirement of NOX2 and reactive oxygen species for efficient RIG-I-mediated antiviral response through regulation of MAVS expression

scientific article

Respiratory Syncytial Virus and Cellular Stress Responses: Impact on Replication and Physiopathology

scientific article

Respiratory syncytial virus-mediated NF-kappa B p65 phosphorylation at serine 536 is dependent on RIG-I, TRAF6, and IKK beta

scientific article published on 21 April 2010

STAT2 and IRF9: Beyond ISGF3.

scientific article published on October 2013

Structural basis of STAT2 recognition by IRF9 reveals molecular insights into ISGF3 function

scientific article published on 9 January 2018

Sustained activation of interferon regulatory factor 3 during infection by paramyxoviruses requires MDA5.

scientific article published on 30 April 2014

Synergistic activation of interferon-beta gene transcription by the viral FLICE inhibitory protein of Kaposi's sarcoma-associated herpesvirus and type I IFN activators

scientific article

TNF receptor-associated factor 6 interacts with ALS-linked misfolded superoxide dismutase 1 and promotes aggregation

scientific article published on 06 February 2020

Targeted impairment of innate antiviral responses in the liver of chronic hepatitis C patients

scientific article

The Combination of IFN β and TNF Induces an Antiviral and Immunoregulatory Program via Non-Canonical Pathways Involving STAT2 and IRF9

scientific article published on 17 August 2019

The IKKε kinase in breast cancer: from oncogenesis to treatment resistance

scientific article

The interferon antiviral response: from viral invasion to evasion

scientific article

The ribonucleotide reductase R1 subunits of herpes simplex virus 1 and 2 protect cells against poly(I · C)-induced apoptosis

scientific article

Therapeutic Targeting of RIG-I and MDA5 Might Not Lead to the Same Rome

scientific article published on 31 December 2018

Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes

scientific article

Triggering the interferon antiviral response through an IKK-related pathway

scientific article

Virus Infection Triggers MAVS Polymers of Distinct Molecular Weight.

scientific article published on 30 January 2018

List of works by Nathalie Grandvaux

1st Workshop of the Canadian Society for Virology

2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV.

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3.

ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities

Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity

Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression

CSV2018: The 2nd Symposium of the Canadian Society for Virology

Cell-specific regulation of TRBP1 promoter by NF-Y transcription factor in lymphocytes and astrocytes

Convergence of the NF-kappaB and interferon signaling pathways in the regulation of antiviral defense and apoptosis

Cryptic O2- -generating NADPH oxidase in dendritic cells

DUSP1 regulates apoptosis and cell migration, but not the JIP1-protected cytokine response, during Respiratory Syncytial Virus and Sendai Virus infection

DUSP1 regulates apoptosis and cell migration, but not the JIP1-protected cytokine response, during Respiratory Syncytial Virus and Sendai Virus infection.

Defective influenza A virus RNA products mediate MAVS-dependent upregulation of human leukocyte antigen class I proteins

Detection of IKKε by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis.

Distinct antiviral signaling pathways in primary human hepatocytes and their differential disruption by HCV NS3 protease

Dual role of NOX2 in respiratory syncytial virus- and sendai virus-induced activation of NF-kappaB in airway epithelial cells

Fludarabine downregulates indoleamine 2,3-dioxygenase in tumors via a proteasome-mediated degradation mechanism

Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses.

HIV-1 selectively targets gut-homing CCR6+CD4+ T cells via mTOR-dependent mechanisms.

Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients

IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH Oxidase-mediated airway antiviral response

IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH oxidase-mediated airway antiviral response.

IRF-4 activities in HTLV-I-induced T cell leukemogenesis

Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA.

Impact of microRNA in normal and pathological respiratory epithelia.

Individual interferon regulatory factor-3 thiol residues are not critical for its activation following virus infection

Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon

Inhibition of transcription of the beta interferon gene by the human herpesvirus 6 immediate-early 1 protein

Innate host defense: Nox and Duox on phox's tail

Interleukin (IL)-6 Inhibits IL-27- and IL-30-Mediated Inflammatory Responses in Human Monocytes.

Involvement of TBK1 and IKKepsilon in lipopolysaccharide-induced activation of the interferon response in primary human macrophages.

Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation

Lung epithelial NOX/DUOX and respiratory virus infections.

Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin β7.

Multiple signaling pathways leading to the activation of interferon regulatory factor 3.

Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon

Pathogen recognition receptor crosstalk in respiratory syncytial virus sensing: a host and cell type perspective.

Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association

Recognition of the measles virus nucleocapsid as a mechanism of IRF-3 activation

Redox-modulating agents target NOX2-dependent IKKε oncogenic kinase expression and proliferation in human breast cancer cell lines

Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells

Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response

Regulation of human immunodeficiency virus type 1 gene expression by clade-specific Tat proteins.

Regulation of normal and cystic fibrosis airway epithelial repair processes by TNF-α after injury.

Repression of IRF-4 target genes in human T cell leukemia virus-1 infection

Requirement of NOX2 and reactive oxygen species for efficient RIG-I-mediated antiviral response through regulation of MAVS expression

Respiratory Syncytial Virus and Cellular Stress Responses: Impact on Replication and Physiopathology

Respiratory syncytial virus-mediated NF-kappa B p65 phosphorylation at serine 536 is dependent on RIG-I, TRAF6, and IKK beta

STAT2 and IRF9: Beyond ISGF3.

Structural basis of STAT2 recognition by IRF9 reveals molecular insights into ISGF3 function

Sustained activation of interferon regulatory factor 3 during infection by paramyxoviruses requires MDA5.

Synergistic activation of interferon-beta gene transcription by the viral FLICE inhibitory protein of Kaposi's sarcoma-associated herpesvirus and type I IFN activators

TNF receptor-associated factor 6 interacts with ALS-linked misfolded superoxide dismutase 1 and promotes aggregation

Targeted impairment of innate antiviral responses in the liver of chronic hepatitis C patients

The Combination of IFN β and TNF Induces an Antiviral and Immunoregulatory Program via Non-Canonical Pathways Involving STAT2 and IRF9

The IKKε kinase in breast cancer: from oncogenesis to treatment resistance

The interferon antiviral response: from viral invasion to evasion

The ribonucleotide reductase R1 subunits of herpes simplex virus 1 and 2 protect cells against poly(I · C)-induced apoptosis

Therapeutic Targeting of RIG-I and MDA5 Might Not Lead to the Same Rome

Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes

Triggering the interferon antiviral response through an IKK-related pathway

Virus Infection Triggers MAVS Polymers of Distinct Molecular Weight.