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List of works by Fran Balkwill

10th Biennial Helene Harris Memorial Trust Meeting

scientific article published on 01 March 2006

2',5'-Oligoadenylate synthetase and interferon in peripheral blood after rubella, measles, or mumps live virus vaccine.

scientific article published in October 1987

A CYTOKINE PROFILE OF NORMAL AND MALIGNANT OVARY

scientific article published on 01 July 1996

A Strong B-cell Response Is Part of the Immune Landscape in Human High-Grade Serous Ovarian Metastases

scientific article published on 27 June 2016

A chemokine receptor antagonist inhibits experimental breast tumor growth

scientific article published on 01 December 2003

A clinical study assessing the tolerability and biological effects of infliximab, a TNF-α inhibitor, in patients with advanced cancer

scientific article published on 05 March 2008

A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment

scientific article published on 7 November 2011

A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors.

scientific article

A modified medium that significantly improves the growth of human normal ovarian surface epithelial (OSE) cells in vitro.

scientific article published in July 2004

A multicentre phase II trial of bryostatin-1 in patients with advanced renal cancer.

scientific article published on October 2003

A novel function of colony-stimulating factor 1 receptor in hTERT immortalization of human epithelial cells

scientific article

A paralytic disease in nude mice associated with polyoma virus infection

scientific article published in January 1983

A phase I study of human lymphoblastoid interferon administered by continuous intravenous infusion

scientific article published on 01 January 1982

A phase I study of human lymphoblastoid interferon in patients with hematological malignancies

scientific article published on 01 January 1981

A phase II study of etanercept (Enbrel), a tumor necrosis factor alpha inhibitor in patients with metastatic breast cancer.

scientific article published on October 2004

A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts

scientific article published on 01 May 1993

A trial of human alpha interferon as an adjuvant agent in breast cancer after loco-regional recurrence

scientific article published on 01 October 1987

Aberrant regulation of argininosuccinate synthetase by TNF-alpha in human epithelial ovarian cancer

scientific article published on July 2007

Action of recombinant alpha interferon against experimental and spontaneous metastases in a murine model

article

Activity of human monocytes in IgE antibody-dependent surveillance and killing of ovarian tumor cells.

scientific article

Activity of type IV collagenases in benign and malignant breast disease

scientific article

Adaptive Upregulation of EGFR Limits Attenuation of Tumor Growth by Neutralizing IL6 Antibodies, with Implications for Combined Therapy in Ovarian Cancer

scientific article

An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells

scientific article

An anti-tumor necrosis factor-alpha antibody inhibits the development of experimental skin tumors

scientific article published in May 2003

An autoimmune aetiology for hypothyroidism following interferon therapy for breast cancer

scientific article published on 01 August 1988

An inflammatory link

scientific article published in Nature

Analysis of CC chemokine and chemokine receptor expression in solid ovarian tumours

scientific article published on September 2001

Analysis of chemokines and chemokine receptor expression in ovarian cancer ascites.

scientific article published in April 2002

Antiproliferative and antitumor activity of TNF in vitro and in vivo.

scientific article

Antitumor activity of gamma-interferon in ascitic and solid tumor models of human ovarian cancer ⬇️

scientific article published on December 15, 1991

Antiviral and antiproliferative effects of interferons in quiescent fibroblasts are dissociable

scientific article published on December 1985

Assessing new anti-tumour agents and strategies in oncogene transgenic mice

scientific article published on June 1995

Association between biosynthesis of nitric oxide and changes in immunological and vascular parameters in patients treated with interleukin-2

scientific article published on 01 April 1994

Augmentation of cytotoxicity of chemotherapy by human alpha-interferons in human non-small cell lung cancer xenografts

scientific article

B regulatory cells and the tumor-promoting actions of TNF-α during squamous carcinogenesis

scientific article

B regulatory cells in cancer ⬇️

scientific article published on December 1, 2012

Barrett's metaplasia

scientific article published in The Lancet

Beta actin expression and organization of actin filaments in colorectal neoplasia

scientific article published on July 1, 1992

Bortezomib therapy in patients with relapsed or refractory lymphoma: potential correlation of in vitro sensitivity and tumor necrosis factor alpha response with clinical activity

scientific article

CANCER: Sex, Cytokines, and Cancer

scientific article published in Science

CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma

scientific article published on 16 August 2016

CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma

scientific article

Cancer and inflammation: implications for pharmacology and therapeutics

scientific article published on 03 March 2010

Cancer and the chemokine network

scientific article

Cancer cell-derived lymphotoxin mediates reciprocal tumour-stromal interactions in human ovarian cancer by inducing CXCL11 in fibroblasts

scientific article published on January 2014

Cancer-related inflammation

scientific article (publication date: 24 July 2008)

Cancer-related inflammation: Common themes and therapeutic opportunities ⬇️

scientific article published on December 24, 2011

Cells secreting tumour necrosis factor show enhanced metastasis in nude mice

scientific article published on 01 January 1990

Central nervous system toxicity of interferon

scientific article published on March 1983

Central nervous system toxicity of interferon

scientific article published in January 1985

Centre of the Cell: Science Comes to Life

scientific article published on 4 September 2015

Changes in endogenous cytokines, adhesion molecules and platelets during cytokine-induced tumour necrosis.

scientific article

Characterization of human breast milk macrophages cytostatic for human cell lines

scientific article published on October 1979

Chemokine biology in cancer.

scientific article

Chemokine stimulation of monocyte matrix metalloproteinase-9 requires endogenous TNF-alpha

scientific article published on February 2002

Chemotherapy, immunity and microbiota--a new triumvirate?

scientific article published on February 2014

Combination antiangiogenesis therapy with marimastat, captopril and fragmin in patients with advanced cancer

scientific article (publication date: 5 July 2004)

Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice

scientific article published on 7 November 2011

Current research and treatment for epithelial ovarian cancer. A Position Paper from the Helene Harris Memorial Trust

scientific article published in September 2003

Cytokine amplification and inhibition of immune and inflammatory responses ⬇️

scientific article published on January 1, 1997

Cytokine therapy of cancer. The importance of knowing the context

scientific article published on July 1994

Cytokines in Hemopoiesis, Oncology, and Immunology III.

scientific article

Cytokines in animal models of cancer

scientific article published on January 1996

Cytokines in health and disease

article

Cytokines in tumour growth, migration and metastasis

scientific article published on January 1996

DNA fragmentation and cytotoxicity caused by tumor necrosis factor is enhanced by interferon-gamma

scientific article published in May 1987

Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma

scientific article

Demyelination and wasting associated with polyomavirus infection in nude (nu/nu) mice

scientific article published on 01 October 1980

Diagnostic and prognostic significance of peripheral blood cultural characteristics in adult acute leukaemia ⬇️

scientific article published on April 1, 1976

Differential action of six human interferons against two human carcinomas growing in nude mice

scientific article published on 01 May 1985

Differential effects of pure human alpha and gamma interferons on fibroblast cell growth and the cell cycle

scientific article published on 01 November 1984

Differential effects of recombinant interferon α on constitutive and inducible cytochrome P450 isozymes in mouse liver

scientific article published on 01 July 1991

EVIDENCE FOR TUMOUR NECROSIS FACTOR/CACHECTIN PRODUCTION IN CANCER

scientific article published in The Lancet

Effect of steroid hormones on human colorectal adenocarcinoma xenografts, of known steroid-receptor status, in nude mice

scientific article published on 01 January 1989

Effects of HuIFN-α2 and HuIFN-α (Namalwa) on Breast Cancer Cells Grown in Culture and as Xenografts in the Nude Mouse

article

Effects of interferons and other cytokines on tumors in animals: a review.

scientific article published on December 1991

Effects of mouse interferon on human tumour xenografts in the nude mouse host

scientific article published on 01 September 1986

Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer.

scientific article published on 03 July 2013

Endothelin-2 is a hypoxia-induced autocrine survival factor for breast tumor cells

scientific article published on 01 December 2002

Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteases

scientific article published on 25 March 2004

Enhanced metastases of a mouse carcinoma after in vitro treatment with murine interferon gamma.

scientific article

Enhancement by gamma-interferon of in vivo tumor radiolocalization by a monoclonal antibody against HLA-DR antigen

scientific article published on 01 December 1986

Enhancement of metastatic potential by gamma-interferon

scientific article

Epithelial cancer cell migration: a role for chemokine receptors?

scientific article

Epithelial ovarian cancer: a cytokine propelled disease?

scientific article published on October 1991

Experience with human lymphoblastoid interferon in acute myelogenous leukaemia (AML)

scientific article published on 01 January 1983

Experimental validation of a flat punch indentation methodology calibrated against unconfined compression tests for determination of soft tissue biomechanics.

scientific article

Expression and activity of MMPS and their regulators in ovarian cancer

scientific article published on 01 July 1994

Expression and regulation of tumor necrosis factor alpha in normal and malignant ovarian epithelium

scientific article published on February 2006

Expression of both TNF-alpha receptor subtypes is essential for optimal skin tumour development

scientific article

Expression of tumour necrosis factor (TNFα) and its receptors in benign and malignant breast tissue

scientific article published on 01 March 1994

Extracts from the last century. Mechanical dentistry--on regulation cases by F.H. Balkwill

scientific article published in July 1981

Factors influencing microculture of leukaemia cells

scientific article published in Nature

Foreword

Fran Balkwill

scientific article published in April 2005

Fusion potential for vaccines

scientific article published in Nature

Future prospects and problems.

scientific article

Growth inhibitory effects of interferon on normal and malignant human haemopoietic cells

scientific article

Growth of acute myeloid leukaemia as discrete subcutaneous tumours in immune-deprived mice ⬇️

scientific article published on May 1, 1977

Human T-lymphotropic virus type 1-induced CC chemokine ligand 22 maintains a high frequency of functional FoxP3+ regulatory T cells.

scientific article published on 4 June 2010

Human interferon inhibits the growth of established human breast tumours in the nude mouse

scientific article published on 01 August 1982

Human interferons inhibit experimental metastases of a human melanoma cell line in nude mice

scientific article

Human lymphoblastoid interferon can inhibit the growth of human breast cancer xenografts in athymic (nude) mice

scientific article published on 01 April 1980

Human ovarian surface epithelial cells immortalized with hTERT maintain functional pRb and p53 expression.

scientific article

Human small-cell lung-cancer cells are cytokine-resistant but NK/LAK-sensitive

scientific article

Human tumor xenografts treated with recombinant human tumor necrosis factor alone or in combination with interferons

scientific article published on 01 August 1986

Hypoxia down-regulates MCP-1 expression: implications for macrophage distribution in tumors.

scientific article published on June 1998

Hypoxia inhibits macrophage migration

scientific article published on July 1999

IFN-gamma induces apoptosis in ovarian cancer cells in vivo and in vitro

scientific article published on 01 July 2003

IL-12 regulates VEGF and MMPs in a murine breast cancer model

scientific article published on October 1998

IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer

scientific article published on 22 February 2011

INTERFERONS IN CANCER THERAPY: A REAPPRAISAL

scientific article published in The Lancet

IgE-antibody-dependent immunotherapy of solid tumors: cytotoxic and phagocytic mechanisms of eradication of ovarian cancer cells.

scientific article published on September 2007

Immunology for the next generation.

scientific article

Implications for clinical application of new developments in interferon research

scientific article published on 01 September 1982

Improving on the formula

scientific article published in Nature

In situ detection of tumour necrosis factor in human ovarian cancer specimens

scientific article published on 01 January 1990

In vivo loss of expression of argininosuccinate synthetase in malignant pleural mesothelioma is a biomarker for susceptibility to arginine depletion

scientific article published on December 2006

Induction and suppression of glutathione transferases by interferon in the mouse.

scientific article

Induction of soluble tumour necrosis factor receptors during treatment with interleukin-2.

scientific article published on December 1992

Inflammation and cancer: a double-edged sword.

scientific article published on October 2007

Inflammation and cancer: advances and new agents

scientific article published on 30 June 2015

Inflammation and cancer: back to Virchow?

scientific article (publication date: 17 February 2001)

Inflammatory cytokine tumor necrosis factor alpha confers precancerous phenotype in an organoid model of normal human ovarian surface epithelial cells

scientific article published on June 2009

Inhibition by lymphoblastoid interferon of growth of cells derived from the human breast

scientific article published on 01 September 1978

Inhibition of the inflammatory cytokine TNF-α increases adenovirus activity in ovarian cancer via modulation of cIAP1/2 expression

scientific article

Integrated transcriptomic and proteomic analysis identifies protein kinase CK2 as a key signaling node in an inflammatory cytokine network in ovarian cancer cells

scientific article published on 08 February 2016

Interferon affects both G1 and S+G2 in cells stimulated from quiescence to growth

scientific article published in August 1978

Interferon gamma induces cell cycle arrest and apoptosis in a model of ovarian cancer: Enhancement of effect by batimastat

scientific article published on 01 June 1997

Interferon gamma regulates HLA-D expression on solid tumors in vivo

scientific article published on 01 January 1987

Interferon in acute myelogenous leukaemia: a preliminary report

scientific article published on 01 January 1983

Interferons

scientific article published in The Lancet

Interferons alpha and gamma differ in their ability to cause tumour stasis and regression in vivo

scientific article published in October 1989

Interferons and cytokines on a grand scale

scientific article

Interferons in oncology: current status and future directions

scientific article published on June 1987

Interferons: from molecular biology to man. Part 2. Interferons and cell function.

scientific article published on August 1986

Interferons: from molecular biology to man. Part 3. Interferons and disease.

scientific article published on September 1986

Interleukin-6 Stimulates Defective Angiogenesis

scientific article published on 16 June 2015

Interleukin-6 as a therapeutic target in human ovarian cancer

scientific article

Intraperitoneal xenografts of human epithelial ovarian cancer in nude mice

scientific article published in May 1987

Involvement of both intrinsic and extrinsic pathways in IFN-gamma-induced apoptosis that are enhanced with cisplatin

scientific article published on July 2005

Levels of matrix metalloproteases in bladder cancer correlate with tumor grade and invasion

scientific article

Low-dose IFN-gamma induces tumor MHC expression in metastatic malignant melanoma

scientific article published in January 2003

MIFed About Cancer?

scientific article published on 01 November 2005

MMP-2 release and activation in ovarian carcinoma: the role of fibroblasts.

scientific article published on May 1999

Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK.

scientific article published on July 2005

Making sense

Making small talk

journal article; published in Nature on 2005-06-29

Matrix metalloprotease 2 (MMP-2) and matrix metalloprotease 9 (MMP-9) type IV collagenases in colorectal cancer

scientific article published on 01 January 1996

Measuring cytokine levels in blood

scientific article published on 01 August 1992

Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis

scientific article published in July 1999

Monoclonal antibodies that distinguish between subspecies of human interferon-alpha and that detect interferon oligomers

scientific article published on 01 December 1984

Morphological characterisation of adult acute leukaemia in short-term liquid culture

scientific article published on January 1, 1976

Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer

scientific article published on October 2002

Multiple molecular and cellular changes associated with tumour stasis and regression during IL-12 therapy of a murine breast cancer model

scientific article published on 01 January 1998

Multiple myeloma: An immunoclinical study of disease and response to treatment

scientific article published on 01 March 1995

Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages

scientific article

Neoadjuvant Chemotherapy Modulates the Immune Microenvironment in Metastases of Tubo-Ovarian High-Grade Serous Carcinoma.

scientific article published in June 2016

Neoplastic macrophages grown from human leukaemic monocytes

scientific article published in May 1977

Oncogene transgenic mice as therapeutic models in cancer research

scientific article published on 01 January 1994

Ovarian cancer cell-derived migration inhibitory factor enhances tumor growth, progression, and angiogenesis

scientific article

PRIMARY HYPOTHYROIDISM ASSOCIATED WITH INTERFERON THERAPY OF BREAST CANCER

scientific article published in The Lancet

Paradoxical effects of tumour necrosis factor in experimental ovarian cancer

scientific article published on 01 November 1989

Paraneoplastic thrombocytosis in ovarian cancer.

scientific article published on February 2012

Phase I study of bryostatin 1: assessment of interleukin 6 and tumor necrosis factor alpha induction in vivo. The Cancer Research Campaign Phase I Committee

scientific article

Positive interactions between human interferon and cyclophosphamide or adriamycin in a human tumor model system

scientific article published on 01 March 1984

Positive interactions between interferon and chemotherapy due to direct tumor action rather than effects on host drug-metabolizing enzymes

scientific article published on 01 November 1984

Preclinical and clinical studies of interferons and interferon inducers in breast cancer

scientific article published on 01 February 1984

REMISSION IN ACUTE MYELOBLASTIC LEUKÆMIA

scientific article published in The Lancet

RalB signaling: a bridge between inflammation and cancer

scientific article published on October 2006

Re: Possible Role of Ovarian Epithelial Inflammation in Ovarian Cancer

scientific article published on 01 January 2000

Recombinant DNA human interferon alpha 2 in advanced breast cancer: a phase 2 trial

scientific article

Reconstitution of interleukin 2 with albumin for infusion

scientific article published in June 1990

Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma

scientific article published on 8 June 2016

Regulation of monocyte MMP-9 production by TNF-α and a tumour-derived soluble factor (MMPSF) ⬇️

scientific article published on September 1, 1998

Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer

scientific article

Rethinking ovarian cancer: recommendations for improving outcomes

scientific article

Role of IgE receptors in IgE antibody-dependent cytotoxicity and phagocytosis of ovarian tumor cells by human monocytic cells.

scientific article

Safety of medicines and the use of animals in research

scientific article published in The Lancet

Sequential genetic change at the TP53 and chemokine receptor CXCR4 locus during transformation of human ovarian surface epithelium.

scientific article

Smoldering and polarized inflammation in the initiation and promotion of malignant disease

scientific article (publication date: March 2005)

Species restriction in cytostatic activity of human and murine monocytes and macrophages

scientific article published on 01 May 1981

Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers

scientific article

Study of etanercept, a tumor necrosis factor-alpha inhibitor, in recurrent ovarian cancer

scientific article

THE role of indoleamine 2,3-dioxygenase in the anti-tumour activity of human interferon-γin vivo

scientific article published on 01 January 1995

TNF is here to stay!

scientific article published on 01 October 2000

TNF-alpha in promotion and progression of cancer

scientific article published on September 2006

TNF-alpha regulates epithelial expression of MMP-9 and integrin alphavbeta6 during tumour promotion. A role for TNF-alpha in keratinocyte migration?

scientific article

TNF: a tumor-suppressing factor or a tumor-promoting factor?

scientific article

The anti-cancer activity of tumour necrosis factor.

scientific article published on May 1988

The chemokine network in cancer--much more than directing cell movement

scientific article published in January 2004

The chemokine system and cancer.

scientific article

The cytokine network

scientific article published on September 1989

The cytokine wall chart

scientific article

The effect of cytokines on cultured mononuclear cells from patients with B cell chronic lymphocytic leukemia

scientific article published on 01 January 1993

The effect of interferon on experimental metastases in immunocompetent and immunodeficient mice

scientific article published in April 1986

The effect of recombinant human tumour necrosis factor on growth and macromolecular synthesis of human epithelial cells

scientific article published in June 1987

The inflammatory cytokine network of epithelial cancer: therapeutic implications.

scientific article published on January 2004

The inflammatory cytokine tumor necrosis factor-alpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cells

scientific article published on January 2007

The inflammatory cytokine tumor necrosis factor-alpha regulates chemokine receptor expression on ovarian cancer cells

scientific article published on November 2005

The molecular and cellular biology of the chemokines ⬇️

scientific article published on January 1, 1998

The peritoneal tumour microenvironment of high-grade serous ovarian cancer.

scientific article published on 18 April 2012

The ppp(A2'p)nA and protein kinase systems in wild-type and interferon-resistant Daudi cells

scientific article

The role of cytokines in the epithelial cancer microenvironment.

scientific article

The significance of cancer cell expression of the chemokine receptor CXCR4.

scientific article published in June 2004

The tumor microenvironment at a glance.

scientific article

The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans

scientific article published on 08 September 2009

Toxicity and reconstitution of recombinant interleukin-2 with albumin

scientific article published in The Lancet

Translating science in more ways than one: an interview with Frances Balkwill ⬇️

scientific article published on May 1, 2011

Translation manual

scientific article published in Nature

Tumor Necrosis Factor α As a New Target for Renal Cell Carcinoma: Two Sequential Phase II Trials of Infliximab at Standard and High Dose

scientific article published on 01 October 2007

Tumor necrosis factor or tumor promoting factor?

scientific article

Tumour necrosis factor

scientific article

Tumour necrosis factor alpha: a potential target for the therapy of solid tumours.

scientific article

Tumour necrosis factor and cancer

scientific article published on 03 April 2009

Tumour necrosis factor-alpha mediates tumour promotion via a PKC alpha- and AP-1-dependent pathway

scientific article

Use of interferon in the management of patients with subacute sclerosing panencephalitis

scientific article published on April 1985

Zymography: a single-step staining method for quantitation of proteolytic activity on substrate gels

scientific article published in June 1997

[85] Animal models for investigating antitumor effects of interferon

scientific article published on 01 January 1986

p21 Promotes oncolytic adenoviral activity in ovarian cancer and is a potential biomarker

scientific article

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