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List of works by Rachel Thijssen

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia

scientific article published on 04 December 2018

CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex.

scientific article published on 29 August 2013

Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia.

scientific article

Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma

scientific article published on 19 November 2018

IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells.

scientific article published on 6 September 2013

Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma

scientific article published on 26 November 2019

Resistance to ABT-199 induced by microenvironmental signals in chronic lymphocytic leukemia can be counteracted by CD20 antibodies or kinase inhibitors.

scientific article published on 8 May 2015

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations

scientific article published on 03 June 2019

Targeting antigen-independent proliferation in chronic lymphocytic leukemia through differential kinase inhibition.

scientific article published on 2 May 2017

The pan phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor SAR245409 (voxtalisib/XL765) blocks survival, adhesion and proliferation of primary chronic lymphocytic leukemia cells.

scientific article published on 4 September 2015

Venetoclax in Lymphoid Malignancies: New Insights, More to Learn

scientific article published on 01 October 2019

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