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List of works by Zofia Tylutki

A four-compartment PBPK heart model accounting for cardiac metabolism - model development and application

scientific article published on 04 January 2017

Abnormal olanzapine toxicokinetic profiles--population pharmacokinetic analysis.

scientific article published on 21 October 2014

Better prediction of the local concentration-effect relationship: the role of physiologically based pharmacokinetics and quantitative systems pharmacology and toxicology in the evolution of model-informed drug discovery and development

scientific article published on 24 May 2019

CardiacPBPK: A tool for the prediction and visualization of time-concentration profiles of drugs in heart tissue

scientific article published on 07 October 2019

Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials

scientific article

How circadian variability of the heart rate and plasma electrolytes concentration influence the cardiac electrophysiology - model-based case study

scientific article published in June 2021

Humans Vary, So Cardiac Models Should Account for That Too!

scientific article

Mechanistic Physiologically Based Pharmacokinetic (PBPK) Model of the Heart Accounting for Inter-individual Variability: Development and Performance Verification

scientific article published on 23 November 2017

Model of the distribution of diastolic left ventricular posterior wall thickness in healthy adults and its impact on the behavior of a string of virtual cardiomyocytes

scientific article

Physiologically based pharmacokinetic-quantitative systems toxicology and safety (PBPK-QSTS) modeling approach applied to predict the variability of amitriptyline pharmacokinetics and cardiac safety in populations and in individuals

scientific article published on 25 June 2018

Plasma vs heart tissue concentration in humans - literature data analysis of drugs distribution

scientific article

Thorough QT (TQT) studies: concordance with torsadogenesis and an evolving cardiac safety testing paradigm

scientific article published on 13 May 2017

Top-down, Bottom-up and Middle-out Strategies for Drug Cardiac Safety Assessment via Modeling and Simulations

scientific article

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