Search filters

List of works by Paul I W de Bakker

52 Genetic Loci Influencing Myocardial Mass

scientific article

A High Density Association Study of the Extended Major Histocompatibility Locus in Ulcerative Colitis

article published in 2007

A genome-wide association study of marginal zone lymphoma shows association to the HLA region

scientific article

A large-scale genetic analysis reveals a strong contribution of the HLA class II region to giant cell arteritis susceptibility ⬇️

scientific article

A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach

scientific article

A reference panel of 64,976 haplotypes for genotype imputation

scientific article

A second generation human haplotype map of over 3.1 million SNPs

scientific article

Abstract 5072: Meta-analysis of genome-wide association studies identifies novel susceptibility loci for follicular lymphoma

Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis

scientific article published on December 2011

Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics

scientific article

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

scientific article

Association of common variation in the HNF1alpha gene region with risk of type 2 diabetes

scientific article published on 01 August 2005

Association testing of variants in the hepatocyte nuclear factor 4alpha gene with risk of type 2 diabetes in 7,883 people

scientific article published on 01 March 2005

Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes

C9orf72 and UNC13A are shared risk loci for amyotrophic lateral sclerosis and frontotemporal dementia: a genome-wide meta-analysis

scientific article

Coding variants at hexa-allelic amino acid 13 of HLA-DRB1 explain independent SNP associations with follicular lymphoma risk

scientific article published on 20 June 2013

Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations

scientific article

Common mitochondrial sequence variants in ischemic stroke

scientific article

Common variants at 30 loci contribute to polygenic dyslipidemia

scientific article

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

scientific article

Common variants in KCNN3 are associated with lone atrial fibrillation

scientific article

Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia.

scientific article

Comprehensive association testing of common mitochondrial DNA variation in metabolic disease

scientific article

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies

scientific article

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study

scientific article

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

ERRATUM: Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

article by Matthew B. Lanktree et al published June 2012 in American Journal of Human Genetics

Efficiency and power in genetic association studies

scientific article

Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk

scientific article published on 2 August 2017

Evaluating and improving power in whole-genome association studies using fixed marker sets.

scientific article published on 21 May 2006

Exome sequencing and the genetic basis of complex traits

scientific article published on 29 May 2012

Exome-chip association analysis of intracranial aneurysms

scientific article published on 15 November 2019

Extremely low-coverage sequencing and imputation increases power for genome-wide association studies

scientific article published on 20 May 2012

Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease

scientific article published on 20 April 2015

Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity.

scientific article published on 20 March 2014

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

scientific article

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci

scientific article published on 20 February 2014

Genetic Susceptibility Loci for Cardiovascular Disease and Their Impact on Atherosclerotic Plaques

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

scientific article

Genetic loci associated with heart rate variability and their effects on cardiac disease risk

scientific article

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

scientific article

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies

scientific article published on 5 October 2012

Genetic risk scores and number of autoantibodies in patients with rheumatoid arthritis

scientific article published on 13 December 2013

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genetic variation at 16q24.2 is associated with small vessel stroke

scientific article

Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes

scientific article

Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

scientific article

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

scientific article published on 25 July 2016

Genome-wide association analysis identifies multiple loci related to resting heart rate

scientific article

Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits

scientific article published on 24 January 2019

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region

scientific article published in October 2014

Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

scientific article

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

scientific article

Genome-wide detection and characterization of positive selection in human populations

scientific article

Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility

scientific article published on 23 April 2015

Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci

scientific article

Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci

scientific article published on 22 January 2015

Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region

scientific article published in May 2004

Haplotype structures and large-scale association testing of the 5' AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB2 [corrected] with type 2 diabetes

scientific article published in March 2006

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

scientific article

High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people

scientific article published in January 2006

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

scientific article published on 14 April 2013

Impact of carotid atherosclerosis loci on cardiovascular events

scientific article published on 19 October 2015

Improved imputation quality of low-frequency and rare variants in European samples using the 'Genome of The Netherlands'.

scientific article published on 4 June 2014

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

scientific article published on 14 March 2012

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci

scientific article

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci

scientific article

Loci influencing blood pressure identified using a cardiovascular gene-centric array

scientific article published on 8 January 2013

Loci influencing blood pressure identified using a cardiovascular gene-centric array.

scientific article

Low frequency and rare coding variation contributes to multiple sclerosis risk

Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases

scientific article published on 21 October 2009

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci ⬇️

scientific article

Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12.

scientific article

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

scientific article

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

scientific article

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

scientific article

Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci

scientific journal article

Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data

scientific article

Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect

scientific article

Negative selection in humans and fruit flies involves synergistic epistasis.

scientific article

No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis

scientific article

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

scientific article published in Nature Communications

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

article

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

scientific article (publication date: 11 August 2012)

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 22 December 2017

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

article

Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

scientific article published on 01 July 2019

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 16 March 2018

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 01 July 2019

Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control

scientific article

Rare and low-frequency coding variants alter human adult height

scientific article (publication date: February 2017)

STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus

scientific article published on September 2007

Seventy-five genetic loci influencing the human red blood cell

scientific article published on 5 December 2012

Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms

scientific article published on 14 July 2016

Stroke Genetics Network (SiGN) study: design and rationale for a genome-wide association study of ischemic stroke subtypes

scientific article

The Genome of the Netherlands: design, and project goals

scientific article (publication date: February 2014)

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

The Multiple Sclerosis Genomic Map: Role of peripheral immune cells and resident microglia in susceptibility

scholarly article published 13 July 2017

The role of the CD58 locus in multiple sclerosis

scientific article

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

scientific article published on 12 September 2016

Transferability of tag SNPs in genetic association studies in multiple populations

scientific article published on 22 October 2006

Two independent alleles at 6q23 associated with risk of rheumatoid arthritis

scientific article

Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: the Athero-Express Genomics Study

scientific article published on 20 January 2015

Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases

scientific article

Paulina is supported by:

About Paulina

Help