List of works - Timothy J Purwin

An In Vivo Reporter to Quantitatively and Temporally Analyze the Effects of CDK4/6 Inhibitor-Based Therapies in Melanoma

scientific article published on 3 August 2016

BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors

scientific article published on 18 November 2020

CADM1 is a TWIST1-regulated suppressor of invasion and survival

scientific article published on 25 March 2019

Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma

scientific article published on 30 January 2017

ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma.

scientific article published on 2 January 2018

Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal Melanoma

scientific article published on 19 December 2018

ErbB3 Targeting Enhances the Effects of MEK Inhibitor in Wild-Type BRAF/NRAS Melanoma

scientific article published on 16 August 2018

FXYD5 is a Marker for Poor Prognosis and a Potential Driver for Metastasis in Ovarian Carcinomas.

scientific article published on 12 October 2015

In Vivo E2F Reporting Reveals Efficacious Schedules of MEK1/2-CDK4/6 Targeting and mTOR-S6 Resistance Mechanisms.

scientific article published in March 2018

In Vivo ERK1/2 Reporter Predictively Models Response and Resistance to Combined BRAF and MEK Inhibitors in Melanoma

scientific article published on 03 July 2019

MIG6 Is MEK Regulated and Affects EGF-Induced Migration in Mutant NRAS Melanoma.

scientific article published on 20 November 2015

Metabolic adaptations to MEK and CDK4/6 co-targeting in uveal melanoma

scientific article published on 19 May 2020

Murine Cytomegalovirus Infection of Melanoma Lesions Delays Tumor Growth by Recruiting and Repolarizing Monocytic Phagocytes in the Tumor

scientific article published on 30 September 2019

Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis

scientific article published on 03 December 2019

Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma

scientific article published on 20 January 2022

RAC1 P29S regulates PD-L1 expression in melanoma.

scientific article

SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects

scientific article published on 01 December 2021

Stromal fibroblast growth factor 2 reduces the efficacy of bromodomain inhibitors in uveal melanoma

scientific article published on 01 February 2019

Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma

scientific article published on 16 March 2022

The next-generation BET inhibitor, PLX51107, delays melanoma growth in a CD8-mediated manner

scientific article published on 20 May 2019

List of works by Timothy J Purwin